Abstract: The present invention relates to a permanent shaping composition for the permanent deformation of hair comprising, in a cosmetically acceptable carrier, at least one reducing agent comprising a mercapto functional group, at least one alkalizing agent, and a malodor suppressant system comprising at least a first malodor suppressant, herein the first malodor suppressant has a molecular weight of from 100 to 400 g/mol, and wherein the malodor suppressant system has a distribution coefficient log P (octanol/water) of 2 or more.

Abstract: The present invention relates to a hair colouring and/or bleaching composition comprising at least a first aqueous component (i) and a second aqueous component (ii) being mixed prior to application onto hair, wherein the first aqueous component (i) comprises, in a cosmetically acceptable carrier one or more oxidizing agent(s), and the second aqueous component (ii) comprises, in a cosmetically acceptable carrier, one or more alkalizing agent(s) selected from the group consisting of ammonia, its salts and mixtures thereof wherein the first component (i) or the second component (ii) or both comprise at least a first and a second malodor suppressant and optionally one or more further malodor suppressants, or the first component (i) comprises at least a first malodor suppressant and the second component (ii) comprises at least a second malodor suppressant, the first and the second malodor suppressant and any further malodor suppressant forming a malodor suppressant system in the hair colouring and/or bleaching com

Abstract: The invention relates to a hair colouring and/or bleaching composition comprising at least a first aqueous component (i) and a second aqueous component (ii) being mixed prior to application onto hair, wherein the first component (i) or the second component (ii) or both components (i) and (ii) comprise a gel-network system consisting of multi-lamellar sheets and vesicles with d-spacing (interlayer spacing between sheets) between 5 nm and 50 nm, preferably 10 nm to 30 nm, more preferred 15 nm to 25 nm as measured by Small Angle X-Ray Scattering (SAXS), and the first component (i) or the second component (ii) or both comprise at least a first malodor suppressant being a compound having a distribution coefficient log P of 2 or more and a molecular weight of between 100 and 400, a method for coloring or bleaching hair, a kit comprising the above components and the use of the described hair coloring composition for colouring and/or bleaching hair with a reduced or eliminated ammonia odour.

Abstract: The present invention relates to methods for predicting the efficacy of anthracycline-based neo-adjuvant chemotherapy in triple-negative breast cancer. This is achieved by determining epigenetic changes within the PITX2 gene. Detection of the methylation state of Cp G sites in a genomic sequence of PITX2 allows an estimate of the response or failure of an individual breast cancer patient to neo-adjuvant therapy.

Abstract: The present invention relates to a method for predicting a breast cancer patient's response to anthracycline treatment.

Abstract: A method for colouring hair, wherein the method comprises: (i) the formation of a first plurality of coated hair fibre portions, wherein the coating comprises a first composition, wherein the first composition comprises a first hair colouring agent, a hydrophobic phase, a hydrophilic phase, a surfactant, and a thickener capable of interacting with the hydrophobic phase and the hydrophilic phase; and subsequently (ii) styling the hair wherein the first plurality of coated hair fibre portions is contacted with a second plurality of hair fibre portions; wherein the method does not comprise the application of a solid barrier means in order to separate the first plurality of coated hair fibre portions from the second plurality of hair fibre portions, and wherein the first composition is substantially free of persulfate.

Abstract: The present invention relates to methods for predicting the efficacy of anthracycline-based neo-adjuvant chemotherapy in triple-negative breast cancer. This is achieved by determining epigenetic changes within the PITX2 gene. Detection of the methylation state of Cp G sites in a genomic sequence of PITX2 allows an estimate of the response or failure of an individual breast cancer patient to neo-adjuvant therapy.

Abstract: The present invention relates to methods for determining a treatment regimen beyond surgical removal of tumor tissue for node negative or node positive breast cancer patient. The method comprises measuring the levels of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in a subject, preferably a tumor; and, based upon the values, predicting the expected benefit including disease-free survival and/or overall survival for the patient without treatment (beyond the surgical removal of tumor tissue) or with a particular treatment and using that information to select a treatment regimen for the subject. High risk subject is identified by high levels of both uPA and PAI-1, high level of uPA and low level of PAI-1 or, low level of uPA and high level of PAI-1.

Abstract: The invention relates to a hair colouring and/or bleaching composition comprising at least a first aqueous component (i) and a second aqueous component (ii) being mixed prior to application onto hair, wherein the first component (i) or the second component (ii) or both components (i) and (ii) comprise a gel-network system consisting of multi-lamellar sheets and vesicles with d-spacing (interlayer spacing between sheets) between 5 nm and 50 nm, preferably 10 nm to 30 nm, more preferred 15 nm to 25 nm as measured by Small Angle X-Ray Scattering (SAXS), and the first component (i) or the second component (ii) or both comprise at least a first malodor suppressant being a compound having a distribution coefficient logP of 2 or more and a molecular weight of between 100 and 400, a method for coloring or bleaching hair, a kit comprising the above components and the use of the described hair coloring composition for colouring and/or bleaching hair with a reduced or eliminated ammonia odour.

Abstract: The present invention relates to a permanent shaping composition for the permanent deformation of hair comprising, in a cosmetically acceptable carrier, at least one reducing agent comprising a mercapto functional group, at least one alkalizing agent, and a malodor suppressant system comprising at least a first malodor suppressant, herein the first malodor suppressant has a molecular weight of from 100 to 400 g/mol, and wherein the malodor suppressant system has a distribution coefficient log P (octanol/water) of 2 or more.

Abstract: The present invention relates to a hair colouring and/or bleaching composition comprising at least a first aqueous component (i) and a second aqueous component (ii) being mixed prior to application onto hair, wherein the first aqueous component (i) comprises, in a cosmetically acceptable carrier one or more oxidizing agent(s), and the second aqueous component (ii) comprises, in a cosmetically acceptable carrier, one or more alkalizing agent(s) selected from the group consisting of ammonia, its salts and mixtures thereof wherein the first component (i) or the second component (ii) or both comprise at least a first and a second malodor suppressant and optionally one or more further malodor suppressants, or the first component (i) comprises at least a first malodor suppressant and the second component (ii) comprises at least a second malodor suppressant, the first and the second malodor suppressant and any further malodor suppressant forming a malodor suppressant system in the hair colouring and/or bleaching com

Abstract: The invention relates to a waste-heat utilization assembly (1) of an internal combustion engine (50), comprising a circuit (2) that conducts a working medium, wherein a pump (6), a distribution valve block (7), two evaporators (10, 11), an expansion machine (3), and a condenser (4) are arranged in the circuit (2) in the flow direction of the working medium. The two evaporators (10, 11) are arranged in a parallel connection, and the parallel connection begins at the distribution valve block (7) and ends at a node point (8). A temperature sensor (21) for determining the outlet temperature of the working medium at the expansion machine (3) is arranged between the expansion machine (3) and the condenser (4).

Abstract: The present invention relates to methods for determining a treatment regimen beyond surgical removal of tumor tissue for node negative or node positive breast cancer patient. The method comprises measuring the levels of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in a subject, preferably a tumor; and, based upon the values, predicting the expected benefit including disease-free survival and/or overall survival for the patient without treatment (beyond the surgical removal of tumor tissue) or with a particular treatment and using that information to select a treatment regimen for the subject. High risk subject is identified by high levels of both uPA and PAI-1, high level of uPA and low level of PAI-1 or, low level of uPA and high level of PAI-1.

Abstract: The present invention relates to methods for predicting the outcome of anthracycline treatment of cell proliferative disorder patients. This is achieved by determining the expression level of at least one gene selected from the group consisting of PITX2; TFF1 and PLAU. The invention also relates to sequences, oligonucleotides and antibodies which can be used within the described methods.

Abstract: The present invention relates to a permanent shaping composition for the permanent deformation of hair comprising, in a cosmetically acceptable carrier, at least one reducing agent comprising a mercapto functional group, at least one alkalizing agent, and a malodor suppressant system comprising at least a first malodor suppressant, herein the first malodor suppressant has a molecular weight of from 100 to 400 g/mol, and wherein the malodor suppressant system has a distribution coefficient log P (octanol/water) of 2 or more.

Abstract: The invention relates to a waste-heat utilization assembly (1) of an internal combustion engine (50), comprising a circuit (2) that conducts a working medium, wherein a pump (6), a distribution valve block (7), two evaporators (10, 11), an expansion machine (3), and a condenser (4) are arranged in the circuit (2) in the flow direction of the working medium. The two evaporators (10, 11) are arranged in a parallel connection, and the parallel connection begins at the distribution valve block (7) and ends at a node point (8). A temperature sensor (21) for determining the outlet temperature of the working medium at the expansion machine (3) is arranged between the expansion machine (3) and the condenser (4).

Abstract: In a Laval nozzle (10) having a flow channel (12), which has a flow cross-section (14) extending in a convergent-divergent manner, according to the invention the flow channel (12) comprises mutually opposing first flow channel walls (16, 16?), which are formed by two nozzle bodies (18, 18?) spaced a fixed distance apart from one another. Two mutually opposite second flow channel walls (20, 20?), which can be moved relative toward one another or away from one another for adjusting the flow cross-section (14) of the flow channel (12), are disposed between the nozzle bodies (18, 18?).

Abstract: In a method for cleaning an absorptive polyester, the polymer is dissolved in a first solvent (12) and subsequently the polymer solution is brought into tight contact with a second solvent (41) in a turbulent shear field under the influence of strong shear forces. Here, the second solvent (41) represents a non-solvent for the absorptive polyester and is mixable with the first solvent (12) to an unlimited extent. Subsequently, the polymer suspension resulting from the addition of the second solvent (41) is conveyed onto or into a rotating, cylindrical screen body (71) of a drum shear screen (70) and then the moist polymer mass is removed from the screen body (71) and subsequently dried. The method is suitable for the production of absorptive polyester with a high degree of quality and may be performed in a cost-effective fashion on an industrial scale as well.

Abstract: There is provided a method of judging a risk of cancer recurrence based on the activity value and expression level of the first CDK, the activity value and expression level of the second CDK, and the expression levels of uPA and PAI-1 and a computer program.

Abstract: In a method for operating a fluid valve for controlling or regulating a fluid, having at least one movable valve component is displaceable with the aid of at least one electrical actuating signal which contains at least one first actuating signal portion which causes an oscillating valve motion of the valve component. Pressure oscillations generated in the fluid due to the oscillating valve motion are detected, and are used for regulation of the oscillating valve motion caused by the first actuating signal portion.