Abstract: The invention concerns a method and a reagent kit for detecting cells in a biological sample using a double-fluorescence technique and the diagnostic and therapeutic application of amino acid sequence-specific antibodies against the urokinase receptor having a high affinity for tumour cell-expressed receptors.

Abstract: The invention concerns a method and a reagent kit for detecting cells in a biological sample using a double-fluorescence technique and the diagnostic and therapeutic application of amino acid sequence-specific antibodies against the urokinase receptor having a high affinity for tumour cell-expressed receptors.

Abstract: The colorants for keratin fibers are based on oxidation dye precursors and/or direct dyes and contain a combination of (a) at least one nonionic, amphiphilic associative thickener, (b) at least one fatty alcohol that is liquid at 25° C. and (c) PEG-150/stearyl alcohol/SMDI copolymer in a suitable cosmetic carrier.

Abstract: The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.

Abstract: The present invention relates to methods for determining a treatment regimen beyond surgical removal of tumor tissue for node negative or node positive breast cancer patient. The method comprises measuring the levels of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1) in a subject, preferably a tumor; and, based upon the values, predicting the expected benefit including disease-free survival and/or overall survival for the patient without treatment (beyond the surgical removal of tumor tissue) or with a particular treatment and using that information to select a treatment regimen for the subject. High risk subject is identified by high levels of both uPA and PAI-1, high level of uPA and low level of PAI-1 or, low level of uPA and high level of PAI-1.

Abstract: The invention relates to a system to regulate the heat balance of a vehicle, with a heat cycle that dissipates engine heat, which features a cooling circuit (38) and a heating circuit (36), through which circuits a coolant can flow, and with at least one component (20) of the vehicle producing waste heat, wherein a system is provided with which the waste heat of at least one component of the vehicle can be transferred to the heat cycle.

Abstract: The invention starts with a volume flow control valve (36, 38) with a flow restrictor (48, 54) that can be displaced axially in a housing (40, 44), via which the volume flow can be diverted. It is proposed that the flow restrictor (48, 54) have a diverting body (54) and the force generated by the diversion at the diverting body (54) be used to adjust the flow restrictor (48, 54).

Abstract: Aspects of the present invention provide compositions and methods for prognosis of, and/or predicting the estrogen treatment outcome of breast cell proliferative disorder patients, and in particular of patients with breast carcinoma. In preferred embodiments, this is achieved, at least in part, by determining the expression level of PITX2, and/or the genetic or the epigenetic modifications of the genomic DNA associated with the gene PITX2. Additional aspects of the invention provide novel sequences, oligomers (e.g., oligonucleotides or peptide nucleic acid (PNA)-oligomers), and antibodies, which have substantial utility in the described inventive methods and compositions.

Abstract: A method for training a neural network in order to optimize the structure of the neural network includes identifying and eliminating synapses that have no significant influence on the curve of the risk function. First and second sending neurons are selected that are connected to the same receiving neuron by respective first and second synapses. It is assumed that there is a correlation of response signals from the first and second sending neurons to the same receiving neuron. The first synapse is interrupted and a weight of the second synapse is adapted in its place. The output signals of the changed neural network are compared with the output signals of the unchanged neural network. If the comparison result does not exceed a predetermined level, the first synapse is eliminated, thereby simplifying the structure of the neural network.

Abstract: A cooling circuit for an internal combustion engine includes a first coolant circuit and a second coolant circuit, the cooling circuit being able to be operated by a distributor so that the internal combustion engine reaches its operating temperature as quickly as possible, and a heat exchanger used to heat the vehicle interior is operational as quickly as possible. The return channel from the second coolant circuit is connectable to either the return channel or the flow channel of the first coolant circuit.

Abstract: The current invention relates to an apparatus for cooling and/or heating a motor vehicle, with at least one coolant pump for circulating a coolant in a cooling and heating system, with a main cooler segment, which has a main cooler inlet and a main cooler outlet, wherein the main cooler inlet is at least intermittently connected to at least one coolant outlet of an engine to be cooled, in particular an internal combustion engine, of the vehicle, and its main cooler outlet is connected to at least one coolant inlet of the engine, and with at least one other, secondary cooler segment provided in addition to the main cooler segment and at least one other unit to be cooled, which is connected to the cooling and heating system, and the apparatus have at least one bypass line with a bypass valve, which is associated with the at least one secondary cooler segment and is disposed parallel to this secondary cooler segment in the cooling and heating system of the motor vehicle.

Abstract: An electric machine, particularly a generator for motor vehicles, includes a housing and a casing enclosing the housing concentrically, the casing, together with the housing, bounding an annular space that is sealed in a fluid-tight manner and is connected to a coolant outflow and a coolant inflow. To achieve a uniform circumflow of the housing with sufficient cooling capacity, even given low volumetric flow of the coolant, a plurality of axial guide bars are arranged in the annular space, so that the coolant restrictedly flows in an axially wide-strip manner through the annular space within space segments arranged in a row in the circumferential direction, with an opposing flow direction in successive space segments.

Abstract: The present invention concerns peptides as inhibitors of the binding of urokinase to the urokinase receptor. These peptides, which are preferably cyclic, are suitable as pharmaceutical agents for diseases that are mediated by urokinase and its receptor.

Abstract: The invention concerns a method and a reagent kit for detecting cells in a biological sample using a double-fluorescence technique and the diagnostic and therapeutic application of amino acid sequence-specific antibodies against the urokinase receptor having a high affinity for tumour cell-expressed receptors.

Abstract: This invention relates to the production of specific antibodies for the detection of human tumor associated urokinase-type plasminogen activator receptor (uPAR) deletion variants in biological samples as well as to their diagnostic and therapeutic application.

Abstract: A method for suppressing mutual interference in optical sensors without additional control or installation requirement and a corresponding multi-sensor system are disclosed. The sensors (13) receive communication calls, by means of a bus (14), with which time windows for the transmission and receiving of light impulses are synchronised. Said multi-sensor system is provided with a control module, which serves for data exchange with the sensors (13) during the communication call by means of a bus (14), whereby a parameterisation of the sensors (13) occurs by means of which the time windows are fixed.

Abstract: The present invention concerns peptides as inhibitors of the binding of urokinase to the urokinase receptor. The peptides, which are preferably cyclic, are suitable as pharmaceutical agents for diseases that are mediated by urokinase and its receptor.

Abstract: The object of the present invention are colorants for keratin fibers based on oxidation dye precursors and/or direct dyes which in a suitable cosmetic carrier contain a combination of (a) at least one nonionic, amphiphilic associative thickener, (b) at least one fatty alcohol that is liquid at 25° C. and (c) PEG-150/stearyl alcohol/SMDI copolymer.

Abstract: An electric machine, particularly a generator for motor vehicles, is indicated, which has a housing (10) and a casing (17) enclosing the housing (10) concentrically, the casing, together with the housing (10), bounding an annular space (18) that is sealed in a fluid-tight manner and is connected to a coolant outflow and a coolant inflow. To achieve a uniform circumflow of the housing (10) with sufficient cooling capacity, even given low volumetric flow of the coolant, a plurality of axial guide bars (25) are arranged in the annular space (18), so that the coolant restrictedly flows in an axially wide-strip manner through the annular space (187) within space segments (26) arranged in a row in the circumferential direction, with an opposing flow direction in successive space segments (26).

Abstract: The current invention relates to an apparatus for cooling and/or heating a motor vehicle, with at least one coolant pump (30, 32) for circulating a coolant in a cooling and heating system, with a main cooler segment (10), which has a main cooler inlet (11) and a main cooler outlet (12), wherein the main cooler inlet (11) is at least intermittently connected to at least one coolant outlet (24, 224, 225, 229) of an engine to be cooled (20), in particular an internal combustion engine, of the vehicle, and its main cooler outlet (12) is connected to at least one coolant inlet (23) of the engine (22), and with at least one other, secondary cooler segment (15, 215, 315, 415, 515) provided in addition to the main cooler segment (10) and at least one other unit to be cooled (60, 61, 70, 80, 90, 97, 170, 186), which is connected to the cooling and heating system.