Abstract: Neutralizing PCSK9 variants that interact with low density lipoprotein receptor (LDLR) are described. Methods and compositions for treating disorders by administering a pharmaceutically effective amount of a neutralizing PCSK9 variant are described.

Abstract: A screen is provided. The screen includes: a substrate; an adhesive affixed to the substrate; and a mixture of reflective beads and transparent beads affixed by the adhesive to the substrate.

Abstract: Compositions and methods for treatment of conditions affecting skin and/or mucosal surfaces of a subject that make use of an imidazoquinoline compound and a retinoid agent are described.

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

Abstract: Systems, methods, and computer-readable media are provided to assist users to locate content of interest based on viewer ratings. First information enabling unique identification of a first user may be processed. Indications of ratings of television programming may be processed, the indications being received from a first media device associated with the first user. Ratings information associated with the first user may be retained in repositories, the ratings information being based on the indications. The first user may be matched to a category that represents a classification of a set of viewers and/or of a set of content based on a set of attributes. Descriptive content indicative of the first user and/or content rated by the first user may be selected and may be transmitted via the network to a second media device associated with a second user.

Abstract: Systems, devices, and methods are described for wireless communication. In one example a first wireless signal is received in a first radio frequency spectrum using a first antenna exterior to a building. The first wireless signal is associated with a first wireless protocol. The first wireless signal is converted into a first intermediate signal associated with a coaxial protocol. The first intermediate signal is transmitted to an interior of the building using a coaxial cable. The first intermediate signal is converted into a second signal associated with a second wireless protocol. The second signal is then transmitted in a second radio frequency spectrum using a second antenna interior to the building. The second signal is transmitted using the second wireless protocol.

Abstract: Various embodiments of systems, devices, and methods are described for wireless communication. In one example a first wireless signal is received in a first radio frequency spectrum using a first antenna exterior to a building. The first wireless signal is associated with a first wireless protocol. The first wireless signal is converted into a first intermediate signal associated with a coaxial protocol. The first intermediate signal is transmitted to an interior of the building using a coaxial cable. The first intermediate signal is converted into a second signal associated with a second wireless protocol. The second signal is then transmitted in a second radio frequency spectrum using a second antenna interior to the building. The second signal is transmitted using the second wireless protocol.

Abstract: Compositions and methods for treatment of conditions affecting skin and/or mucosal surfaces of a subject that make use of an imidazoquinoline compound and a retinoid agent are described.

Abstract: The invention relates to a method and system that implements a payment initialization input that receives an electronic payment; the payment initialization input generates a payment context with an execution plan; a payments topology comprising a stage router, coupled to the payment initialization input and further in communication with a transform-to-external component and de-duplication component; and the stage router routes the payment context in accordance with the execution plan to a plurality of stages, the plurality of stages comprising a validation stage, an enrichment stage, a controls stage and a clearing stage where after each stage, the payment context is routed back to the stage router before being routed to a subsequent stage.

Abstract: A method, system, and computer program product for detecting and enforcing compliance with access requirements for a computer system in a restricted computer network. A compliance validation configuration file is created for the computer system. A maintenance service utility is configured to launch a compliance validation executable file at a specified time during operation of the computer system. A digital hash is generated for the compliance validation executable file and for the compliance validation configuration file. A determination is made if the computer system or a computer system user is a member of a configured restricted group. If the computer system or the computer system user is a member of a configured restricted group, a determination is made if a directory site code for a subnet of the restricted computer network to which the computer system is connected corresponds to a configured and allowed site.

Abstract: Compositions and methods for treatment of conditions affecting skin and/or mucosal surfaces of a subject that make use of an imidazoquinoline compound and a retinoid agent are described.

Abstract: A method for removing volatile organic compounds (VOC's) from toner slurries is described, including the isolated toner particles generated by that method.

Abstract: Techniques for authenticating client applications to services and/or applications that are provided within an environment that may become disconnected, as a whole, from other networks (e.g., on-board a vehicle) may include receiving an indication of a local service that may be provided within the dis-connectable environment, and authenticating/registering the local service. A request for service(s) may be received from a client application within the dis-connectable environment, and the client application may be authenticated/authorized to access one or more local services. An indication of a session key may be provided to the local service provider and to the authenticated/authorized client application for use in establishing a secure connection therebetween, thereby providing the client application access to the registered local service.

Abstract: Techniques for providing access control in environments that may become disconnected, as a whole, from other networks (e.g., on-board a vehicle) may include locally storing access control information within the dis-connectable environment, and locally providing discovery and authentication/authorization services. Local services and/or applications may be registered and authenticated and client applications may be authenticated and/or authorized to one or more locally provided services and/or applications even when the environment is in a disconnected state. Local access control information may be synchronized with source access control information stored externally to the environment (e.g., on the ground).

Abstract: Compositions and methods for treatment of conditions affecting skin and/or mucosal surfaces of a subject that make use of an imidazoquinoline compound and a retinoid agent are described.

Abstract: A medical accessory holder (10) is provided, for use during reprocessing and/or conditioning of medical equipment. The holder comprises a planar base portion (11). At least one recess (12, 13, 14) is provided in the planar base portion, and is adapted to receive a medical accessory (15, 16, 17) firmly engaged therein. The holder (10) further comprises retaining means (22) associated with the base portion (11) and adapted to engage therewith. Once engaged, the retaining means (22) cannot be disengaged, and the medical accessory (15, 16, 17) cannot be removed from the recess (12, 13, 14), without breaking the retaining means (22), thereby rendering the holder suitable only for single use. Attachment means (26) are further provided to enable the holder (10) to be secured to an article of medical equipment with which the medical accessory (15, 16, 17) is associated, during reprocessing thereof.

Abstract: A method for removing volatile organic compounds (VOC's) from toner slurries is described, including the isolated toner particles generated by that method.

Abstract: Disclosed is an invention that relates to the formation of microsclerotial propagules by mycoparasitic fungi and the use of those microsclerotia for plant disease control. Representative microsclerotia propagules formed are from fungal species Trichoderma harzianum, Trichoderma lignorum, Trichoderma viridae, Trichoderma reesei, Trichoderma koningii, Trichoderma pseudokoningii, Trichoderma polysporum, Trichoderma hamatum, and Trichoderma asperellum.

Abstract: The invention relates to pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) of formula (I) and in particular to PBD dimers linked through the C1 position, and PBD monomers linked through the C1 position to aromatic groups, and pharmaceutically acceptable salts thereof, which are useful as medicaments, in particular as anti-proliferative agents.

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.