Abstract: The present invention provides a compound of Formula I: useful for treating chronic kidney disease and diabetic kidney disease.

Abstract: A compound of Formula (I): or a pharmaceutically acceptable salt thereof, where: Q can be 5-methylpyridazin-3-yl,5-chloropyridazin-3-yl, 6-methylpyridazin-3-yl, or 6-fluoropyridazin-3-yl; R can be hydrogen, fluoro, or methoxy; R1 can be hydrogen, methoxy, difluoromethoxy, or trifluoromethoxy; and R2 can be methyl or ethyl. The compound of formula (I) can inhibit glutaminase, e.g., GLS1.

Abstract: Generating a token for tracking a state of communications with multiple external services. Data is caused to be acquired from external services as a result of interpreting a communication from a client. The causing of the data to be acquired comprises causing a request to be issued for data from a first external service and receiving a response from the first external service. The response from the first external service includes at least a token associated with the first external service. In response to receiving the response from the first external service, an aggregate token is generated that includes the token associated with the first external service and a status of the request to the first external service. The aggregate token is caused to be sent to the client and is interpretable to inform the computer system of the status of the request to the first external service.

Abstract: This invention relates to oral veterinary compositions for combating ectoparasites and endoparasites in animals, comprising at least one systemically-acting active agent in combination with a pharmaceutically acceptable carrier. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

Abstract: A method is described that includes generating, by a controller of a storage device, operating statistics associated with an operating state of the storage device. The method includes receiving, by the controller and from a host device, a non-interrupt command frame that requests transfer of data blocks between the storage device and the host device. The method further includes, in response to receiving the non-interrupt command frame, generating, by the controller, a response frame associated with the non-interrupt command frame, wherein the response frame includes the operating statistics. The method includes transmitting, by the controller and to the host device, the response frame.

Abstract: A radiation detector assembly is provided that includes a semiconductor detector having a surface, plural pixelated anodes, and at least one processor. The pixelated anodes are disposed on the surface. Each pixelated anode is configured to generate a primary signal responsive to reception of a photon by the pixelated anode and to generate at least one secondary signal responsive to an induced charge caused by reception of a photon by at least one adjacent anode. The at least one processor is operably coupled to the pixelated anodes. The at least one processor configured to define sub-pixels for each pixelated anode; acquire signals corresponding to acquisition events from the pixelated anodes; determine sub-pixel locations for the acquisition events using the signals; and apply at least one calibration parameter on a per sub-pixel basis for the acquisition events based on the determined sub-pixel locations.

Abstract: This invention relates to compounds that are agonists of the muscarinic M1 receptor and/or M4 receptor and which are useful in the treatment of muscarinic M1/M4 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds include those according to formula 1, or a salt thereof, wherein Q, R1, R2, R3 and R4 are as defined herein.

Abstract: A data recorder stores endpoint activity on an ongoing basis as sequences of events that causally relate computer objects such as processes and files, and patterns within this event graph can be used to detect the presence of malware on the endpoint. The underlying recording process may be dynamically adjusted in order to vary the amount and location of recording as the security state of the endpoint changes over time.

Abstract: An actuator for use in a control valve assembly that has a structure amenable to manufacture. The actuator may comprise a housing comprising a plurality of walls secured to one another with fasteners to form an interior cavity, a torque hub disposed in the interior cavity, the torque hub comprising a torque body and a torque arm that are releasably engaged with one another via fasteners, each of the torque body and the torque arm having interfacing geometry that defines surfaces that engage with opposing surfaces on the other; and a load generator coupled with the torque hub.

Abstract: Sharing a bundle. A method includes identifying a bundle defined by a first user. The bundle includes a number of portions. One or more portions are configured to provide data from a data source. The method further includes identifying within the bundle one or more portions of the bundle that can be changed when the bundle is consumed by other users. The method further includes modifying the identified portions before the bundle is consumed by other users.

Abstract: Disclosed are systems, methods, and computer program products to implement product group mappings. In order for different CRM applications (e.g., sell side and internal side applications) to work in cohesive manner, the disclosed approaches provide mapping functionality that can map product groups captured in one system using one hierarchy to be translated to the other system using the hierarchy that the consuming system understands.

Abstract: Static analysis is applied to unrecognized software objects in order to identify and address potential anti-sandboxing techniques. Where static analysis suggests the presence of any such corresponding code, the software object may be forwarded to a sandbox for further analysis. In another aspect, multiple types of sandboxes may be provided, with the type being selected according to the type of exploit suggested by the static analysis.

Abstract: A constricting clutch brake element is operable to selectively transmit mechanical power between relatively movable rotating members. A plurality of backing plates are movably mounted and selectively movable radially on an annular body of the clutch brake element. The backing plates engage a plurality of friction linings. Each backing plate is configured for usage with different numbers of torques bars to meet different torque carrying capacities, all within the same envelope size. The configuration also allows plural torque bars to be relatively positioned so that they can engagingly guide the backing plate during its radial movement.

Abstract: A method of data replication from a first data storage device to a second data storage device. The method may include generating, at the first data storage device, at spaced time intervals, a plurality of snapshots for a logical data volume of the first data storage device, the logical data volume being an abstraction of data blocks from one or more physical storage devices, each snapshot identifying changes of data for at least a portion of the logical data volume since a most previous snapshot. Also at the first data storage device, the method includes generating a delta volume, the delta volume indicating changes in the data of at least a portion of the logical data volume between two non-consecutive snapshots. The method further involves replicating the delta volume to the second data storage device, and replicating the changes to the data indicated therein at the second data storage device.

Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.

Abstract: A programmable circuit includes an array of printed groups of microscopic transistors or diodes. The devices are pre-formed and printed as an ink and cured. A patterned hydrophobic layer defines the locations of the printed dots of the devices. The devices in each group are connected in parallel so that each group acts as a single device. Each group has at least one electrical lead that terminates in a patch area on the substrate. An interconnection conductor pattern interconnects at least some of the leads of the groups in the patch area to create logic circuits for a customized application of the generic circuit. The groups may also be interconnected to be logic gates, and the gate leads terminate in the patch area. The interconnection conductor pattern then interconnects the gates for form complex logic circuits.

Abstract: Systems and processes for performing solid phase peptide synthesis are generally described. Solid phase peptide synthesis is a known process in which amino acid residues are added to peptides that have been immobilized on a solid support. In certain embodiments, the inventive systems and methods can be used to perform solid phase peptide synthesis quickly while maintaining high yields. Certain embodiments relate to processes and systems that may be used to heat, transport, and/or mix reagents in ways that reduce the amount of time required to perform solid phase peptide synthesis.

Abstract: Navigating directly to a modal dialog overlaying a base web page. User input associated with navigating to a modal dialog overlaying a base web page is detected. In response to detecting the user input, the computer system navigates directly to the modal dialog overlaying the base web page. The base web page acts as a background of the modal dialog, such that interaction with the model dialog is required prior to interaction with the base web page. Additionally, the modal dialog is associated with a first uniform resource locator, while the base web page is associated with a second, different uniform resource locator. As such, direct navigation can be performed either to the modal dialog or the base web page.

Abstract: The present invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof, for use as a human PDE1 inhibitor.

Abstract: Backup objects, native security descriptors that describe access rights to the backup objects, and object metadata are received from platforms where each backup object has corresponding object metadata. Each native security descriptor is transformed into a platform independent security descriptor. A partitioned structure is generated, including by associating each platform independent security descriptor with those object metadata that correspond to the plurality of backup objects for which that platform independent security descriptor describes access rights to.