Abstract: Apparatuses and methods of optically analyzing fluid within a pipette are described herein. In an embodiment, an optical reader subassembly includes a housing including an internal area, a container configured to hold a fluid sample at a sample position in a light tight manner within the internal area of the housing, a light source configured to project light onto the fluid sample within the container, and an optical sensor configured to move between different sensor positions while the fluid sample remains stationary at the sample position, the different sensor positions including at least two of: (i) a first sensor position for taking a luminescence reading of the fluid sample; (ii) a second sensor position for taking a dark current or other background measurement; and (iii) a third sensor position for taking a fluorescence reading of the fluid sample.

Abstract: In some examples, a port of an electronic device includes a connector movable between a recessed position and an extended position, and an actuator to move the connector from the recessed position to the extended position in response to insertion of a plug into the connector, the connector when in the extended position to engage the plug.

Abstract: Apparatuses and methods of optically analyzing fluid within a pipette are described herein. In an embodiment, an optical reader subassembly includes a pipette having a tip, the pipette configured to aspirate a fluid sample and hold the fluid sample within the tip, a housing including a reentrant seal and an internal area, the housing configured to receive at least the tip of the pipette through the reentrant seal so that the tip of the pipette is located in a light tight manner within the internal area, a light source positioned to be in proximity to the tip of the pipette when the tip of the pipette is received by the housing, the light source configured to project light through the tip of the pipette and onto the fluid sample held within the tip, and an optical sensor configured to take a reading of the fluid sample held within the tip of the pipette without any of the fluid sample being injected from the pipette.

Abstract: A corrosion sensor for detecting the action of corrosive media on a metallic component when the sensor is mounted in the vicinity of the metallic component in use is disclosed. The sensor includes an electrically conducting corrodible element mounted on a non conducting substrate, the corrodible element being covered with a protective coating such as paint adapted to protect the corrodible element from corrosive media. The protective coating defines a temporary feature such as a paint defect which extends across the corrodible element and is designed to permit attack on the corrodible element by corrosive media after a predetermined period of time. The corrodible element comprises a pair of spaced tracks extending generally in a longitudinal direction and a series of corrodible tracks, each corrodible track extending generally in a lateral direction and forming an electrical connection between the spaced tracks.

Abstract: The present invention provides 1,2-benzothiazole compounds particularly useful in the treatment of diabetic nephropathy and other chronic kidney disorders and other diabetic complications.

Abstract: This invention relates to compounds that are agonists of the muscarinic M1 receptor and/or M4 receptor and which are useful in the treatment of muscarinic M1/M4 receptor mediated diseases. Also provided are pharmaceutical compositions containing the compounds and the therapeutic uses of the compounds. Compounds include those according to formula 1, or a salt thereof, wherein Q, R1, R2, R3 and R4 are as defined herein.

Abstract: A novel maize variety designated X08H753 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X08H753 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X08H753 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. This invention relates to the maize variety X08H753, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X08H753. This invention further relates to methods for producing maize varieties derived from maize variety X08H753.

Abstract: This invention relates to genetic markers of mental illness, e.g., schizophrenia (SZ), and methods of use thereof.

Abstract: The present invention provides a compound of Formula I: useful for treating chronic kidney disease and diabetic kidney disease.

Abstract: A radiation detection system includes a detector unit and at least one processor. The detector unit is configured to generate signals responsive to radiation. The at least one processor is operably coupled to the detector unit and configured to receive the signals from the detector unit. The at least one processor is configured to obtain, during an imaging process, a first count for at least one of the signals corresponding to a first intrinsic energy window, the first energy window corresponding to values higher than an intrinsic peak value; obtain a second count for the at least one of the signals corresponding to a second intrinsic energy window, the second energy window corresponding to values lower than the intrinsic peak value; and adjust a gain applied to the signals based on at least the first count and the second count.

Abstract: A method, computer-readable storage device and apparatus for routing traffic in a reconfigurable optical add-drop multiplexer layer of a dense wavelength division multiplexing network are disclosed. For example, the method determines the reconfigurable optical add-drop multiplexer layer has asymmetric traffic, and routes the asymmetric traffic in the reconfigurable optical add-drop multiplexer layer over a plurality of asymmetrical optical connections, wherein the plurality of asymmetrical optical connections is provided with only uni-directional equipment in the reconfigurable optical add-drop multiplexer layer.

Abstract: A system and method for flame stabilization is provided that forestalls incipient lean blow out by improving flame stabilization. A combustor profile is selected that maintains desired levels of power output while minimizing or eliminating overboard air bleed and minimizing emissions. The selected combustor profile maintains average shaft power in a range of from approximately 50% up to full power while eliminating overboard air bleed in maintaining such power settings. Embodiments allow for a combustor to operate with acceptable emissions at lower flame temperature. Because the combustor can operate at lower bulk flame temperatures during part power operation, the usage of inefficient overboard bleed can be reduced or even eliminated.

Abstract: In an aspect, a method of operating a plunger lift system, a controller and a plunger lift system in a well is provided. The velocity of a plunger is measured by a velocity sensor positioned proximate a top of the well when the plunger passes the velocity sensor. The measured velocity can then be used to determine a kinetic energy of the plunger as it passed the velocity sensor. Each time the plunger passes the velocity sensors, the kinetic energy of the plunger can be determined. This determined kinetic energy can then be used to determine if the well should be shut down or if portions of the plunger lift system should be replaced.

Abstract: A quantitative method for performing an automated diagnostic assay, comprising: incubating a capture reagent with a streptavidin-coated medium to form a solid phase complex; washing the solid phase complex to remove excess capture reagent; incubating the solid phase complex with a serum sample to form an immune complex; washing the immune complex to remove any unbound sample; incubating the immune complex with a conjugate to create an immune-conjugate complex; washing the immune-conjugate complex to remove any unbound conjugate; introducing a substrate capable of generating a quantifiable response; and calibrating the response generated from introducing the substrate.

Abstract: A quantitative method for diagnosing an autoimmune disease or an infectious disease comprising performing an automated diagnostic assay, comprising: incubating a capture reagent with a streptavidin-coated medium to form a solid phase complex, wherein the capture reagent is a biotinylated autoantigen or infectious disease antigen; washing the solid phase complex to remove excess capture reagent; incubating the solid phase complex with a serum sample to form an immune complex; washing the immune complex to remove any unbound sample; incubating the immune complex with a conjugate to create an immune-conjugate complex; washing the immune-conjugate complex to remove any unbound conjugate; introducing a substrate capable of generating a quantifiable response; and calibrating the response generated from introducing the substrate.

Abstract: Methods or systems (7000) are implemented for treatment with or monitoring use of respiratory pressure therapy device(s). The device may be for a respiratory disorder. A processor, such as a processor of a server communicating with the therapy device, may analyse data relating to respiratory therapy delivered by the device. The processor may generate data in the processor representing a prediction, such as compliance prediction(s), about progress of therapy based on the analysis. The processor may select an action to improve therapy based on data representing the prediction. The processor may take or prompt selected action to improve the therapy. In some cases, a processor may analyse usage data concerning a period of days with a therapy device and generate compliance prediction indicators based on the analysis. The indicators indicate whether compliance will be likely. The processor may recommend engagement action to improve compliance based on evaluation of the indicators.

Abstract: This disclosure relates to medical fluid sensors and related systems and methods. In some aspects, a circuit includes a radio frequency coil tuned to at least one frequency and at least one switching circuit directly connected to the radio frequency coil. The radio frequency coil is characterized by a high impedance.

Abstract: A quantitative method for diagnosing an autoimmune disease or an infectious disease comprising performing an automated diagnostic assay, comprising: incubating a capture reagent with a streptavidin-coated medium to form a solid phase complex, wherein the capture reagent is a biotinylated autoantigen or infectious disease antigen; washing the solid phase complex to remove excess capture reagent; incubating the solid phase complex with a serum sample to form an immune complex; washing the immune complex to remove any unbound sample; incubating the immune complex with a conjugate to create an immune-conjugate complex; washing the immune-conjugate complex to remove any unbound conjugate; introducing a substrate capable of generating a quantifiable response; and calibrating the response generated from introducing the substrate.

Abstract: A locking assembly may be to locate a display member of a computing device relative to a base member of the computing device. A spring may be to attach to the display member. A first magnetic member may be in contact with to the spring. A wheel may be to attach to the display member to roll on the base member. A lock may be to engage the spring to lock the wheel when the first magnetic member is in proximity to a second magnetic member of the base member such that a magnetic force is exerted therebetween.

Abstract: The specification relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, where Q, R, R1 and R2 have any of the meanings defined herein. The specification also relates to the use of such compounds and salts thereof to treat or prevent GLS1 mediated disease, including cancer. The specification further relates to crystalline forms of compounds of Formula (I) and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds and salts; kits comprising such compounds and salts; methods of manufacture of such compounds and salts; intermediates useful in the manufacture of such compounds and salts; and to methods of treating GLS1 kinase mediated disease, including cancer, using such compounds and salts.