Abstract: Articles and/or integrated articles comprising a body portion (e.g., a catheter) and a component (e.g., a cuff) physically integrated with the body portion are generally provided. For example, materials, methods, and uses are set forth herein for forming a body portion comprising a first material physically integrated with a component comprising a second material, same or different, than the first material. The disclosed compositions and devices may be useful for administration to a subject (e.g., a patient). Advantageously, the compositions and/or devices described herein may be substantially non-thrombogenic, lubricious, and/or biocompatible. In some embodiments, the devices described herein may be useful for the delivery of a biologically active agent (e.g., a therapeutic agent such as a drug) to a subject. Methods for forming such compositions and/or devices are also provided.

Abstract: A method is directed to controlling a sleep environment and includes providing a control system that is communicatively coupled to one or more sleep contributors. The control system is configured to adjust the one or more sleep contributors and monitor, via one or more sensors, a physical condition of the user that is indicative of a sleep state of the user. A change is detected in the physical condition that indicates onset of an initial sleep state of the user, in response to which at least one sleep contributor is automatically adjusted to begin inducing a deeper sleep state for the user. The inducing guides the user from the initial sleep state to a subsequent sleep state, without user conscious effort, the subsequent sleep state being associated with a deeper sleep for the user than the initial sleep state.

Abstract: A ground traversing, electrically driven drone travels along a preprogrammed path that corresponds to pass catcher's travel path during a play, matching the pass catcher's speed and run cuts. The play is wirelessly communicated to the drone by a handheld electronic device located remote of the drone. A target is located on the drone so that a quarterback can throw a football at the target in order to refine the quarterback's timing and accuracy for the play. Sensors onboard the drone track both the football's and quarterback's speed and travel trajectories so that such data can be collected, along with the drone's travel path, and stored onboard the drone's control unit and eventually fed into 3-D reconstruction software for analysis by the quarterback and coaching staff. The target rotates so that the target either faces in a fixed direction or constantly faces the quarterback during execution of drone's maneuvers.

Abstract: Network route control plane data, advertised by one or more routers on a network, is received from a passive discovery module. The passive discovery module is configured to communicate with the routers using one or more routing protocols, but not to advertise route data. The received network route control plane data is compared to network element data stored in a network element database. If the received network route control plane data is not contained in the network element database, the received network route control plane data is stored in the network element database. If the received network route control plane data is contained in the network element data database, the received network route control plane data is compared to target asset data stored in a target asset database. If the received network route control plane data is not contained in the target asset database, the received network route control plane data is stored in the target asset database.

Abstract: Compounds of formula I and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: A processor and method for detecting pain and non-pain arousal responsive to physical stimuli applied to oral surfaces of a subject. A biological signal such as skin conductance, or another physiological parameter, can be used as a proxy measure for acute pain and/or non-pain arousal. The instances of mechanical engagement with the oral surfaces can be detected or tracked. Differential detection of pain vs non-pain arousal is achieved based on assessing signal synchronization or correlation between the biological signal and the oral contact events.

Abstract: Provided herein are high energy ion beam generator systems and methods that provide low cost, high performance, robust, consistent, uniform, low gas consumption and high current/high-moderate voltage generation of neutrons and protons. Such systems and methods find use for the commercial-scale generation of neutrons and protons for a wide variety of research, medical, security, and industrial processes.

Abstract: A system and method for obtaining provisional credit for operators of kiosks, such as cryptocurrency automated teller machines, comprises a kiosk application server disposed in connection with a financial institution, the kiosk application server configured to execute a transaction between the kiosk and a customer thereof, to record transaction data associated with such transaction, and to generate a file comprising same. Such generated file may comprise a first entry, disposed to post to the operator's account, and a second entry, disposed to post to the financial institution's general ledger account, wherein the posting of each entry will offset, thereby enabling the posting of provisional credit to the kiosk operator. Such a kiosk application server may further comprise a reconciliation component configured to remediate any imbalances between the posted provisional credit and the cash disposed within the kiosk via monitoring and verification procedures, and the transmission of a remedial file.

Abstract: The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.

Abstract: A user guidance system (SYS) and related method. The system comprises an interface (IN) for receiving a specification of a medical protocol for a given patient, the specification defining a sequence of medical action points. A synthesizer (S) of the system is configured to synthesize a media sequence in accordance with the sequence of medical action points, to obtain a synthesized media sequence for the said patient, the media sequence configurable to guide the patient in a medical procedure, based on the protocol. The media sequence may be used to support imaging protocols to encourage patient compliance, and hence better imaging for example.

Abstract: Method starts with processor causing virtual reality (VR) interface for communication session to be displayed on first user interface of a first head-wearable apparatus and on second user interface of second head-wearable apparatus. Processor detects first touch input from first VR input device and second touch input from second VR input device. Processor monitors location of the first touch input within the first user interface and location of the second touch input within second user interface. Processor determines distance between location of the first touch input within first user interface and location on first user interface corresponding to location of second touch input within second user interface. Processor causes first and second VR input devices to generate haptic feedback response based on the distance. Haptic feedback response increases in intensity or speed as distance decreases and decreases in intensity or speed as distance increases. Other embodiments are described herein.

Abstract: A plurality of design iterations are executed for a flow to design a circuit. The design flow includes a sequence of at least two stages. Each stage produces an output design of the circuit from an input design of the circuit, in accordance with parameters for that stage. The design iterations select parameter values for slices of one or more stages of the design flow. In the design iterations for at least one of the slices, parameter values for a non-final stage of the design flow are selected based on a final quality of result (QoR) of the design flow. The design iterations for this slice are adapted based on final QoRs produced by the design iterations.

Abstract: Disclosed herein are external fixation frames for correcting bone deformities. The external fixation frames include a top fixation ring and a bottom fixation ring coupled to one another by at least two struts. A half ring is coupled to bottom fixation ring. The bottom fixation ring is u-shaped. One or more rocker members may be coupled to the bottom fixation ring. The half ring may be hingedly coupled to the bottom fixation ring such that it can rotate with respect to the bottom fixation ring from a first position to a second position.

Abstract: Provided herein are high energy ion beam generator systems and methods that provide low cost, high performance, robust, consistent, uniform, low gas consumption and high current/high-moderate voltage generation of neutrons and protons. Such systems and methods find use for the commercial-scale generation of neutrons and protons for a wide variety of research, medical, security, and industrial processes.

Abstract: Systems and methods for handheld tubing welders are herein disclosed. In an embodiment, a handheld tubing welder can include a housing configured to be held by a user and a tubing retainer coupled to the housing. The tubing retainer can include a first and second retainer slot configured to receive and retain a first section of a first tubing and a second tubing, respectively. A tubing shifter can be positioned adjacent to the housing and the tubing retainer, the tubing shifter includes a first shifter slot and a second shifter slot that is configured to receive and retain a second section of the first tubing and a second section of the second tubing, respectively. A cutting element can be configured to be movable between the tubing shifter and the tubing retainer to cut the first and second tubing extending between the tubing shifter and tubing retainer.

Abstract: A drop kit that attaches to a pair of parallel picatinny rails one drone uses a pair of drop mechanisms that hold one side of a load bearing basket. The opposing side of the basket is pivotally secured to a goggle plate. Each drop mechanism is attached to one of the rails and the goggle plate to both of the rails via a spring-loaded centering clamp system. The drop mechanisms use a drop cam that rotates between and open and closed position so that when the drone arrives at a desired spot, a signal is provided to a pair of motors, each motor associated with one of the drop mechanisms, in order to rotate the drop cam into its open position, releasing its side of the basket with the opposing side of the basket pivoting and then falling free of the goggle plate.