Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: A patient monitoring method comprises receiving (103, 109) input data indicative of shivering episodes (52) and sweating episodes (54) of a patient; recording (105, 111) the respective points in time at which the shivering episodes and sweating episodes occur; and generating (115, 117) an output based on an alternating pattern of the shivering episodes and sweating episodes from the recorded respective points in time of the respective shivering and/or episodes. Also disclosed is a computer program product for implementing such a method and a monitoring system (10) arranged to implement such a method.

Abstract: Methods for manufacturing a glass ribbon include moving the glass ribbon along a travel path in a travel direction. Methods include directing a first ribbon portion of the glass ribbon to a winding apparatus to wind the first ribbon portion into a roll. Methods include detaching the first ribbon portion from a second ribbon portion of the glass ribbon. Methods include separating the second ribbon portion into a plurality of separated ribbon portions. Methods include directing a first set of the plurality of separated ribbon portions toward a disposal apparatus to crush the first set of the plurality of separated ribbon portions. Methods include forming a stack with a second set of the plurality of separated ribbon portions. A glass manufacturing apparatus is provided.

Abstract: The disclosure relates to a magnetic resonance imaging device comprising a main magnet, a gradient system including at least one gradient coil, a thermal bus structure, a shield structure arranged between the gradient system and the main magnet and a cryocooler including a cold head, wherein the shield structure is configured to reduce a transport of heat energy to the main magnet and wherein the main magnet comprises a magnet spacer configured for spacing individual coils of the main magnet, wherein the thermal bus structure comprises at least one thermal bus element extending through the magnet spacer for providing a thermal connection between the cold head of the cryocooler and the shield structure.

Abstract: Disclosed herein is a medical instrument (100, 300) comprising an activity measurement system (110, 301, 302) configured for measuring brain activity data (136) from a subject (102), a memory (120) storing machine executable instructions (130) and storing a simulation model (132), wherein the simulation model is configured to generating simulation data (134), wherein the simulation model is configured for modifying the simulation data using a model parameter (140), a virtual reality system (106, 106?, 106?, 106??, 106??) configured for rendering the simulation data; and a computational system (114) for controlling the medical instrument. Execution of the machine executable instructions causes the computational system to set (200) the model parameter to an initial value (142).

Abstract: A non-local spin valve (NLSV) sensor includes a bearing surface and a detector located proximate to the bearing surface. The NLSV sensor also includes a channel layer located behind the detector relative to the bearing surface, and in a substantially same plane as the detector. The channel layer has a front end that is proximate to the detector and a rear end that is distal to the detector. The NLSV sensor further includes first and second spin injectors, with the first spin injector located proximate to the rear end of the channel layer and positioned above the channel layer, and the second spin injector located proximate the rear end of the channel layer and positioned below the channel layer.

Abstract: In various embodiments, a stylization application generates designs that reflect stylistic preferences. In operation, the stylization application computes characterization information based on a first design and a trained machine-learning model that maps one or more designs to characterization information associated with one or more styles. The stylization application then computes a style score based on the characterization information and a target style that is included in the one or more styles. Subsequently, the stylization application generates a second design based on the style score, where the second design is more representative of the target style than the first design. Advantageously, because the stylization application can substantially increase the number of designs that can be generated based on the target style in a given amount of time, relative to more manual prior art techniques, the overall quality of the design ultimately selected for production can be improved.

Abstract: The present invention is related generally to recovering metals from waste electronics, and more particularly to a process to recover copper and gold commonly found in waste printed circuit boards using a lixiviant containing a weak acid such as citric acid or acetic acid, a particular concentration of table salt and an oxidizer. By using this lixiviant, the copper found in the printed circuit board reacts to form copper salts and gold becomes detached. Importantly this recovery method of copper and gold found in waste PCBs is fast, does not pose environmental hazards and is economically feasible.

Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) having core structure (I), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, combination pharmaceutical compositions and combination therapies, and processes and intermediates for making such modulators.

Abstract: A specialized mortgage constant calculator may include at least four different modes, each mode associated with a graphical user interface tailored to the mode and displayed on an electronic display. In addition, the mortgage constant calculator may include an adjustable table with a persistent, adjustable frame of reference and other navigational tools that facilitate use of a table that may be far larger than a display area of the electronic display.

Abstract: A magnetic resonance imaging device having a field generation unit configured to provide a magnetic field in an imaging volume of the magnetic resonance imaging device. The field generation unit has at least one magnet. A surface of the field generation unit directed towards the imaging volume of the at least one magnet has a concave shape, wherein a direction of access to the imaging volume is oriented essentially perpendicular to a main direction of magnetic field lines in the imaging volume.

Abstract: A synthesized, advertisement-based, video stream is generated first by receiving a video stream essentially consisting of a representative image of a person, a video stream comprising a place, and a video stream comprising an advertisement, and then combining the video stream essentially consisting of the representative image of the person with the video stream comprising the place and with the video stream comprising the advertisement into the synthesized, advertisement-based, video stream for transmission to an end-user device via which to display the synthesized, advertisement-based, video stream.

Abstract: An oral care system (10) comprises an oral care device (12). The oral care device is designed to either comprise or attach to a cleaning or treatment portion (14), e.g. a brush head or mouthpiece. The oral care device thus has a cleaning or treatment function. The oral care device is further provided with an electromagnetic (EM) field or radiation generator (22) adapted to generate and emit radio or microwave frequency electromagnetic energy in a space around an emitter arrangement (24) (sanitization area) used to emit the radiation or field. The EM emissions are configured to have electromagnetic properties suitable for heating water or water-containing fluid located within the sanitization area (34). This allows for a sanitization or disinfection function in a dedicated mode, wherein the EM emissions of the EM generator causes heating to a temperature of at least 50° C., preferably at least 70° C.

Abstract: A wear-out assessment for an oral care system (14) (e.g. an oral cleaning device) is disclosed. A sensor unit (16) of the oral care system is adapted to provide a sensor signal related to a cleaning efficacy of a cleaning function of the oral care system. The sensor unit (16) may be, or may be coupled to, a component which is used during execution of an oral care function of the device, for example a sensor for detecting cleaning progress in the mouth, or a component which drives a cleaning or treatment action in the mouth. The sensor signal (20) is used for performing a wear-out assessment via monitoring characteristics of a signal which is indicative of progress of the oral cleaning efficacy during an operation session (e.g. a clean level in the mouth) and monitoring a length of time that it takes for a certain threshold of efficacy to be reached in a session. If the length of time is over a certain threshold, this can be an indication that the relevant components of the oral care system are wearing out.

Abstract: Techniques for updating blockchains using a proof of work determined serially include receiving a block of data for inclusion in a new block of a blockchain; deterministically determining an initial nonce, hashing a combination of the block of data and the initial nonce to create a hashed value; iteratively deterministically determining an updated nonce based on a combination of the hashed value and updating the hashed value by hashing the updated nonce until the updated hashed value satisfies a proof of work criteria; creating the new block based on the block of data, the initial nonce, and the updated hashed value that satisfies the proof of work criteria; and having the new block stored in the blockchain.

Abstract: The disclosure provides processes for synthesizing Compound I, and pharmaceutically acceptable salts thereof.

Abstract: Novel tools and techniques are provided for implementing network service ordering and provisioning of secure access service edge (“SASE”) software packages. In various embodiments, a computing system may provide a user experience (“UX”) platform for a customer portal, the UX platform being accessible by a user via a user device over a first network(s); may provide, via the UX platform, options to configure, via the customer portal, one or more SASE-based network services among a plurality of network services provided by a service provider; and may autonomously orchestrate deployment and configuration of the one or more SASE-based network services via one or more customer premises equipment (“CPE”) that are associated with the user or to an entity with which the user is associated, over a second network(s), based at least in part on user selection of at least one option to configure the one or more SASE-based network services.

Abstract: An aftertreatment device includes flow guides disposed within a dosing conduit. Exhaust enters through a perforated region of the dosing conduit and passes through the flow guides. The flow guides induce swirling or other turbulence to mix injected reactant with the exhaust gas. Various types of flow guides include cantilevered vanes, guide passageways, and louvered openings of a second conduit. Some types of flow guides induce localized mixing to inhibit deposit formation at the doser mounting unit. Other types of flow guides induce mixing downstream of the dosing conduit.

Abstract: A system is provided. The system comprises an image projection device (6) configured to project display information; a wearable or hand-held device (100) which when worn is subjected to spatial movement; and a compensation element (7) configured to adjust the image projection device (6) based on the spatial movement such that the movement of the wearable or hand-held device (100) is compensated for during projection of the display information by the image projection device (6). Further, a method of spatially stabilizing display information projected by an image projection device (6) upon operation of a wearable or hand-held device is provided.

Abstract: Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.