Abstract: A switching valve includes a spool, a first cylinder port that communicates with the piston side chamber, a second cylinder port that communicates with the rod side chamber, a bridge passage having a first opening which is adjacent to the first cylinder port and a second opening which is adjacent to the second cylinder port, a regeneration passage formed in the spool to connect the second cylinder port communicating with the rod side chamber to the first cylinder port in accordance with a switching position of the spool, and a first communication port and a second communication port formed in the spool to communicate with the regeneration passage. The first communication port communicates with the second opening of the bridge passage, which is adjacent to the second cylinder port, and the second communication port communicates with the second cylinder port in accordance with the switching position of the spool.

Abstract: A method for treating rheumatoid arthritis, multiple sclerosis, or a disease involving JAK3, including administering a compound of the formula (I) or a salt thereof to a subject

Abstract: Guanidine-functionalized particles and methods of making and using such particles.

Abstract: A fluid pressure control device for a power shovel includes: a first switching valve configured to permit or prohibit communication between a first pump and a first cylinder; a second switching valve configured to permit or prohibit communication between a second pump and a second cylinder; a third pump configured to allow to supply working fluid to the first cylinder and the second cylinder; a first junction control valve configured to permit or prohibit communication between the third pump and the first cylinder or the second cylinder; and a communication control valve configured to prohibit communication between the third pump and the first cylinder to guide the working fluid discharged by the third pump to the second cylinder by controlling the first junction control valve in a case where the second pump is communicated with the second cylinder by the second switching valve regardless of whether or not the first pump is communicated with the first cylinder by the first switching valve.

Abstract: A fluid pressure control device for a power shovel including first, second, and third pumps, a first switching valve connected to the first pump, a second switching valve connected to the second pump, a first merge control valve connected to the third pump, and a second merge control valve provided downstream of the first merge control valve, in which the first merge control valve is switched by a pilot pressure of the first switching valve or the second switching valve to enable communication between the third pump and a downstream side, and the second merge control valve is switched by a pilot pressure of the second switching valve to block communication between the third pump and the first switching valve.

Abstract: A control valve apparatus includes a second-working-actuator acceleration control valve connected to a first working control valve in parallel. The second-working-actuator acceleration control valve includes pilot chambers receiving a pilot pressure for switching first and second working control valves and a flow channel that guides a pressure fluid of a first pump port to an entrance port side of the second working control valve. The second-working-actuator acceleration control valve is switchable between a first priority position in which a pressure fluid is guided to the first working control valve with a higher priority than the second working control valve and a second priority position in which a pressure fluid is guided to the second working control valve with a higher priority than the first working control valve.

Abstract: Disclosed is a resin-metal bonded body of an aluminum metal member and a thermoplastic resin member, which has improved bonding strength and good durability. Also disclosed is a method for producing such a resin-metal bonded body. Specifically disclosed is a resin-metal bonded body which is obtained by bonding an aluminum metal member with a thermoplastic resin member. In this resin-metal bonded body, the aluminum metal member and the thermoplastic resin member are bonded together by an anodic oxide coating having a film thickness of 70-1500 nm or an anodic oxide coating having a triazine thiol in the inner and upper portions. The anodic oxide coating has an infrared absorption spectrum peak intensity ascribed to OH group at 0.0001-0.16.

Abstract: Provided is a novel compound having a selective JAK3-inhibitory effect and also having excellent oral absorbability. Also provided is a pharmaceutical agent, which is based on a JAK3-inhibitory effect and is useful for preventing and/or treating a disease involving the JAK3, and in particular, rheumatoid arthritis or multiple sclerosis. An azaindole derivative having a cycloalkenyl group, which is represented by the following formula (I), or a salt thereof, and a pharmaceutical composition containing the same: where R1 to R4, m and n have the same meanings as those defined in the description.

Abstract: The present invention is directed to a system and method for producing an organic compound using fermentation wherein multiple components of the system are recycled within the system. The system and method allow for extraction of a high concentration of the organic compound from the fermentation broth in a continuous system that allows recycling of the biomass, aqueous fermentation broth and extraction solvents. The system and method are particularly well adapted for producing and extracting ethanol.

Abstract: Guanidine-functionalized particles and methods of making and using such particles.

Abstract: A composition for use in bioseparation. The composition includes a plurality of hollow particles having a siliceous surface. The composition further includes a surface-modifying agent bonded to the hollow particles. The surface-modifying agent includes a binding segment and a reactive segment. The binding segment includes a silyl group and the reactive segment includes a reactive nitrogen group.

Abstract: A method for treating rheumatoid arthritis, multiple sclerosis, or a disease involving JAK3, including administering a compound of the formula (I) or a salt thereof to a subject

Abstract: An aqueous enzyme cleaning and protecting composition that includes: water; a protease; a surfactant selected from an anionic surfactant, a nonionic surfactant, an amphoteric surfactant, and a combination thereof; and a (meth)acrylic acid polymer component that is non-emulsifying; wherein the composition demonstrates protease activity.

Abstract: A grinding mill includes: a disc having a plurality of pins that grind a material to be ground; a housing that rotatably houses the disc; a collection port through which a ground material obtained by grinding the material to be ground is collected; a ground material flow passage that connects the housing and the collection port to each other; and an air return flow passage that is branched from the ground material flow passage and connected to the housing.

Abstract: A valve structure includes a switching valve; and a compensator valve configured to maintain a flow dividing ratio determined by a switching amount of the switching valve to be constant irrespective of a load change of an actuator connected to the switching valve. An axis line of a main spool provided in the switching valve and an axis line of a compensator spool provided in the compensator valve are parallel to each other.

Abstract: Provided is a novel compound having a selective JAK3-inhibitory effect and also having excellent oral absorbability. Also provided is a pharmaceutical agent, which is based on a JAK3-inhibitory effect and is useful for preventing and/or treating a disease involving the JAK3, and in particular, rheumatoid arthritis or multiple sclerosis. An azaindole derivative having a cycloalkenyl group, which is represented by the following formula (I), or a salt thereof, and a pharmaceutical composition containing the same: where R1 to R4, m and n have the same meanings as those defined in the description.

Abstract: A can body inspection apparatus which prevents a drop in resistance to noise while enabling high speed inspection is provided. It is comprised of a light source control means (21, 22) for turning on the light source unit a predetermined number of times of two times or more at predetermined timings at which light can be taken in by the light-detection unit through the open end face of the can body W which is moving along the path of conveyance W, a detection signal integrating means 23 for integrating signal values based on the detection signal which is output from the light-detection unit 15 due to on operations of the light source unit 10, and a condition judging means 24 for using an integrated value which is obtained by the detection signal integrating means 23 as the basis to judge the condition of the can body.

Abstract: A metal gasket material plate includes a sealing layer formed by layering a chemical coating layer, an adhesive layer, and a rubber coating layer in this order on at least one side of a metal plate. The chemical coating layer is formed by a thermosetting surface preparation agent including inorganic compound particles and a metal alkoxide compound. The adhesive layer is formed by an adhesive including an epoxy compound and an anti-corrosive pigment. The rubber coating layer is formed by a rubber agent including rubber.

Abstract: A semiconductor storage device is provided with a memory cell array comprising a plurality of word lines including word lines that are adjacent to one another; and a TRR address conversion unit that selects the word line in response to the input of an address signal indicating a first value while in a first operation mode and selects the word line in response to the input of an address signal indicating a first value while in a target row refresh mode. Due to the fact that address conversion is performed on the semiconductor storage device side in the present invention, it is sufficient for a control device to output, for example, the address of a word line having a high access count to the semiconductor storage device during a target row refresh operation. As a result, control of the target row refresh operation on the control device side is facilitated.

Abstract: A pump discharge amount is divided in accordance with switch amounts of respective switch valves (V1, V2) by leading load pressures of actuators (A1, A2) to which compensator valves (C1, C2) are connected to respective first pressure chambers (9, 10) of the compensator valves (C1, C2), leading a maximum load pressure selected by a selection unit (4) to respective second pressure chambers (11, 12) of the compensator valves (C1, C2), and controlling respective openings of the compensator valves (C1, C2) in accordance with respective pressure actions between the respective pressure chambers (9, 10, 11, 12). A drain passage (13) is provided to connect the first pressure chamber (10) of the compensator valve (C2) to a tank (T), and a flow dividing ratio modification valve (CV) is provided to control a pressure in the first pressure chamber (10).