Patents by Inventor Nan Ji

Nan Ji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • KRAS Proteolysis Targeting Chimeras
    Publication number: 20250144225
    Abstract: Provided herein are KRAS proteolysis targeting chimeras (PROTACs), compositions comprising the KRAS PROTACs, and methods of making and using the KRAS PROTACs, e.g., to promote degradation of KRAS and/or treat KRAS-associated cancers. In an embodiment, the KRAS PROTAC has the following structural formula: or a pharmaceutically acceptable salt thereof, wherein values for the variables are as described herein.
    Type: Application
    Filed: October 2, 2024
    Publication date: May 8, 2025
    Applicant: PAQ Therapeutics Inc.
    Inventors: Nan Ji, Hui Qiu, Ruoxi Lan
  • PROTEIN DEGRADERS AND USES THEREOF
    Publication number: 20250145636
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.
    Type: Application
    Filed: March 12, 2024
    Publication date: May 8, 2025
    Inventors: Nello MAINOLFI, Nan ji, Arthur F. Kluge
  • Aminocarboxymuconate Semialdehyde Decarboxylase (ACMSD) Inhibitors
    Publication number: 20250145572
    Abstract: The present invention is related to a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of aminocarboxymuconate semialdehyde decarboxylase (ACMSD).
    Type: Application
    Filed: January 9, 2025
    Publication date: May 8, 2025
    Inventors: Taisuke Takahashi, Nan Ji
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20250121073
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: October 10, 2024
    Publication date: April 17, 2025
    Inventors: Nello Mainolfi, Nan Ji, Matthew M. Weiss, Xiaozhang Zheng, Yi Zhang, Paul R. Fleming, Xiao Zhu
  • IRAK degraders and uses thereof
    Patent number: 12258341
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: July 19, 2023
    Date of Patent: March 25, 2025
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Nello Mainolfi, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang, Xiaozhang Zheng
  • STAT DEGRADERS AND USES THEREOF
    Publication number: 20250059221
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: July 3, 2024
    Publication date: February 20, 2025
    Inventors: Nello Mainolfi, Nan Ji, Bin Yang, Yi Zhang
  • COMPOUNDS FOR TREATING POLYQ-RELATED NEURODEGENERATIVE DISORDERS
    Publication number: 20250051282
    Abstract: One embodiment of the disclosure is a compound represented by Formula (I) or a pharmaceutically acceptable salt thereof. The variables in Formula (I) are defined herein. Compounds of Formula (I) can be used to treat polyQ-related neurodegenerative disorders.
    Type: Application
    Filed: December 8, 2022
    Publication date: February 13, 2025
    Inventors: Ning Yin, Nan Ji
  • CRBN LIGANDS AND USES THEREOF
    Publication number: 20250051320
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
    Type: Application
    Filed: February 21, 2024
    Publication date: February 13, 2025
    Inventors: Nello MAINOLFI, Nan JI, Arthur F. KLUGE
  • KRAS G12D Proteolysis Targeting Chimeras
    Publication number: 20250051364
    Abstract: Provided herein are KRAS G12D proteolysis targeting chimeras (PROTACs), compositions comprising the KRAS G12D PROTACs, and methods of making and using the KRAS G12D PROTACs, e.g., to promote degradation of KRAS G12D and/or treat KRAS G12D-associated cancers. In an embodiment, the KRAS G12D PROTAC has the following structural formula: [KRAS G12Di]-L?-[Degron], or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., KRAS G12Di, L?, Degron) are as described herein.
    Type: Application
    Filed: August 29, 2024
    Publication date: February 13, 2025
    Applicant: PAQ Therapeutics Inc.
    Inventors: Nan Ji, Ning Yin, Hui Qiu
  • TRICYCLIC CRBN LIGANDS AND USES THEREOF
    Publication number: 20250042902
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
    Type: Application
    Filed: January 10, 2024
    Publication date: February 6, 2025
    Inventors: Nan JI, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20250000985
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: February 20, 2024
    Publication date: January 2, 2025
    Inventors: Nello MAINOLFI, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang
  • MDM2 DEGRADERS AND USES THEREOF
    Publication number: 20240424110
    Abstract: The present invention relates to compounds and methods useful for the modulation of mouse double minute 2 homolog (“MDM2”) protein via ubiquitination and/or degradation by compounds according to the present invention.
    Type: Application
    Filed: March 19, 2021
    Publication date: December 26, 2024
    Inventors: Nan JI, Matthew M. WEISS, Xiaozhang ZHENG, Xiao ZHU
  • IRAK degraders and uses thereof
    Patent number: 12168057
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: April 24, 2023
    Date of Patent: December 17, 2024
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Nello Mainolfi, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang
  • IRAK degraders and uses thereof
    Patent number: 12150995
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: December 30, 2021
    Date of Patent: November 26, 2024
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Nello Mainolfi, Nan Ji, Matthew M. Weiss, Xiaozhang Zheng, Yi Zhang, Paul R. Fleming, Xiao Zhu
  • STAT degraders and uses thereof
    Patent number: 12077555
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: May 4, 2022
    Date of Patent: September 3, 2024
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Nello Mainolfi, Nan Ji, Bin Yang, Yi Zhang
  • KRAS G12D Proteolysis Targeting Chimeras
    Publication number: 20240247000
    Abstract: Provided herein are KRAS G12D proteolysis targeting chimeras (PROTACs), compositions comprising the KRAS G12D PROTACs, and methods of making and using the KRAS G12D PROTACs, e.g., to promote degradation of KRAS G12D and/or treat KRAS G12D-associated cancers. In an embodiment, the KRAS G12D PROTAC has the following structural formula: [KRAS G12Di]-L?-[Degron], or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., KRAS G12Di, L?, Degron) are as described herein.
    Type: Application
    Filed: February 8, 2024
    Publication date: July 25, 2024
    Applicant: PAQ Therapeutics Inc.
    Inventors: Nan Ji, Ning Yin, Hui Qiu
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20240239777
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: July 19, 2023
    Publication date: July 18, 2024
    Inventors: Nello Mainolfi, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang, Xiaozhang Zheng
  • Protein degraders and uses thereof
    Patent number: 12006329
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.
    Type: Grant
    Filed: August 18, 2022
    Date of Patent: June 11, 2024
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Nello Mainolfi, Nan Ji, Arthur F. Kluge
  • Poly-ADP ribose polymerase (PARP) inhibitors
    Patent number: 11993585
    Abstract: The present invention is related to a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of poly(ADP-ribose)polymerase (PARP). The definitions of the variables are provided herein.
    Type: Grant
    Filed: June 9, 2021
    Date of Patent: May 28, 2024
    Assignee: Mitobridge, Inc.
    Inventors: Taisuke Takahashi, Arthur Kluge, Bharat Lagu, Nan Ji
  • Method and apparatus of analyzing the ECG frequency parameters for the diagnosis of STEMI diseases
    Patent number: 11963782
    Abstract: This application provides a method and apparatus of analyzing the ECG frequency parameters with applications for the diagnosis of ST-segment elevation myocardial infarction (STEMI) diseases, which relates to the interdisciplinary field of biomedical and science engineering. The method includes obtaining ECG signals from subjects through the designed electrodes; calculating ECG frequency domain parameters of the subjects based on the proposed power spectrum model and getting the analytical validation results after studying and verifying the parameters; generating indicators based on the analytical validation results, which could be potentially used as alternative indicators for STEMI diagnosis; and alerting when the indicators meet preset abnormal conditions. The present embodiment is a powerful tool to diagnose STEMI diseases faster and more effectively and helps patients receive timely assistance and treatment.
    Type: Grant
    Filed: November 3, 2021
    Date of Patent: April 23, 2024
    Inventors: Yuanting Zhang, Ting Xiang, Nan Ji