Abstract: The present invention is related to a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of poly(ADP-ribose)polymerase (PARP). The definitions of the variables are provided herein.

Abstract: This application is directed to inhibitors of dynamin-1-like protein (Drp1) represented by the following structural formula (I): and methods for their use, such as to treat one or more DRP1-related diseases.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: An inspection system and method with a variable-diameter traveling robot for inspection of a natural gas pipeline. The inspection system includes a pipeline inspection robot, a cable reel, a hydraulic pump and an information acquisition control terminal. The pipeline inspection robot includes an electronic cabin and a traveling mechanism. The electronic cabin includes a first digital camera, a second digital camera, a first digital camera mounting plate, a second digital camera mounting plate, a drum, a printed circuit board, a magnetic flux leakage probe, and a backup battery. The traveling mechanism includes a first traveling part, a second traveling part, an inner ratchet, an inner ratchet base, a slider, a long shaft, a hydraulic cylinder, and a hydraulic pipe. The cable reel includes a power line, a conversion module, and a communication line. The information acquisition control terminal is a mobile terminal having an analysis module and a control module.

Abstract: Aspects of the present disclosure describe systems, methods and structures employing time-space de-noising for distributed sensor.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: An inspection system and method with a variable-diameter traveling robot for inspection of a natural gas pipeline. The inspection system includes a pipeline inspection robot, a cable reel, a hydraulic pump and an information acquisition control terminal. The pipeline inspection robot includes an electronic cabin and a traveling mechanism. The electronic cabin includes a first digital camera, a second digital camera, a first digital camera mounting plate, a second digital camera mounting plate, a drum, a printed circuit board, a magnetic flux leakage probe, and a backup battery. The traveling mechanism includes a first traveling part, a second traveling part, an inner ratchet, an inner ratchet base, a slider, a long shaft, a hydraulic cylinder, and a hydraulic pipe. The cable reel includes a power line, a conversion module, and a communication line. The information acquisition control terminal is a mobile terminal having an analysis module and a control module.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.

Abstract: The present invention is related to a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of poly(ADP-ribose)polymerase (PARP). The definitions of the variables are provided herein.

Abstract: The present invention is related to a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of aminocarboxymuconate semialdehyde decarboxylase

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.

Abstract: Aspects of the present disclosure describe systems, methods and structures providing bidirectional optical fiber communication and sensing using the same fiber transmission band and bidirectional WDM fiber sharing such that communications channels and optical fiber sensing channel(s) coexist on the same fiber. As a result, nonlinear interaction between communications channels and interrogating pulse(s) of sensing are much reduced or eliminated.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: The present invention also contemplates a method of treating a human patient with acute kidney injury or reducing the likelihood of developing acute kidney injury in a human patient at risk of developing acute kidney injury comprising administering to the patient a poly-ADP ribose polymerase (PARP) inhibitor in a therapeutically effective dose so as to thereby treat the patient.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

Abstract: A lithium secondary battery includes a positive electrode including a lithium manganese-based first positive electrode active material having a spinel structure doped and coated and a lithium nickel-manganese-cobalt-based second positive active material, a negative electrode including artificial graphite having a specific surface area (BET) of 0.1-1.2 m2/g and at least one selected from the group consisting of soft carbon and natural graphite which have a greater specific surface area than the artificial graphite, a separator interposed between the positive electrode and the negative electrode, and an electrolyte.

Abstract: Aspects of the present disclosure describe systems, methods and structures providing bidirectional optical fiber communication and sensing using the same fiber transmission band and bidirectional WDM fiber sharing such that communications channels and optical fiber sensing channel(s) coexist on the same fiber. As a result, nonlinear interaction between communications channels and interrogating pulse(s) of sensing are much reduced or eliminated.

Abstract: This application is directed to inhibitors of dynamin-1-like protein (Drp1) represented by the following structural formula (I): and methods for their use, such as to treat one or more DRP1-related diseases.

Abstract: Provided herein are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, and compositions comprising such compounds that are useful for increasing the amount of NAD+ in cells. Also disclosed are methods of using the disclosed compounds and compositions for treating mitochondrial-related diseases or disorders.