Abstract: This application provides a method and apparatus of analyzing the ECG frequency parameters with applications for the diagnosis of ST-segment elevation myocardial infarction (STEMI) diseases, which relates to the interdisciplinary field of biomedical and science engineering. The method includes obtaining ECG signals from subjects through the designed electrodes; calculating ECG frequency domain parameters of the subjects based on the proposed power spectrum model and getting the analytical validation results after studying and verifying the parameters; generating indicators based on the analytical validation results, which could be potentially used as alternative indicators for STEMI diagnosis; and alerting when the indicators meet preset abnormal conditions. The present embodiment is a powerful tool to diagnose STEMI diseases faster and more effectively and helps patients receive timely assistance and treatment.

Abstract: A pouch type battery case configured to accommodate an electrode assembly, in which electrodes and separators are stacked, according to an embodiment of the present invention for achieving the above object includes: a first cup part and a second cup part, which are arranged parallel to a pouch film and formed to be recessed; and a bridge formed between the first cup part and the second cup part and having a constant width and height, wherein the first cup part includes: a first outer wall formed toward an opposite to the bridge; a second outer wall formed toward the bridge; and a first bottom portion configured to connect the first outer wall to the second outer wall, and the second cup part includes: a third outer wall formed toward the bridge; a fourth outer wall formed toward the opposite to the bridge; and a second bottom portion configured to connect the third outer wall to the fourth outer wall, wherein the fourth outer wall has a height greater than that of the first outer wall.

Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same for the modulation of one or more SWI/SNF-related matrix associated actin dependent regulator of chromatin subfamily A (SMARCA) and/or polybromo-1 (PB-1) protein via ubiquitination and/or degradation by compounds. The compounds are bifunctional molecules that link a cereblon-binding moiety to a ligand that binds SMARCA and/or PB1 proteins.

Abstract: The present invention provides a method and an apparatus for obtaining relevant characteristic parameters and indexes of tonoarteriogram (TAG) signals, relating to the technical field of blood pressure monitoring.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety capable of binding to IRAK4 and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same for the modulation of one or more SWI/SNF-related matrix associated actin dependent regulator of chromatin subfamily A (SMARCA) and/or polybromo-1 (PB-1) protein via ubiqitination and/or degradation by compounds. The compounds are useful in treatment of cancer.

Abstract: Aspects of the present disclosure describe systems, methods and structures providing bidirectional optical fiber communication and sensing using the same fiber transmission band and bidirectional WDM fiber sharing such that communications channels and optical fiber sensing channel(s) coexist on the same fiber. As a result, nonlinear interaction between communications channels and interrogating pulse(s) of sensing are much reduced or eliminated.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same. The present invention also relates to compounds and methods useful for binding and modulating the activity of cereblon (CRBN), especially for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.