Abstract: The present invention is related to a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of poly(ADP-ribose)polymerase (PARP). The definitions of the variables are provided herein.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

Abstract: Aspects of the present disclosure describe systems, methods and structures employing time-space de-noising for distributed sensor.

Abstract: Aspects of the present disclosure describe systems, methods and structures providing bidirectional optical fiber communication and sensing using the same fiber transmission band and bidirectional WDM fiber sharing such that communications channels and optical fiber sensing channel(s) coexist on the same fiber. As a result, nonlinear interaction between communications channels and interrogating pulse(s) of sensing are much reduced or eliminated.

Abstract: The present invention is related to a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of aminocarboxymuconate semialdehyde decarboxylase (ACMSD).

Abstract: The present invention also contemplates a method of treating a human patient with acute kidney injury or reducing the likelihood of developing acute kidney injury in a human patient at risk of developing acute kidney injury comprising administering to the patient a poly-ADP ribose polymerase (PARP) inhibitor in a therapeutically effective dose so as to thereby treat the patient.

Abstract: A system to perform distributed acoustic sensing (DAS) in an environment with acoustic vibrations present includes at least an optical fiber positioned in said environment, wherein the optical fiber comprises N spatial channels and N laser pulses are launched into the N spatial channels of the optical fiber and propagate over a fiber length; and one or more sensors to measure N signals of acoustic vibration amplitude and frequency from each of N spatial channels, wherein the N signals are digitally added for spatial averaging and applied to determine DAS.

Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: Provided herein are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, and compositions comprising such compounds that are useful for increasing the amount of NAD+ in cells. Also disclosed are methods of using the disclosed compounds and compositions for treating mitochondrial-related diseases or disorders.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: A sensing system adapted to receive backscattered signal from a sensing fiber includes a first Faraday rotator mirror; a second Faraday rotator mirror; an optical hybrid coupled to the Faraday rotator mirrors, wherein one of the mirrors is coupled with an optical path difference; a 3-port optical circulator coupled to the sensing fiber and the optical hybrid; a first photodetector coupled to the circulator; and three photodetectors coupled to the optical hybrid.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract: Methods and systems for embedding VI demands in a software-defined network include mapping virtual nodes over physical nodes in a network topology. An auxiliary graph including virtual links between physical nodes that have a residual capacity sufficient to meet a virtual infrastructure demand is constructed. Virtual links over physical links are mapped to maximize use of existing optical channels and to minimize switching of a virtual link between a wavelength division multiplexing layer and an IP layer. New optical channels with a maximum spectral efficiency are established. A set of potential solutions for embedding a set of virtual infrastructure demands is determined. A solution is selected from the set of potential solutions that maximizes a weighted average of spectrum needed to support the set of virtual infrastructure demands and a cost of provisioning the virtual infrastructure demands.

Abstract: Aspects of the present disclosure describe systems, structures and methods providing fully reconfigurable optical add-drop multiplexing (ROADM) that provide redundancy protection against any two (2) simultaneous wavelength selective switch (WSS) failures with only four 2×1 WSS structures for both Eastbound and Westbound traffic, while not requiring bidirectional operation of the WSS structures.

Abstract: A sensing system adapted to receive backscattered signal from a sensing fiber includes a first Faraday rotator mirror; a second Faraday rotator mirror; an optical hybrid coupled to the Faraday rotator mirrors, wherein one of the mirrors is coupled with an optical path difference; a 3-port optical circulator coupled to the sensing fiber and the optical hybrid; a first photodetector coupled to the circulator; and three photodetectors coupled to the optical hybrid.

Abstract: Systems and methods for optical communication are disclosed that include communicating data using one or more transceiver pairs coupled to a spatial-multiplexer (S-MUX); performing bi-directional transmissions over an elliptical core optical fiber to a spatial-demultiplexer (S-DEMUX) using spatial modes to communicate data in either direction between two transceiver pairs with low crosstalk and without optical circulators or wavelength-division multiplexing (WDM); and communicating data from the S-DEMUX with g one or more transceiver pairs.

Abstract: Provided are a secondary battery, a battery module, and a battery pack, which have improved safety. Particularly, since a bulletproof material is disposed on the inside and/or the outside of an exterior part, even when a conductive needle-shaped member penetrates a secondary battery, heating, burning, discharge of evaporated electrolyte, and electrical contact between the needle-shaped member and an electrode can be prevented, thereby improving safety of the secondary battery, the battery module, and the battery pack.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.