Patents by Inventor Nan Ji

Nan Ji has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method, a Device, an Electronic Apparatus and a Storage Medium for Processing Multi-Modal Physiological Signals
    Publication number: 20230371821
    Abstract: The present invention provides a method, a device, an electronic apparatus, and a storage medium for processing multi-modal physiological signals, which relates to the field of health engineering. The method comprises: acquiring continuous target multi-modal physiological signals, the target multi-modal physiological signals comprise at least three target physiological signals of a target temperature signal, a target impedance plethysmogram (IPG) signal, a target electrocardiogram (ECG) signal, a target photoplethysmogram (PPG) signal and a target ultrasound signal; determining a continuous physiological information of a target subject, especially a continuous blood pressure information, according to the continuous target multi-modal physiological signals.
    Type: Application
    Filed: November 5, 2022
    Publication date: November 23, 2023
    Inventors: Yuanting ZHANG, Ting XIANG, Zijun LIU, Nan JI
  • IRAK degraders and uses thereof
    Patent number: 11807636
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: February 14, 2022
    Date of Patent: November 7, 2023
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Nello Mainolfi, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang, Xiaozhang Zheng
  • Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors
    Patent number: 11780812
    Abstract: The present invention is related to a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of aminocarboxymuconate semialdehyde decarboxylase (ACMSD).
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: October 10, 2023
    Assignee: OrsoBio, Inc.
    Inventors: Taisuke Takahashi, Nan Ji
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230303526
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: May 10, 2023
    Publication date: September 28, 2023
    Inventors: Nello MAINOLFI, Nan JI, Matthew M. WEISS, Xiaozhang ZHENG, Yi ZHANG, Paul R. FLEMING
  • PROTEIN DEGRADERS AND USES THEREOF
    Publication number: 20230295180
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.
    Type: Application
    Filed: August 18, 2022
    Publication date: September 21, 2023
    Inventors: Nello Mainolfi, Nan Ji, Arthur F. Kluge
  • Stat degraders and uses thereof
    Patent number: 11746120
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: October 10, 2022
    Date of Patent: September 5, 2023
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Nello Mainolfi, Nan Ji, Bin Yang, Yi Zhang
  • IRAK degraders and uses thereof
    Patent number: 11723980
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Grant
    Filed: February 10, 2022
    Date of Patent: August 15, 2023
    Assignee: Kymera Therapeutics, Inc.
    Inventors: Nello Mainolfi, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang
  • CRBN LIGANDS AND USES THEREOF
    Publication number: 20230234950
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.
    Type: Application
    Filed: November 28, 2022
    Publication date: July 27, 2023
    Inventors: Nello MAINOLFI, Nan JI, Arthur F. KLUGE
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230219945
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: December 17, 2020
    Publication date: July 13, 2023
    Inventors: Nello MAINOLFI, Nan JI, Matthew M. WEISS, Xiaozhang ZHENG, Yi ZHANG, Paul R. FLEMING, Xiao ZHU
  • SMARCA DEGRADERS AND USES THEREOF
    Publication number: 20230149549
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same for the modulation of one or more SWI/SNF-related matrix associated actin dependent regulator of chromatin subfamily A (SMARCA) and/or polybromo-1 (PB-1) protein via ubiqitination and/or degradation by compounds. The compounds are bifunctional molecules that link a cereblon-binding moiety to a ligand that binds SMARCA and/or PB1 proteins.
    Type: Application
    Filed: June 10, 2020
    Publication date: May 18, 2023
    Inventors: Nan JI, Yi ZHANG, Michael D. SINTCHAK, Paul R. FLEMING
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230132715
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: July 17, 2020
    Publication date: May 4, 2023
    Inventors: Nan JI, Michael D. SINTCHAK, Yi ZHANG, Xiaozhang ZHENG
  • STAT DEGRADERS AND USES THEREOF
    Publication number: 20230120381
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: October 10, 2022
    Publication date: April 20, 2023
    Inventors: Nello MAINOLFI, Nan JI, Bin YANG, Yi ZHANG
  • PROTEIN DEGRADERS AND USES THEREOF
    Publication number: 20230115184
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.
    Type: Application
    Filed: June 10, 2022
    Publication date: April 13, 2023
    Inventors: Nello MAINOLFI, Nan Ji, Yi Zhang, Matthew M. Weiss
  • Protein degraders and uses thereof
    Patent number: 11623932
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: April 11, 2023
    Assignee: KYMERA THERAPEUTICS, INC.
    Inventors: Nello Mainolfi, Nan Ji, Yi Zhang, Matthew M. Weiss
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230106066
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: February 10, 2022
    Publication date: April 6, 2023
    Inventors: Nello MAINOLFI, Nan Ji, Arthur F. Kluge, Matthew M. Weiss, Yi Zhang
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230101353
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: December 30, 2021
    Publication date: March 30, 2023
    Inventors: Nello Mainolfi, Nan Ji, Matthew M. Weiss, Xiaozhang Zheng, Yi Zhang, Paul R. Fleming, Xiao Zhu
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230089916
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.
    Type: Application
    Filed: June 29, 2020
    Publication date: March 23, 2023
    Inventors: Nello MAINOLFI, Nan JI, Matthew M. WEISS, Xiaozhang ZHENG, Yi ZHANG, Paul R. FLEMING
  • SMARCA DEGRADERS AND USES THEREOF
    Publication number: 20230087825
    Abstract: The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same for the modulation of one or more SWI/SNF-related matrix associated actin dependent regulator of chromatin subfamily A (SMARCA) and/or polybromo-1 (PB-1) protein via ubiqitination and/or degradation by compounds. The compounds are bifunctional molecules that link a cereblon-binding moiety to a ligand that binds SMARCA and/or PB1 proteins.
    Type: Application
    Filed: June 10, 2020
    Publication date: March 23, 2023
    Inventors: Nan JI, Yi ZHANG, Matthew M. WEISS
  • PROTEIN DEGRADERS AND USES THEREOF
    Publication number: 20230093080
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the targeted degradation of proteins, and the treatment of target protein-mediated disorders.
    Type: Application
    Filed: July 15, 2020
    Publication date: March 23, 2023
    Inventors: Nan JI, Michael D. SINTCHAK, Yi ZHANG, Xiaozhang ZHENG
  • STAT DEGRADERS AND USES THEREOF
    Publication number: 20230084113
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same.
    Type: Application
    Filed: May 4, 2022
    Publication date: March 16, 2023
    Inventors: Nello MAINOLFI, Nan Ji, Bin Yang, Yi Zhang