Abstract: A system may include a communications interface and a processor. The communications interface may be configured to receive ride requests from first communication devices associated with users and receive location information from second communication devices associated with vehicles. The processor may be configured to: assign a first vehicle to pick up a first group of users from the users; for each of the first group of users, determine pick-up and drop-off locations and provide a description of the pick-up location and an estimated pick-up time; after picking up some of the first group of users and before dropping them off, receive an indication of an unanticipated ridesharing event; determine an inability of the first vehicle to pick up a next user from the first group of users at a corresponding estimated pick-up time due to the unanticipated ridesharing event; and reassign the next user to a second vehicle.

Abstract: A pressure-sensing device (900, 1100) is provided that includes a user-activatable power-ON element, and a pressure sensor (143), which is in fluid communication with a connector port (122) configured to be coupled in fluid communication with an inflatable cuff (11) of an airway ventilation device (10), and is configured to sense an air pressure. Circuitry (141, 1141) is electrically coupled to the pressure sensor (143) and a relative-pressure display (140, 1140), and is configured to: (i) be activated by activation of the user-activatable power-ON element to (a) turn on the pressure-sensing device (900, 1100) and (b) perform a calibration procedure by setting a baseline pressure equal to a current air pressure sensed by the pressure sensor (143), and (ii) after setting the baseline pressure, periodically drive the relative-pressure display (140, 1140) to display the difference between (a) the air pressure currently sensed by the pressure sensor (143) and (b) the baseline pressure.

Abstract: The present disclosure relates to systems and methods for managing a fleet of multi-person transportation vehicles and a fleet of personal transportation vehicles. In some implementations, an urban mobility management system is provided. The system may determine first transportation routes for a plurality of users. The first transportation routes include at least one route in which a user uses a personal transportation vehicle for transportation and at least one route in which another user uses a multi-person transportation vehicle for transportation. The system may also determine second transportation routes for a plurality of personal transportation vehicles. The second transportation routes include at least one route in which a personal transportation vehicle is being relocated by a multi-person transportation vehicle. The system may also provide driving instructions to at least one multi-person transportation vehicle for transporting multiple users and at least personal transportation vehicle.

Abstract: A systems and methods for ridesharing are provided. The systems and method can include receiving a request for a ride share from a user and assigning a ride sharing vehicle based on a current number of unreserved reservable capacity spaces in a vehicle and a desired number of shared riders for a ride.

Abstract: A system may include a communications interface and a processor. The communications interface may be configured to receive ride requests from first communication devices associated with users and receive location information from second communication devices associated with vehicles. The processor may be configured to: assign a first vehicle to pick up a first group of users from the users; for each of the first group of users, determine pick-up and drop-off locations and provide a description of the pick-up location and an estimated pick-up time; after picking up some of the first group of users and before dropping them off, receive an indication of an unanticipated ridesharing event; determine an inability of the first vehicle to pick up a next user from the first group of users at a corresponding estimated pick-up time due to the unanticipated ridesharing event; and reassign the next user to a second vehicle.

Abstract: A system for directing a vehicle may include a processor configured to receive, from a wireless communication device, location data indicative of a current location of the vehicle and direct the vehicle to a desired destination using a first driving route. The processor may also be configured to receive, at a first time, data indicating that a new route for the vehicle is requested, and predict a location of the vehicle at a second time that will occur after the first time. The location may be one where a driver of the vehicle can safely implement instructions associated with changing the first driving route. The may further be configured to determine, based on the predicted location of the vehicle at the second time, a second driving route and prior to the second time, send instructions associated with the second driving route to the wireless communication device.

Abstract: A cuff pressure stabilizer (100, 200, 300, 500, 600, 800) is provided that includes an inflation lumen proximal port connector (134), which is shaped to form an air-tight seal with an inflation lumen proximal port (15) of a catheter (10) additionally having an inflatable cuff (11) and an inflation lumen (13); a fluid reservoir (120, 524, 624); a liquid column container (118, 518, 618), which is (a) open to the atmosphere (99) at at least one site along the liquid column container, (b) in fluid communication with the fluid reservoir (120, 524, 624), and (c) in communication with the inflation lumen proximal port connector (134) via the fluid reservoir (120, 524, 624); and a liquid (121), which is contained (a) in the fluid reservoir (120, 524, 624), (b) in the liquid column container (118, 518, 618), or (c) partially in the fluid reservoir (120, 524, 624) and partially in the liquid column container (118, 518, 618), and which has a density of between 1.5 and 5 g/cm3 at 4 degrees Celsius at 1 atm.

Abstract: A cuff pressure stabilizer includes a substantially rigid protective housing and a balloon disposed therein. The balloon has a base low pressure of 10 cm H2O when it contains a base low-pressure volume of air. When the balloon contains a first medium-pressure volume of air, the balloon has a first medium pressure of 25 cm H2O. When the balloon contains a second medium-pressure volume of air, the balloon has a second medium pressure of 40 cm H2O, and at least 20% of an outer surface of the balloon touches a portion of the inner surface of the housing. The second medium-pressure volume of air equals the base low-pressure volume of air plus a second incremental quantity of air that is less than 60 cc. Other embodiments are also described.

Abstract: A system may include a processor configured to receive a first request from a first user; electronically assign a ridesharing vehicle to pick up the first user and determine a driving route for transporting the first user; determine a target arrival time at a first drop-off location; receive a second request from a second user; calculate an estimated delay that would be caused to the first user by picking up of the second user; determine whether the delay would cause the first user to arrive at a first drop-off location after a target arrival time; determine that picking up the second user will not cause the first user to arrive at the first drop-off location after the target arrival time and electronically assign the ridesharing vehicle to pick up the second user; and direct the ridesharing vehicle according to an updated driving route.

Abstract: The present disclosure relates to systems and methods for managing and routing ridesharing vehicles. In some implementations, the systems and methods may count the number of passengers entering a ridesharing vehicle, distribute vehicles in need of charge to charging stations based on predicted future demand, manage a fleet of petrol and electric ridesharing vehicles, route autonomous and non-autonomous vehicles, automatically adjust drop-off locations based on safety constraints, and preschedule a rideshare with an unknown pick-up location.

Abstract: Systems and methods for managing a fleet of ridesharing vehicles are provided. The systems and method for ridesharing include ridesharing between users and a driver that may or may not have access to restricted areas.

Abstract: A cleaning catheter insertable into a ventilation tube and an input module are provided, the input module coupled to the cleaning catheter and including (i) an inflation module including an inflation chamber; (ii) a flow regulator operable to assume first and second fluid-control states; and (iii) a mechanical user control element operable (a) to mechanically and non-electrically set the first and second fluid-control states, (b) to assume first and second configurations, and (c) to mechanically and non-electrically increase pressure in an interior of an inflation chamber of the cleaning catheter during a transition of the mechanical user control element from the first configuration to the second configuration. The inflation chamber is disposed within the mechanical user control element.

Abstract: Systems and methods for providing real time dynamic modification of content in a video receive a markup defining a placement of at least one element in a predefined segment of the video and at least one range regarding the placement; stream the video over a streaming platform to at least a first viewer; initiate a creative request at a predetermined proximity to the placement; receive, based on the creative request, one or more creatives to be rendered as an element within the video based at least on the defined placement and the at least one range; render the creative into the segment; and stream the segment with the rendering to the first viewer in accord with the video.

Abstract: Provided herein are methods for enhancing epidermal regeneration in a patient in need thereof, comprising topically administering to said patient a pharmaceutically acceptable composition comprising N-acetyl-3-(4-aminophenyl)-2-methoxypropionic acid or a pharmaceutically acceptable salt or stereoisomer thereof, and a pharmaceutically acceptable excipient. For example, provided are methods for treating or ameliorating cicatricial alopecia, comprising topically administering to a patient in need thereof a pharmaceutically acceptable composition comprising the disclosed compounds. Also provided are methods for protecting hair follicle progenitor cells and compositions comprising same using the disclosed compounds.

Abstract: A cleaning catheter insertable into a tracheal ventilation tube and an input module are provided for use with a suction source, the input module coupled to the cleaning catheter and including (i) an inflation module, including an inflation chamber separate from the suction source; (ii) a flow regulator, configured to assume first and second fluid-control states; and (iii) a mechanical user control element, which is configured (a) to mechanically and non-electrically set the fluid-control states, (b) to assume first and second configurations, and (c) to mechanically and non-electrically increase pressure in an interior of an inflation chamber during a transition of the mechanical user control element from the first configuration to the second configuration. The flow regulator, when in the first fluid-control state connects the suction source and an interior of an inflatable element of the cleaning catheter in fluid communication to deflate the inflatable element.

Abstract: A cleaning catheter insertable into a ventilation tube and an input module are provided, the input module coupled to the cleaning catheter and including (i) an inflation module, including an inflation chamber and a one-way air inlet valve; (ii) a flow regulator operable to assume first and second fluid-control states; and (iii) a mechanical user control element operable (a) to mechanically and non-electrically set the fluid-control states, (b) to assume first and second configurations, and (c) to mechanically and non-electrically increase pressure in an interior of an inflation chamber of the cleaning catheter during a transition of the mechanical user control element from the first configuration to the second configuration. The one-way air inlet valve is arranged to allow air to flow into the inflation chamber during a transition of the mechanical user control element from the second configuration to the first configuration.

Abstract: The present disclosure relates to systems and methods for directing ridesharing vehicles. In some implementations, the systems and methods may include.

Abstract: The present disclosure relates to systems and methods for directing ridesharing vehicles.

Abstract: A multi-lumen catheter for cleaning an inner surface of a tracheal ventilation tube is provided, which enables single-handed simultaneous activation of inflation of an inflatable element and suctioning in a closed suction system for use with the in tracheal ventilation tube. The closed suction system allows catheters to be used repeatedly without being detached from the tube system including the ventilation air supply. The cleaning catheter is insertable into the tracheal ventilation tube, and is shaped so as to define one or more distal suction orifices. The cleaning catheter comprises an elongate, flexible, tubular catheter main body, and an inflatable element, which is mounted to the catheter main body. An input module is coupled to the cleaning catheter, and comprises an inflation module, which comprises an inflation chamber separate from a suction source.