Abstract: An custom page server is provided with user preferences organized into templates stored in compact data structures and the live data used to fill the templates stored local to the page server which is handing user requests for custom pages. One process is executed on the page server for every request. The process is provided a user template is either generated from user preferences or retrieved from a cache of recently used user templates. Each user process is provided access to a large region of shared memory which contains all of the live data needed to fill any user template. Typically, the pages served are news pages, giving the user a custom selection of stock quotes, news headlines, sports scores, weather, and the like. With the live data stored in a local, shared memory, any custom page can be built within the page server, eliminating the need to make requests from other servers for portions of the live data.

Abstract: Disclosed is a pharmaceutical composition suitable for oral administration in the form of a homogeneous solution which on exposure to water or gastrointestinal fluids forms an emulsion having a particle size of less than 5 microns, the solution containing: (a) a pharmaceutically effective amount of a cyclosporin, in particular Cyclosporin A, (b) a carrier medium which is a dialkyl ester of an aliphatic or aromatic dioic acid, the alkyl group of said dialkyl ester having from 2 to 8 carbon atoms, and said aliphatic or aromatic dioic acid having from 6 to 20 carbon atoms, (c) a co-carrier having a hydrophilic lipophilic balance (HLB) of from 3 to 6, and (d) a non-ionic surfactant having a hydrophilic lipophilic balance (HLB) greater than 10. Examples of the carrier medium are dibutyl sebacate and dibutyl phthalate. Examples of the co-carrier are glycerol monooleate, sorbitan monooleate, glycerol monocaprylate, and sorbitan monolaurate.

Abstract: A multi-layer microfluidic separation device comprises a polymeric membrane frit that may be securely bonded within the device and minimizes lateral wicking. Stationary phase material having an average particle size is retained by a frit having an average pore size that is smaller than the average particle size. In one embodiment, a secure bond is ensured by treating the polymer to match its surface energy to that of the materials to which it is bound. Treatments include plasma treatment, irradiation and the application of acids.

Abstract: The present invention involves reducing the amount of unsolicited e-mail. In one embodiment, a method for automatically detecting unsolicited electronic mail from a mailer and automatically notifying facilitators of the mailer of the unsolicited electronic mail is disclosed. In one step, an electronic mail message is received from the mailer. It is automatically determined if the electronic mail message is probably unsolicited. A check for an open relay in routing information of a header of the electronic mail message is performed. The facilitating party of the mailer is determined. Information relating to the electronic mail message is automatically reported to the facilitating party.

Abstract: The present invention is directed to resist and etching residue removing compositions containing at least one nucleophilic amine compound possessing reduction and oxidation potentials, a two-carbon atom linkage alkanolamine compound, and optionally water and/or one or more corrosion inhibitors. The compositions may be substantially free of hydroxylamine, polar organic solvents, water, corrosion inhibitors, or a combination thereof. The compositions are useful in processes for removing resists and etching residue from metal or metal alloy substrates or substrate layers used in micro-circuitry fabrication.

Abstract: The present invention provides a process for preparing compounds of formula (I) or a pharmaceutically acceptable salt thereof. The compounds prepared by the process of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.

Abstract: A method to increase the efficiency of transduction of hematopoietic and other cells by retroviruses includes infecting the cells in the presence of fibronectin or fibronectin fragments. The fibronectin and fibronectin fragments significantly enhance retroviral-mediated gene transfer into the cells, particularly hematopoietic cells including committed progenitors and primitive hematopoietic stem cells. The invention also provides improved methods for somatic gene therapy capitalizing on enhanced gene transfer, hematopoietic cellular populations, and novel constructs for enhancing retroviral-mediated DNA transfer into cells and their use.

Abstract: Stable solutions of lipophilic drugs, such as cyclosporin, forming a polar lipid self-emulsifying drug delivery system. The solutions can include lipophilic drugs, such as cyclosporin, dissolved in a polar lipid, such as having a C6-C12 fatty acid monoglyceride content of at least about 50%, surfactants and triglycerides. The composition forms a fine emulsion on exposure to water. The encapsulated dosage form of this composition needs neither a hydrophilic component nor air-tight blister packaging, and is particularly suitable for oral administration.

Abstract: Microfluidic analytical devices and systems have at least one porous element disposed downstream of one or more optical detection regions in a pressure-based separation system. A porous element elevates the backpressure within an optical detection region, thus suppressing bubble formation and enhancing optical detection. Various types of porous elements include porous membranes, packed particulate material, and polymerized monoliths. Preferred devices may be fabricated with substantially planar device layers, including stencil layers, that are directly bonded without adhesives to form a substantially sealed microstructure suitable for performing pressure-based chromatographic separations at elevated operating pressures and with organic solvents.

Abstract: The present invention relates to deletion and substitution mutant polypeptides of human chemokine ?-7 (Ck?-7), as well as nucleic acid molecules encoding such polypeptides and processes for producing such polypeptides using recombinant techniques. In one aspect, the invention also relates to uses of the full-length and mature forms of Ck?-7, as well as deletion and substitution mutants, in medical treatment regimens. In particular, the Ck?-7 polypeptides described herein may be employed to treat a variety of conditions, including rheumatoid arthritis, inflammation, respiratory diseases, allergy, and IgE-mediated allergic reactions.

Abstract: Microfluidic devices capable of efficiently mixing two or more fluid are provided. Two or more microfluidic inlet channels defined in different sheets of material meet at an overlap region in fluid communication with an outlet channel. The channels are defined through the entire thickness of stencil sheets. The overlap region may include an aperture-defining spacer layer, and/or an impedance element, such as a porous membrane, adapted to distribute at least one fluid across the entire width of the outlet channel to promote reliable fluid mixing.

Abstract: Pressure-driven microfluidic separation devices, such as may be used for performing high performance liquid chromatography, are provided. Multiple separation columns may be defined in a single device and packed with stationary phase material retained by porous frits. One or more splitters may be provided to distribute slurry and/or mobile phase among multiple separation columns. In one embodiment, separation devices are substantially planar and fabricated with multiple device layers. Systems and methods employing slurry for packing separation devices are also provided.

Abstract: Disclosed is a pharmaceutical composition suitable for oral administration in the form of a homogeneous solution which on exposure to water or gastrointestinal fluids forms an emulsion having a particle size of less than 5 microns, the solution containing: (a) a pharmaceutically effective amount of a cyclosporin, in particular Cyclosporin A (b) a carrier medium which is a triglycerol monoester of a fatty acid having from 6 to 30 carbon atoms or mixtures thereof, (c) polyethylene glycol, (d) a non-ionic surfactant having a hydrophilic lipophilic balance (HLB) greater than 10, and (e) optionally, a viscosity reducing agent, the composition being substantially free from ethanol. The preferred carrier medium is triglycerol monooleate. Examples of the viscosity reducing agent are glycerol monocaprylate and glycerol monooleate.

Abstract: A UV-curable composition is disclosed. The composition comprises a crosslinking agent, a hydroxyalkyl acrylate or methacrylate, and an acrylic polyol. The crosslinking agent is selected from the group consisting of multifunctional isocyanates, melamines, and silanes. The acrylic polyol comprises recurring units of an allylic alcohol. The composition can be irradiated to be solidified and then fully cured by the urethane, melamine, or silane reactions. Alternatively, the composition can be cured by the urethane, melamine, or silane reactions, and then fully cured by radiation. The invention provides low VOC but high performance coatings. More importantly, the invention provides a UV-curable system without the need for acrylated oligomers.

Abstract: A scroll compressor includes a protection device that has a valve movable between a position blocking flow from the back pressure chamber into the suction chamber, and a position allowing such flow. The valve is movable dependent on an oil temperature. Under adverse conditions, the oil will reach higher temperatures and the valve will open allowing flow of refrigerant from the back pressure chamber into the suction chamber. This refrigerant will likely be at an elevated temperature, and will assist the heated oil in moving a motor protection switch associated with the motor to shut down the motor. Moreover, by relieving the back pressure chamber, the two scroll members are allowed to move out of contact with each other, thereby reducing potential damage due to the adverse conditions.

Abstract: The present invention relates to a reconfigurable porous technology for fluid flow control system and more particularly to reconfigurable porosity fluid flow control system for vehicles such as aircraft, missiles, ground and water vehicles to improve the performance of such vehicles. The present invention further relates to a method of operating the reconfigurable fluid flow control system. In one embodiment, the present invention includes a reconfigurable porosity system for fluid flow control on the surface of an aircraft, missile, water-craft or ground vehicle comprising a porous outer skin comprising individual pores; individually addressable valves corresponding and connected to the individual pores for opening and closing the pores; and a pneumatic system for connecting the pores wherein fluid from a high pressure area of the porous outer skin can be directed to a low pressure area of the porous outer skin by opening and closing the individually addressable valves.

Abstract: A method for fabricating a microfluidic device where first and second substantially flat platens are provided. Multiple substantially planar, substantially metal-free, adhesiveless polymer device layers, the device layers including a first cover layer, second cover layer, and at least one stencil layer defining a microfluidic channel penetrating through the entire thickness of the stencil layer also are provided. Each stencil layer is disposed between other device layers such that the channel is bounded laterally by a stencil layer, and bounded from above and below by surrounding device layers to define an upper channel surface and a lower channel surface. The device layers are stacked between the first platen and the second platen. The stacked device layers are controllably heated according to a heating profile adapted to form a substantially sealed adhesiveless microfluidic device wherein each upper channel surface remains distinct from its corresponding lower channel surface.

Abstract: The present invention relates to a flow control device and more particularly to reactive modular flow control device with deployable flow effectors. The present invention further relates to a method of operating the flow control device. One embodiment of the present invention includes a method of controlling air flow across a surface of an aircraft under certain flight conditions comprising the steps of sensing fluid separation from the surface by measuring the pressure on the surface; determining a standard deviation of the pressure measurements over a period of time; and deploying a flow of effector in response to the standard deviation of the pressure measurements exceeding a predetermined threshold number.

Abstract: Disclosed is a roofing system for adhering two or more roofing tiles together to form a substantially impermeable barrier of a roof. Additionally disclosed is a roofing tile having a pre-applied adhesives strip and a method for forming a roof. The adhesive strip comprises a foamed polymer which in combination with an adhesive layer binds or seals the roofing tiles.

Abstract: A frit for use in multi-layer microfluidic separation devices is provided. The frit comprises a polymeric membrane that may be securely bonded within the device and minimizes lateral wicking. A secure bond is ensured by treating the polymer to match its surface energy to that of the materials to which it is bound. Treatments include plasma treatment, irradiation and the application of acids.