Patents by Inventor Patrick Henry

Patrick Henry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and system for identification of a given geometrical feature of an optical component
    Patent number: 9726572
    Abstract: A method and system for identifying a given geometrical feature of an optical component or semi-finished ophthalmic lens blank, where an optical component is made of an organic material that can emit light at an emission wavelength ?e when being lighten at an illumination wavelength ?i different from the emission wavelength ?e, a surface of the optical component is illuminated with an incident light beam including at least light at the illumination wavelength but devoid from light at the emission wavelength, light emitted at the emission wavelength by the illuminated surface is collected to build an image of the surface, and the surface image is processed to apply metrics to compare the image with reference data specific to the given geometrical feature.
    Type: Grant
    Filed: July 5, 2013
    Date of Patent: August 8, 2017
    Assignee: ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE
    Inventors: Patrick Henry, Thomas Lassier, Laurent Occhini, Christian Rehn
  • PROCESS FOR MAKING DUOCARMYCIN PRODRUGS
    Publication number: 20170145006
    Abstract: The present invention relates to a process comprising converting a compound of formula (I) into a compound of formula (II) by reaction with an organolithium reagent, which compound can be further converted into duocarmycin analogues consisting of a DNA-alkylating and a DNA-binding part, and still further into corresponding antibody-drug conjugates.
    Type: Application
    Filed: June 5, 2014
    Publication date: May 25, 2017
    Applicant: SYNTHON BIOPHARMACEUTICALS B.V.
    Inventors: Tijl HUIJBREGTS, Ronald Christiaan ELGERSMA, Patrick Henry BEUSKER, Johannes Albertus Frederikus JOOSTEN, Rudy Gerardus Elisabeth COUMANS, Henri Johannes SPIJKER, Wiro MENGE, Franciscus Marinus Hendrikus DE GROOT
  • METHOD OF IMPROVING HAIR QUALITY BY IMPROVING SCALP HEALTH
    Publication number: 20170135932
    Abstract: A method of improving the health of hair emerging from a scalp comprising application of a composition to reduce oxidative stress in the scalp causing reduced oxidative stress in pre-emergent hair resulting in healthier emergent hair having reduced water absorption and reduced surface energy
    Type: Application
    Filed: May 26, 2016
    Publication date: May 18, 2017
    Inventors: James Robert Schwartz, James Patrick Henry, Michael Joseph Flagler, Steven Hardy Page, Kathleen Marie Kerr, Kenneth Robert Wehmeyer, Lijuan Li, Nancy Lee Redman-Furey
  • Conjugates of CC-1065 analogs and bifunctional linkers
    Patent number: 9629924
    Abstract: This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.
    Type: Grant
    Filed: April 21, 2011
    Date of Patent: April 25, 2017
    Assignee: Syntarga BV
    Inventors: Patrick Henry Beusker, Rudy Gerardus Elisabeth Coumans, Ronald Christiaan Elgersma, Wiro Michael Petrus Bernardus Menge, Johannes Albertus Frederikus Joosten, Henri Johannes Spijker, Franciscus Marinus Hendrikus De Groot
  • Assays, Methods and Means
    Publication number: 20170088876
    Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
    Type: Application
    Filed: October 3, 2016
    Publication date: March 30, 2017
    Applicant: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Patrick Henry Maxwell, Christopher William Pugh, Peter John Ratcliffe, Christopher Joseph Schofield
  • DUOCARMYCIN ADCS SHOWING IMPROVED IN VIVO ANTITUMOR ACTIVITY
    Publication number: 20170014525
    Abstract: The present invention relates to duocarmycin-containing antibody-drug conjugates (ADCs) for use in the treatment of human solid tumours and haematological malignancies expressing HER2, in particular breast cancer, gastric cancer, bladder cancer, ovarian cancer, lung cancer, prostate cancer, pancreatic cancer, colorectal cancer, head and neck squamous cell cancer or osteosarcoma, and acute lymphoblastic leukaemia. In particular, the present invention relates to duocarmycin-containing ADCs for use in the treatment of human solid tumours with HER2 IHC 2+ or 1+ and HER2 FISH negative tissue status. Advantageously, the present invention relates to duocarmycin-containing ADCs for use in the treatment of triple negative breast cancer (TNBC).
    Type: Application
    Filed: July 21, 2016
    Publication date: January 19, 2017
    Applicant: Synthon Biopharmaceuticals B.V.
    Inventors: Willem DOKTER, Peter Johannes GOEDINGS, Gijsbertus Franciscus Maria VERHEIJDEN, Patrick Henry BEUSKER
  • METHOD OF IMPROVING HAIR QUALITY BY IMPROVING SCALP HEALTH
    Publication number: 20160346184
    Abstract: A method of improving the health of hair emerging from a scalp comprising a reduction of oxidative stress in the scalp by application of a composition resulting in reduction in oxidative stress in pre-emergent hair as demonstrated by reduced oxidative stress in emergent hair.
    Type: Application
    Filed: May 26, 2016
    Publication date: December 1, 2016
    Inventors: James Robert Schwartz, James Patrick Henry, Kathleen Marie Kerr, Kenneth Robert Wehmeyer, Lijuan Li, Haruko Mizoguchi
  • ASSAYS, METHODS AND MEANS
    Publication number: 20160243099
    Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
    Type: Application
    Filed: November 18, 2015
    Publication date: August 25, 2016
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Patrick Henry Maxwell, Christopher William Pugh, Peter John Ratcliffe, Christopher Joseph Schofield
  • Duocarmycin ADCS showing improved in vivo antitumor activity
    Patent number: 9421278
    Abstract: The present invention relates to duocarmycin-containing antibody-drug conjugates (ADCs) for use in the treatment of human solid tumors and haematological malignancies expressing HER2, in particular breast cancer, gastric cancer, bladder cancer, ovarian cancer, lung cancer, prostate cancer, pancreatic cancer, colorectal cancer, head and neck squamous cell cancer or osteosarcoma, and acute lymphoblastic leukaemia. In particular, the present invention relates to duocarmycin-containing ADCs for use in the treatment of human solid tumors with HER2 IHC 2+ or 1+ and HER2 FISH negative tissue status. Advantageously, the present invention relates to duocarmycin-containing ADCs for use in the treatment of triple negative breast cancer (TNBC).
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: August 23, 2016
    Assignee: Synthon Biopharmaceuticals B.V.
    Inventors: Willem Dokter, Peter Johannes Goedings, Gijsbertus Franciscus Maria Verheijden, Patrick Henry Beusker
  • Cartridge drive
    Patent number: 9377097
    Abstract: A drive system includes a drive housing and one or more drivetrain cartridges. The one or more drivetrain cartridges enables better manufacturability by allowing drivetrain components to be installed together outside the housing and then installed as a unit together into the housing. Serviceability is improved by allowing one or more of the drivetrain cartridges to be removed individually from the housing for maintenance or repair. The housing may include mounting surfaces to securely engage the one or more drivetrain cartridges to the housing to prevent play. The housing may include a bottom or side panel with installation mounts to fasten the drivetrain cartridge or cartridges securely to the bottom or side panel of the housing.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: June 28, 2016
    Assignee: KUHN NORTH AMERICA, INC.
    Inventors: Thomas Hoffman, Todd Gibson, Casey Fennell, Patrick Henry
  • SENSOR SYSTEM AND METHOD FOR SENSING CHLORINE CONCENTRATION
    Publication number: 20160123950
    Abstract: Certain embodiments include a sensor system for measuring chlorine concentration in water. The sensor system can have a manifold including one or more flow passages for receiving fluid flow. The sensor system can have a probe for measuring chlorine concentration in fluid communication with a flow passage of the one or more flow passages of the manifold. The probe can have a probe body oriented to direct incoming fluid from one or more flow passages of the manifold toward an end of the probe body. The probe can have a plurality of flutes defined on an outer surface of the probe body. The flutes can be shaped and oriented to direct fluid from the end proximal to the electrodes, back toward the one or more flow passages of the manifold.
    Type: Application
    Filed: November 5, 2014
    Publication date: May 5, 2016
    Inventors: Ronald Bruce Howes, JR., Patrick Henry Kilawee, Michael Patrick Kremer, Leonard John Kadlec
  • ASSAYS, METHODS AND MEANS
    Publication number: 20160101080
    Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the IIIF hydroxylase with a substrate. Modulators of IIIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
    Type: Application
    Filed: November 18, 2015
    Publication date: April 14, 2016
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Patrick Henry Maxwell, Christopher William Pugh, Peter John Ratcliffe, Christopher Joseph Schofield
  • ASSAYS, METHODS AND MEANS
    Publication number: 20160101094
    Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the IIIF hydroxylase with a substrate. Modulators of IIIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
    Type: Application
    Filed: November 18, 2015
    Publication date: April 14, 2016
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Patrick Henry Maxwell, Christopher William Pugh, Peter John Ratcliffe, Christopher Joseph Schofield
  • ASSAYS, METHODS AND MEANS
    Publication number: 20160097076
    Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
    Type: Application
    Filed: November 18, 2015
    Publication date: April 7, 2016
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Patrick Henry Maxwell, Christopher William Pugh, Peter John Ratcliffe, Christopher Joseph Schofield
  • ASSAYS, METHODS AND MEANS
    Publication number: 20160097078
    Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
    Type: Application
    Filed: November 18, 2015
    Publication date: April 7, 2016
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Patrick Henry Maxwell, Christopher William Pugh, Peter John Ratcliffe, Christopher Joseph Schofield
  • ASSAYS, METHODS AND MEANS
    Publication number: 20160097077
    Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the IIIF hydroxylase with a substrate. Modulators of IIIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
    Type: Application
    Filed: November 18, 2015
    Publication date: April 7, 2016
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Patrick Henry Maxwell, Christopher William Pugh, Peter John Ratcliffe, Christopher Joseph Schofield
  • ASSAYS, METHODS AND MEANS
    Publication number: 20160097080
    Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
    Type: Application
    Filed: November 18, 2015
    Publication date: April 7, 2016
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Patrick Henry Maxwell, Christopher William Pugh, Peter John Ratcliffe, Christopher Joseph Schofield
  • ASSAYS, METHODS AND MEANS
    Publication number: 20160097079
    Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the IIIF hydroxylase with a substrate. Modulators of IIIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.
    Type: Application
    Filed: November 18, 2015
    Publication date: April 7, 2016
    Applicant: ISIS INNOVATION LIMITED
    Inventors: Patrick Henry Maxwell, Christopher William Pugh, Peter John Ratcliffe, Christopher Joseph Schofield
  • Searching for multicast consumers in a network of interconnected nodes
    Patent number: 9306836
    Abstract: Examples described herein provide for generating a multicast consumer search request from a request node in the network. The request is then routed to the interconnected nodes and received at a target node having a directly-connected multicast consumer. Identification information associated with the directly-connected multicast consumer is forwarded from the target node back to the request node.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: April 5, 2016
    Assignee: HEWLETT PACKARD ENTERPRISE DEVELOPMENT LP
    Inventors: Richard J Rollins, Duane Edward Mentze, Mark Patrick Henry
  • Novel CC-1065 Analogs and Their Conjugates
    Publication number: 20160052880
    Abstract: This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.
    Type: Application
    Filed: October 28, 2014
    Publication date: February 25, 2016
    Applicant: Syntarga BV
    Inventors: Patrick Henry Beusker, Rudy Gerardus Elisabeth Coumans, Ronald Christiaan Elgersma, Wiro Michael Petrus Bernardus Menge, Johannes Albertus Frederikus Joosten, Henri Johannes Spijker, Franciscus Marinus Hendrikus de Groot