Abstract: This invention relates to novel analogs of the DNA-binding alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and their conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.

Abstract: A coating composition comprising a binder of a. polyisocyanate crosslinking agent; b. an isocyanate-reactive component having at least one compound having the following formula: wherein n on average is 1.7 to 2 and X stands for a cycloaliphatic norbornane derivative containing methylene amine groups of formula (II) either alone, as combinations of these, and/or as mixtures of isomers of these, in which the exact point of attachment and orientation of —CH2— group to the NH group and R20—R22 to the norbornane scaffold can vary and mixtures of compounds and isomers are commonly utilized by this invention; two component compositions and articles coated with the novel composition also are part of the invention.

Abstract: Use of xenon is described. Xenon is used as an organ and/or tissue and/or cell protectant in the manufacture of a pharmaceutical for the protection from injury of organs and/or tissue and/or cells that express HIF.

Abstract: Carpet protectants comprising an aqueous dispersion comprising A. a partially fluorinated urethane polymer having at least one urea linkage, which compound is the product of the reaction of: (1) at least one organic polyisocyanate containing at least three isocyanate groups; (2) at least one fluorochemical compound which contains per molecule (a) a single functional group having one or more Zerewitinoff hydrogen atoms and (b) at least two carbon atoms, each of which is attached to at least two fluorine atoms; and (3) water in an amount sufficient to react with from about 5% to about 60% of the isocyanate groups in said polyisocyanate; B. a non-fluorinated cationic surfactant; and C. a non-fluorinated nonionic surfactant are disclosed.

Abstract: A cartridge carrier has a base with a recessed plate, a top surface, and a bottom surface. An locking ejection mechanism is coupled to the base. A guide may be coupled to the top surface of the base to receive the cartridge and an interposer board may be coupled to the guide.

Abstract: The present invention relates to novel poly(meth)acrylate compositions formed by polymerization of (meth)acrylate amide acetals.

Abstract: This invention relates to compounds comprising one or more therapeutic and/or diagnostic moieties and one or more functional moieties linked together via one or more triazole-containing linkers and to their intermediates and methods of their preparation. The triazole-containing linker may optionally contain one or more conditionally-cleavable or conditionally-transformable moieties and one or more spacer systems in between said moiety/moieties and the one or more therapeutic and/or diagnostic moieties.

Abstract: The invention includes a corrugated decking flooring system. The corrugated decking flooring system can include a corrugated deck having at least two flutes and a trough between the flutes. A sound insulation layer generally conformal with both the flutes and the troughs of the corrugated deck can be provided. An underlayment layer can be provided over the sound insulation layer.

Abstract: The present process is directed to preparation of addition polymers in diluents that are subsequently reactive in coatings during cure, instead of in traditional hydrocarbon solvents. The polymers so prepared can be used as the main film-forming polymer in high solids coating compositions, especially those useful for finishing automobiles and truck exteriors.

Abstract: Personal care composition comprising at least one hair growth regulating compound selected from the group consisting of glyceryl dilaurate, apigenin, tetrahydrocurcumin, oleanolic acid, azelaic acid, sulforaphane, canavanine, pyridoxal 5-phosphate, phytic acid, tannic acid, grape seed extract, NG-nitro-L-arginine-methyl ester, benzamidine, sodium butyrate, betulinic acid, polyornithine, polyarginine, fisetin, jasmonates, methyl-jasmonate, cis-jasmone, caffeic acid phenethyl ester, delphinidin, ethyl abietate, esculetin, sorbic acid methyl ester, canaline, N-formyl-methionine, N-formyl-alanine, taurine, palmitoyl carnitine, undecanol, undecylenic acid, rutin, fusidic acid, phenyl pyruvic acid, L-isoleucine, phenyl glycine, silibinin, silymarin, L-ascorbic acid-6-palmitate, N-undecylenoyl-L-phenylalanine, and salts, derivatives and mixtures of any of the foregoing; and a dermatologically-acceptable carrier.

Abstract: A blister package is provided in which the lidding component includes a tear-resistant nonwoven layer and a barrier layer wherein the controlled delamination of the nonwoven layer increases the puncture resistance, thereby improving the child-resistant properties of the package.

Abstract: A coating composition useful for coating automobile and truck bodies comprising a binder of a. polyisocyanate crosslinking agent; b. an isocyanate-reactive component having at least one compound having the following formula: wherein X, Y, R1, R2, m and n are described in the specification, and c. 0.05 to 10% by weight, based on the total weight of the coating composition, of a metal alkoxide compound; and containing optional additional polymeric components, oligomeric components and antioxidants, light absorbers and light stabilizers.

Abstract: A composition comprising monomers copolymerized in the following percentages by weight: (a) from about 20% to about 95% of a monomer, or mixture of monomers, of formula (I): Rf—(CH2CF2)q(CH2CH2)r-Z-C(O)—C(R)?CH2 ??(I) wherein q and r are each independently integers of 1 to 3; Rf is a linear or branched perfluoroalkyl group having 2 to 6 carbon atoms; Z is —O—, —NR1— or —S—; R is hydrogen, Cl, F or CH3; R1 is hydrogen, or a C1 to C4 alkyl; and (b) from about 5% to about 80% of at least one of: (i) an alkyl (meth)acrylate monomer having a linear, branched or cyclic alkyl group of 6 to 18 carbons; or (ii) a monomer of formula (II): (R2)2N—R3—O—C(O)—C(R)?CH2 ??(II) wherein R is as defined above; each R2 is independently a C1 to C4 alkyl; and R3 is a divalent linear or branched C1 to C4 alkylene; and wherein the nitrogen is from about 40% to 100% salinized; or (iii) a mixture thereof; said composition providing oil repellency, water repellency, and stain resistance to substrates contacted therewi

Abstract: Insulating members are provided for use in nozzles of elevated temperature process vessels employing a structural metal shell (24), an insulating refractory lining (14) and a corrosion-resistant membrane (18) lining between the structural shell and refractory lining. The insulating members comprise pre-formed insulating sleeves and inserts and are made of a thermally insulating material having sufficient thickness and sufficiently low thermal conductivity such that, when the sleeve or insert is heated by the process temperature during operation of the vessel, the thermal energy transmitted through the sleeve or insert to the membrane is insufficient to raise the temperature of the membrane above a target temperature. The most preferred thermally insulating materials are fluoropolymers such as poly(tetrafluoroethylene) flouropolymer resins.

Abstract: An improved child-resistant blister package is provided in which the lidding component includes a tear-resistant nonwoven layer with a thermally resistant layer adhered thereto and a barrier layer.

Abstract: A polymer extender composition for use with fluorochemical repellents, said composition comprising monomers copolymerized in the following percentages by weight: (a) from about 60% to about 94% of a monomer, or mixture of monomers, of the formula I: [CH3—(CH2)p][CH3(CH2)n]CHCH2—OC(O)—C(R)?CH2, and ??(I) (b) from about 5% to about 20% of a monomer, or mixture of monomers, of the formula II: H—(OCH2CH2)m—O—C(O)—C(R)?CH2 ??(II) wherein each R is independently H or CH3; n is 1 to 10; p is 1 to 20 and m is 2 to 10 is disclosed.

Abstract: An improved child-resistant blister package is provided in which the lidding component includes a tear-resistant nonwoven layer and a barrier layer. The nonwoven layer can be a melt-spun continuous filament nonwoven web. The lidding component used in peel off-push through blister packages of the invention contains fewer layers, can be processed at higher blister package sealing temperatures and has improved puncture resistance compared to lidding components used in child-resistant packages known in the art. In addition, in peel off-push through and peel-open package designs of the present invention, the lidding peels more cleanly from the blister component compared to packages known in the art which have a tendency to tear during peeling.

Abstract: The present invention is directed to a portable kit that includes a tray having disposed therein at least two compartments containing reactive components of a coating composition, the compartments being sealed with a single cover or wherein each said compartment is sealed with a discreet cover; and a spatula positioned across an exposed face of said tray. The portable kit is suitable for use in repairing minor automotive coating defects, such as chipped, scratched, cracked, delaminated, etched and marred areas on automotive bodies.

Abstract: A coating composition comprising a binder of a. polyisocyanate crosslinking agent; b. an isocyanate-reactive component having at least one compound having the following formula: wherein X is an aliphatic or cycloaliphatic group, R1 and R2 are the same or different organic groups that are inert to isocyanate groups, and n is 2 to 4, and c. optionally, a polymeric component having a number average molecular weight of 5,000 to 50,000 having reactive groups that crosslink with an isocyanate, where the reactive groups are hydroxyl, carboxyl, glycidyl, amine and any mixtures thereof; and d.

Abstract: A fast hardening clear coating composition for repairing a clear coat/color coat finish or a pigmented mono-coat of a vehicle comprising a film forming binder and an organic liquid carrier, where the binder contains a hydroxyl polymer component comprising (A) hydroxyl-containing acrylic polymer, (B) at least one hydroxyl-terminated component selected from the group consisting of (1) an organic diol having the formula where R1 and R2 are individually selected from the group of hydrogen and an alkyl group having 1, 3-5 carbon atoms and (2) a hydroxyl terminated reaction product of trimethylol propane and a lactone; (C) an organic polyisocyanate crosslinking component, at least portion of which comprises a trimer of isophorone diisocyanate or hexamethylene diisocyanate and the composition further contains, a curing catalyst, of a dialkyl tin aliphatic carboxylate, a tertiary aliphatic mono or diamine, an aliphatic carboxylic acid, and optionally, a zinc or calcium organic acid salt in an effective amount s