Abstract: A composition comprising monomers copolymerized in the following percentages by weight: (a) from about 20% to about 95% of a monomer, or mixture of monomers, of formula (I): Rf—(CH2CF2)q(CH2CH2)r—Z—C(O)—C(R)?CH2??(I) wherein q and r are each independently integers of 1 to 3; Rf is a linear or branched perfluoroalkyl group having 2 to 6 carbon atoms; Z is —O—, —NR1— or —S—; R is hydrogen, Cl, F or CH3; R1 is hydrogen, or a C1 to C4 alkyl; and (b) from about 5% to about 80% of at least one of: (i) an alkyl (meth)acrylate monomer having a linear, branched or cyclic alkyl group of 6 to 18 carbons; or (ii) a monomer of formula (II): (R2)2N—R3—O—C(O)—C(R)?CH2??(II) wherein R is as defined above; each R2 is independently a C1 to C4 alkyl; and R3 is a divalent linear or branched C1 to C4 alkylene; and wherein the nitrogen is from about 40% to 100% salinized; or (iii) a mixture thereof; said composition providing oil repellency, water repellency, and stain resistance to substrates contacted therewith;

Abstract: A fast hardening clear coating composition for repairing a clear coat/color coat finish or a pigmented mono-coat of a vehicle comprising a film forming binder and an organic liquid carrier, where the binder contains a hydroxyl polymer component comprising (A) hydroxyl-containing acrylic polymer, (B) at least one hydroxyl-terminated component selected from the group consisting of (1) an organic diol having the formula where R1 and R2 are individually selected from the group of hydrogen and an alkyl group having 1, 3-5 carbon atoms and (2) a hydroxyl terminated reaction product of trimethylol propane and a lactone; (C) an organic polyisocyanate crosslinking component, at least portion of which comprises a trimer of isophorone diisocyanate or hexamethylene diisocyanate and the composition further contains, a curing catalyst, of a dialkyl tin aliphatic carboxylate, a tertiary aliphatic mono or diamine, an aliphatic carboxylic acid, and optionally, a zinc or calcium organic acid salt in an effective amount suc

Abstract: A blister package is provided in which the lidding component includes a tear-resistant nonwoven layer and a barrier layer wherein the controlled delamination of the nonwoven layer increases the puncture resistance, thereby improving the child-resistant properties of the package.

Abstract: The invention includes a corrugated decking flooring system. The corrugated decking flooring system can include a corrugated deck having at least two flutes and a trough between the flutes. A sound insulation layer generally conformal with both the flutes and the troughs of the corrugated deck can be provided. An underlayment layer can be provided over the sound insulation layer.

Abstract: This invention relates to novel agents that are analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and their conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.

Abstract: The present process is directed to preparation of addition polymers in diluents that are subsequently reactive in coatings during cure, instead of in traditional hydrocarbon solvents. The polymers so prepared can be used as the main film-forming polymer in high solids coating compositions, especially those useful for finishing automobiles and truck exteriors.

Abstract: A fast hardening clear coating composition for repairing a clear coat/color coat finish or a pigmented mono-coat of a vehicle comprising a film forming binder and an organic liquid carrier, where the binder contains a hydroxyl polymer component comprising (A) hydroxyl-containing acrylic polymer, (B) at least one hydroxyl-terminated component selected from the group consisting of (1) an organic diol having the formula where R1 and R2 are individually selected from the group of hydrogen and an alkyl group having 1, 3-5 carbon atoms and (2) a hydroxyl terminated reaction product of trimethylol propane and a lactone; (C) an organic polyisocyanate crosslinking component, at least portion of which comprises a trimer of isophorone diisocyanate or hexamethylene diisocyanate and the composition further contains, a curing catalyst, of a dialkyl tin aliphatic carboxylate, a tertiary aliphatic mono or diamine, an aliphatic carboxylic acid, and optionally, a zinc or calcium organic acid salt in an effective amount s

Abstract: A container or tray having various features. Also, the invention is generally directed to a method of forming the container or tray and a tool or apparatus for forming the container or tray.

Abstract: The invention includes a corrugated decking flooring system. The corrugated decking flooring system can include a corrugated deck having at least two flutes and a trough between the flutes. A sound insulation layer generally conformal with both the flutes and the troughs of the corrugated deck can be provided. An underlayment layer can be provided over the sound insulation layer.

Abstract: The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor ? subunits, by targeting HIF ? for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF ? subunit sequences which may modulate this interaction.

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: Polyethers of 1,3-propane diol are terminated with polyisocyanates. The isocyanate terminated polytrimethylene ether polyols provide crosslinking agents that provide coating compositions having short dry time, excellent appearance, and resistance to chipping damage.

Abstract: A non-woven web, comprising one or more polymeric fibers, wherein the number-average fiber diameter distribution of said one or more polymeric fibers conforms to a Johnson unbounded distribution. Non-woven webs comprising such polymeric fibers are rendered with mean-flow pore size and porosity desirable for specific filtration applications such as hepafiltration.

Abstract: The present invention is directed to a method of producing an adherent coating over untreated thermoplastic and thermosetting resinous substrates from a coating composition that includes a crosslinkable component and a crosslinking component that are mixed prior to application and applied over the substrate. The crosslinkable component includes a polymeric mix containing at least one crosslinkable copolymer polymerized from a monomer mixture comprising one or more ethylenically unsaturated monomers having on average 1 to 10, preferably 1 to 4 and more preferably 1 to 2 hydroxyl groups and a saturated hydrocarbon polymer. The crosslinkable component includes one or more cycloaliphatic polyisocyanate of the formula: R1—(R2—NCO)n wherein R1 is a substituted or unsubstituted cycloaliphatic group, R2 is independently selected from a direct bond, a straight aliphatic group or branched aliphatic group, and wherein n ranges from 2 to 10.

Abstract: The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor ? subunits, by targeting HIF ? for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF ? subunit sequences which may modulate this interaction.

Abstract: This invention concerns multiple release spacers and spacer systems, which release multiple leaving groups following a single activation. It concerns compounds comprising a specifier linked to two or more of the same or different leaving groups (L in the figure) via a self-eliminating multiple release spacer or spacer system, which compounds upon a single activation step, in particular removal or transformation of the specifier, release at least two leaving groups.

Abstract: A coating composition comprising a binder of a. polyisocyanate crosslinking agent; b. an isocyanate-reactive component having at least one compound having the following formula: wherein X, R1, R2, p, m and n are described in the specification, or isomer or mixture of isomers thereof, two component compositions, articles coated with the novel composition and novel hydroxy amines are also part of the invention.

Abstract: A coating composition comprising a binder of a. polyisocyanate crosslinking agent; b. an isocyanate-reactive component having at least one compound having the following formula: wherein X, R1, R2, p, m and n are described in the specification, or isomer or mixture of isomers thereof, two component compositions, articles coated with the novel composition and novel hydroxy amines are also part of the invention.

Abstract: The invention provides a compound of one of the formulae (A), (B), (C), (D), (E), (F) as herein defined, or a salt thereof, for use in the treatment of a condition associated with increased or decreased HIF levels or activity, or a condition in which an increase or decrease in HIF levels or activity may be beneficial.

Abstract: The present invention relates to an adhesion promoting cleaner solution for producing and adherent coating on a resinous substrate. The adhesion promoting cleaning solution comprises a telechelic diol in a carrier liquid such as an organic solvent. Also disclosed is a process of using the adhesion promoting cleaner solution to produce an adherent coating on a resinous substrate.