Abstract: This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.

Abstract: The invention is directed to furniture such as of floor independently standing or wall mounted furniture, cabinetry, containers, boxes that can be lightweight, modular, easily assembled and disassembled.

Abstract: The present invention relates to duocarmycin-containing antibody-drug conjugates (ADCs) for use in the treatment of human solid tumours and haematological malignancies expressing HER2, in particular breast cancer, gastric cancer, bladder cancer, ovarian cancer, lung cancer, prostate cancer, pancreatic cancer, colorectal cancer, head and neck squamous cell cancer or osteosarcoma, and acute lymphoblastic leukaemia. In particular, the present invention relates to duocarmycin-containing ADCs for use in the treatment of human solid tumours with HER2 IHC 2+ or 1+ and HER2 FISH negative tissue status. Advantageously, the present invention relates to duocarmycin-containing ADCs for use in the treatment of triple negative breast cancer (TNBC).

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: The present disclosure relates to an isocyanate terminated saturated hydrocarbon polymer that can be used as a crosslinking agent in a coating composition. The coating composition can provide a composition that adheres well to resinous substrates. Also provided are coating composition comprising the crosslinking agent and methods for producing the adherent coating composition.

Abstract: A sound control mat includes a waterproof separation layer, an entangled monofilament structure, and a meltblown nonwoven. The sounds control mat provides improved sound control such as improved impact insulation.

Abstract: A discharge device includes a plurality of material conveying components, an adjustable shear ledge, and an adjustable shroud to convey materials from a container of a material spreader out onto an open area. The adjustable shear ledge includes at least one longitudinal mounting member such that the adjustable shear ledge may be translated towards or away from the plurality of material conveying components to maintain a predetermined gap distance. The adjustable shroud may also be pivotably connected to the adjustable shear ledge such that the adjustable shroud can be pivoted towards or away from the plurality of material conveying components. The adjustable shear ledge and the adjustable shroud may be moved accordingly to maintain a preferred gap distance and to maintain concentricity with a swing of the material conveying components in order to reduce wear on components and promote spread performance of the material spreader.

Abstract: A drive system includes a drive housing and one or more drivetrain cartridges. The one or more drivetrain cartridges enables better manufacturability by allowing drivetrain components to be installed together outside the housing and then installed as a unit together into the housing. Serviceability is improved by allowing one or more of the drivetrain cartridges to be removed individually from the housing for maintenance or repair. The housing may include mounting surfaces to securely engage the one or more drivetrain cartridges to the housing to prevent play. The housing may include a bottom or side panel with installation mounts to fasten the drivetrain cartridge or cartridges securely to the bottom or side panel of the housing.

Abstract: A method and system for identifying a given geometrical feature of an optical component chosen from an ophthalmic lens or a semi-finished lens blank for ophthalmic lens. The method includes: providing the optical component made of an organic material that can emit light at an emission wavelength ?e when being lighten at an illumination wavelength ?i different from the emission wavelength ?e; illuminating a surface of the optical component with an incident light beam including at least light at the illumination wavelength but devoid from light at the emission wavelength; collecting light emitted at the emission wavelength by the illuminated surface of the optical component to build an image of the surface; and processing the image via computer elements and applying a metrics to compare the image with reference data specific to the given geometrical feature, and providing an identification output of the given geometrical feature.

Abstract: This invention relates to novel agents that are analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and their conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.

Abstract: This invention relates to novel analogs of the DNA-binding alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and their conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.

Abstract: The invention relates to an assistive device for positioning a medical instrument (2) inserted into a natural duct (100) or an artificial duct of a patient relative to an internal organ (P) of a patient, wherein the device comprises a support (1) that is to be inserted at least in part into the body of the patient and supports the medical instrument, means for moving the support, wherein said movement means comprise an articulated arm (9) that includes a plurality of degrees of freedom for moving a proximal end (1a) of the support, means for acquiring images of the internal organ for positioning the medical instrument relative to the internal organ, wherein the image acquisition means comprise a probe (5) supported by the support such that the medical instrument and the probe are rigidly connected, and a control unit (10) for controlling the movement means, which is connected to the image acquisition means and comprises image analyzing means (11) for generating control commands for the articulated arm in orde

Abstract: This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and to their conjugates. Furthermore this invention concerns intermediates for the preparation of said agents and conjugates. The conjugates are designed to release their (multiple) payload after one or more activation steps and/or at a rate and time span controlled by the conjugate in order to selectively deliver and/or controllably release one or more of said DNA alkylating agents. The agents, conjugates, and intermediates can be used to treat an illness that is characterized by undesired (cell) proliferation. As an example, the agents and the conjugates of this invention may be used to treat a tumor.

Abstract: A spreading apparatus for spreading material onto a target area is disclosed. The spreading apparatus includes a container for the material, a discharge unit which discharges the material, a deflector door disposed on a discharge port of the discharge unit, a positioning device which positions the deflector door and a controller configured to control the deflector door so that the deflector door is positioned between a first closed position and a second open position. The material is substantially prevented from exiting through the discharge port when the deflector door is in the first position. The deflector door may further be positioned at a position between the first closed position and second open position to control a distance of the material discharged from the discharge port.

Abstract: A method of forming a container from a construct. The method includes obtaining a tool having a cavity, a core, and an articulated section for being moveable within the cavity relative to the cavity and the core. The method further includes placing a construct between the cavity and the core, moving the core relative to the cavity so that the articulated section at least partially initially grips a portion of the construct, and further moving the core into the cavity. The portion of the construct remains gripped by the articulated section in the cavity during the further moving of the core.

Abstract: A composite batt structure that forms an effective low frequency sound absorber for use in buildings, appliances, automotive vehicles, and the like. The composite structure uses a facer covering a batt comprised of carded and crosslapped mixture of fibers. The general acoustic behavior of the composite batt structure has a low frequency absorption maximum by varying the number of crosslaps or the proportions of the fiber mixture. This allows for the composite batt structure to be tunable or layered with different laps.

Abstract: A novel class of hydroxylases is described having the amino acid sequence of SEQ ID No. 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity.

Abstract: The automatic reset of an evaporative cooling water dissolved solids set point based on detection of water softener performance is provided. A controller has a sensor, or is given an input signal, which confirms that the softener is operating properly. Positive confirmation of water softener performance allows the controller to maintain a user specified high total dissolved solids set point in the evaporative cooling water. Should a failure of the softener be detected, the controller then maintains a user specified lower total dissolved solids set point.

Abstract: The invention is directed to furniture such as of floor independently standing or wall mounted furniture, cabinetry, containers, boxes that can be lightweight, modular, easily assembled and disassembled.

Abstract: A tool for forming a container from a construct. The container comprises a bottom wall and at least one sidewall foldably connected to and extending upwardly from the bottom wall to form an interior space of the container. The tool comprises a cavity having at least one peripheral wall for at least partially forming the sidewall of the container. The tool comprises a core operatively associated with the cavity and being operable to move within the cavity to position the at least one sidewall of the container relative to the bottom wall to form the interior space. The tool comprises at least one articulated section movably received in the cavity. The at least one articulated section being for gripping at least a portion of the at least one sidewall of the construct, when the core is moved relative to the cavity to form the interior space of the container.