Abstract: The present invention concerns antigen binding proteins and fragments thereof which specifically bind B Cell Maturation Antigen (BCMA), particularly human BCMA (hBCMA) and which inhibit the binding of BAFF and APRIL to the BCMA receptor. Further disclosed are pharmaceutical compositions, screening and medical treatment methods.

Abstract: A modular sensor and display module comprises an enclosure with a rigid frame and front and back visor lens encapsulating sensors, waveguide optics, and display/projection devices that provide various functions for a typical head-mounted device. A front visor may conceal sensors and other components and may further provide dimming for holographic displays. The modular sensor and display module may include a standard interface for attachment to various fit systems, including, for example, headband, VR headset, glasses temples, helmet, and the like. A further module, such as a rear-attachment module, may be provided that can provide auxiliary compute, storage, and power resources for the modular sensor and display module.

Abstract: A technique is described for the application of three-dimensional (3D) relief to a substrate such as a ceramic tile using digital inkjet technology. In an example embodiment, the introduced technique includes application of binder ink to a portion of the surface of a substrate using a digital inkjet process. This binder ink forms a barrier layer which protects the portion of the surface of the substrate. Next, a brushing process is applied to remove unprotected portions of the substrate, thereby forming the 3D relief in the substrate.

Abstract: Systems and methods are disclosed to implement an endpoint command invocation system (“ECIS”). In some embodiments, ECIS can quickly dispatch a command to a large number of endpoint components, where the endpoint components are online. ECIS can receive an invocation of a command, which can include the command recipients. In some embodiments, ECIS determines that some of the command recipients are online, while some of the command recipients are offline. ECIS determines connections to the online command recipients based on a connection map, which is updated whenever an endpoint component opens a connection to ask for a command. ECIS can deliver the command to the online command recipients using the connections. ECIS can also deliver the command to dispatch queues corresponding to the offline command recipients, where the dispatch queues store the command as a pending command that can be delivered to their respective command recipients whenever they come online.

Abstract: The invention provides a p38 MAPK inhibitor of Formula I, or a pharmaceutically acceptable salt or solvate thereof: for use in the treatment or prevention of hypercytokinemia in a human patient; wherein R is C1-3alkyl, optionally substituted by one or more halo, NR1R2 or hydroxy, and R1and R2 are independently H, halo or C1-3alkyl, optionally substituted by one or more F. Also provided are compositions for use in the treatment or prevention of hypercytokinemia comprising the p38 MAPK inhibitor of Formula I; and methods for treating or preventing hypercytokinemia in a human patient in need thereof comprising administering to the patient a therapeutically or prophylactically effective amount of a p38 MAPK inhibitor of Formula I. The invention also provides a p38 MAPK inhibitor and an antimicrobial agent, such as an antiviral agent, for use in the treatment or prevention of hypercytokinemia.

Abstract: Apparatus and methods automate selection of patient interface(s). Image data captured by an image sensor may contain facial feature(s) of a user. The facial features may be captured in association with a predetermined reference feature of known dimension(s) such as with a user interface display that is generated with a sequence of icons that are activated for directing and tracking movement within the interface for desired image capture. The user's facial feature(s) and the reference feature may be detected in the captured image data. The image may be processed to measure an aspect of the detected facial feature(s) based on the reference feature. A patient interface size may be detected from standard patient interface sizes based on a comparison between the measured aspect of the facial feature(s) and a data record relating sizing information of the standard patient interface sizes and the measured aspect of the facial feature(s).

Abstract: The present disclosure is directed to processes, compositions and agents for inhibiting corrosion in various substrates, for example metal substrates. The present disclosure is also directed to corrosion inhibitors comprising organometallic polymers such as metal-organic frameworks (MOFs), including compositions and processes comprising MOFs for inhibiting corrosion in metal substrates.

Abstract: Pesticidal compositions are provided that include at least one pesticidal active ingredient and benzyl alcohol. Adjuvant compositions and associated methods are provided for use with at least one pesticidal active ingredient that include benzyl alcohol.

Abstract: A pessary system for providing pelvic floor support for USL and other ligaments. The pessary has an elongated probe with independently inflatable balloons each located substantially the same distance from the insertion end of the probe and which inflate into separate radial sectors. The probe can be inserted into a vaginal cavity and the balloons inflated provide mechanical support to the USLs. Independent inflation of each balloon allows the mechanical USL support provided to be varied on left and right sides to compensate for differences in the degree of degradation and positioning of the USL ligaments on either side.

Abstract: An oxygen concentrator 100 apparatus and a method thereof implement operations control to efficiently release oxygen enriched gas to reduce potential waste. The control methodology may include generating a profile such as a minimum inhalation flow profile of the user. The profile may be based on a size parameter of the user. The method may determine one or more control parameters characterizing a bolus of oxygen enriched gas based on the generated flow profile. The control methodology may then generate a bolus release control signal, such as for a supply valve, according to the determined one or more control parameters. The oxygen concentrator may then, with the control signal, release and deliver a bolus of oxygen enriched gas for a user such as for reducing waste.

Abstract: The present invention provides processes for the preparation of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3, 5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same.

Abstract: The present disclosure is directed to one or more embodiments of mailer package assemblies including a fixed release liner and a mailer package. The fixed release liner is removably or detachably coupled to the mailer package by an adhesive layer. The fixed release liner includes one or more wickets (e.g., openings) such that the fixed release liner may be mounted to a wall by inserting fasteners (e.g., tack(s), pin(s), etc.) into the openings. The mailer package may be removed, detached, or decoupled from the fixed release liner by pulling on the mailer package decoupling the fixed release liner from the mailer package. After the mailer package is removed, an packaging associate may place an item or product within the mailer package to be shipped to a consumer. After the mailer package is removed from the fixed release liner, the fixed release liner remains mounted to the wall.

Abstract: The invention provides a p38 MAPK inhibitor of Formula I, or a pharmaceutically acceptable salt or solvate thereof: Formula I for use in the treatment or prevention of hypercytokinemia in a human patient; wherein R is C1-3alkyl, optionally substituted by one or more halo, NR1R2 or hydroxy, and R1 and R2 are independently H, halo or C1-3alkyl, optionally substituted by one or more F. Also provided are compositions for use in the treatment or prevention of hypercytokinemia comprising the p38 MAPK inhibitor of Formula I; and methods for treating or preventing hypercytokinemia in a human patient in need thereof comprising administering to the patient a therapeutically or prophylactically effective amount of a p38 MAPK inhibitor of Formula I. The invention also provides a p38 MAPK inhibitor and an antimicrobial agent, such as an antiviral agent, for use in the treatment or prevention of hypercytokinemia.

Abstract: A heavy truck tire is provided that includes a casing with a central axis, and a rubber tread that has a first layer and a second layer. The first layer is located farther from the central axis in a radial direction than the second layer. The first layer has a lower max tan(?) than a max tan(?) of the second layer. The max tan(?) of the first layer is from 0.06-0.15, and the max tan(?) of the second layer is from 0.12-0.27. The tire also has a sculptural feature that reduces irregular wear.

Abstract: Systems and methods are disclosed to implement a delta data collection technique for collecting machine characteristics data from client machines. In embodiments, the collected data is used by a machine assessment service to maintain a virtual representation of the client machine for assessments. To initialize the collection process, the client uploads an initial copy of the data in full. Subsequently, the client determines periodic deltas between a current baseline of the data and a last reported baseline, and the deltas are uploaded as patches. The machine assessment service then applies these patches to update the virtual representation of the client machine. In embodiments, to facilitate the generation or uploading of the patches, the client may generate the baselines in a different encoding format as used by the data. For example, baselines in the new encoding format may be more easily compared and manipulated during the patch generation process.

Abstract: The disclosed systems and methods relate to allowing trading of over the counter (“OTC”) foreign exchange (“FX”) contracts on a centralized matching and clearing mechanism, such as that of the Chicago Mercantile Exchange's (“CME”'s) futures exchange system (the “Exchange”). The disclosed systems and methods allow for anonymous transactions, centralized clearing, efficient settlement and the provision of risk management/credit screening mechanisms to lower risk, reduce transaction costs and improve the liquidity in the FX market place. In particular, the disclosed embodiments increase speed of execution facilitating growing demand for algorithmic trading, increased price transparency, lower cost of trading, customer to customer trading, and automated asset allocations, recurring trades as well as clearing and settlement efficiencies.

Abstract: Multiple aspects of systems and methods for voice control and related features and functionality for various embodiments of media playback devices, networked microphone devices, microphone-equipped media playback devices, and speaker-equipped networked microphone devices are disclosed and described herein, including but not limited to designating and managing default networked devices, audio response playback, room-corrected voice detection, content mixing, music service selection, metadata exchange between networked playback systems and networked microphone systems, handling loss of pairing between networked devices, actions based on user identification, and other voice control of networked devices.

Abstract: Disclosed herein are methods, systems, and processes to perform self-dependent upgrades of Java Runtime Environments (JREs). A request to update a plugin to a new version with a new configuration that includes a location to download a new upgrader-executable is received from a platform computing device at an endpoint computing device. The plugin is uploaded to the new version. The new upgrader-executable that includes an executable with an executable table executed by the plugin is downloaded from the location. The executable is used to halt execution of a JRE application (e.g., a Collector) and download JRE files required for the upgrade. The JRE application (e.g., the Collector) is then re-started with the new configuration, which can be rolled back if the upgrade is unsuccessful.

Abstract: Pesticidal compositions are provided that include at least one pesticidal active ingredient and at least one organic solvent. Adjuvant compositions are provided for use with at least one pesticidal active ingredient that include at least one organic solvent. Methods of producing an adjuvant composition and pesticidal composition are also provided.

Abstract: Provided herein are indole compounds that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease