Patents by Inventor Pei Pei
Pei Pei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10570121Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.Type: GrantFiled: October 10, 2018Date of Patent: February 25, 2020Assignee: Pfizer Inc.Inventors: Michael Raymond Collins, Robert Steven Kania, Robert Arnold Kumpf, Pei-Pei Kung, Daniel Tyler Richter, Scott Channing Sutton, Martin James Wythes
-
Patent number: 10519500Abstract: A method of preparing a crystalline copper-based coordination polymer comprises preparing a mixture of copper ions and a first quaternized carboxylate pyridyl ligand; adding a second polypyridyl ligand; and forming crystals of a copper-based coordination polymer therefrom. The crystalline copper-based coordination polymer is suitable for providing a sensing platform for detecting the presence of one or more target nucleic acid sequences such as viral RNA, in particular Dengue virus and/or Zika virus RNA with high selectivity and high specificity. A method of detecting at least a first target nucleic acid sequence, in particular from a viral RNA, in particular it is Flavivirus RNA, in a sample is also provided. Further provided is a kit including the crystalline copper-based coordination polymer and an oligonucleotide probe.Type: GrantFiled: May 22, 2017Date of Patent: December 31, 2019Assignees: MACAU UNIVERSITY OF SCIENCE AND TECHNOLOGY, SOUTHERN MEDICAL UNIVERSITYInventors: Jin-Xiang Chen, Bao-Ping Xie, Gui-Hua Qiu, Pei-Pei Hu, Zhen Liang, Ye-Mei Liang, Bin Sun, Li-Ping Bai, Zhi-Hong Jiang
-
Publication number: 20190270737Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.Type: ApplicationFiled: May 20, 2019Publication date: September 5, 2019Applicant: Pfizer Inc.Inventors: Aaron Craig Burns, Michael Raymond Collins, Samantha Elizabeth Greasley, Robert Louis Hoffman, Peter Qinhua Huang, Robert Steven Kania, Pei-Pei Kung, Maria Angelica Linton, Lakshmi Sourirajan Narasimhan, Paul Francis Richardson, Daniel Tyler Richter, Graham Smith
-
Patent number: 10296624Abstract: A method for curating documents, executed by a computer, includes detecting one or more themes in a document, identifying one or more user interests for a user, presenting a ranked list of the one or more themes to the user, and dynamically updating the ranked list based on user feedback. The ranked list may be ranked according to the one or more user interests. A computer program product and computer system corresponding to the above method are also disclosed herein.Type: GrantFiled: June 12, 2017Date of Patent: May 21, 2019Assignee: International Business Machines CorporationInventors: Shuo Li, Yue Li, Zhao Wei Li, Pei Pei Liang, Jun Liu, Yun Ting Wang, Xin Ying Yang, Guang Ming Zhang, Zhi Hui Zhu
-
Patent number: 10296623Abstract: A method for curating documents, executed by a computer, includes detecting one or more themes in a document, identifying one or more user interests for a user, presenting a ranked list of the one or more themes to the user, and dynamically updating the ranked list based on user feedback. The ranked list may be ranked according to the one or more user interests. A computer program product and computer system corresponding to the above method are also disclosed herein.Type: GrantFiled: November 3, 2015Date of Patent: May 21, 2019Assignee: International Business Machines CorporationInventors: Shuo Li, Yue Li, Zhao Wei Li, Pei Pei Liang, Jun Liu, Yun Ting Wang, Xin Ying Yang, Guang Ming Zhang, Zhi Hui Zhu
-
Patent number: 10246433Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.Type: GrantFiled: May 3, 2017Date of Patent: April 2, 2019Assignee: Pfizer Inc.Inventors: Martin Paul Edwards, Robert Arnold Kumpf, Pei-Pei Kung, Indrawan James McAlpine, Sacha Ninkovic, Eugene Yuanjin Rui, Scott Channing Sutton, John Howard Tatlock, Martin James Wythes, Luke Raymond Zehnder
-
Publication number: 20190040055Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.Type: ApplicationFiled: October 11, 2018Publication date: February 7, 2019Applicant: Pfizer Inc.Inventors: Aaron Craig Burns, Michael Raymond Collins, Samantha Elizabeth Greasley, Robert Louis Hoffman, Peter Qinhua Huang, Robert Steven Kania, Pei-Pei Kung, Maria Angelica Linton, Lakshmi Sourirajan Narasimhan, Paul Francis Richardson, Daniel Tyler Richter, Graham Smith
-
Publication number: 20190040047Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.Type: ApplicationFiled: October 10, 2018Publication date: February 7, 2019Applicant: Pfizer Inc.Inventors: Michael Raymond Collins, Robert Steven Kania, Robert Arnold Kumpf, Pei-Pei Kung, Daniel Tyler Richter, Scott Channing Sutton, Martin James Wythes
-
Publication number: 20180334713Abstract: A method of preparing a crystalline copper-based coordination polymer comprises preparing a mixture of copper ions and a first quaternized carboxylate pyridyl ligand; adding a second polypyridyl ligand; and forming crystals of a copper-based coordination polymer therefrom. The crystalline copper-based coordination polymer is suitable for providing a sensing platform for detecting the presence of one or more target nucleic acid sequences such as viral RNA, in particular Dengue virus and/or Zika virus RNA with high selectivity and high specificity. A method of detecting at least a first target nucleic acid sequence, in particular from a viral RNA, in particular it is Flavivirus RNA, in a sample is also provided. Further provided is a kit including the crystalline copper-based coordination polymer and an oligonucleotide probe.Type: ApplicationFiled: May 22, 2017Publication date: November 22, 2018Inventors: Jin-Xiang Chen, Bao-Ping Xie, Gui-Hua Qiu, Pei-Pei Hu, Zhen Liang, Ye-Mei Liang, Bin Sun, Li-Ping Bai, Zhi-Hong Jiang
-
Patent number: 10125130Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.Type: GrantFiled: November 29, 2017Date of Patent: November 13, 2018Assignee: Pfizer Inc.Inventors: Aaron Craig Burns, Michael Raymond Collins, Samantha Elizabeth Greasley, Robert Louis Hoffman, Peter Qinhua Huang, Robert Steven Kania, Pei-Pei Kung, Maria Angelica Linton, Lakshmi Sourirajan Narasimhan, Paul Francis Richardson, Daniel Tyler Richter, Graham Smith
-
Publication number: 20180148441Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.Type: ApplicationFiled: November 29, 2017Publication date: May 31, 2018Applicant: PFIZER INC.Inventors: Aaron Craig BURNS, Michael Raymond COLLINS, Samantha Elizabeth GREASLEY, Robert Louis Hoffman, Peter Qinhua HUANG, Robert Steven Kania, Pei-Pei KUNG, Maria Angelica LINTON, Lakshmi Sourirajan NARASIMHAN, Paul Francis RICHARDSON, Daniel Tyler RICHTER, Graham SMITH
-
Publication number: 20170298048Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.Type: ApplicationFiled: June 28, 2017Publication date: October 19, 2017Applicant: Pfizer Inc.Inventors: Michael Raymond Collins, Robert Steven Kania, Robert Arnold Kumpf, Pei-Pei Kung, Daniel Tyler Richter, Scott Channing Sutton, Martin James Wythes
-
Publication number: 20170277695Abstract: A method for curating documents, executed by a computer, includes detecting one or more themes in a document, identifying one or more user interests for a user, presenting a ranked list of the one or more themes to the user, and dynamically updating the ranked list based on user feedback. The ranked list may be ranked according to the one or more user interests. A computer program product and computer system corresponding to the above method are also disclosed herein.Type: ApplicationFiled: June 12, 2017Publication date: September 28, 2017Inventors: Shuo Li, Yue Li, Zhao Wei Li, Pei Pei Liang, Jun Liu, Yun Ting Wang, Xin Ying Yang, Guang Ming Zhang, Zhi Hui Zhu
-
Publication number: 20170262129Abstract: According to an embodiment of the present disclosure, an electrical device may include a substrate, an electrical element, a first barrier structure and a gas barrier layer. The substrate includes an active region and a periphery region surrounding the active region. The electrical element is disposed in the active region. The first barrier structure is disposed in the periphery region and surrounds the electrical element, wherein the first barrier structure includes a first conductive layer. The gas barrier layer covers the electrical element and the first barrier structure.Type: ApplicationFiled: August 12, 2016Publication date: September 14, 2017Applicant: Industrial Technology Research InstituteInventors: Wei-Yuan Cheng, Chih-Chia Chang, Ruo-Lan Chang, Pei-Pei Cheng, Chao-Wen Chen
-
Publication number: 20170233368Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.Type: ApplicationFiled: May 3, 2017Publication date: August 17, 2017Applicant: Pfizer Inc.Inventors: Martin Paul EDWARDS, Robert Arnold KUMPF, Pei-Pei KUNG, lndrawan James MCALPINE, Sacha NINKOVIC, Eugene Yuanjin RUI, Scott Channing SUTTON, John Howard TATLOCK, Martin James WYTHES, Luke Raymond ZEHNDER
-
Publication number: 20170152239Abstract: This invention relates to compounds of general formula in which R1, R2, R6, U, V, W, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, pharmaceutical compositions containing such compounds and salts, and to methods of using such compounds, salts and compositions.Type: ApplicationFiled: February 6, 2017Publication date: June 1, 2017Applicant: Pfizer Inc.Inventors: Martin Paul EDWARDS, Robert Arnold KUMPF, Pei-Pei KUNG, Indrawan James MCALPINE, Eugene Yuanjin RUI, Scott Channing SUTTON, John Howard TATLOCK, Martin James WYTHES
-
Publication number: 20170124083Abstract: A method for curating documents, executed by a computer, includes detecting one or more themes in a document, identifying one or more user interests for a user, presenting a ranked list of the one or more themes to the user, and dynamically updating the ranked list based on user feedback. The ranked list may be ranked according to the one or more user interests. A computer program product and computer system corresponding to the above method are also disclosed herein.Type: ApplicationFiled: November 3, 2015Publication date: May 4, 2017Inventors: Shuo Li, Yue Li, Zhao Wei Li, Pei Pei Liang, Jun Liu, Yun Ting Wang, Xin Ying Yang, Guang Ming Zhang, Zhi Hui Zhu
-
Publication number: 20170050958Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein A, L, D, R1-R15, w, x, y, and z are defined herein. The novel cycloalkyl-linked diheterocycle derivatives that are useful in the treatment of abnormal cell growth, such as cancer, in mammals. The present invention also relates to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in mammals.Type: ApplicationFiled: April 17, 2015Publication date: February 23, 2017Applicant: PFIZER INC.Inventors: Aaron Craig BURNS, Michael Raymond COLLINS, Samantha Elizabeth GREASLEY, Robert Louis Hoffman, Peter Qinhua HUANG, Robert Steven Kania, Pei-Pei KUNG, Maria Angelica LINTON, Lakshmi Sourirajan NARASIMHAN, Paul Francis RICHARDSON, Daniel Tyler RICHTER, Graham SMITH
-
Publication number: 20160376254Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.Type: ApplicationFiled: September 12, 2016Publication date: December 29, 2016Applicant: Pfizer Inc.Inventors: Michael Raymond COLLINS, Robert Steven Kania, Robert Arnold Kumpf, Pei-Pei Kung, Daniel Tyler Richter, Scott Channing Sutton, Martin James Wythes
-
Patent number: 9481666Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.Type: GrantFiled: June 16, 2015Date of Patent: November 1, 2016Assignee: PFIZER INC.Inventors: Robert Steven Kania, Robert Arnold Kumpf, Pei-Pei Kung, Scott Channing Sutton, Martin James Wythes