Abstract: Provided herein is a method of screening a tumour cell for resistance to a tubulin-binding agent, the method comprising detecting the expression of any one or more of class II, class III and class IVb ?-tubulin by the tumour cell, wherein the expression of any one or more of class II, class III and class IVb ?-tubulin indicates that the tumour cell has resistance or potential resistance to the tubulin-binding agent. Also provided are methods of modulating the sensitivity of a tumour cell Also provided is a method of modulating the tumorigenesis of a tumour cell.

Abstract: A lead frame strip includes a plurality of connected unit lead frames, each unit lead frame having a die paddle and a plurality of leads connected to a periphery of the unit lead frame. A semiconductor die is attached to the die paddles. A molding compound covers the unit lead frames, including the semiconductor dies. Prior to testing or other processing of the lead frame strip, a gap is etched into a region of the leads which are shared by adjacent ones of the unit lead frames. The gap extends at least mostly through the shared leads. A partial cut is made in the molding compound around the periphery of the unit lead frames prior to the subsequent processing, including below the gap in the shared leads, to electrically isolate the leads of the unit lead frames.

Abstract: A display including a plurality of display units and a plurality of holes is provided. Each of the display units includes a transparent area. Each of the holes is formed by a part of the transparent areas. At least one of the holes satisfies 2 ? ? ? ? A ? S < 8 3 ? 3 ? ? A , wherein A is an area of each of the holes and the S is a perimeter of each of the holes, and the at least one of the holes is a hole of a non-quadrilateral-type shape. These holes are arranged along a first direction in staggered arrangement, parts of projections of the holes along a second direction are overlapped with one another, and the first direction is different from the second direction.

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: This invention relates to compounds of general formula (I), in which R1, R2, R6, U, V, W, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, pharmaceutical compositions containing such compounds and salts, and to methods of using such compounds, salts and compositions.

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: A lead frame strip includes a plurality of connected unit lead frames, each unit lead frame having a die paddle and a plurality of leads connected to a periphery of the unit lead frame. A semiconductor die is attached to the die paddles. A molding compound covers the unit lead frames, including the semiconductor dies. Prior to testing or other processing of the lead frame strip, a gap is etched into a region of the leads which are shared by adjacent ones of the unit lead frames. The gap extends at least mostly through the shared leads. A partial cut is made in the molding compound around the periphery of the unit lead frames prior to the subsequent processing, including below the gap in the shared leads, to electrically isolate the leads of the unit lead frames.

Abstract: Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

Abstract: The disclosure provides an electrowetting display device. The electrowetting display device includes a first substrate and a second substrate disposed to each other. A first electrode layer may dispose on the first substrate. A second electrode layer may dispose on the second substrate. A hydrophobic dielectric layer is disposed on the first electrode layer. A first pixel rib is disposed on the first substrate. A second pixel rib is disposed on the first pixel rib. A water contact angle of the second pixel rib may be larger than that of the first pixel rib. A first liquid and a second liquid may be disposed in between the first substrate and the second substrate.

Abstract: Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract: The present invention describes a method, based on a semi-nested polymerase chain reaction (PCR), for the detection and identification of ten clinically relevant Candida species. The method involves a first PCR amplification of the internal transcribed spacer region ITS2 of fungal ribosomal RNA, followed by a second PCR reaction with a species-specific primer. Custom-designed primers are provided.

Abstract: A search engine system is described herein that provides an alternative data path for collecting results provided by index servers. The alternative data path collects the results in a direct and asynchronous manner; this is in contrast to a synchronous path used to deliver search results to end users via one or more aggregator modules. An analysis system can use the alternative data path to collect a large amount of richly descriptive information regarding the performance of the search engine system, circumventing bottlenecks and other constraints that would otherwise be imposed by the synchronous data path. The analysis system can analyze the information collected from the index servers to improve the performance of the search engine system.

Abstract: Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

Abstract: Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.

Abstract: A search engine system is described herein that provides an alternative data path for collecting results provided by index servers. The alternative data path collects the results in a direct and asynchronous manner; this is in contrast to a synchronous path used to deliver search results to end users via one or more aggregator modules. An analysis system can use the alternative data path to collect a large amount of richly descriptive information regarding the performance of the search engine system, circumventing bottlenecks and other constraints that would otherwise be imposed by the synchronous data path. The analysis system can analyze the information collected from the index servers to improve the performance of the search engine system.

Abstract: The present invention is directed to compounds of formula (I), or pharmaceutically acceptable salts thereof, their synthesis, and their use as HSP-90 inhibitors.

Abstract: A flat type heat pipe device includes a packaging unit and a bonding member. The packaging unit further includes a first shell member and a second shell member. The first shell member has a work zone, a first joining part surrounding the work zone and an upright stop part disposed between the work zone and the joining part. The second shell member provides a shape corresponding to the first shell member to cover the first shell member and has a shell lid part spacing apart from the work zone and a second joining part disposed on the first joining part. The bonding member is disposed between the first joining part and the second joining part to adhere the first joining part to the second joining part. When the first shell member is pressingly fit with second shell member, the stop part is capable of preventing the bonding member from entering the packaging unit.

Abstract: An aliphatic polyester polymer compositions and preparation method thereof. The invention provides a bioresorbable aliphatic polyester copolymer, comprising the reaction product of a first polyester, a second polyester, and a coupling agent. Specifically, the first polyester and second polyester have the same repeat units, but different weight average molecular weights. Methods for preparing the aliphatic polyester copolymer are provided, in which the first polyester reacts with the second polyester in the presence of the coupling agent, undergoing copolymerization.