Abstract: A method and a circuit for controlling a switching frequency signal used in a direct current to direct current (DC to DC) converter are proposed. The DC to DC converter generates an output voltage to drive a system. The switching frequency signal is generated by inputting a modulation frequency to a pulse width modulation (PWM) circuit. The method includes steps of: 1. generating a control signal from the system to stop the pulse width modulation (PWM) circuit to generate the switching frequency signal when a signal is received by the system; and 2. restarting the pulse width modulation (PWM) circuit to generate the switching frequency signal in order to increase the output voltage to drive the system when the output voltage from the DC to DC converter is under a predetermined voltage.

Abstract: A method for making a heat dissipating device includes the steps of: preparing a container body that has a fluid passage and opposite upper and lower walls, the fluid passage being in fluid communication with an inner space in the container body; vacuuming the inner space through the fluid passage; filling the inner space with a predetermined amount of a working fluid through the fluid passage; and depressing a wall portion of a selected one of the upper and lower walls in such a manner that the depressed wall portion is deformed toward the other of the upper and lower walls so as to form a depression in the selected one of the upper and lower walls, and so as to form a sealing mechanism that functions to isolate the fluid passage from the inner space.

Abstract: A heat dissipating device includes: a container body defining an inner space therein and having a fluid passage and opposite upper and lower walls; a working fluid received in the inner space in the container body; a wick structure mounted in the inner space; and a sealing material that seals the fluid passage of the container body. One of the upper and lower walls has a wall portion that is disposed adjacent to the fluid passage and that is depressed in such a manner that the depressed wall portion cooperates with the other of the upper and lower walls to form a sealing mechanism that functions to isolate the fluid passage from the inner space.

Abstract: A method for making a heat dissipating device includes the steps of: mounting an elastically deformable member on a container body in such a manner that the elastically deformable member covers a periphery of an opening in the container body and that the elastically deformable member cooperates with the container body to define a cavity in fluid communication with an inner space in the container body through the opening; vacuuming the inner space in such a manner that air in the inner space is drawn through the opening and the cavity to the outside of the container body; filling the inner space with a predetermined amount of a working fluid through the opening and the cavity; and forming a sealing mechanism that functions to isolate the inner space from the opening.

Abstract: A manufacturing system for processing a container body into a heat dissipating device includes: a support for supporting the container body thereon; an elastically deformable member covering a periphery of an opening in an upper wall of the container body and defining a cavity in fluid communication with interior of the container body through the opening; a vacuuming device connected to the elastically deformable member for vacuuming the inner space; a working fluid-loading device connected to the elastically deformable member for filling a predetermined amount of the working fluid into the container body; a depressing device including opposite upper and lower pressing members; and a driving mechanism for driving movement of at least one of the upper and lower pressing members.

Abstract: A heat dissipating microdevice includes a board, a fluid microsystem, and a coolant. The board includes an insulator layer that has first and second surfaces, a conductor layer formed on the first surface, and a cover member disposed on the second surface. The fluid microsystem is formed in the insulator layer of the board, and includes first and second micro-channel structures, and first and second micro-conduit structures that permit fluid communication between the first and second micro-channel structures. The coolant is contained in the fluid microsystem, and flows from the second micro-channel structure to the first micro-channel structure through the first micro-conduit structure, and from the first micro-channel structure back to the second micro-channel structure through the second micro-conduit structure.

Abstract: Aminoheteroaryl compounds are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

Abstract: Compounds of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

Abstract: A dyeing method for a substrate material and the colored substrate material thereby produced comprises the steps of laying a substrate film made of melted TPU on a surface of a substrate material (a fabric or a non-fabric), cooling the film, coloring the film with a water soluble dyes free of solvents, washing extra dyes off the film, and drying the substrate material. Because of the covalent bond between TPU and the water soluble dyes, the adhesion of the dyes is greatly enhanced. Since the steps of laying substrate films and coloring are independent, small amounts of coloring pieces can be done without raising production cost too much. Further, since the water soluble dyes do not contain solvents, the product thereby produced is free from pollutant emission, which is environmentally friendly.

Abstract: Enantiomerically pure compound of formula 1 are provided, as well as methods for their synthesis and use. Preferred compounds are potent inhibitors of the c-Met protein kinase, and are useful in the treatment of abnormal cell growth disorders, such as cancers.

Abstract: The invention relates to biocatalytic methods for preparing enantiomerically pure stereoisomers of 1-(2,6-dichloro-3-fluorophenyl)ethanol. Disclosed are methods of preparation of the desired (S)-enantiomer, which methods are based on a combination of enzymatic resolution, chemical esterification and chemical hydrolysis with inversion of 1-(2,6-dichloro-3-fluorophenyl)ethyl esters or stereoselective bio-reduction of 2,6-dichloro-3-fluoro-acetophenone with a biocatalyst such as an enzyme or a microorganism. The chiral (S)-enantiomer can be used in the synthesis of certain enantiomerically enriched, ether linked 2-aminopyridine compounds that potently inhibit auto-phosphorylation of human heptocyte growth factor receptor.

Abstract: Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors of c-MET.

Abstract: A heat dissipating microdevice includes a board, a fluid microsystem, and a coolant. The board includes an insulator layer that has first and second surfaces, a conductor layer formed on the first surface, and a cover member disposed on the second surface. The fluid microsystem is formed in the insulator layer of the board, and includes first and second micro-channel structures, and first and second micro-conduit structures that permit fluid communication between the first and second micro-channel structures. The coolant is contained in the fluid microsystem, and flows from the second micro-channel structure to the first micro-channel structure through the first micro-conduit structure, and from the first micro-channel structure back to the second micro-channel structure through the second micro-conduit structure.

Abstract: A method of making a microstructure includes the steps of providing a circuit board that includes a dielectric layer and a conductor layer formed on the dielectric layer, forming a metal structure on the circuit board such that the metal structure extends through the dielectric layer, and removing at least a portion of the dielectric layer adjacent to the conductor layer and the metal structure to result in the microstructure.

Abstract: The DC to DC converter has an oscillator and generates an output voltage to drive a system. The modulation frequency is used for modulating a pulse width modulation (PWM) circuit in the DC to DC converter. The method includes steps of: 1. providing the modulation frequency from the oscillator; 2. switching the source of the modulation frequency from the oscillator to the system clock to provide the modulation frequency when the system is driven by the output voltage from the DC to DC converter; and 3. stopping the oscillator for reducing a power loss.

Abstract: The present invention is directed to combination therapies for treating cell proliferative disorders associated with methylthioadenosine phosphorylase (MTAP) deficient cells in a mammal. The combination therapies selectively kill MTAP-deficient cells by administering an inhibitor of de novo inosinate synthesis and administering an anti-toxicity agent, wherein the inhibitors of de novo inosinate synthesis are inhibitors of glycinamide ribonucleotide formyltransferase (“GARFT”) and/or aminoinidazolecarboximide ribonucleotide formyltransferase (“AICARFT”), and the anti-toxicity agent is an MTAP substrate (e.g. methylthioadenosine or “MTA”), a precursor of MTA, an analog of an MTA precursor or a prodrug of an MTAP substrate.

Abstract: Compositions comprising novel di-nitrogen heterocycle compounds containing at least one N-meta-substituted alkaryl group are prepared. The compounds of the present invention are useful as antibacterial and as other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compounds of the present invention are useful as research reagents.

Abstract: A method and a circuit for controlling a switching frequency signal used in a direct current to direct current (DC to DC) converter are proposed. The DC to DC converter generates an output voltage to drive a system. The switching frequency signal is generated by inputting a modulation frequency to a pulse width modulation (PWM) circuit. The method includes steps of: 1. generating a control signal from the system to stop the pulse width modulation (PWM) circuit to generate the switching frequency signal when a signal is received by the system; and 2. restarting the pulse width modulation (PWM) circuit to generate the switching frequency signal in order to increase the output voltage to drive the system when the output voltage from the DC to DC converter is under a predetermined voltage.

Abstract: A method and a circuit for switching a source of a modulation frequency used in a direct current to direct current (DC to DC) converter are proposed. The DC to DC converter has an oscillator and generates an output voltage to drive a system. The modulation frequency is used for modulating a pulse width modulation (PWM) circuit in the DC to DC converter. The method includes steps of: 1. providing the modulation frequency from the oscillator; 2. switching the source of the modulation frequency from the oscillator to the system clock to provide the modulation frequency when the system is driven by the output voltage from the DC to DC converter; and 3. stopping the oscillator for reducing a power loss.