Abstract: There is provided a system configured to receive data associated with a vehicle operating within an environment; generate, based at least in part on the data, a graph comprising a plurality of nodes, a node of the plurality associated with one or more of a vehicle operating in the environment, a road feature, an additional vehicle, or a pedestrian; input the graph into a self-supervised machine learned model comprising an encoder, wherein the machine learned model is trained to output a representation associated with the node; receive, from the self-supervised machine learned model, a representation associated with the node; and transmit the representation to a downstream machine learned model trained to output control data based at least in part on the representation, wherein the control data is configured to control the vehicle or another vehicle.

Abstract: There is provided a the system configured to receive a pretrained model configured to output a plurality of representations based at least in part on an input comprising a graph representing an environment through which a vehicle is traversing, a node of the graph comprising, as an embedding, a vector encoding; receive a task comprising: a function to append to the pretrained model, a dataset, a loss function; and update, based at least in part on the task, the pretrained model to generate an updated machine learned model; and deploy the updated machine learned model to a vehicle computing system associated with a vehicle configured to be controlled based at least in part on an output of the updated machine learned model.

Abstract: A method for measuring a neural response to a stimulus. Measurement circuitry is settled prior to a stimulus, by connecting a sense electrode to the measurement circuitry to allow the measurement circuitry to settle towards a bio-electrically defined steady state. Charge is recovered on stimulus electrodes by short circuiting the stimulus electrodes to each other. An electrical stimulus is then applied from the stimulus electrodes to neural tissue, while keeping the sense electrode disconnected from the measurement circuitry. After the stimulus, a delay is imposed during which the stimulus electrodes are open circuited and the sense electrode is disconnected from the measurement circuitry and from the stimulus electrodes. After the delay, a neural response signal present at the sense electrode is measured by connecting the sense electrode to the measurement circuitry.

Abstract: A machine-learned architecture for generating a single trajectory or multiple trajectories for controlling a vehicle may comprise an embedding model that generates an embedding of a world state indicating environment, object, and/or other states, one or more machine-learned layers that determine a predicted world state embedding using the world state embedding, and concatenating, as combined data, that predicted world state embedding to a steering angle distribution and a velocity distribution. The combined data is provided as input to a machine-learned model (that may be a single machine-learned model or may comprise two separate machine-learned models) that determines a next steering angle distribution and a next velocity distribution. These distributions may be used as part of generating one or more trajectories for controlling the vehicle. The architecture may be iteratively used to create a series of distributions that are used to create one or more trajectories.

Abstract: A patient monitoring hub can communicate bidirectionally with external devices such as a board-in-cable or a dongle. Medical data can be communicated from the patient monitoring hub to the external devices to cause the external devices to initiate actions. For example, an external device can perform calculations based on data received from the patient monitoring hub, or take other actions (for example, creating a new patient profile, resetting baseline values for algorithms, calibrating algorithms, etc.). The external device can also communicate display characteristics associated with its data to the monitoring hub. The monitoring hub can calculate a set of options for combined layouts corresponding to different external devices or parameters. A display option may be selected for arranging a display screen estate on the monitoring hub.

Abstract: Pixelated-LED chips include substrate sidewalls with sidewall involutions and/or increased sidewall surface area regions to affect light extraction therefrom. A LED lighting device incorporates a superstrate that supports lumiphoric material and includes sidewalls with sidewall involutions and/or increased sidewall surface area regions. Methods for fabricating sidewall features may include etching (e.g., deep etching) of substrate or superstrate materials, such as by using an etch mask having edges with non-linear shapes to produce and/or enhance sidewall involutions when an etchant is supplied through the etch mask to selectively consume substrate or superstrate material.

Abstract: The present invention is related to a novel process on biological production of lipophilic substances in an oleaginous host cell, particularly Yarrowia lipolytica, comprising modification in the N-glycosylation pathway, leading to higher yield and product purity with further facilitating the overall production process.

Abstract: A method for measuring a neural response to a stimulus. Measurement circuitry is settled prior to a stimulus, by connecting a sense electrode to the measurement circuitry to allow the measurement circuitry to settle towards a bio-electrically defined steady state. Charge is recovered on stimulus electrodes by short circuiting the stimulus electrodes to each other. An electrical stimulus is then applied from the stimulus electrodes to neural tissue, while keeping the sense electrode disconnected from the measurement circuitry. After the stimulus, a delay is imposed during which the stimulus electrodes are open circuited and the sense electrode is disconnected from the measurement circuitry and from the stimulus electrodes. After the delay, a neural response signal present at the sense electrode is measured by connecting the sense electrode to the measurement circuitry.

Abstract: A method of controlling a neural stimulus by use of feedback. The neural stimulus is applied to a neural pathway in order to give rise to an evoked action potential on the neural pathway. The stimulus is defined by at least one stimulus parameter. A neural compound action potential response evoked by the stimulus is measured. From the measured evoked response a feedback variable is derived. A feedback loop is completed by using the feedback variable to control the at least one stimulus parameter value. The feedback loop adaptively compensates for changes in a gain of the feedback loop caused by electrode movement relative to the neural pathway.

Abstract: Techniques are disclosed for utilizing synchronized robot observations. The techniques may include receiving first log data associated with a first vehicle, receiving second log data associated with a second vehicle, determining that a first portion of the first log data is time related to a second portion of the second log data, and using the first portion and the second portion for mapping and/or training models.

Abstract: The subject matter described herein is directed to molecules referred to herein as chemical inducers of degradation (CIDEs) and antibody-conjugated CIDEs (Ab-CIDEs), wherein the Ab-CIDEs comprise an antibody covalently bound to the CIDE through a linker, wherein the CIDE can be further covalently bound to a phosphate moiety, and to the uses of the molecules in treating diseases and conditions where targeted protein degradation is beneficial.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: The subject matter described herein relates generally to hydrolysable maleimide-containing molecules that are useful as linkers to covalently bind chemical inducers of degradation to antibodies and to the conjugates produced therefrom and their uses to treat conditions, and to the uses of the conjugates in treating diseases and conditions where targeted protein degradation is beneficial.

Abstract: The present disclosure relates to bifunctional compounds, which find utility as modulators of SMARCA2 or BRM (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand that binds to the Von Hippel-Lindau E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

Abstract: The present disclosure relates to bifunctional compounds, which find utility as modulators of SMARCA2 or BRM (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand that binds to the Von Hippel-Lindau E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

Abstract: Solid state light emitting components include novel lens structures arranged in contact with at least one solid state light emitters, without an intervening air gap, to provide desirable combinations of output characteristics and dispensing with the need for secondary optics. A lens structure includes an inclined or curved surface having an orientation configured to produce total internal reflection (TIR) of light emissions toward light exit surfaces. A non-Lambertian lens structure is configured to produce focused output emissions or dispersed output emissions with specified distributions over angular ranges. A unitary lens structure may include a recess shaped as an inverted pyramid, an inverted cone, or a trench with a nadir that is registered with an emissive center of a solid state emitter, with walls configured to produce TIR.

Abstract: Disclosed are methods and devices for analysing signal windows captured subsequent to delivered neural stimuli and for providing a quality score for each signal window. The quality score is indicative of how closely the captured signal window resembles, or how likely that the captured signal window contains, an ECAP. The quality score may be provided to a process supervising a feedback loop of the closed-loop neural stimulation device delivering the stimuli and capturing the signal windows to ensure the delivered stimuli are appropriate. For example, if the score falls below a predetermined threshold, the supervisor may take a mitigation action to prevent inappropriate adjustment to the intensity of the delivered stimuli by the feedback loop, such as suspending operation of the feedback loop.

Abstract: A medical communication protocol translator can be configured to facilitate communication between medical devices that are programmed to communicate with different protocol formats. The medical communication protocol translator can receive an input message formatted according to a first protocol format from a first medical device and to output an output message formatted according to a second protocol format supported by a second medical device using a set of translation rules. For example, a medical communication protocol translator can receive an input message from a hospital information system formatted according to a first HL7 protocol format and output an output message formatted according to a second HL7 protocol format based on a comparison with the set of translation rules.

Abstract: A patient monitoring hub can communicate bidirectionally with external devices such as a board-in-cable or a dongle. Medical data can be communicated from the patient monitoring hub to the external devices to cause the external devices to initiate actions. For example, an external device can perform calculations based on data received from the patient monitoring hub, or take other actions (for example, creating a new patient profile, resetting baseline values for algorithms, calibrating algorithms, etc.). The external device can also communicate display characteristics associated with its data to the monitoring hub. The monitoring hub can calculate a set of options for combined layouts corresponding to different external devices or parameters. A display option may be selected for arranging a display screen estate on the monitoring hub.

Abstract: There is provided a method of controlling a neural stimulus. The neural stimulus is defined by at least one stimulus parameter. The method comprises generating a neural stimulus for application to a neural tissue of a patient in accordance with a stimulus parameter, at a first stimulus intensity level, and measuring a response of the neural tissue, the response being evoked by the neural stimulus. The method further comprises determining a second stimulus intensity level, based on an activation plot intercept point, the first stimulus intensity level, the measured response of the neural tissue and a target recruitment level, and adjusting the at least one stimulus parameter to the second stimulus intensity level.