Abstract: A remote computer system may receive data representative of a state of an autonomous vehicle traversing an environment. A representation of the environment and the state may be input to a first machine learned model, which may output a vector representation of the environment at a first time. The vector representation may be input to a second machine learned model, which may output a second vector representation of the environment at a second time. A third machine learned model may receive the second vector representation and may output a mean velocity and a mean steering angle of the vehicle at the first time and associated uncertainty variables. Based on the mean velocity, the mean steering angle, and the uncertainty variables, a predicted vehicle state at the first time and an associated uncertainty may be determined and the vehicle may be controlled based on the predicted vehicle state and the uncertainty.

Abstract: A method for processing a neural measurement obtained in the presence of artifact, in order to detect whether a neural response is present in the neural measurement. A neural measurement is obtained from one or more sense electrodes. The neural measurement is correlated against a filter template, the filter template comprising at least three half cycles of an alternating waveform, amplitude modulated by a window. From an output of the correlating, it is determined whether a neural response is present in the neural measurement.

Abstract: The invention is related to the preparation of protected piperidine carboxylates suitable for use as intermediates that lead, via a series of additional process steps, including a sulfation of a hydroxy urea compound, to the preparation of the beta lactamase inhibitor (2S,5R)-7-oxo-N-piperidin-4-yl-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide.

Abstract: Techniques for generating a tree structure based on multiple machine-learned trajectories are described herein. A planning component (“ML system”) within a vehicle may receive and encode various types of sensor and/or vehicle data. The ML system can provide the encoded data as input to multiple machine-learning models (“ML models”), each of which may be trained to output a unique candidate trajectory for the vehicle follow. In some examples, each ML model may be trained to output a unique type of learned trajectory that causes the vehicle to perform a certain type of action. Using the learned candidate trajectories, the ML system may generate a tree structure that includes some or all of the candidate trajectories. The vehicle may determine a control trajectory based on the generation and traversal of the tree structure using a tree search algorithm, and may follow the control trajectory within the environment.

Abstract: A neuromodulation system and method. An implantable electrode array comprises a plurality of electrodes. A stimulus source provides neural stimuli delivered via stimulus electrodes to neural tissue to evoke neural responses. Measurement circuitry captures signal windows sensed from the neural tissue subsequent to each stimulus. A control unit controls the neural stimuli according to a stimulus intensity parameter. A processor introduces a perturbation to the parameter from a baseline stimulus intensity. A time series of intensities of the evoked neural responses is obtained. from which a time series of estimates of at least one physiological characteristic of the neural tissue is obtained. Each physiological characteristic being variable as a result of a posture wave. A baseline value of each physiological characteristic is estimated from the time series of estimates of each physiological characteristic.

Abstract: Light emitting diodes, components, and related methods, with improved performance over existing light emitting diodes. In some embodiments, light emitter devices included herein include a submount, a light emitter, a light affecting material, and a wavelength conversion component. Wavelength conversion components provided herein include a transparent substrate having an upper surface and a lower surface, and a phosphor compound disposed on the upper surface or lower surface, wherein the wavelength conversion component is configured to alter a wavelength of a light emitted from a light source when positioned proximate to the light source.

Abstract: Techniques for determining classifications associated with vehicle behavior by a machine learned model are discussed herein. A computing device can combine a variety of classifier labels as input to train a machine learned model to determine classifications that represent a vehicle behavior as either good behavior or bad behavior. The machine learned model may receive weak classifier labels that classify an aspect of a vehicle behavior as “good,” “bad,” or “unknown” (relative to the classification) to generate training data for training the machine learning model. Data associated with a vehicle or simulated vehicle may be input to the trained machine learned model to classify good vehicle behavior or bad vehicle behavior even when the model has not been exposed to the precise scenarios represented in the training data.

Abstract: Disclosed is an implantable neural stimulation device, the device comprising: an electrode array comprising a plurality of electrodes, the electrodes comprising a first stimulus electrode and a second stimulus electrode; a pulse generator connectable to the stimulus electrodes, the pulse generator configured to generate a multiphasic stimulus pulse of current from a supply voltage and deliver the multiphasic stimulus pulse via the stimulus electrodes to an electrically excitable tissue in order to evoke a neural response on a neural pathway in the electrically excitable tissue; and modulation circuitry connectable to a regulation electrode of the plurality of electrodes, the modulation circuitry configured to modulate a voltage on the regulation electrode during the delivery of the multiphasic stimulus pulse such that a corresponding voltage on each stimulus electrode varies substantially symmetrically around a value which is about half the supply voltage over the multiphasic stimulus pulse.

Abstract: A method for measuring a neural response to a stimulus. Measurement circuitry is settled prior to a stimulus, by connecting a sense electrode to the measurement circuitry to allow the measurement circuitry to settle towards a bio-electrically defined steady state. Charge is recovered on stimulus electrodes by short circuiting the stimulus electrodes to each other. An electrical stimulus is then applied from the stimulus electrodes to neural tissue, while keeping the sense electrode disconnected from the measurement circuitry. After the stimulus, a delay is imposed during which the stimulus electrodes are open circuited and the sense electrode is disconnected from the measurement circuitry and from the stimulus electrodes. After the delay, a neural response signal present at the sense electrode is measured by connecting the sense electrode to the measurement circuitry.

Abstract: A method for controlling access to a disk device connected to an execution platform that includes reserving a first region of the disk device and storing an unique disk label in said first region, wherein said first region is not encrypted, encrypting a second region of the disk device, wherein the second region includes user data and file information, said method further comprises providing a cipher agent running on said execution platform and carrying out the following steps in case an opening of the disk device is requested, reading the unique disk label stored in the first region, retrieving a protection policy for the disk device based on the unique disk label and handling the further access to the disk device based on the protection policy.

Abstract: A method (100) of manufacturing a lead for an implantable medical device. The method includes: depositing (110) a base layer (3) of biocompatible, electrically non-conductive material; depositing (120) one or more complementary layers (5) of biocompatible, electrically non-conductive material to the base layer (3), wherein the base layer (3) and complementary layer (5) form at least one slot (7); and depositing (130) biocompatible, electrically conductive material (9) into the slot (7). There is also disclosed a lead for an implantable medical device and an apparatus (41) to manufacture the lead.

Abstract: The use of a block copolymer of the following structure. Wherein R and R1 may be the same or different and each independently represents an alkyl or aryl group, X may be hydrogen or C1 to C20 alkyl group which may be branched or linear and wherein the aromatic ring substituent joined to polymer B is positioned meta or para to the aromatic ring substituent joined to polymer A and, wherein polymer A is a polymer (or copolymer) of ethylene and polymer B is a polymer of monomers selected from vinyl acetate, C1-C9 acrylate esters, acrylic acid and mixtures thereof as an additive in polyethylene or polyethylene terephthalate to improve the adhesion between co-extruded layers of the polyethylene and the polyethylene terephthalate and laminated films derived from such use.

Abstract: A method for measuring a neural response to a stimulus. Measurement circuitry is settled prior to a stimulus, by connecting a sense electrode to the measurement circuitry to allow the measurement circuitry to settle towards a bio-electrically defined steady state. Charge is recovered on stimulus electrodes by short circuiting the stimulus electrodes to each other. An electrical stimulus is then applied from the stimulus electrodes to neural tissue, while keeping the sense electrode disconnected from the measurement circuitry. After the stimulus, a delay is imposed during which the stimulus electrodes are open circuited and the sense electrode is disconnected from the measurement circuitry and from the stimulus electrodes. After the delay, a neural response signal present at the sense electrode is measured by connecting the sense electrode to the measurement circuitry.

Abstract: Techniques for determining whether to yield a vehicle to an oncoming object based on a stationary object are discussed herein. A vehicle can determine a drivable area in an environment through which the vehicle is travelling. A trajectory associated with the vehicle can be determined. A probability that the oncoming object will intersect a drive path associated with a vehicle trajectory can be determined. In some case, the probability can be based on various distance metric(s) of the environment. If the oncoming object is determined to intersect the drive path, a stopping location for the vehicle can be determined to allow the oncoming object to traverse around the stationary object. The vehicle can be controlled based on sensor data captured by the vehicle and the probability.

Abstract: Techniques for analyzing driving simulations and determining simulation stability metrics are discussed herein. Various techniques may include receiving a driving simulation and determining a number of perturbed simulations based on the driving simulation. The perturbed simulations may include, for example, one or more perturbed object attributes, perturbed simulation failure conditions, and/or perturbed behaviors of the vehicle system on which the simulation is executed. The perturbed simulations may be executed, and the results may be analyzed to determine a stability score associated with the driving simulation. Stability scores for driving simulations may be determined and maintained based on different simulation data perturbations received based on perturbation models, and the stability scores may be used in various implementations to generate simulation batteries for regression testing and for analyzing and routing simulation failures.

Abstract: A composition is provided to comprise a non-aqueous medium and a 3,4-oxypyridinone compound of structure (I): with each A being oxygen and/or sulfur, and with a variety of substituents at R1-R5 to enable a solution or an at least semi-stable emulsion to be formed in the non-aqueous medium. Methods of use are included herein, which may be focused on situations where the composition can be used as a lubricant and/or coolant.

Abstract: Techniques for determining whether to yield a vehicle to an oncoming object based on a stationary object are discussed herein. A vehicle can determine a drivable area in an environment through which the vehicle is travelling. A trajectory associated with the vehicle can be determined. A probability that the oncoming object will intersect a drive path associated with a vehicle trajectory can be determined. In some case, the probability can be based on various distance metric(s) (e.g., dynamic distance metrics) of the environment. If the oncoming object is determined to intersect the drive path, a stopping location for the vehicle can be determined to allow the oncoming object to traverse around the stationary object. The vehicle can be controlled based on sensor data captured by the vehicle and the probability.

Abstract: An implantable device for estimating neural recruitment arising from a stimulus, has a plurality of electrodes. A stimulus source provides stimuli to be delivered from the electrodes to neural tissue. Measurement circuitry obtains a measurement of a neural signal sensed at the electrodes. A control unit is configured to control application of a selected stimulus to neural tissue using the stimulus electrodes; and after the selected neural stimulus, apply a probe stimulus having a short pulse width. A remnant neural response evoked by the probe stimulus is measured; and the control unit estimates from the remnant neural response a neural recruitment caused by the selected neural stimulus.

Abstract: A method of controlling a neural stimulus by use of feedback. The neural stimulus is applied to a neural pathway in order to give rise to an evoked action potential on the neural pathway. The stimulus is defined by at least one stimulus parameter. A neural compound action potential response evoked by the stimulus is measured. From the measured evoked response a feedback variable is derived. A feedback loop is completed by using the feedback variable to control the at least one stimulus parameter value. The feedback loop adaptively compensates for changes in a gain of the feedback loop caused by electrode movement relative to the neural pathway.

Abstract: A medical communication protocol translator can be configured to facilitate communication between medical devices that are programmed to communicate with different protocol formats. The medical communication protocol translator can receive an input message formatted according to a first protocol format from a first medical device and to output an output message formatted according to a second protocol format supported by a second medical device using a set of translation rules. For example, a medical communication protocol translator can receive an input message from a hospital information system formatted according to a first HL7 protocol format and output an output message formatted according to a second HL7 protocol format based on a comparison with the set of translation rules.