Abstract: A method of controlling a neural stimulus, the neural stimulus being defined by at least one stimulus intensity parameter. The method comprises generating a stimulus intensity parameter to control a stimulator that generates a stimulus current for application to a tissue, measuring a response of the tissue, evoked by the stimulus current, determining a forward adjustment parameter as a function of the stimulus intensity parameter, determining a feedback parameter derived from the measured response and the forward adjustment parameter and adjusting the stimulus intensity parameter according to the feedback parameter.

Abstract: A three-dimensional (3D) printing system for manufacturing a 3D article includes a resin vessel, a build tray, a movement mechanism, a light engine, a housing, a gas handling system, and a controller. The resin vessel includes a transparent sheet on a lower side. The housing defines two chambers including an upper chamber and a lower chamber. The upper chamber is in fluidic communication with the resin contained by the resin vessel. The lower chamber is in fluid communication with a lower surface of the transparent sheet. The controller is configured to (a) operate the gas handling system to reduce and control a partial pressure of oxygen in the upper and lower chambers, (b) operate the movement mechanism and the light engine to form the 3D article in a layer-by-layer manner.

Abstract: A neural stimulus comprises at least three stimulus components, each comprising at least one of a temporal stimulus phase and a spatial stimulus pole. A first stimulus component delivers a first charge which is unequal to a third charge delivered by a third stimulus component, and the first charge and third charge are selected so as to give rise to reduced artefact at recording electrodes. In turn this may be exploited to independently control a correlation delay of a vector detector and an artefact vector to be non-parallel or orthogonal.

Abstract: A pixelated-LED chip includes an active layer with active layer portions, segregated by streets, that are configured to illuminate different light-transmissive substrate portions to form pixels. A light extraction surface of each substrate portion includes protruding features and light extraction surface recesses that may be formed by sawing. Underfill material may be provided between a pixelated-LED chip and a mounting surface, as well as between pixels and between anodes and cathodes thereof. Certain implementations provide light extraction surface recesses that are non-parallel to each street defined through the active layer. Certain implementations provide light extraction surface recesses that are non-aligned with (e.g., non-parallel to) anode-cathode boundaries of each anode-cathode pair. Such arrangements reduce a likelihood of cracking in portions of a pixelated-LED chip. Methods for fabricating pixelated-LED chips are also provided.

Abstract: There is provided a method and implantable device for controlling a neural stimulus, the neural stimulus being defined by an artefact mitigation status. The method comprises generating a first neural stimulus for delivery to neural tissue, sensing a first signal subsequent to the first neural stimulus, generating a second neural stimulus for delivery to the neural tissue, and sensing a second signal subsequent to the second neural stimulus. The method further comprises determining an artefact mitigation measure (AMM) effect level based on the first sensed signal and the second sensed signal, and setting, in response to comparing the AMM effect level with an AMM effect threshold, the artefact mitigation status of a third neural stimulus to active.

Abstract: The subject matter described herein is directed to antibody-CIDE conjugates (Ab-CIDEs) that target BRM for degradation, to pharmaceutical compositions containing them, and to their use in treating diseases and conditions where BRM degradation is beneficial.

Abstract: A patient movement detector can receive inputs from position sensors, a thermal imaging camera, a video camera, and/or triangulation data. Based on one or more of these inputs, the patient movement detector can perform one or more of the following: fall prevention detection, bedsore prevention analysis, patient location detection, and patient walk test scoring. The patient movement detector can, for example, output a fall warning alarm, a bedsore warning alarm, patient location information, and walk test scores.

Abstract: The present disclosure includes a medical monitoring hub as the center of monitoring for a monitored patient. The hub includes configurable medical ports and serial ports for communicating with other medical devices in the patient's proximity. Moreover, the hub communicates with a portable patient monitor. The monitor, when docked with the hub provides display graphics different from when undocked, the display graphics including anatomical information. The hub assembles the often vast amount of electronic medical data, associates it with the monitored patient, and in some embodiments, communicates the data to the patient's medical records.

Abstract: A method of controlling a neural stimulus, the neural stimulus being defined by at least one stimulus intensity parameter. The method comprises, generating a stimulus intensity parameter to control a stimulator that generates a stimulus current for application to a tissue, measuring a response of the tissue, evoked by the stimulus current, determining a response parameter indicative of the measured response, in response to the response parameter being less than a first threshold, setting the stimulus intensity parameter to a desired stimulus intensity level; and in response to the response parameter being greater than a second threshold, adjust the stimulus intensity parameter according to a feedback variable derived from the measured response.

Abstract: An implantable pulse generator device (110) comprising a processor (117) configured to: receive, in a charging mode, electromagnetic radiation (106) from a charging device (102) wherein the electromagnetic radiation (106) transfers energy to the implantable device (110) to charge an energy storage device (104); measure, in a measurement mode, an electrical field parameter signal representing a neural response; and selectively transition between the charging mode and the measurement mode, such that the implantable device (110) does not receive electromagnetic radiation (106) from the charging device (102) during the measurement of the electrical field parameter signal.

Abstract: At least one array of LEDs (e.g., in a flip chip configuration) is supported by a substrate having a light extraction surface overlaid with at least one lumiphoric material. Light segregation elements registered with gaps between LEDs are configured to reduce interaction between emissions of different LEDs and/or lumiphoric material regions to reduce scattering and/or optical crosstalk, thereby preserving pixel-like resolution of the resulting emissions. Light segregation elements may be formed by mechanical sawing or etching to define grooves or recesses in a substrate, and filling the grooves or recesses with light-reflective or light-absorptive material. Light segregation elements external to a substrate may be defined by photolithographic patterning and etching of a sacrificial material, and/or by 3D printing.

Abstract: The present disclosure relates to compounds and pharmaceutical compositions thereof, and methods of using the compounds and compositions in therapy, such as methods of treating cancer.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: Methods to securely remediate a captive portal are provided. In these methods, a processor of a user device detects a connection, via a network, to a captive portal. Based on the detected connection to the captive portal, the processor launches a dedicated secure web browser, and selectively restricts access of the user device to the network in order to only allow, via the dedicated secure web browser, communications related to remediation with the captive portal.

Abstract: An implantable device for controllably stimulating a neural target. The device configured to electrically couple to a paddle electrode assembly, the paddle electrode assembly comprising a plurality of electrodes including a first group of one or more electrodes arranged on a ventral surface of a paddle body, and a second group of one or more electrodes arranged on a dorsal surface of the paddle body. The implantable device comprises stimulation circuitry, configured to provide stimulation energy to one or more electrodes of the paddle electrode assembly, measurement circuitry, configured to measure a response evoked from the neural target by the stimulation energy and sensed by one or more electrodes of the paddle electrode assembly, and an electrode selection module.

Abstract: A pipe fitting system, including a first pipe section with at least one male end, a second pipe section with at least one female end, and a connecting means for releasably connecting the pipe sections together such that the male end is at least partially received within the female end. The connecting means comprising releasably engageable first and second connectors associated with the first and second pipe sections respectively, wherein the first connector comprises at least one outwardly extending protrusion and wherein the second connector comprises corresponding recesses adapted to releasable receive the or each protrusion of the first connector. The pipe fitting system is suitable for applications such as end of line connections, repair/replacement of fixed existing pipes, and in enabling temporary removal of pipes for maintenance or access purposes.

Abstract: This disclosure relates to a device for applying a neural stimulus. A battery supplies electrical energy at a battery voltage and an electrode applies the electrical energy to neural tissue. A circuit measures the nervous response of the tissue and a voltage converter receives the electrical energy from the battery and controls a voltage applied to the electrode based on the measured nervous response of the tissue. This direct voltage control is energy efficient because losses across a typical current mirror are avoided. Further, the control based on the measured nervous response leads to automatic compensation of impedance variation due to in-growth or change in posture. As a result, the stimulation results in a desired neural response.

Abstract: A device for recording evoked neural responses, comprising one or more stimulus electrodes and one or more sense electrodes. The device has a stimulus source for providing a stimulus to be delivered from the stimulus electrodes to a neural pathway in order to give rise to an evoked action potential on the neural pathway. The device has measurement circuitry for recording a neural compound action potential signal sensed at the sense electrodes. Crosstalk cancellation circuitry is configured to produce a stimulus crosstalk cancellation signal, and is configured to inject the stimulus crosstalk cancellation signal into the measurement circuitry. The stimulus crosstalk cancellation signal is configured to cancel a stimulus crosstalk voltage arising upon the one or more sense electrodes as a result of delivery of the stimulus.

Abstract: A lead (1) for an active implantable medical device comprising: an elongated, biocompatible, electrically non-conductive body (3); a plurality of electrically conductive filaments (5) inside the elongated body (3) to electrically connect electrical connectors (6) to corresponding electrodes (8); and at least one elongated decoy conductor (10) inside the elongated body (3) to electromagnetically couple with the plurality of electrically conductive filaments (5), wherein the at least one decoy conductor (10) has a higher electrical resistance than the plurality of electrical conductive filaments (5) to dissipate energy from currents induced by radio frequencies.

Abstract: Pixelated-LED chips and related methods are disclosed. A pixelated-LED chip includes an active layer with independently electrically accessible active layer portions arranged on or over a light-transmissive substrate. The active layer portions are configured to illuminate different light-transmissive substrate portions to form pixels. Various enhancements may beneficially provide increased contrast (i.e., reduced cross-talk between pixels) and/or promote inter-pixel illumination homogeneity, without unduly restricting light utilization efficiency. In some aspects, an underfill material with improved surface coverage is provided between adjacent pixels of a pixelated-LED chip. The underfill material may be arranged to cover all lateral surfaces between the adjacent pixels. In some aspects, discontinuous substrate portions are formed before application of underfill materials. In some aspects, a wetting layer is provided to improve wicking or flow of underfill materials during various fabrication steps.