Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.

Abstract: The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.

Abstract: Methods of treating a head and neck cancer are disclosed.

Abstract: Dust accumulation monitors are provided to autonomously monitor dust accumulations. The dust accumulation monitors include a casing having a translucent portion, a light sensor configured to output a sensing signal based on sensed light penetrating through the translucent portion, a controller coupled to the light sensor to receive the sensing signal and configured to output a dust alert signal based on the received sensing signal, and a communication interface coupled to the controller and configured to output an alert based on the dust alert signal output by the controller. A dust accumulation monitoring system includes a plurality of dust accumulation monitors, and a central monitor communicatively connected to each of the plurality of dust accumulation monitors and configured to receive dust sensing signals from each of the plurality of dust accumulation monitors. The dust accumulation monitors may communicate through wired or wireless links with the central monitor.

Abstract: The present disclosure relates to a system which may have an electronic controller, an optical light source controlled by the electronic controller which generates a beam having an output power level, and a current measuring subsystem (CMS) electrically coupled to a conductive substrate (e.g., metal substrate (MS)) while a powder bed layer (PBL) is deposited on the MS. The CMS may be in communication with the electronic controller and detects a current flow as at least one of the MS or the PBL is heated when the beam is scanned over the PBL. The CMS generates a current flow signal in accordance with the detected current flow. The current flow signal is used by the electronic controller to determine when the temperature of at least one of the substrate or the PBL is at least one of above or below a desired temperature.

Abstract: The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.

Abstract: A method of creating a parameter based reconditioning index for use in the estimation of reconditioning cost of vehicles based upon the historical reconditioning cost of similar vehicles. A modeling software component operates in conjunction with a reconditioning database containing historical reconditioning cost information to generate a mathematical reconditioning cost function corresponding to a parameter value in respect of the reconditioned vehicle for a parameter set—the function correlates historical reconditioning costs with parameter values of the related reconditioned vehicle for cost records having vehicle parameters within their historical parameter sets that correspond to the vehicle parameters within an index parameter set and which will, when applied to current parameter values of a target vehicle, yield an estimated reconditioning cost for the target vehicle. Periodic updates can be applied on receipt of additional historical reconditioning cost information.

Abstract: A method of generating and honoring a time-limited net valuation guarantee for used target vehicles in purchase and trade-in transactions. A user would submit a captured parameter set of details related to at least one target vehicle to a pricing software component. The captured parameter set would be used to identify a gross value for the target vehicle as well as to generate an estimated reconditioning cost. The net valuation of the target vehicle, being the gross value less the estimated reconditioning cost, would be stored along with a calculated expiry date in a valuation record. Subsequent and before the calculated expiry date, the owner of the target vehicle could redeem the guarantee at a subscribing vehicle acquisition outlet and the subscribing vehicle acquisition outlet would honor the net valuation stored within the record.

Abstract: Methods and compositions for treating cholangiocarcinoma.

Abstract: A method for reducing loads of a wind turbine includes determining an operational state of the wind turbine. The method also includes commanding a predetermined pitch event. Further, the method includes monitoring at least one operating condition of a pitch drive mechanism of a rotor blade of the wind turbine during the predetermined pitch event. If the operational state corresponds to a predetermined operational state and the operating condition(s) follows a pitch fault pattern during the predetermined pitch event, the method also include yawing a nacelle of the wind turbine away from an incoming wind direction.

Abstract: The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.

Abstract: Dust accumulation monitors are provided to autonomously monitor dust accumulations. The dust accumulation monitors include a casing having a translucent portion, a light sensor configured to output a sensing signal based on sensed light penetrating through the translucent portion, a controller coupled to the light sensor to receive the sensing signal and configured to output a dust alert signal based on the received sensing signal, and a communication interface coupled to the controller and configured to output an alert based on the dust alert signal output by the controller. A dust accumulation monitoring system includes a plurality of dust accumulation monitors, and a central monitor communicatively connected to each of the plurality of dust accumulation monitors and configured to receive dust sensing signals from each of the plurality of dust accumulation monitors. The dust accumulation monitors may communicate through wired or wireless links with the central monitor.

Abstract: The invention provides antibodies to tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.

Abstract: A method of custom labeling products in which users specify, via a purchasing interface, product label images in correspondence with products. A label group is generated for each of the users. The label group includes an indicator label image providing a purchase identifier and product identifiers, and the product label images arranged in a sequence specified by the product identifiers. The label groups are printed to produce printed label groups. The printed label groups are transferred to a labeling machine. A conveyor system is controlled to release, for each of the printed label groups, the sequence of the products specified by the product identifiers. Printed product labels of each of the printed label groups are applied to the corresponding sequence of the products.

Abstract: The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.

Abstract: The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.

Abstract: Systems and methods are disclosed herein for recommending an educational course to a user, and may comprise receiving data records associated with availability of a plurality of educational courses at one or more institutions; receiving educational course data and educational course focus data associated with the user; receiving prior user data records comprising prior user educational course data and prior user educational course focus data; determining index scores for each of the plurality of educational courses based upon a similarity between the educational course data and prior user educational course data, and based upon a similarity between the educational course focus data and prior user educational course focus data; and providing a recommended educational course from the plurality of educational courses to the user based upon the determined index scores.

Abstract: A sealing system for a rotary machine is provided. The sealing system includes a pair of circumferentially adjacent rotary components. Each of the rotary components includes a platform, a shank, and a radial seal. The shank extends radially inwardly from the platform and includes a radially extending first side channel and an opposite radially extending second side channel. The radial seal includes a first leg received in the first side channel of a first of the pair of rotary components, a second leg received in the second side channel of a second of the pair of rotary components (201), and a resiliently deformable body extending therebetween, the body including a U-shaped portion located generally centrally between the first leg and the second leg.

Abstract: The invention provides antibodies that specifically bind tau. The antibodies inhibit or delay tau-associated pathologies and associated symptomatic deterioration.

Abstract: A computer readable storage medium includes executable instructions to receive from a mobile device a request regarding a stranded vehicle. The request is processed to determine the location of the stranded vehicle. Additional information regarding the stranded vehicle may be retrieved. The location of the stranded vehicle and the additional information may be communicated as a dispatch request. The location of the stranded vehicle relative to a dispatched vehicle is delivered to the mobile device.