Abstract: The invention concerns compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection. (Formula I).

Abstract: The application describes fused heterocycle derivative compounds, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of diseases associated with HBV infection.

Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

Abstract: A coated part includes a metallic substrate, a thermal barrier comprising a ceramic material and covering the metallic substrate, wherein the coated part further includes a protective coating covering the thermal barrier, the protective coating including, in a first region, a first MAX phase, denoted PZ2, of formula (ZrxTi1-x,)2AlC or a first MAX phase, denoted PC2, of formula (CrxTi1-x,)2AlC with x non-zero and less than or equal to 1 in the MAX phases PZ2 and PC2, and the protective coating includes, in a second region covering the first region, a second MAX phase of formula Ti2AlC.

Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: A battery module can include multiple cell tubes and a conductive plate. The multiple cell tubes can accommodate multiple battery cells within the multiple cell tubes so that individual of the multiple battery cells are positioned within individual of the multiple cell tubes. The conductive plate can include a printed circuit board. The printed circuit board can include a first conductive layer and an isolating layer. The isolating layer can include a blind hole through which a wire bonding extends. The wire bonding can be electrically connected to the first conductive layer.

Abstract: The present disclosure provides a scalable container-based system implemented in computer instructions stored in a non-transitory medium. The present disclosure further provides a method of creating and operating a scalable container-based system.

Abstract: The present invention relates to a detection system designed to allow the detection of an underground pipe, the system comprising: a flexible element comprising a downstream free end capable of being inserted into the underground pipe through an upstream opening, the upstream free end remaining outside the underground pipe, a detection device provided to be positioned above the underground pipe so as to detect the position of the underground pipe by detecting the presence of a section of the flexible element, characterized in that the flexible element is constituted by a current supplied electrical wire whose downstream free end is provided with a drive element, the drive element having a drive surface allowing a fluid to drive the drive element with the downstream free end of the wire downstream into the underground pipe.

Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

Abstract: The application describes fused heterocycle derivative compounds, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of diseases associated with HBV infection.

Abstract: Turbomachine output bearing support extending according to an axial direction, said support being formed by one and the same piece and comprising an annular inner wall having an inner side and an outer side, an annular outer wall and a twist support.

Abstract: The present invention relates to purine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

Abstract: The present invention relates to a method for verifying the presence of equipment (E) on board an aircraft, the method comprising the following steps:—during a flight of the aircraft, implementing (102) radio communication tests by means of a device (2) on board the aircraft so as to determine an in-flight list of equipment consisting of any equipment having a quality of radio link with the radio communication device (2) higher than a first predetermined quality threshold;—after the flight, implementing (104) radio communication tests by means of the device (2) so as to determine a post-flight list of equipment consisting of any equipment having a quality of radio link with the radio communication device (2) higher than a second predetermined threshold after the flight;—generating (108) an alert when an item of equipment is present on the in-flight list and absent from the post-flight list.

Abstract: The invention relates to a method for manufacturing a power electronic module (1) by additive manufacturing, characterized in that it comprises the steps of: making or fixing preforms (15) of polymer material on at least one face of an insulating substrate (2a) covered with at least one layer of metal (2b, 2c), referred to as a metallized substrate (2), depositing a first metal layer (17) on the preform (15), depositing by electroforming a second metal layer (18) on the first metal layer (17).

Abstract: A cooling fluid distribution element intended to be fixed to a support structure for supplying cooling fluid to a wall to be cooled, typically a turbine ring sector, facing it, the distribution element including a body defining a cooling fluid distribution internal volume and a multi-perforated plate which delimits this internal volume and includes a plurality of outlet through-perforations which put the internal volume into communication with the turbine ring sector, the distribution element further including an inlet orifice opening into the cooling fluid distribution internal volume, which internal volume includes directional fins for directing this cooling fluid from this inlet orifice to the outlet through-perforations.

Abstract: A method for manufacturing a power electronic module by additive manufacturing includes the step of depositing a layer of an electrically conductive nanoporous material on a substrate that includes an electrically insulating layer and at least one layer of conductive metal material, called a metallized substrate. The method further includes the step of placing an element for example an active component of the semiconductor power component type, on the layer of nanoporous material and sintering the layer of nanoporous material, so as to ensure a mechanical and electrical connection between said element and the metallized substrate.

Abstract: The present invention relates to a bypass air/fluid heat exchanger (2) for a turbofan engine. According to the invention, this exchanger (2) comprises: —an annular outer shroud (3) with two walls, an inner wall (32) and an outer wall (31), —an annular inner shroud (4) concentric with the outer shroud (3), —a series of OGV guide vanes (5) which connect said outer shroud to said inner shroud, —and a circulation circuit (6) for circulating said fluid, the two shrouds delimiting a bypass air flow path, the fluid circulation circuit (6) is formed in the body of the outer shroud (3) and in the body of at least one of the OGV guide vanes (5), this circulation circuit (6) opening at the two respective ends thereof into an inlet opening (34) and into an outlet opening (35), formed through said outer wall (31) of the outer shroud, and the two shrouds (3, 4), the OGV guide vanes (5) and the circulation circuit (6) of said fluid are integral.

Abstract: The invention relates to a nozzle (1) for separating a primary flow from a secondary flow in a double-flow turbomachine. The separation nozzle comprises an outer annular wall (12), an inner annular wall (13), a radial annular wall (14) and an inner annular baffle (16). and defines a first cavity (17) between the outer annular wall (12) and the inner annular baffle (16), and a second cavity (18) between the inner annular wall (13), the radial annular wall (14) and the inner annular baffle (16).

Abstract: The present invention relates to a method for transmitting data from an object (6) on board an aircraft (1) to a server (3) of a network of connected objects (4), the method comprising: if the aircraft (1) is detected as being in flight, the sending (108) of the data item by the object (6) to an aircraft radio communication device (10) of the aircraft (1) for communication with the ground, and the transmission of the data item by the aircraft communication system (10) to a ground station (2), for subsequent retransmission of the data item by the ground station (2) to the server (3); and, if the aircraft (1) is detected as not being in flight, the sending (116) of the data item by the object (6) to the server (3) without passing through the aircraft radio communication system (10) of the aircraft (1).