Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.

Abstract: Disclosed herein are compounds of Formula I: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.

Abstract: A casting ring having a first section made of a heat-conductive material and a second section made of a MAX phase alloy material, and a method for obtaining a product made of titanium alloy or a titanium-aluminum intermetallic compound by plasma torch melting, the alloy having an oriented structure, the method including heating the molten alloy surface in the casting ring with a plasma torch; cooling a cold zone of the casting ring over a length L1, the cooling forming a semi-solid crown of alloy; heating a hot zone of the casting ring over a length L2, thereby forming a solidification front, the flatness of which relative to a plane perpendicular to a drawing direction is less than 10°; and drawing the solidified alloy at a speed of more than 10?4 m/s in the drawing direction.

Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: A method for manufacturing a turbine engine vane a root connected to a blade extending in a longitudinal direction includes the steps of providing a root; and providing mold with a first cavity and a second cavity that together define a recess in which the vane is formed. The recess includes a first space in which the blade is formed and a second space in which the root (1), c) is formed. The method further includes the steps of providing aluminum strips; positioning a fibrous reinforcement; arranging the vane root in the second space; and injecting a foam comprising aluminum or injecting an aluminum alloy into the first space of the recess of the mold such that the foam impregnates the fibrous reinforcement.

Abstract: A method for manufacturing a blade for a turbine engine, including a root connected to a vane extending in a longitudinal direction, includes providing an assembly having a first part intended to form a root of the blade and a projecting second part projecting in the longitudinal direction from the first part; providing a mold comprising a first impression and a second impression delimiting together a cavity, said cavity comprising a first space and a second space; arranging the first part in the first space of the cavity and the second part in the second space of the cavity; and forming a third part by injecting an aluminium-based alloy in the cavity.

Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: A connecting rod includes a hollow body with a ring at each end and a centre, a thickness wall e, the wall defining an outer perimeter pe and an inner perimeter pi, a surface section s being contained between the outer and inner perimeters, wherein the outer perimeter pe increases from the ends of the hollow body to the centre of the connecting rod, the hollow body maintaining a constant surface section s, the thickness e decreasing from the end to the centre of the connecting rod.

Abstract: A method for delivering an audio and/or video content using adaptive streaming to a terminal, the audio and/or video content being segmented into data segments available in various representations with respective audio and/or video qualities, the representations being time-aligned per segment, the segments being further divided into chunks, a controller selects, from a set of candidate caching platforms, the caching platform to be used to deliver the audio and/or video content to the terminal, as a function of a minimum burst transfer duration compared with the chunk duration as defined by an origin server providing the audio and/or video content. The controller redirects the terminal to the selected platform for further delivery of the audio and/or video content in the form bursts of chunks in response to requests for segments.

Abstract: Disclosed herein are compounds of Formula I?: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a patient with one or more of the above compounds.

Abstract: An acoustic sensor is disclosed, the sensor including a laser and a membrane configured to vibrate in the presence of an acoustic wave, and to reflect radiation emitted by the laser back toward the laser to produce a self-mixing interference effect corresponding to the acoustic wave. The sensor also includes a cavity separating the membrane from the laser and extending rearward of a radiation-emitting surface of the laser, a majority volume of the cavity being disposed rearward of the radiation-emitting surface of the laser. Also disclosed is an apparatus including the acoustic sensor, and a method of manufacturing the acoustic sensor.

Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using the compounds and also relates to use of the compounds as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: A nickel-based superalloy includes, in atomic percentages, 13% to 21% chromium, 15% to 26% cobalt, 4% to 8% aluminum, 4.5% to 8% titanium, 8% to 18% iron, boron in an atomic percentage less than or equal to 0.5% or no boron, carbon in an atomic percentage less than or equal to 1% or no carbon, at least one additional element selected from molybdenum, tungsten, tantalum and niobium, a total atomic content of the at least one additional element being less than or equal to 1.5% or no such at least one additional element, the remainder being nickel and unavoidable impurities, with a sum of the atomic percentages of aluminum and titanium being comprised between 8.5% and 15%. The novel superalloy composition has a limited density and exhibiting, when hot, good mechanical properties as well as good resistance to oxidation and corrosion.

Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: A method for manufacturing a conductor of a winding of a coil, includes manufacturing a heat-sink preform including a phase-change material, depositing a conductive element by layer deposition of electrically conductive material on the heat-sink preform, including inserting the heat-sink preform into an electrolytic solution of the electrically conductive material, and; electrodeposition for depositing the electrically conductive material on the heat-sink preform.

Abstract: The present invention relates to a polyamide, to a composition comprising same, and to the use thereof, and also to a molded article deriving therefrom and to a process for producing same. The polyamide is particularly suitable as hot-melt adhesive for the low-pressure and low-temperature overmolding of a heat-sensitive battery, for example a lithium-polymer battery.

Abstract: Sensors that include carbon nanotubes, and articles that include the sensors. The sensors may include a buckypaper. The sensors may be flexible. Methods of making sensors, which may include printing an electrode on a substrate. The printing of an electrode may be achieved with an inkjet printer.