Abstract: For delivering an audio and/or video content using adaptive streaming from a cache server to a client device, the audio and/or video content being segmented into data segments available in various representations with respective audio and/or video qualities, the representations being time-aligned per segment, the segments being further divided into chunks, a method includes: obtaining a round-trip time value applicable between the cache server and the client device; computing a minimum bulk transfer size from the maximum average bitrate of the various representations of the audio and/or video content and from the obtained round-trip time value; computing a minimum bulk duration, with respect to the audio and/or video content, for the representation to be delivered to the client device; and delivering the audio and/or video content by burst transfers in the form of bulks of aggregated successive chunks for each segment in accordance with the computed minimum bulk duration.

Abstract: A production of a structure for a turbomachine by additive manufacturing, including the following steps: a) providing an element having at least one localised rough region, in particular produced by machining, b) using powder bed fusion additive manufacturing in order to deposit a layer of material resulting from the fusion on the element.

Abstract: Disclosed herein are compounds of Formula I?: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.

Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

Abstract: Disclosed herein are compounds of Formula I?: or a stereoisomer or a tautomer thereof, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising such compounds, and methods of treating disease by administering or contacting a subject with one or more of the above compounds.

Abstract: The present disclosure related to compounds that can be useful as inhibitors of PD-1, PD-L1 or the PD-1/PD-L1 interaction. Also disclosed herein are pharmaceutical compositions of that can include a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and uses of or methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of PD-L1 related diseases including but not limited to liver diseases, cancer, hepatocellular carcinoma, viral diseases, or hepatitis B.

Abstract: The present disclosure provides a scalable container-based system implemented in computer instructions stored in a non-transitory medium. The present disclosure further provides a method of creating and operating a scalable container-based system.

Abstract: The present disclosure related to compounds that can be useful as inhibitors of PD-1, PD-L1 or the PD-1/PD-L1 interaction. Also disclosed herein are pharmaceutical compositions of that can include a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and uses of or methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of PD-L1 related diseases including but not limited to liver diseases, cancer, hepatocellular carcinoma, viral diseases, or hepatitis B.

Abstract: The present invention relates to a bypass air/fluid heat exchanger (2) for a turbofan engine. According to the invention, this exchanger (2) comprises: —an annular outer shroud (3) with two walls, an inner wall (32) and an outer wall (31), —an annular inner shroud (4) concentric with the outer shroud (3), —a series of OGV guide vanes (5) which connect said outer shroud to said inner shroud, —and a circulation circuit (6) for circulating said fluid, the two shrouds delimiting a bypass air flow path, the fluid circulation circuit (6) is formed in the body of the outer shroud (3) and in the body of at least one of the OGV guide vanes (5), this circulation circuit (6) opening at the two respective ends thereof into an inlet opening (34) and into an outlet opening (35), formed through said outer wall (31) of the outer shroud, and the two shrouds (3, 4), the OGV guide vanes (5) and the circulation circuit (6) of said fluid are integral.

Abstract: A distribution element intended to be fixed to a support structure for supplying cooling fluid to a wall to be cooled facing the distribution element, the distribution element including a body defining a cooling fluid distribution internal volume and a multi-perforated plate which delimits the internal volume and includes a plurality of outlet through-perforations which put the cooling fluid distribution internal volume into communication with the wall to be cooled, the distribution element including an inlet orifice opening into the cooling fluid distribution internal volume, wherein for directing the cooling fluid from the inlet orifice to the plurality of outlet through-perforations the cooling fluid distribution internal volume includes directional fins.

Abstract: This application relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and medical uses thereof.

Abstract: A power supply system can include an electrical power source and a power converter connectable to a load. The electrical power source can provide a first DC voltage with a first potential difference (VH) between a first DC potential output and a second DC potential output, and a third DC potential output having a potential between the potential at the first DC potential output and the potential at the second DC potential output. The power converter can provide a second voltage with a second potential difference (VL) between a first potential output (V+) and a second potential output (V-). The second potential difference (VL) can be less than the first potential difference (VH). The power converter can electrically isolate the first DC voltage from the second voltage, and the second potential output (V-) can be connected to the third DC potential output using a first connection including an impedance.

Abstract: The invention provides compounds of formula (I): wherein X is and the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are useful as JAK kinase inhibitors. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat respiratory diseases, and processes and intermediates useful for preparing such compounds.

Abstract: The invention concerns compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection.

Abstract: A battery module can include multiple battery cells, multiple cell tubes, and a first plate. The multiple cell tubes can accommodate the multiple battery cells within the plurality of cell tubes so that individual of the plurality of battery cells are positioned within individual of the plurality of cell tubes. Each battery cell can have a first electric pole and a second electric pole. The first plate can include a printed circuit board. The printed circuit board can include a first conductive layer and an isolating layer. The isolating layer can include at least one blind hole for wire-bonding the conductive layer to one of the battery cells.

Abstract: The present invention concerns substituted indoline derivatives, methods to prevent or treat dengue viral infections by using said compounds and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

Abstract: This invention relates to macrocyclic deaza-purinones derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

Abstract: Techniques are described herein that are capable of integrating an IDE with game engines. States of the game engines are identified. Each state indicates whether the IDE enables a game developer to interact with the respective game engine and/or game(s) created by the respective game engine. A subset of the game engines is caused to be displayed to the game developer based at least in part on the IDE enabling the game developer to interact with each game engine in the subset and/or game(s) created by the respective game engine. A selection indicator, which indicates that a game engine is selected from the game engines in the subset, is received. An integration infrastructure, including a game engine-agnostic messaging protocol and game engine-agnostic messages, is provided. At least a portion of game code and/or test unit(s) are run and/or debugged using the IDE in a context of the selected game engine.

Abstract: The invention concerns compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection.

Abstract: An imaging system including a front aperture, two or more refractive lens elements mounted in a lens barrel, and a photosensor. One or more of the components of the imaging system (e.g., the aperture, lenses, lens groups, and/or photosensor) are tilted with respect to each other and/or with respect to a center (or mechanical) axis of the imaging system to compensate for effects including but not limited to keystone distortion, resolution non-uniformity, and gradient blur that result from tilt of an object in the field of view of the camera with respect to the center axis of the camera.