Abstract: Techniques are described herein that are capable of integrating an IDE with game engines. States of the game engines are identified. Each state indicates whether the IDE enables a game developer to interact with the respective game engine and/or game(s) created by the respective game engine. A subset of the game engines is caused to be displayed to the game developer based at least in part on the IDE enabling the game developer to interact with each game engine in the subset and/or game(s) created by the respective game engine. A selection indicator, which indicates that a game engine is selected from the game engines in the subset, is received. An integration infrastructure, including a game engine-agnostic messaging protocol and game engine-agnostic messages, is provided. At least a portion of game code and/or test unit(s) are run and/or debugged using the IDE in a context of the selected game engine.

Abstract: The application describes fused heterocycle derivative compounds, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of diseases associated with HBV infection.

Abstract: The present disclosure related to compounds that can be useful as inhibitors of PD-1, PD-L1 or the PD-1/PD-L1 interaction. Also disclosed herein are pharmaceutical compositions of that can include a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and uses of or methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of PD-L1 related diseases including but not limited to liver diseases, cancer, hepatocellular carcinoma, viral diseases, or hepatitis B.

Abstract: The application describes fused heterocycle derivative compounds, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of diseases associated with HBV infection.

Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to a fan rotor for a turbomachine, including a fan disk, fan blades with a leading edge and a trailing edge, platforms inserted between the blades and fixed to the periphery of the disk, each including an aerodynamic surface extending from the leading edges to the trailing edges of the blades. The aerodynamic surface includes an upstream longitudinal portion on the side of the leading edges and a downstream longitudinal portion on the side of the trailing edges, the upstream longitudinal portion being supported by a first member of the platform fixed to the disk in a pivotable manner, and the downstream longitudinal portion being independent of the upstream longitudinal portion and supported by a second member of the platform which is independent of the first member and fixed to the disk in a pivotable manner.

Abstract: A splitter between a primary flow and a secondary flow of a dual flow turbomachine includes a single-piece structure including an outer annular wall, an inner annular wall, a radial annular wall and an inner annular baffle, defining a first cavity between the outer annular wall and the inner annular baffle, and a second cavity between the inner annular wall, the radial annular wall and the inner annular baffle.

Abstract: A casting ring having a first section made of a heat-conductive material and a second section made of a MAX phase alloy material, and a method for obtaining a product made of titanium alloy or a titanium-aluminum intermetallic compound by plasma torch melting, the alloy having an oriented structure, the method including heating the molten alloy surface in the casting ring with a plasma torch; cooling a cold zone of the casting ring over a length L1, the cooling forming a semi-solid crown of alloy; heating a hot zone of the casting ring over a length L2, thereby forming a solidification front, the flatness of which relative to a plane perpendicular to a drawing direction is less than 10°; and drawing the solidified alloy at a speed of more than 10?4 m/s in the drawing direction.

Abstract: An imaging system including a front aperture, two or more refractive lens elements mounted in a lens barrel, and a photosensor. One or more of the components of the imaging system (e.g., the aperture, lenses, lens groups, and/or photosensor) are tilted with respect to each other and/or with respect to a center (or mechanical) axis of the imaging system to compensate for effects including but not limited to keystone distortion, resolution non-uniformity, and gradient blur that result from tilt of an object in the field of view of the camera with respect to the center axis of the camera.

Abstract: The present disclosure related to compounds that can be useful as inhibitors of PD-1, PD-L1 or the PD-1/PD-L1 interaction. Also disclosed herein are pharmaceutical compositions of that can include a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and uses of or methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of PD-L1 related diseases including but not limited to liver diseases, cancer, hepatocellular carcinoma, viral diseases, or hepatitis B.

Abstract: Systems and methods for determining if a wearable photoplethysmography device is correctly positioned in operating to medical signs of a user by using a classifier to determine if a signal is valid or invalid. In some embodiments, in using the classifier to determine in a signal is valid or invalid, a lean method of linear computational complexity and minimal memory complexity is provided for determining at the wearable photoplethysmography device if it is correctly positioned. In some embodiments, in using the classifier minimal computational complexity is used in determining at the wearable photoplethysmography device if it is correctly positioned.

Abstract: Blower vane for an aircraft turbine engine, the vane comprising a blade connected to a root, the vane being made of a woven fibre-based composite material embedded in a polymeric resin, the vane further comprising a medium for identifying the vane, which is a radio-identification medium, the blower vane being characterised in that it comprises at least a first portion the fibres of which are only electrically conductive fibres, and at least a second portion the fibres of which are formed by a mixture of electrically conductive fibres and non-electrically conductive fibres, and in that the identification medium is located in or on the second portion.

Abstract: A device, system and method for providing a hybrid command line is provided. The device provides, at a display screen, a command line in association with a page defined by a document object model that includes metadata defining available natural language (NL) based commands for the device and/or the page. Partial text, received at the command line according to an NL-based format, is used to populate an autocomplete list of NL-based commands, mapped to corresponding server-compatible commands, and filtered by the metadata. An NL-based command is selected from the autocomplete list is provided to a server which converts the NL-based command to a corresponding server-compatible command. Results from the server are provided at the display screen in a graphical format which include graphical selectable options which, when selected, cause corresponding commands to be provided to the server in a server-compatible and/or NL-based format.

Abstract: The present invention relates to mono- or di-substituted indole compounds, methods to prevent or treat dengue viral infections by using the compounds and also relates to use of the compounds as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

Abstract: The present disclosure relates to the technical field of TiAl intermetallic foundry alloys. More particularly, it relates to such an alloy comprising: 44?Al?47 at. %; 0<Zr<2 at. %; 1?W?2 at. %; and only one of the following elements: 0.5?V?2 at. %; 0.5?Cr?2 at. %; 0<Nb<4 at. %.

Abstract: A method for separating a part blank from a support, wherein the support and the part blank are manufactured by additive manufacturing. The support includes an inner cavity containing a fluid. The separation method includes a heating of the support to deform the support by fluid expansion in the inner cavity until the support is separated from the part blank.

Abstract: The invention concerns compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns pharmaceutical compositions comprising these compounds and the compounds for use in the treatment of respiratory syncytial virus infection.

Abstract: A method for manufacturing a turbine engine vane a root connected to a blade extending in a longitudinal direction includes the steps of providing a root; and providing mold with a first cavity and a second cavity that together define a recess in which the vane is formed. The recess includes a first space in which the blade is formed and a second space in which the root is formed. The method further includes the steps of providing aluminum strips; positioning a fibrous reinforcement; arranging the vane root in the second space; and injecting a foam comprising aluminum or injecting an aluminum alloy into the first space of the recess of the mold such that the foam impregnates the fibrous reinforcement.

Abstract: A splitter between a primary flow and a secondary flow of a dual flow turbomachine includes a single-piece structure including an outer annular wall, an inner annular wall, a radial annular wall and an inner annular baffle, defining a first cavity between the outer annular wall and the inner annular baffle, and a second cavity between the inner annular wall, the radial annular wall and the inner annular baffle.

Abstract: A method for delivering an audio and/or video content using adaptive streaming to a terminal, the audio and/or video content being segmented into data segments available in various representations with respective audio and/or video qualities, the representations being time-aligned per segment, the segments being further divided into chunks, a controller selects, from a set of candidate caching platforms, the caching platform to be used to deliver the audio and/or video content to the terminal, as a function of a minimum burst transfer duration compared with the chunk duration as defined by an origin server providing the audio and/or video content. The controller redirects the terminal to the selected platform for further delivery of the audio and/or video content in the form bursts of chunks in response to requests for segments.