Abstract: Systems and methods for non-invasive blood pressure measurement are disclosed. In some embodiments, a system comprises a wearable member configured to generate first and second signals, and a blood pressure calculation system. The blood pressure calculation system a pre-processing module configured to filter noise from the signals, and a wave selection module configured to identify subsets of waves of the signals, a feature extraction module configured to generate sets of feature vectors form the subsets of waves, and a blood pressure processing module configured to calculate an arterial blood pressure value based on the sets of feature vectors and an empirical blood pressure calculation model, the empirical blood pressure calculation model configured to receive the sets of feature vectors as input values. The blood pressure calculation system further includes a communication module configured to provide a message including or being based on the arterial blood pressure value.

Abstract: Turbomachine output bearing support extending according to an axial direction, said support being formed by one and the same piece and comprising an annular inner wall having an inner side and an outer side, an annular outer wall and a twist support.

Abstract: The present disclosure provides a scalable container-based system implemented in computer instructions stored in a non-transitory medium. The present disclosure further provides a method of creating and operating a scalable container-based system.

Abstract: The present disclosure related to compounds that can be useful as inhibitors of PD-1, PD-L1 or the PD-1/PD-L1 interaction. Also disclosed herein are pharmaceutical compositions of that can include a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and uses of or methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of PD-L1 related diseases including but not limited to liver diseases, cancer, hepatocellular carcinoma, viral diseases, or hepatitis B.

Abstract: A wearable member may include a plurality of energy transmitters that are arranged on a surface of the wearable member, each of the energy transmitters being configured to project energy into tissue of a user. A wearable member may include a plurality of energy receivers each of which is configured to generate a signal based on a received portion of the energy that is projected by one or more of the energy transmitters and reflected by the tissue of the user, wherein at least one of the energy transmitters and the energy receivers are multi-dimensionally arranged on the wearable member such that energy reflected by the tissue of the user at locations that are multi-dimensionally different is incident on the plurality of energy receivers. The processor may be configured to calculate a biological metric based on signals generated by at least part of the plurality of energy receivers.

Abstract: A tower crane includes a tower on which is pivotally mounted a boom displaceable between a lowered position and a raised position. The crane is configurable between a service configuration in which the boom is controlled in rotation and a weather vane configuration in which the boom is in the raised position and is released in rotation on the tower to allow orientation in the direction of the wind. A wind load system is mounted on the boom and is adjustable between a retracted shape in the service configuration providing a reduced surface exposed to the wind, and a deployed shape in the weather vane configuration providing an extended surface exposed to the wind. The wind load system is configured to move from the retracted shape to the deployed shape under the effect of its own weight alone (i.e., under gravity) when the boom is raised.

Abstract: The present disclosure provides a three-dimensional micro-electrode that comprises an electrically conductive, elongate body with: a base that is electrically connectible to a recording system; a tip that is opposite the base and that is configured to establish electrical communication with an excitable cellular-network or a cell therein; and an elongate portion between the base and the tip. The elongate portion is covered with at least one layer of an electrical-insulator coating that extends from the base to proximal the tip. The present disclosure also provides a micro-electrode array comprising at least two three-dimensional micro-electrodes that are electrically connective to at least one recording system. The present disclosure also provides a method of making and using a three-dimensional micro-electrode and an array that comprises three-dimensional micro-electrodes.

Abstract: The invention relates to a method for storing and re-releasing dihydrogen (1) comprising at least: a step of generating hydrogen (G) by dehydrogenating hydroxyl groups of dipropylene glycol into respective carbonyl groups, in order to produce a dehydrogenated substrate (SD) and gaseous dihydrogen (H2), a step of regenerating (R) at least a portion of the dipropylene glycol (DG), by hydrogenating said carbonyl groups into respective hydroxyl groups by means of gaseous dihydrogen (H2). The invention is particularly suitable for storing dihydrogen as an energy carrier.

Abstract: For delivering an audio and/or video content using adaptive streaming from a cache server to a client device, the audio and/or video content being segmented into data segments available in various representations with respective audio and/or video qualities, the representations being time-aligned per segment, the segments being further divided into chunks, a method includes: obtaining a round-trip time value applicable between the cache server and the client device; computing a minimum bulk transfer size from the maximum average bitrate of the various representations of the audio and/or video content and from the obtained round-trip time value; computing a minimum bulk duration, with respect to the audio and/or video content, for the representation to be delivered to the client device; and delivering the audio and/or video content by burst transfers in the form of bulks of aggregated successive chunks for each segment in accordance with the computed minimum bulk duration.

Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to a turbomachine rotary-fan blade (2), comprising a body (20) made of a composite material, a metal reinforcement part (3) comprising a metal upstream nose (31), characterised in that the metal upstream nose (31) comprises, at least on the metal part (27b) of the blade tip, a recess (4) of longitudinally tapering thickness (AX), delimiting on the metal part (27b) over a height (H) at least one metal projection (5) with prescribed wear, which has a longitudinally tapering thickness and which is configured to detach at least partially in the presence of tangential friction in the second thickness direction (EP) against the metal part (27b), the recess (4) and the metal projection (5) with prescribed wear extending the first metal fin (32) and/or the second metal fin (33) and/or the upstream edge (22) of the body (20) made of composite material.

Abstract: A content delivery system for delivering an audio and/or video content to a mobile terminal is deployed on top of a mobile network and includes plural edge cache servers arranged using a star or hierarchical topology. The edge cache servers are connected to respective aggregation nodes of the mobile network such that a configurable breakout function of the nodes enables routing thereto packets addressed to an anycast addressing associated with the servers. When receiving a request, from the mobile terminal, for obtaining a manifest file of the audio and/or video content, an edge cache controller of the content delivery system creates a session identifier including a unicast addressing part pointing to the controller, and redirects the mobile terminal to the anycast addressing of the servers. The servers then obtain the session identifier from the mobile terminal and use the unicast addressing contained therein to receive context information from the controller.

Abstract: A landing zone landing assistance system for a rotary wing aircraft, the system includes a computer, an HMI for interacting with the pilot of the aircraft, an optical assembly provided with at least one optical sensor, a radar assembly provided with at least one radar detector and an inertial unit, wherein the computer is configured to implement the following steps: a first step (Step1) consisting in determining an optical image of the possible landing zone; a second step (Step2) consisting in determining the relative position of the landing zone with respect to said system in the terrestrial reference frame; a third step (Step3) consisting in determining a landing zone approach path; and a fourth step (Step4) consisting in supplying to the HMI a deviation between the position of the system and the approach path.

Abstract: A constant volume combustion system includes at least one combustion chamber having at least one admission port and an exhaust port. The system also includes at least one elastically deformable tongue made of ceramic matrix composite material forming an air admission valve, the tongue being present inside the chamber and being positioned facing the admission port, the tongue having a first end that is stationary relative to an inside wall of the chamber and a second end, opposite from the first end, the second end being free and movable relative to the inside wall.

Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: The present application relates to compounds according to Formula (I), pharmaceutical compositions comprising at least one of said compounds, their use as a medicament, and their use in treating chronic hepatitis B virus (HBV) infection. The disclosure further pertains to methods for preparing compounds according to Formula (I).

Abstract: An imaging system including a front aperture, two or more refractive lens elements mounted in a lens barrel, and a photosensor. One or more of the components of the imaging system (e.g., the aperture, lenses, lens groups, and/or photosensor) are tilted with respect to each other and/or with respect to a center (or mechanical) axis of the imaging system to compensate for effects including but not limited to keystone distortion, resolution non-uniformity, and gradient blur that result from tilt of an object in the field of view of the camera with respect to the center axis of the camera.

Abstract: This application relates to quinazoline derivatives of formula (I), pharmaceutical compositions comprising the compounds of formula (I), and the use of the compounds of formula (I) in the treatment or prevention of a viral infection, of a virus-induced disease, of cancer or of an allergy.

Abstract: The present disclosure related to compounds that can be useful as inhibitors of PD-1, PD-L1 or the PD-1/PD-L1 interaction. Also disclosed herein are pharmaceutical compositions of that can include a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and uses of or methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for the treatment of PD-L1 related diseases including but not limited to liver diseases, cancer, hepatocellular carcinoma, viral diseases, or hepatitis B.

Abstract: Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.