Abstract: A method and apparatus for inscribing a Bragg grating in an optical waveguide, comprising: providing electromagnetic radiation from an ultrashort pulse duration laser, wherein the electromagnetic radiation has a pulse duration of less than or equal to 5 picoseconds, and wherein the wavelength of the electromagnetic radiation has a characteristic wavelength in the wavelength range from 150 nanometers (nm) to 2.0 microns (?m): providing cylindrical focusing optics corrected for spherical aberration: providing a diffractive optical element that when exposed to the focused ultrashort laser pulse, creates an interference pattern on the optical waveguide, wherein the irradiation step comprises irradiating a surface of the diffractive optical element with the focused electromagnetic radiation, the electromagnetic radiation incident on the optical waveguide, from the diffractive optical element, being sufficiently intense to cause the permanent change in the index of refraction in the core of the optical waveguide.

Abstract: Provided are novel pyrimidine dione compounds and pharmaceutically acceptable salts thereof, that are useful for the treatment of hypertrophic cardiomyopathy (HCM) and conditions associated with left ventricular hypertrophy or diastolic dysfunction. The synthesis and characterization of the compounds and pharmaceutically acceptable salts thereof, are described, as well as methods for treating HCM and other forms of heart disease.

Abstract: The present invention relates to the technical field of medicine, and in particular, relates to a composition of vancomycin aqueous solution. The pharmaceutical composition contains vancomycin or a pharmaceutically acceptable salt thereof, N-methylalanine, and water. The stability of vancomycin in the state of an aqueous solution can be improved by using N-methylalanine.

Abstract: A medicine image recognition method applied to an electronic device is provided. The method includes obtaining target images by inputting medicine images into a position detection network. Character feature matrices are generated according to the target images and a character recognition network. Image feature matrices are generated by inputting the target images into a category recognition network. Reference matrices are generated according to the image feature matrices and corresponding character feature matrices. Once a matrix to be tested is generated by processing an image to be tested, and a recognition result of the image to be tested is generated according to a similarity between the matrix to be tested and each of the reference matrices.

Abstract: Provided herein are compounds of formula (I): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Abstract: Time-to-digital converters (TDC) employing a single-stage delay pair for a wide input range and reduced quantization noise in a phase-locked loop (PLL) and related fabrication methods are disclosed. Aspects disclosed in the detailed description include a single-stage Vernier time-to-digital converter (TDC) which mitigates the device mismatch impact and therefore avoids possible spurious tones in a fractional-N PLL application. Combined with a delta-sigma noise shaping stage and a ring-oscillator based coarse TDC, the invention achieves a good trade-off between resolution, detection range and PLL locking speed.

Abstract: A method of making an ejector device. The method includes providing a substrate and forming one or more ejector conduits on the substrate. The one or more ejector conduits comprise: a first end configured to accept a print material; a second end comprising an ejector nozzle, the ejector nozzle comprising a first electrode pair that includes a first electrode and a second electrode, at least one surface of the first electrode being exposed in the ejector nozzle and at least one surface of the second electrode being exposed in the ejector nozzle; and at least one passageway for allowing the print material to flow from the first end to the second end. A method of printing a three-dimensional object and a method for jetting print material from a printer jetting mechanism are also disclosed.

Abstract: The method includes: obtaining point cloud information collected by a depth camera, laser information collected by a lidar, and motion information of an unmanned aerial vehicle (UAV); generating a raster map based on the laser information, and obtaining pose information of the UAV based on the motion information; obtaining a map model through fusing the point cloud information, the raster map, and the pose information by a Bayesian fusion method; and correcting a latest map model by feature matching based on a previous map model.

Abstract: In a calibrated phase-locked loop (PLL), a time-to-digital (TDC) converter circuit can be calibrated to a nominal gain by a calibration circuit to achieve a desired jitter response in the PLL. The TDC circuit in the PLL measures a time difference between the reference clock and a feedback signal as a number of time increments, and the calibration circuit adjusts a resolution of the measurement by adjusting the length of the time increments (i.e., resolution). In a Vernier method employed to measure the time difference, the length of a time increment is determined by a delay difference between a first delay of a first delay circuit in a first series of first delay circuits and a second delay of a second delay circuit in a second series of second delay circuits. Adjusting the resolution of the TDC circuit includes adjusting the delay difference between the first delay and the second delay.

Abstract: Aspects of the present disclosure configure a system component, such as a memory sub-system controller, to track a quantity of translational units stored for each of a plurality of namespaces on an individual namespace basis. To format a given one of the plurality of namespaces, the individually tracked quantity of translational units can be deducted from a global quantity tracked for each respective block of the memory sub-system.

Abstract: Provided are compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein Ring A, Ring B, L, RB, RC, n, and p are as defined herein. Also provided are pharmaceutically acceptable compositions comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: Interfaces between clock domains of an integrated circuit (IC) depend on synchronization of phase-locked loops (PLLs) that generate clocks in the different domains and on how each PLL responds to jitter in a shared reference clock. The well-controlled same bandwidth (and loop dynamic) for those PLLs renders the same and, therefore, ignorable reference jitter contribution. As a key component that determines a digital PLL bandwidth, digitally controlled oscillator (DCO) may have its gain vary with process, temperature, and supply IR drop from chip to chip or even module to module. A calibration circuit provides a gain correction factor to achieve a nominal gain in DCO as well as a desired/target PLL loop bandwidth. In some examples, the calibration circuit in each PLL determines a gain correction factor that causes the PLLs to have a common jitter response and stores the gain correction factors in the calibration circuits.

Abstract: A method of making an ejector device. The method includes providing a substrate and forming one or more ejector conduits on the substrate. The one or more ejector conduits comprise: a first end configured to accept a print material; a second end comprising an ejector nozzle, the ejector nozzle comprising a first electrode pair that includes a first electrode and a second electrode, at least one surface of the first electrode being exposed in the ejector nozzle and at least one surface of the second electrode being exposed in the ejector nozzle; and at least one passageway for allowing the print material to flow from the first end to the second end. A method of printing a three-dimensional object and a method for jetting print material from a printer jetting mechanism are also disclosed.

Abstract: A pneumonia area detecting system includes an information obtaining module, an image preprocessing module, a calculating module, and a pneumonia area detecting model. The information obtaining module obtains medical images and a frame size of an initial pneumonia area. The image preprocessing module processes the medical images to obtain a standard format image. The calculating module processes the frame size of the initial pneumonia area through a preset algorithm and the standard format image, to obtain a frame size of a standard format pneumonia area. The pneumonia area detecting model obtains an output pneumonia area according to the standard format image and the frame size of the standard format pneumonia area. A pneumonia area detecting method and an electronic device are also provided in the present disclosure.

Abstract: A fast processing method of massive time-series data based on aggregated edges and time-series aggregated edges implements fast and real-time processing based on an association of a graph data structure under a massive data pattern. In terms of incremental flow calculation based on time windows, the present disclosure proposes an innovative data structure of “aggregated edge” and “time-series aggregated edge”, which is suitable for data modeling of real-time dynamic graph. The present disclosure introduces a time-series graph query language, which adds descriptive semantics of time series information, and not only supports basic queries based on vertices, edges, and attributes, but also can implement users' graph queries for index calculation results in a time window. The graph query includes graph matching and graph filtering. The present disclosure is especially suitable for fields such as marketing and real-time risk control based on massive data mining and has good timeliness control and high scalability.

Abstract: A 3D printer includes an ejector device for mixing and ejecting print material. The ejector device includes a substrate and a plurality of ejector conduits on the substrate. The ejector conduits are arranged in an array. Each ejector conduit includes a first passageway fluidly connecting a first end of the ejector conduit to a conduit junction. The first end is configured to accept a first print material. Each ejector conduit also includes a second passageway fluidly connecting a second end of the ejector conduit to the conduit junction. The second end is configured to accept a second print material. Each ejector conduit also includes a third passageway fluidly connecting a third end of the ejector conduit to the conduit junction. The third end includes an ejector nozzle. The ejector nozzle includes a first electrode and a second electrode.

Abstract: An example method may include receiving, at a device, a first frame over a wireless network and constructing a preliminary data portion of a second frame. The second frame may be configured for transmission over the wireless network. The method may also include in response to the receiving of the first frame at the device, beginning transmission of a header portion of the second frame over the wireless network and after the beginning transmission of the header portion of the second frame, constructing, based on the preliminary data portion, a finalized data portion of the second frame for transmission over the wireless network.

Abstract: A compound of Formula (I): or a pharmaceutically acceptable salt thereof, in which Ring X is a 3 to 7 membered monocyclic ring, at least one of R1, R2, R3, and R4 is OR5 or CH2OR5 and the other R1, R2, R3, and R4 each independently are halogen, OH, OR5, CH2OR5, CO2H, OC?OR6, (C?O)R6, R6, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, H, or absent. Also provided herein are therapeutic uses of the compound of Formula (I).

Abstract: Provided herein are compounds of formula (1): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Abstract: A peak detector comprises multiple small-size amplitude detection circuits coupled in parallel to signal inputs at which a signal is received from a VCO. Each amplitude detection circuit generates a voltage on an output, indicating a voltage peak or amplitude of a first signal input and a second signal input (specifically, differential output of VCO). At a given time, only one small-size amplitude detection circuit is activated to load VCO, reducing the impact on LC resonant frequency. The plurality of small-size detection circuits work sequentially, and an automatic averaging of their outputs can significantly improve the peak detector fluctuation (caused by process variation and device mismatch) compared to each single small-size amplitude detection circuit.