Abstract: System and method that allow utilize machine learning algorithms to move a micro-object to a desired position are described. A sensor such as a high speed camera or capacitive sensing, tracks the locations of the objects. A dynamic potential energy landscape for manipulating objects is generated by controlling each of the electrodes in an array of electrodes. One or more computing devices are used to: estimate an initial position of a micro-object using the sensor; generate a continuous representation of a dynamic model for movement of the micro-object due to electrode potentials generated by at least some of the electrodes and use automatic differentiation and Gauss quadrature rules on the dynamic model to derive optimum potentials to be generated by the electrodes to move the micro-object to the desired position; and map the calculated optimized electrode potentials to the array to activate the electrodes.

Abstract: Control loop latency can be accounted for in predicting positions of micro-objects being moved by using a hybrid model that includes both at least one physics-based model and machine-learning models. The models are combined using gradient boosting, with a model created during at least one of the stages being fitted based on residuals calculated during a previous stage based on comparison to training data. The loss function for each stage is selected based on the model being created. The hybrid model is evaluated with data extrapolated and interpolated from the training data to prevent overfitting and ensure the hybrid model has sufficient predictive ability. By including both physics-based and machine-learning models, the hybrid model can account for both deterministic and stochastic components involved in the movement of the micro-objects, thus increasing the accuracy and throughput of the micro-assembly.

Abstract: An automatic detection and recovery device for residual agricultural mulch film, and a method of using the device, comprising a quadcopter, a wheeled robot (9), and a host computer (8); the quadcopter is provided with a controller (1), a near infrared water content analyzer, and a WiFi module that are used to measure water content in soil and communicate with the host computer; the wheeled robot (9) comprises a water sprinkling device (2), a soil grabbing device (3), a sifting device (4), a delivery device (5), a recognition device (6), and a sorting device (7).

Abstract: A method and apparatus for inscribing a high-temperature stable Bragg grating in an optical waveguide, comprising the steps of: providing the optical waveguide; providing electromagnetic radiation from an ultrashort pulse duration laser, wherein the wavelength of the electromagnetic radiation has a characteristic wavelength in the wavelength range from 150 nanometers (nm) to 2.

Abstract: The system and method described allow for real-time control over positioning of a micro-object. A movement of at least one micro-object suspended in a medium can be induced by a generation of one or more forces by electrodes proximate to the micro-object. Prior to inducing the movement, a simulation is used to develop a model describing a parameter of an interaction between each of the electrodes and the micro-object. A function describing the forces generated by an electrode and an extent of the movement induced due to the forces is generated using the model. The function is used to design closed loop policy control scheme for moving the micro-object towards a desired position. The position of the micro-object is tracked and taken into account when generating voltage patterns in the scheme.

Abstract: A system and a method are provided for feasibility evaluation of UAV Digital Twin based on Vicon motion capture system is disclosed, which establishes a mission feasibility evaluation model according to flight history data of a target UAV acquired by the UAV Digital Twin system. The mission feasibility evaluation model includes a UAV trajectory prediction module and a mission feasibility determination module. The UAV trajectory prediction module acquires real-time position and attitude information of the target UAV according to the Vicon motion capture system, and predicts target flight trajectory of the target UAV according to the real-time position and attitude information. The mission feasibility determination module compares the position difference between an end point of the target flight trajectory and preset designated mission point to evaluate feasibility of target mission of the target UAV.

Abstract: An example method may include receiving, at a device, a first frame over a wireless network and constructing a preliminary data portion of a second frame. The second frame may be configured for transmission over the wireless network. The method may also include in response to the receiving of the first frame at the device, beginning transmission of a header portion of the second frame over the wireless network and after the beginning transmission of the header portion of the second frame, constructing, based on the preliminary data portion, a finalized data portion of the second frame for transmission over the wireless network.

Abstract: A time-to-digital converter (TDC) circuit generates a digital output indicating a time, known as a phase difference, from a phase of the generated signal to a corresponding phase of a reference signal. The digital output is used by the digitally controlled oscillator (DCO) to correct for the phase/frequency difference to synchronize the generated signal with the reference signal. In an aspect, an adaptive TDC circuit generates a first digital indication in a coarse mode when the offset time is above a threshold and generates a second digital indication in a fine mode when the offset time is below the threshold. The first digital indication and the second digital indication each comprise a same number of bits, and the first digital indication is normalized to the second digital indication for the digital output of the adaptive TDC circuit. A fractional bit may be employed to compensate for a quantization error.

Abstract: The present disclosure provides antibodies or antigen-binding fragments thereof that specifically bind to the cis conformation of phosphorylated-Threonine231-Proline (pThr231-Pro) of tau protein. This disclosure also provides methods for treating a subject having or at risk of developing a neurological disorder. This disclosure includes related pharmaceutical compositions, polynucleotides, vectors, host cells, methods of production, methods of treatment, diagnostic methods, and kits.

Abstract: A compound of Formula (I): or a pharmaceutically acceptable salt thereof, in which Ring X is a 3 to 7 membered monocyclic ring, at least one of R1, R2, R3, and R4 is OR5 or CH2OR5 and the other R1, R2, R3, and R4 each independently are halogen, OH, OR5, CH2OR5, CO2H, OC?OR6, (C?O)R6, R6, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, H, or absent. Also provided herein are therapeutic uses of the compound of Formula (I).

Abstract: Aspects of the present disclosure configure a system component, such as a memory sub-system controller, to track a quantity of translational units stored for each of a plurality of namespaces on an individual namespace basis. To format a given one of the plurality of namespaces, the individually tracked quantity of translational units can be deducted from a global quantity tracked for each respective block of the memory sub-system.

Abstract: T-phase-shifted fiber Bragg gratings in optical waveguides, and methods of formation thereof. Sensing apparatus comprising such gratings using femtosecond pulse duration lasers and specialized transmission diffraction elements or phase masks.

Abstract: A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Control loop latency can be accounted for in predicting positions of micro-objects being moved by using a hybrid model that includes both at least one physics-based model and machine-learning models. The models are combined using gradient boosting, with a model created during at least one of the stages being fitted based on residuals calculated during a previous stage based on comparison to training data. The loss function for each stage is selected based on the model being created. The hybrid model is evaluated with data extrapolated and interpolated from the training data to prevent overfitting and ensure the hybrid model has sufficient predictive ability. By including both physics-based and machine-learning models, the hybrid model can account for both deterministic and stochastic components involved in the movement of the micro-objects, thus increasing the accuracy and throughput of the micro-assembly.

Abstract: The system and method described allow for real-time control over positioning of a micro-object. A movement of at least one micro-object suspended in a medium can be induced by a generation of one or more forces by electrodes proximate to the micro-object. Prior to inducing the movement, a simulation is used to develop a model describing a parameter of an interaction between each of the electrodes and the micro-object. A function describing the forces generated by an electrode and an extent of the movement induced due to the forces is generated using the model. The function is used to design closed loop policy control scheme for moving the micro-object towards a desired position. The position of the micro-object is tracked and taken into account when generating voltage patterns in the scheme.

Abstract: The present invention is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements, and methods of identifying the promoters, control elements, or fragments thereof. The invention further relates to the use of the present promoters or promoter control elements to modulate transcript levels.

Abstract: Materials, methods of making, and methods of sensing liquid droplets with high spatial resolution as a signature of the on-set of corrosion using a hierarchical sensor network A hierarchical sensor network for sensing liquid droplets with high spatial resolution as a signature of the on-set of corrosion, including an interrogation system; and an intermediate sensor array layer in communication with the interrogation system. The network includes an interrogation system and an intermediate sensor array layer in communication with the interrogation system.

Abstract: A phase-locked loop (PLL) circuit generates an analog signal in phase-lock with a reference signal at a reference frequency. The PLL circuit includes a charge pump circuit, a loop filter circuit, a feedback divider, and a voltage controlled oscillator (VCO). The charge pump circuit charges a sample capacitor of the loop filter circuit to a sample voltage based on a phase difference between the generated analog signal and the reference signal. The loop filter circuit stores the sample voltage as a proportional control voltage in a hold capacitor to reduce or avoid ripple in the control voltage that causes jitter in the analog signal. The loop filter circuit also provides the sample voltage to an integral component circuit comprising a comparator and digital accumulator producing an integral control. The VCO generates the analog signal at a frequency based on the proportional control voltage and the integral control voltage.

Abstract: The present invention provides a mass spectrometry-based method and a kit for genotyping of platelet and neutrophil antigens and glycoproteins, which are used for genotyping of platelet-specific antigens, platelet CD36 glycoproteins and neutrophil antigens; by designing an optimal primer combination, problems such as homologous sequences and rich GC are overcome, moreover, by improving amplification reaction conditions and using nucleic acid mass spectrometry as a platform, 35 platelet-specific antigen polymorphic sites, 10 CD36 polymorphic sites and 8 neutrophil antigen polymorphic sites can be simultaneously detected in 2 reactions. The present invention has the characteristics of high specificity and sensitivity, and fast and high throughput, and can be used in clinic, scientific research, platelet donor routine screening, etc.

Abstract: A solution is provided comprising boron nitride nanotubes (BNNTs) in a liquid solvent. An optical waveguide, such as an optical fiber, is contacted with the solution so as to form a layer of the solution supported on at least a portion of the optical waveguide. The liquid solvent is then removed from the layer of the solution supported on the optical waveguide in order to form a coating of the BNNTs on the optical waveguide. Further provided is a BNNT coated optical waveguide for use as a sensor.