Abstract: The present invention is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements, and methods of identifying the promoters, control elements, or fragments thereof. The invention further relates to the use of the present promoters or promoter control elements to modulate transcript levels.

Abstract: Materials, methods of making, and methods of sensing liquid droplets with high spatial resolution as a signature of the on-set of corrosion using a hierarchical sensor network A hierarchical sensor network for sensing liquid droplets with high spatial resolution as a signature of the on-set of corrosion, including an interrogation system; and an intermediate sensor array layer in communication with the interrogation system. The network includes an interrogation system and an intermediate sensor array layer in communication with the interrogation system.

Abstract: A phase-locked loop (PLL) circuit generates an analog signal in phase-lock with a reference signal at a reference frequency. The PLL circuit includes a charge pump circuit, a loop filter circuit, a feedback divider, and a voltage controlled oscillator (VCO). The charge pump circuit charges a sample capacitor of the loop filter circuit to a sample voltage based on a phase difference between the generated analog signal and the reference signal. The loop filter circuit stores the sample voltage as a proportional control voltage in a hold capacitor to reduce or avoid ripple in the control voltage that causes jitter in the analog signal. The loop filter circuit also provides the sample voltage to an integral component circuit comprising a comparator and digital accumulator producing an integral control. The VCO generates the analog signal at a frequency based on the proportional control voltage and the integral control voltage.

Abstract: The present invention provides a mass spectrometry-based method and a kit for genotyping of platelet and neutrophil antigens and glycoproteins, which are used for genotyping of platelet-specific antigens, platelet CD36 glycoproteins and neutrophil antigens; by designing an optimal primer combination, problems such as homologous sequences and rich GC are overcome, moreover, by improving amplification reaction conditions and using nucleic acid mass spectrometry as a platform, 35 platelet-specific antigen polymorphic sites, 10 CD36 polymorphic sites and 8 neutrophil antigen polymorphic sites can be simultaneously detected in 2 reactions. The present invention has the characteristics of high specificity and sensitivity, and fast and high throughput, and can be used in clinic, scientific research, platelet donor routine screening, etc.

Abstract: A solution is provided comprising boron nitride nanotubes (BNNTs) in a liquid solvent. An optical waveguide, such as an optical fiber, is contacted with the solution so as to form a layer of the solution supported on at least a portion of the optical waveguide. The liquid solvent is then removed from the layer of the solution supported on the optical waveguide in order to form a coating of the BNNTs on the optical waveguide. Further provided is a BNNT coated optical waveguide for use as a sensor.

Abstract: A cracking process for a reaction distillation of chlorosilane slurry includes feeding a chlorosilane slurry into a phase separator, drying a solid phase, feeding a chlorosilane polymer into a plate distillation column, returning kettle materials of the plate distillation column, and dividing a material produced from a top of the column. The process adopts an ionic liquid catalyst, which is environmentally friendly and reusable. The cracking and distillation of chlorosilane polymer are carried out simultaneously to shorten the time and increase the utilization rate of raw materials, which can reduce energy consumption and save costs and facilitate industrial production. A plate column is used as a distillation column, in which the two phases of the gas and liquid are sufficiently contacted. Therefore, the transfer of mass and heat is good, the production capacity is good, and the tower is not easily blocked, thereby making it easy to clean.

Abstract: A phase-locked loop (PLL) circuit generates an analog signal in phase-lock with a reference signal at a reference frequency. The PLL circuit includes a charge pump circuit, a loop filter circuit, a feedback divider, and a voltage controlled oscillator (VCO). The charge pump circuit charges a sample capacitor of the loop filter circuit to a sample voltage based on a phase difference between the generated analog signal and the reference signal. The loop filter circuit stores the sample voltage as a proportional control voltage in a hold capacitor to reduce or avoid ripple in the control voltage that causes jitter in the analog signal. The loop filter circuit also provides the sample voltage to an integral component circuit comprising a comparator and digital accumulator producing an integral control. The VCO generates the analog signal at a frequency based on the proportional control voltage and the integral control voltage.

Abstract: A method and apparatus for inscribing a Bragg grating in an optical waveguide, comprising: providing electromagnetic radiation from an ultrashort pulse duration laser, wherein the electromagnetic radiation has a pulse duration of less than or equal to 5 picoseconds, and wherein the wavelength of the electromagnetic radiation has a characteristic wavelength in the wavelength range from 150 nanometers (nm) to 2.0 microns (µm); providing cylindrical focusing optics corrected for spherical aberration; providing a diffractive optical element that when exposed to the focused ultrashort laser pulse, creates an interference pattern on the optical waveguide, wherein the irradiation step comprises irradiating a surface of the diffractive optical element with the focused electromagnetic radiation, the electromagnetic radiation incident on the optical waveguide, from the diffractive optical element, being sufficiently intense to cause the permanent change in the index of refraction in the core of the optical waveguide.

Abstract: A medicine image recognition method applied to an electronic device is provided. The method includes obtaining target images by inputting medicine images into a position detection network. Character feature matrices are generated according to the target images and a character recognition network. Image feature matrices are generated by inputting the target images into a category recognition network. Reference matrices are generated according to the image feature matrices and corresponding character feature matrices. Once a matrix to be tested is generated by processing an image to be tested, and a recognition result of the image to be tested is generated according to a similarity between the matrix to be tested and each of the reference matrices.

Abstract: A composite motor having high-precision positioning, comprising: a housing (1), a rough positioning assembly, a hollow output shaft (2), a fine positioning assembly, a power switching apparatus and a controller (6). A stepper motor (3) in the rough positioning assembly is responsible for rough positioning of the composite motor, an annular travelling wave ultrasonic motor in the fine positioning assembly is responsible for tail end fine positioning of the composite motor, and the controller (6) implements power output switching between the annular travelling wave ultrasonic motor and the stepper motor (3). The composite motor effectively solves the problem that annular travelling wave ultrasonic motors which operate continuously for a long time have a short service life, and ensures high-precision positioning while also extending motor service life.

Abstract: Novel tetrahydroisoquinoline derivative compounds are disclosed herein that may be used as an active ingredient for a pharmaceutical composition, and in particular, for a pharmaceutical composition useful for preventing or treating a disease or condition responsive to modulation of the contractility of the skeletal sarcomere. This may be accomplished, for example, by modulation of the troponin complex of the fast skeletal muscle sarcomere through one or more of fast skeletal myosin, actin, tropomyosin, troponin C, troponin I, and troponin T, and fragments and isoforms thereof. The tetrahydroisoquinoline derivative compounds can thus be used as an agent for preventing or treating 1) neuromuscular disorders, 2) disorders of voluntary muscle, 3) CNS disorders in which muscle weakness, atrophy, and fatigue are prominent symptoms, 4) muscle symptoms stemming from systemic disorders, and 5) dysfunctions of pelvic floor and urethral/anal sphincter muscle.

Abstract: The present invention is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements, and methods of identifying the promoters, control elements, or fragments thereof. The invention further relates to the use of the present promoters or promoter control elements to modulate transcript levels.

Abstract: The present disclosure relates to an electrolyte solution for a lithium-ion battery. The electrolyte solution includes an organic solvent, a lithium salt, and an additive. The electrolyte solution provided in the present disclosure includes a 6-membered heterocyclyl carboxylic anhydride additive, and can effectively inhibit gas production and the increase of interface impedance in the battery, improve the high-temperature stability of the battery, and prolong the service life of the battery.

Abstract: One or more embodiments relates to a system for simultaneously detecting vibration and the presence of a target gas having a tunable fiber ring laser in electronic and optical communication with a vibration sensor and a gas detection sensor. One or more embodiments relate to a method for simultaneously measuring vibration and detecting the presence of a target gas in an environment having the steps of providing a system for simultaneously measuring vibration and detecting a target gas into an environment; sending an optical signal to a vibration sensor and gas detection sensor; and collecting and analyzing modified signals from the vibration sensor and gas detection sensor.

Abstract: A 3D printer includes an ejector device for mixing and ejecting print material, the ejector device comprising a substrate and a plurality of ejector conduits on the substrate. The ejector conduits are arranged in an array, each ejector conduit comprising: a first passageway fluidly connecting a first end of the ejector conduit to a conduit junction, the first end configured to accept a first print material; a second passageway fluidly connecting a second end of the ejector conduit to the conduit junction, the second end configured to accept a second print material; and a third passageway fluidly connecting a third end of the ejector conduit to the conduit junction. The third end comprises an ejector nozzle, the ejector nozzle comprising a first electrode and a second electrode, at least one surface of the first electrode being exposed in the third passageway and at least one surface of the second electrode being exposed in the third passageway.

Abstract: A method of making an ejector device. The method includes providing a substrate and forming one or more ejector conduits on the substrate. The one or more ejector conduits comprise: a first end configured to accept a print material; a second end comprising an ejector nozzle, the ejector nozzle comprising a first electrode pair that includes a first electrode and a second electrode, at least one surface of the first electrode being exposed in the ejector nozzle and at least one surface of the second electrode being exposed in the ejector nozzle; and at least one passageway for allowing the print material to flow from the first end to the second end. A method of printing a three-dimensional object and a method for jetting print material from a printer jetting mechanism are also disclosed.

Abstract: A 3D printer includes an ejector device comprising a substrate and a plurality of ejector conduits on the substrate, the ejector conduits being arranged in an array. Each ejector conduit includes: a first end positioned to accept a print material, a second end comprising an ejector nozzle, the ejector nozzle comprising a first electrode and a second electrode, and a passageway for allowing the print material to flow from the first end to the second end, at least one surface of the first electrode being exposed in the passageway and at least one surface of the second electrode being exposed in the passageway. A current pulse generating system is in electrical connection with the first electrode and the second electrode of the plurality of ejector conduits. A magnetic field source is sufficiently proximate the second end of the plurality of ejector conduits so as to generate a flux region disposed within the ejector nozzle of the plurality of ejector conduits during operation of the 3D printer.

Abstract: The present disclosure provides a method and a system for modelling a poor texture tunnel based on a vision-lidar coupling. The method includes: obtaining point cloud information collected by a depth camera, laser information collected by a lidar, and motion information of an unmanned aerial vehicle (UAV); generating a raster map based on the laser information, and obtaining pose information of the UAV based on the motion information; obtaining a map model through fusing the point cloud information, the raster map, and the pose information by a Bayesian fusion method; and correcting a latest map model by feature matching based on a previous map model.

Abstract: Provided herein are compounds of formula (I): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

Abstract: The present disclosure is generally directed to antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a CD33 protein, e.g., human CD33 or a mammalian CD33, and have improved and/or enhanced functional characteristics. The present disclosure is further directed to the methods of treating and/or delaying the progression of a disease or injury in an individual by administering such antibodies.