Abstract: Control loop latency can be accounted for in predicting positions of micro-objects being moved by using a hybrid model that includes both at least one physics-based model and machine-learning models. The models are combined using gradient boosting, with a model created during at least one of the stages being fitted based on residuals calculated during a previous stage based on comparison to training data. The loss function for each stage is selected based on the model being created. The hybrid model is evaluated with data extrapolated and interpolated from the training data to prevent overfitting and ensure the hybrid model has sufficient predictive ability. By including both physics-based and machine-learning models, the hybrid model can account for both deterministic and stochastic components involved in the movement of the micro-objects, thus increasing the accuracy and throughput of the micro-assembly.

Abstract: Disclosed are a running method and device for a stored procedure, a database system and a storage medium. The method includes: sending, by a Structured Query Language (SQL) processing engine, a stored procedure execution request message to a stored procedure engine (S110); executing, by the SQL processing engine, the SQL execution request messages sent by the stored procedure engine for a plurality of times (S120); and receiving, by the SQL processing engine, a stored procedure execution response message sent by the stored procedure engine (S130).

Abstract: Provided is a method for reverse real-time matching based on event-driven graph patterns. The method includes definition of a graph pattern, establishment of reverse matching architecture and a reverse matching method; and the graph pattern is used for describing a spatial connection relationship among vertices and edges in a graph in a reverse order and attribute constraints thereof, and includes a linked list of matching steps and matching contexts. Reverse real-time matching of the graph pattern is realized according to the reverse matching architecture, and the problem of event-driven subgraph matching in a real-time scene is solved.

Abstract: Described are conformation-specific antibodies or antigen-binding fragments that specifically bind to the trans conformation of phosphorylated-Threonine254-Proline (pThr254-Pro) of the p65 subunit of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B). Also described are related pharmaceutical compositions, polynucleotides, peptides, vectors, host cells, methods of production, methods of treatment, diagnostic methods, and kits.

Abstract: Provided is an aggregation index structure and an aggregation index method for improving aggregation query efficiency. The aggregation index partitions streaming data through two dimensions of grouping and slicing, and then aggregates the partitioned data. The structure includes index metadata, a sliced data list and a detailed data store; the aggregation index method includes three parts: aggregation index definition, aggregation index creation and aggregation index query. The aggregation index structure and method provided by the present disclosure can greatly improve the efficiency of aggregation query, support the ad hoc aggregation query of PB-level data, complete the aggregation query of a large amount of data in seconds, support the insertion of new data at any time, and return the query results in minutes or even seconds latency in the event of changes of the query range conditions.

Abstract: A system for determining pH of a fluid and a method to determine the pH of a fluid contacting a sensor, the method having the steps of: providing the sensor to an environment such that the sensor is in contact with the fluid, wherein the sensor features a fiber extending between a first end and a second end along a longitudinal axis, wherein the fiber further features a medial portion positioned between the first and second ends, wherein the sensor further features a pH sensitive coating on the medial portion of the fiber, and wherein the pH sensitive material features a metal oxide including but not limited to SiO2, TiO2, ZrO2, Ta2O5, A2O3, and combinations thereof; interrogating the sensor with an optical signal; collecting a modified optical signal after the sensor has been interrogated; and determining the pH of the fluid contacting the pH sensor using the modified optical signal.

Abstract: Novel tetrahydroisoquinoline derivative compounds are disclosed herein that may be used as an active ingredient for a pharmaceutical composition, and in particular, for a pharmaceutical composition useful for preventing or treating a disease or condition responsive to modulation of the contractility of the skeletal sarcomere. This may be accomplished, for example, by modulation of the troponin complex of the fast skeletal muscle sarcomere through one or more of fast skeletal myosin, actin, tropomyosin, troponin C, troponin I, and troponin T, and fragments and isoforms thereof. The tetrahydroisoquinoline derivative compounds can thus be used as an agent for preventing or treating 1) neuromuscular disorders, 2) disorders of voluntary muscle, 3) CNS disorders in which muscle weakness, atrophy, and fatigue are prominent symptoms, 4) muscle symptoms stemming from systemic disorders, and 5) dysfunctions of pelvic floor and urethral/anal sphincter muscle.

Abstract: The embodiment of this present disclosure provides a control method of unmanned aerial vehicle (UAV) hovering in tunnel, which comprises the following steps: acquiring hovering information of hovering position of UAV; acquiring the position information of the current position of the UAV; determining flight parameters based on hovering information and position information. The flight parameters are used to control the UAV to move from the current position to the hovering position.

Abstract: Materials, methods of making, and methods of sensing liquid droplets with high spatial resolution as a signature of the on-set of corrosion using a hierarchical sensor network A hierarchical sensor network for sensing liquid droplets with high spatial resolution as a signature of the on-set of corrosion, including an interrogation system; and an intermediate sensor array layer in communication with the interrogation system. The network includes an interrogation system and an intermediate sensor array layer in communication with the interrogation system.

Abstract: A solution is provided comprising boron nitride nanotubes (BNNTs) in a liquid solvent. An optical waveguide, such as an optical fiber, is contacted with the solution so as to form a layer of the solution supported on at least a portion of the optical waveguide. The liquid solvent is then removed from the layer of the solution supported on the optical waveguide in order to form a coating of the BNNTs on the optical waveguide. Further provided is a BNNT coated optical waveguide for use as a sensor.

Abstract: A compound of Formula (I): or a pharmaceutically acceptable salt thereof, in which Ring X is a 3 to 7 membered monocyclic ring, at least one of R1, R2, R3, and R4 is OR5 or CH2OR5 and the other R1, R2, R3, and R4 each independently are halogen, OH, OR5, CH2OR5, CO2H, OC?OR6, (C?O)R6, R6, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, H, or absent. Also provided herein are therapeutic uses of the compound of Formula (I).

Abstract: A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: An example method may include receiving, at a device, a first frame over a wireless network and constructing a preliminary data portion of a second frame. The second frame may be configured for transmission over the wireless network. The method may also include in response to the receiving of the first frame at the device, beginning transmission of a header portion of the second frame over the wireless network and after the beginning transmission of the header portion of the second frame, constructing, based on the preliminary data portion, a finalized data portion of the second frame for transmission over the wireless network.

Abstract: Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and mare as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

Abstract: An apparatus, method and system are set forth for detection of fluids using Bragg grating sensors, wherein the Bragg grating sensing element comprises an optical fiber having a Bragg grating inscribed therein characterized by optical properties that are dependent upon the periodicity and effective refractive index of the grating, and a package for subjecting the Bragg grating to a change in strain when contacted by a fluid such that periodicity and effective refractive index of the grating changes, whereby when interrogated with laser light any such change in periodicity and effective refractive index may be detected.

Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

Abstract: System and method that allow utilize machine learning algorithms to move a micro-object to a desired position are described. A sensor such as a high speed camera or capacitive sensing, tracks the locations of the objects. A dynamic potential energy landscape for manipulating objects is generated by controlling each of the electrodes in an array of electrodes. One or more computing devices are used to: estimate an initial position of a micro-object using the sensor; generate a continuous representation of a dynamic model for movement of the micro-object due to electrode potentials generated by at least some of the electrodes and use automatic differentiation and Gauss quadrature rules on the dynamic model to derive optimum potentials to be generated by the electrodes to move the micro-object to the desired position; and map the calculated optimized electrode potentials to the array to activate the electrodes.

Abstract: Provided is an optical waveguide with an inscribed Bragg grating, where the Bragg grating is stable at high temperature, has low scattering loss and high reflectivity. Also provided is a method for inscribing a Bragg grating in an optical waveguide, the method comprising irradiating the optical waveguide with electromagnetic radiation from an ultrashort pulse duration laser of sufficient intensity to cause a permanent change in an index of refraction within a core of the optical waveguide, where the irradiating step is terminated prior to erasure of a Bragg resonance, and heating the optical waveguide to a temperature and for a duration sufficient to substantially remove a non-permanent grating formed in the optical waveguide by the irradiating step.

Abstract: A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A system and a method are provided for feasibility evaluation of UAV Digital Twin based on Vicon motion capture system is disclosed, which establishes a mission feasibility evaluation model according to flight history data of a target UAV acquired by the UAV Digital Twin system. The mission feasibility evaluation model includes a UAV trajectory prediction module and a mission feasibility determination module. The UAV trajectory prediction module acquires real-time position and attitude information of the target UAV according to the Vicon motion capture system, and predicts target flight trajectory of the target UAV according to the real-time position and attitude information. The mission feasibility determination module compares the position difference between an end point of the target flight trajectory and preset designated mission point to evaluate feasibility of target mission of the target UAV.