Patents by Inventor Ping Lu

Ping Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHASE-SHIFTED FIBER BRAGG GRATING SENSOR AND METHOD FOR PRODUCING SAME
    Publication number: 20210318488
    Abstract: T-phase-shifted fiber Bragg gratings in optical waveguides, and methods of formation thereof. Sensing apparatus comprising such gratings using femtosecond pulse duration lasers and specialized transmission diffraction elements or phase masks.
    Type: Application
    Filed: June 18, 2019
    Publication date: October 14, 2021
    Inventors: Cyril HNATOVSKY, Dan GROBNIC, Stephen MIHAILOV, Robert WALKER, Ping LU, Huimin DING, David COULAS, Kasthuri DE SILVA,
  • Methods and compositions for the inhibition of PIN1
    Patent number: 11129835
    Abstract: The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: September 28, 2021
    Assignees: Beth Israel Deaconess Medical Center, Inc., The United States of America, as represented by the Secretary, Department of Health and Human Services Office of Technology Transfer, National Institutes of Health
    Inventors: Kun Ping Lu, Matthew Brian Boxer, Mindy Irene Emily Davis, Rajan Pragani, Min Shen, Anton Momtchilov Simeonov, Shuo Wei, Xiao Zhen Zhou
  • WIRELESS DATA TRANSMISSION
    Publication number: 20210289059
    Abstract: An example method may include receiving, at a device, a first frame over a wireless network and constructing a preliminary data portion of a second frame. The second frame may be configured for transmission over the wireless network. The method may also include in response to the receiving of the first frame at the device, beginning transmission of a header portion of the second frame over the wireless network and after the beginning transmission of the header portion of the second frame, constructing, based on the preliminary data portion, a finalized data portion of the second frame for transmission over the wireless network.
    Type: Application
    Filed: March 11, 2020
    Publication date: September 16, 2021
    Applicant: SEMICONDUCTOR COMPONENTS INDUSTRIES, LLC
    Inventors: Huizhao WANG, Karthik RAMASUBRAMANIAN, Denis BYKOV, James WOOD, Jun JIN, Lin FANG, Hongping LIU, Benjamin MUNG, Ping LU
  • Optical fiber temperature sensor
    Patent number: 11112316
    Abstract: An optical fiber temperature sensor includes a broadband light source, a first optical fiber patch cord, a first single-mode optical fiber, a single-hole twin-core eccentric core optical fiber, a second single-mode optical fiber, a second optical fiber patch cord, and an optical spectrum analyzer.
    Type: Grant
    Filed: February 11, 2018
    Date of Patent: September 7, 2021
    Assignee: Huazhong University of Science and Technology
    Inventors: Ping Lu, Wenjun Ni, Deming Liu, Xin Fu, Hao Liao
  • COMPOUNDS AND PHARMACEUTICAL USES THEREOF
    Publication number: 20210251945
    Abstract: A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 8, 2020
    Publication date: August 19, 2021
    Inventors: Guochuan Emil Tsai, Yi-Wen Mao, Lu-Ping Lu, Wei-Hua Chang, Han-Yi Hsieh, Jhe Wei Hu, Tsai-Miao Shih, ChanHui Huang
  • Driving protection circuit, operating circuit and control method
    Patent number: 11095112
    Abstract: A driving protection circuit is coupled to a load via an input/output pin. A signal generator circuit is configured to generate a driving signal. An input/output circuit transmits the driving signal to the input/output pin according to an enable signal. A counter circuit adjusts the count value when the enable signal is at a predetermined level. A detection circuit detects the voltage level of the input/output pin to generate a detection signal. When the count value is equal to a predetermined value, a control circuit determines whether the level of the detection signal is the same as the level of the driving signal. When the level of the detection signal is not the same as the level of the driving signal, the control circuit sends an error signal to turn off power to the load.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: August 17, 2021
    Assignee: NUVOTON TECHNOLOGY CORPORATION
    Inventors: Cheng-Chih Wang, Chih-Ping Lu
  • PEPTIDOMIMETIC INHIBITORS OF THE PEPTIDYL-PROLYL CIS/TRANS ISOMERASE (PIN1)
    Publication number: 20210238225
    Abstract: Disclosed are compounds which inhibit Pin1 activity, methods of making the compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds to treat diseases or disorders characterized or mediated by dysregulated Pin1 activity.
    Type: Application
    Filed: June 13, 2019
    Publication date: August 5, 2021
    Applicants: DANA-FARBER CANCER INSTITUTE, INC., BETH ISRAEL DEACONESS MEDICAL CENTER, INC.
    Inventors: Nathanael GRAY, Benika PINCH, Sirano DHE-PAGANON, Hyuk-Soo SEO, Chris BROWNE, Jarrod MARTO, Zainab DOCTOR, Kun Ping LU, Xiao ZHOU, Shingo KOZONO, Xiaolan LIAN
  • System and method for capacitance-based real-time micro-object position control with the aid of a digital computer
    Patent number: 11079747
    Abstract: The system and method described allow for real-time control over positioning of a micro-object. A movement of at least one micro-object suspended in a medium can be induced by a generation of one or more forces by electrodes proximate to the micro-object. Prior to inducing the movement, a simulation is used to develop a model describing a parameter of an interaction between each of the electrodes and the micro-object. A function describing the forces generated by an electrode and an extent of the movement induced due to the forces is generated using the model. The function is used to design closed loop policy control scheme for moving the micro-object towards a desired position. The position of the micro-object is tracked and taken into account when generating control signals in the scheme.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: August 3, 2021
    Assignee: PALO ALTO RESEARCH CENTER INCORPORATED
    Inventors: Ion Matei, Jeng Ping Lu, Saigopal Nelaturi, Julie A. Bert, Lara S. Crawford, Armin R. Volkel, Eugene M. Chow
  • COMPOUNDS, COMPOSITIONS AND METHODS
    Publication number: 20210198203
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: March 12, 2021
    Publication date: July 1, 2021
    Inventors: Bradley Paul Morgan, Alex Muci, Pu-Ping Lu, Erica Anne Kraynack, Todd Tochimoto, David J. Morgans, JR.
  • WAVEFORM GENERATOR AND WAVEFORM GENERATING METHOD
    Publication number: 20210203335
    Abstract: A waveform generator is provided. The waveform generator includes a timer and a digital to analog converter (DAC). The timer periodically provides a trigger signal according to a fixed time period. In response to the trigger signal, the DAC is configured to convert first digital data into output voltage of an analog signal. A data hold register is configured to store second digital data that corresponds to the previous output voltage of the analog signal. A judgment circuit is configured to provide a first control signal according to the second digital data, and the first control signal indicates that the previous output voltage is within a first voltage range. A calculation circuit is configured to obtain the first digital data according to the second control signal, the second digital data, and a voltage variation that corresponds to the first voltage range and to update the second digital data.
    Type: Application
    Filed: December 28, 2020
    Publication date: July 1, 2021
    Inventors: Cheng-Chih WANG, Chih-Ping LU
  • Arsenic trioxide for treatment of PIN1-associated disorders
    Patent number: 10980835
    Abstract: The present invention relates to the treatment of Pin1-associated disorders (e.g., disorders characterized by elevated Pin1 activity) with arsenic trioxide, optionally in combination with a retinoic acid compound. Pin1-associated disorders may include, for example, proliferative disorders (e.g., cancers), inflammatory conditions, and autoimmune disorders associated with aberrant levels of Pin1 activity.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: April 20, 2021
    Assignee: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Kun Ping Lu, Xiao Zhen Zhou
  • Compounds, compositions and methods
    Patent number: 10975034
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: April 13, 2021
    Assignee: CYTOKINETICS, INC.
    Inventors: Bradley Paul Morgan, Alex Muci, Pu-Ping Lu, Erica Anne Kraynack, Todd Tochimoto, David J. Morgans, Jr.
  • LOW INSERTION LOSS HIGH TEMPERATURE STABLE FIBER BRAGG GRATING SENSOR AND METHOD FOR PRODUCING SAME
    Publication number: 20210072050
    Abstract: Provided is an optical waveguide with an inscribed Bragg grating, where the Bragg grating is stable at high temperature, has low scattering loss and high reflectivity. Also provided is a method for inscribing a Bragg grating in an optical waveguide, the method comprising irradiating the optical waveguide with electromagnetic radiation from an ultrashort pulse duration laser of sufficient intensity to cause a permanent change in an index of refraction within a core of the optical waveguide, where the irradiating step is terminated prior to erasure of a Bragg resonance, and heating the optical waveguide to a temperature and for a duration sufficient to substantially remove a non-permanent grating formed in the optical waveguide by the irradiating step.
    Type: Application
    Filed: November 19, 2020
    Publication date: March 11, 2021
    Inventors: Dan GROBNIC, Stephen MIHAILOV, Robert WALKER, Ping LU, Huimin DING, David COULAS, Cyril HNATOVSKY
  • PROMOTER, PROMOTER CONTROL ELEMENTS, AND COMBINATIONS, AND USES THEREOF
    Publication number: 20210062205
    Abstract: The present invention is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements, and methods of identifying the promoters, control elements, or fragments thereof. The invention further relates to the use of the present promoters or promoter control elements to modulate transcript levels.
    Type: Application
    Filed: July 24, 2020
    Publication date: March 4, 2021
    Inventors: Zhihong Cook, Yiwen Fang, Kenneth A. Feldmann, Edward Kiegle, Shing Kwok, Yu-Ping Lu, Leonard Medrano, Roger Pennell, Richard Schneeberger, Chuan-Yin Wu, Nestor Apuya, Jack K. Okamuro, Diane K. Jofuku, Jonathan Donson, David Van-Dinh Dang, Emilio Margolles-Clark, Nickolai Alexandrov, Tatiana Tatarinova, Noah Theiss, Danielle Grizard, Shawna Davis, Dennis Robles, Michael Portereiko
  • PROMOTER, PROMOTER CONTROL ELEMENTS, AND COMBINATIONS, AND USES THEREOF
    Publication number: 20210062204
    Abstract: The present invention is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements, and methods of identifying the promoters, control elements, or fragments thereof. The invention further relates to the use of the present promoters or promoter control elements to modulate transcript levels.
    Type: Application
    Filed: July 24, 2020
    Publication date: March 4, 2021
    Inventors: Zhihong Cook, Yiwen Fang, Kenneth A. Feldmann, Edward Kiegle, Shing Kwok, Yu-Ping Lu, Leonard Medrano, Roger Pennell, Richard Schneeberger, Chuan-Yin Wu, Nestor Apuya, Jack K. Okamuro, Diane K. Jofuku, Jonathan Donson, David Van-Dinh Dang, Emilio Margolles-Clark, Nickolai Alexandrov, Tatiana Tatarinova, Noah Theiss, Danielle Grizard, Shawna Davis, Dennis Robles, Michael Portereiko
  • AMINO-PYRIMIDINE SKELETAL MUSCLE MODULATORS
    Publication number: 20210045997
    Abstract: Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and mare as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: July 28, 2020
    Publication date: February 18, 2021
    Inventors: Zhe YANG, Alex R. MUCI, Jeffrey WARRINGTON, Gustave BERGNES, Bradley P. MORGAN, Chihyuan CHUANG, Antonio ROMERO, Scott COLLIBEE, Xiangping QIAN, Pu-Ping LU
  • CONTROL DEVICE AND ADJUSTMENT METHOD
    Publication number: 20210034025
    Abstract: A control device for adjusting the output voltage of a voltage generator, wherein the control device includes a master circuit, a slave circuit, and a power-scaling control circuit, is provided. The master circuit is coupled to a system bus. The slave circuit is coupled to the system bus. The power-scaling control circuit is coupled between the master circuit and the slave circuit. In response to the master circuit sending a voltage-scaling command, the power-scaling control circuit sets a control signal at a suspension level so that the slave circuit sets a specific signal transmitted by the system bus at a wait level. In response to the specific signal being at the wait level, the master circuit stops accessing the first specific device of the slave circuit. In response to the control signal being at the suspension level, the power-scaling control circuit adjusts the output voltage.
    Type: Application
    Filed: December 27, 2019
    Publication date: February 4, 2021
    Inventors: Yung-Chi LAN, Chun-Chi CHEN, Cheng-Chih WANG, Chih-Ping LU
  • CONTROL DEVICE AND ADJUSTMENT METHOD
    Publication number: 20210034551
    Abstract: A control device is used to adjust an output voltage of a voltage generator, and includes a master circuit, a slave circuit, and a power-scaling control circuit. The master circuit is coupled to a first bus. The slave circuit is coupled to a second bus. In a normal mode, the first and second buses are connected to each other via the power-scaling control circuit, the master circuit accesses the slave circuit via the first and second buses. In an adjustment mode, the power-scaling control circuit controls the master circuit to stop accessing the slave circuit, and the power-scaling control circuit adjusts the output voltage. When the master circuit sends a trigger signal, the power-scaling control circuit enters the adjustment mode. When the master circuit does not send the trigger signal, the power-scaling control circuit enters the normal mode.
    Type: Application
    Filed: December 31, 2019
    Publication date: February 4, 2021
    Inventors: Cheng-Chih WANG, Chih-Ping LU, Yung-Chi LAN, Chun-Chi CHEN
  • METHODS OF USE OF ANTI-SORTILIN ANTIBODIES
    Publication number: 20200392229
    Abstract: The present disclosure is generally directed to the use of compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, in treating and/or delaying progression of a disease or injury in an individual in need thereof.
    Type: Application
    Filed: June 10, 2020
    Publication date: December 17, 2020
    Applicant: Alector LLC
    Inventors: Robert PAUL, Michael F. WARD, Hua LONG, Shiao-Ping LU, Omer Rizwan SIDDIQUI, Arnon ROSENTHAL, Herve RHINN
  • Low insertion loss high temperature stable fiber Bragg grating sensor and method for producing same
    Patent number: 10866125
    Abstract: Provided is an optical waveguide with an inscribed Bragg grating, where the Bragg grating is stable at high temperature, has low scattering loss and high reflectivity. Also provided is a method for inscribing a Bragg grating in an optical waveguide, the method comprising irradiating the optical waveguide with electromagnetic radiation from an ultrashort pulse duration laser of sufficient intensity to cause a permanent change in an index of refraction within a core of the optical waveguide, where the irradiating step is terminated prior to erasure of a Bragg resonance, and heating the optical waveguide to a temperature and for a duration sufficient to substantially remove a non-permanent grating formed in the optical waveguide by the irradiating step.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: December 15, 2020
    Assignee: NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Dan Grobnic, Stephen Mihailov, Robert Walker, Ping Lu, Huimin Ding, David Coulas, Cyril Hnatovsky