Abstract: A waveform generator is provided. The waveform generator includes a timer and a digital to analog converter (DAC). The timer periodically provides a trigger signal according to a fixed time period. In response to the trigger signal, the DAC is configured to convert first digital data into output voltage of an analog signal. A data hold register is configured to store second digital data that corresponds to the previous output voltage of the analog signal. A judgment circuit is configured to provide a first control signal according to the second digital data, and the first control signal indicates that the previous output voltage is within a first voltage range. A calculation circuit is configured to obtain the first digital data according to the second control signal, the second digital data, and a voltage variation that corresponds to the first voltage range and to update the second digital data.

Abstract: A method of manufacturing an intermediate transfer surface includes depositing an array of etch stops on a conductive surface, etching the conductive surface to form mesas of the conductive surface separated by gaps, and coating the mesas with a dielectric coating. A method of performing microassembly includes forming an assembly of particles on an assembly plane, providing an intermediate transfer surface having an array of electrodes, applying a bias to the intermediate transfer surface to form an electrostatic field between the assembly plane and the intermediate transfer surface, and moving the intermediate transfer surface towards the assembly surface until the electrostatic field strength is strong enough to cause transfer of the assembly to the intermediate transfer surface.

Abstract: A system and method for forming a low cost optical sensor array. The sensor includes an optical fiber; a first nanocomposite thin film along at least a portion of the optical fiber for interrogating a first parameter through a correlated signal having a first wavelength; and a second nanocomposite thin film along at least a portion of the optical fiber for interrogating a second parameter through a correlated signal having a second wavelength different from the wavelength of the first parameter.

Abstract: The present disclosure relates to a touch display panel and an electronic device. The touch display panel includes: a substrate; a light-emitting unit layer located on a side of the substrate and including a cathode metal layer; multiple touch induction electrodes arranged in an array and arranged on a side of the light-emitting unit layer facing away from the substrate; multiple touch signal lines, wherein each of the touch signal lines is electrically connected to one touch induction electrode, and the touch signal lines are located between the substrate and the cathode metal layer; and an encapsulation layer located on a surface of the touch induction electrodes facing away from the substrate and covering the touch induction electrode. The touch display panel according to the present disclosure is more integrated, and has a smaller thickness and reduces steps of a preparation process.

Abstract: A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A control device for adjusting the output voltage of a voltage generator, wherein the control device includes a master circuit, a slave circuit, and a power-scaling control circuit, is provided. The master circuit is coupled to a system bus. The slave circuit is coupled to the system bus. The power-scaling control circuit is coupled between the master circuit and the slave circuit. In response to the master circuit sending a voltage-scaling command, the power-scaling control circuit sets a control signal at a suspension level so that the slave circuit sets a specific signal transmitted by the system bus at a wait level. In response to the specific signal being at the wait level, the master circuit stops accessing the first specific device of the slave circuit. In response to the control signal being at the suspension level, the power-scaling control circuit adjusts the output voltage.

Abstract: A control device is used to adjust an output voltage of a voltage generator, and includes a master circuit, a slave circuit, and a power-scaling control circuit. The master circuit is coupled to a first bus. The slave circuit is coupled to a second bus. In a normal mode, the first and second buses are connected to each other via the power-scaling control circuit, the master circuit accesses the slave circuit via the first and second buses. In an adjustment mode, the power-scaling control circuit controls the master circuit to stop accessing the slave circuit, and the power-scaling control circuit adjusts the output voltage. When the master circuit sends a trigger signal, the power-scaling control circuit enters the adjustment mode. When the master circuit does not send the trigger signal, the power-scaling control circuit enters the normal mode.

Abstract: The system and method described allow for real-time control over positioning of a micro-object. A movement of at least one micro-object suspended in a medium can be induced by a generation of one or more forces by electrodes proximate to the micro-object. Prior to inducing the movement, a simulation is used to develop a model describing a parameter of an interaction between each of the electrodes and the micro-object. A function describing the forces generated by an electrode and an extent of the movement induced due to the forces is generated using the model. The function is used to design closed loop policy control scheme for moving the micro-object towards a desired position. The position of the micro-object is tracked and taken into account when generating voltage patterns in the scheme.

Abstract: Disclosed herein are compounds comprising an electrophilic moiety and rigid moiety for use in modulating an activity of Pin1. The rigid moiety comprises at least one functional group that is capable of forming hydrogen bonds with hydrogen atoms, wherein the electrophilic moiety and the rigid moiety are arranged such that the electrophilic moiety is capable of covalently binding to the Cys113 residue of Pin1, and the rigid moiety is capable of forming hydrogen bonds with the Gln131 and His 157 residues of Pin1. Further disclosed are novel compounds having Formula Id: wherein the dashed line, W, X, Y, Z, Ra-Rc, R1, R2, L1, L2 and n are as defined herein, and libraries comprising such compounds. Further disclosed are methods of identifying a compound capable of modulating an activity of Pin1, by screening a library of compounds.

Abstract: A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: Systems and methods related to calibrating a phase interpolator by amplifying timing differences are described. An example system includes a calibration stage configured to output a calibration code for a phase interpolator. The system further includes control logic configured to: (1) at least partially discharge a first pre-charged capacitive load in response to a signal output by the phase interpolator based on the calibration code, and (2) at least partially discharge a second pre-charged capacitive load in response to a reference signal associated with the phase interpolator. The system further includes a feedback path configured to provide feedback to the calibration stage to allow for a modification of the calibration code, where the feedback is dependent on a first voltage provided by the first pre-charged capacitive load and a second voltage provided by the second pre-charged capacitive load.

Abstract: A fast processing method of massive time-series data based on aggregated edges and time-series aggregated edges implements fast and real-time processing based on an association of a graph data structure under a massive data pattern. In terms of incremental flow calculation based on time windows, the present disclosure proposes an innovative data structure of “aggregated edge” and “time-series aggregated edge”, which is suitable for data modeling of real-time dynamic graph. The present disclosure introduces a time-series graph query language, which adds descriptive semantics of time series information, and not only supports basic queries based on vertices, edges, and attributes, but also can implement users' graph queries for index calculation results in a time window. The graph query includes graph matching and graph filtering. The present disclosure is especially suitable for fields such as marketing and real-time risk control based on massive data mining and has good timeliness control and high scalability.

Abstract: T-phase-shifted fiber Bragg gratings in optical waveguides, and methods of formation thereof. Sensing apparatus comprising such gratings using femtosecond pulse duration lasers and specialized transmission diffraction elements or phase masks.

Abstract: The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.

Abstract: An example method may include receiving, at a device, a first frame over a wireless network and constructing a preliminary data portion of a second frame. The second frame may be configured for transmission over the wireless network. The method may also include in response to the receiving of the first frame at the device, beginning transmission of a header portion of the second frame over the wireless network and after the beginning transmission of the header portion of the second frame, constructing, based on the preliminary data portion, a finalized data portion of the second frame for transmission over the wireless network.

Abstract: An optical fiber temperature sensor includes a broadband light source, a first optical fiber patch cord, a first single-mode optical fiber, a single-hole twin-core eccentric core optical fiber, a second single-mode optical fiber, a second optical fiber patch cord, and an optical spectrum analyzer.

Abstract: A method of treating coronavirus infection, comprising administering to a subject in need thereof an effective amount of a composition, wherein the composition comprises one or more compounds of Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A driving protection circuit is coupled to a load via an input/output pin. A signal generator circuit is configured to generate a driving signal. An input/output circuit transmits the driving signal to the input/output pin according to an enable signal. A counter circuit adjusts the count value when the enable signal is at a predetermined level. A detection circuit detects the voltage level of the input/output pin to generate a detection signal. When the count value is equal to a predetermined value, a control circuit determines whether the level of the detection signal is the same as the level of the driving signal. When the level of the detection signal is not the same as the level of the driving signal, the control circuit sends an error signal to turn off power to the load.

Abstract: Disclosed are compounds which inhibit Pin1 activity, methods of making the compounds, pharmaceutical compositions containing the compounds, and methods of using the compounds to treat diseases or disorders characterized or mediated by dysregulated Pin1 activity.

Abstract: The system and method described allow for real-time control over positioning of a micro-object. A movement of at least one micro-object suspended in a medium can be induced by a generation of one or more forces by electrodes proximate to the micro-object. Prior to inducing the movement, a simulation is used to develop a model describing a parameter of an interaction between each of the electrodes and the micro-object. A function describing the forces generated by an electrode and an extent of the movement induced due to the forces is generated using the model. The function is used to design closed loop policy control scheme for moving the micro-object towards a desired position. The position of the micro-object is tracked and taken into account when generating control signals in the scheme.