Abstract: The present invention is directed to promoter sequences and promoter control elements, polynucleotide constructs comprising the promoters and control elements, and methods of identifying the promoters, control elements, or fragments thereof. The invention further relates to the use of the present promoters or promoter control elements to modulate transcript levels.

Abstract: Methods, computing systems, and computer-readable media for predicting pore pressure. As an example, the method includes receiving data representing a subterranean domain, modeling the domain based on the data, ranking the data, testing and validating the model, calibrating the model, and predicting a pore pressure in the domain.

Abstract: A display panel includes a first substrate, a second substrate, pixel structures, a sensing structure, a display medium layer, a first control structure, a second control structure, and color filter patterns. The sensing structure includes a first photosensor and a second photosensor. The display medium layer disposed between the first substrate and the second substrate includes a first modulation portion overlapping a first sensing active device of the first photosensor and a second modulation portion overlapping a second sensing active device of the second photosensor. The first control structure is disposed between the first substrate and the display medium layer. The second control structure is disposed between the second substrate and the display medium layer. The first sensing active device and the second sensing active device respectively overlap a first color filter pattern and a second color filter pattern among the color filter patterns.

Abstract: The present invention features methods and compositions for the generation and use of conformation-specific antibodies or fragments thereof.

Abstract: An optical fiber temperature sensor includes a broadband light source, a first optical fiber patch cord, a first single-mode optical fiber, a single-hole twin-core eccentric core optical fiber, a second single-mode optical fiber, a second optical fiber patch cord, and an optical spectrum analyzer.

Abstract: A display panel includes a first substrate, a second substrate, pixel structures, a sensing structure, a display medium layer, a first control structure, a second control structure, and color filter patterns. The sensing structure includes a first photosensor and a second photosensor. The display medium layer disposed between the first substrate and the second substrate includes a first modulation portion overlapping a first sensing active device of the first photosensor and a second modulation portion overlapping a second sensing active device of the second photosensor. The first control structure is disposed between the first substrate and the display medium layer. The second control structure is disposed between the second substrate and the display medium layer. The first sensing active device and the second sensing active device respectively overlap a first color filter pattern and a second color filter pattern among the color filter patterns.

Abstract: Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

Abstract: The present invention relates to metal coatings and methods thereof. In certain embodiments, the invention relates to ultra-low wear noble metal alloys, such as for use in electrical contact coatings.

Abstract: Novel tetrahydroisoquinoline derivative compounds are disclosed herein that may be used as an active ingredient for a pharmaceutical composition, and in particular, for a pharmaceutical composition useful for preventing or treating a disease or condition responsive to modulation of the contractility of the skeletal sarcomere. This may be accomplished, for example, by modulation of the troponin complex of the fast skeletal muscle sarcomere through one or more of fast skeletal myosin, actin, tropomyosin, troponin C, troponin I, and troponin T, and fragments and isoforms thereof. The tetrahydroisoquinoline derivative compounds can thus be used as an agent for preventing or treating 1) neuromuscular disorders, 2) disorders of voluntary muscle, 3) CNS disorders in which muscle weakness, atrophy, and fatigue are prominent symptoms, 4) muscle symptoms stemming from systemic disorders, and 5) dysfunctions of pelvic floor and urethral/anal sphincter muscle.

Abstract: The present invention relates to methods for modulating immune response based on binding I-domain of CD11b on the tumor associated myeloid cells (TAMCs) in the tumor microenvironment. Particularly, binding to I-domain of CD11b with anti-CD11b-I-domain antibody triggers immunostimulatory environment that have one or more of the following effects in the tumor microenvironment: increase the inflammatory cytokine in the tumor microenvironment, decrease the population of IDO+ myeloid suppresser cells, up-regulate M1 marker over M2 marker on the tumor associated macrophage, increase M1:M2 tumor associated macrophage ratio, promote differentiation of dendritic cells (DC), nature killer dendritic cells (NKDC), and plasmacytoid dendritic cells (pDC), increase population of 4?1BB+PD?1+ neoantigen specific CD8 T cells. Converting cold (non-inflamed) to hot (inflamed) tumor by binding to I-domain of CD11b with anti-CD11b-I-domain antibody allows enhanced effectiveness of immune response modulator.

Abstract: A network security system includes: a plurality of sub-nodes and an identity authentication device. The identity authentication device is configured to generate an initial dynamic subnet key, and group the sub-nodes into one or more subnets according to the initial dynamic subnet key and at least one preconfigured characteristic parameter. For each subnet of the one or more subnets, the identity authentication device respectively selects a virtual authenticator to manage each of the sub-nodes of each of the subnets. When a new member sub-node joins one subnet of the one or more subnets, each of the sub-nodes existed in the one subnet and the virtual authenticator of the one subnet each input a current version dynamic subnet key into a hash algorithm to update the current version dynamic subnet key for performing a consensus update process.

Abstract: The system and method described allow for real-time control over positioning of a micro-object. A movement of at least one micro-object suspended in a medium can be induced by a generation of one or more forces by electrodes proximate to the micro-object. Prior to inducing the movement, a simulation is used to develop a model describing a parameter of an interaction between each of the electrodes and the micro-object. A function describing the forces generated by an electrode and an extent of the movement induced due to the forces is generated using the model. The function is used to design closed loop policy control scheme for moving the micro-object towards a desired position. The position of the micro-object is tracked and taken into account when generating control signals in the scheme.

Abstract: Novel tetrahydroisoquinoline derivative compounds are disclosed herein that may be used as an active ingredient for a pharmaceutical composition, and in particular, for a pharmaceutical composition useful for preventing or treating a disease or condition responsive to modulation of the contractility of the skeletal sarcomere. This may be accomplished, for example, by modulation of the troponin complex of the fast skeletal muscle sarcomere through one or more of fast skeletal myosin, actin, tropomyosin, troponin C, troponin I, and troponin T, and fragments and isoforms thereof. The tetrahydroisoquinoline derivative compounds can thus be used as an agent for preventing or treating 1) neuromuscular disorders, 2) disorders of voluntary muscle, 3) CNS disorders in which muscle weakness, atrophy, and fatigue are prominent symptoms, 4) muscle symptoms stemming from systemic disorders, and 5) dysfunctions of pelvic floor and urethral/anal sphincter muscle.

Abstract: A light-emitting device comprises a light-emitting stack; a reflective structure comprising a reflective layer on the light-emitting stack and a first insulating layer covering the reflective layer; and a first conductive layer on the reflective structure; wherein the first insulating layer isolates the reflective layer from the first conductive layer.

Abstract: A driving protection circuit is coupled to a load via an input/output pin. A signal generator circuit is configured to generate a driving signal. An input/output circuit transmits the driving signal to the input/output pin according to an enable signal. A counter circuit adjusts the count value when the enable signal is at a predetermined level. A detection circuit detects the voltage level of the input/output pin to generate a detection signal. When the count value is equal to a predetermined value, a control circuit determines whether the level of the detection signal is the same as the level of the driving signal. When the level of the detection signal is not the same as the level of the driving signal, the control circuit sends an error signal to turn off power to the load.

Abstract: A mechanism for rewriting a bounded query onto a view is disclosed. A query, access constraints, and cached view(s) are obtained. The cached view(s) contain results of the query as applied to a dataset stored in a database. A query rewriting plan is generated by adding a fetch from query operation to the plan when a rewritten query variable can be fetched from a query constant. A fetch from database operation is added to the plan when a rewritten query variable can be fetched as a query variable that obtains bounded data from the database. An access view operation is added to the plan when a rewritten query variable can be fetched from the cached view. The query rewriting plan is executed to fetch retrieved data. The query is executed on the retrieved data to determine updated results to the query without reapplying the query to the dataset.

Abstract: Provided are methods, apparatuses and a system for synchronizing call media and content. In a process of playing call media to a user and displaying content associated with the call media, a terminal acquires new call media from a call media server and acquires, after querying a synchronization server for content information corresponding to the new call media, content associated with the new call media from a content server, respectively, in response to a user operation. The terminal plays the new call media to the user, and displays the content associated with the new call media simultaneously.

Abstract: A method of manufacturing an intermediate transfer surface includes depositing an array of etch stops on a conductive surface, etching the conductive surface to form mesas of the conductive surface separated by gaps, and coating the mesas with a dielectric coating. A method of performing microassembly includes forming an assembly of particles on an assembly plane, providing an intermediate transfer surface having an array of electrodes, applying a bias to the intermediate transfer surface to form an electrostatic field between the assembly plane and the intermediate transfer surface, and moving the intermediate transfer surface towards the assembly surface until the electrostatic field strength is strong enough to cause transfer of the assembly to the intermediate transfer surface.

Abstract: The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.

Abstract: The system and method described below allow for real-time control over positioning of a micro-object. A movement of at least one micro-object suspended in a medium can be induced by a generation of one or more forces by electrodes proximate to the micro-object. Prior to inducing the movement, a simulation is used to develop a model describing a parameter of an interaction between each of the electrodes and the micro-object. A function describing the forces generated by an electrode and an extent of the movement induced due to the forces is generated using the model. The function is used to design closed loop policy control scheme for moving the micro-object towards a desired position. The position of the micro-object is tracked and taken into account when generating control signals in the scheme.