Abstract: The invention features all-trans retinoic acid (ATRA)-related compounds capable of associating with Pin1 and methods of treating a proliferative disorder characterized by elevated Pin1 marker levels, Pin1 degradation, and/or reduced Pin1 Ser71 phosphorylation in a subject by administering an ATRA-related compound. The invention also features methods of treating proliferative disorders, autoimmune diseases, and addiction conditions (e.g., diseases, disorders, and conditions characterized by elevated Pin1 marker levels) by administering an ATRA-related compound in combination with another therapeutic compound.

Abstract: An intermediate transfer surface includes a substrate, a two-dimensional array of electrodes, a dielectric spacer layer on the two-dimensional array of electrodes, and a voltage controller electrically connected to the array of electrodes. A method of manufacturing an intermediate transfer surface, depositing an array of etch stops on a conductive surface, etching the conductive surface to form mesas of the conductive surface separated by gaps, and coating the mesas with a dielectric coating. A microassembly system includes an assembly surface having a first two dimensional array of potential wells on a first surface, a first voltage source electrically connected to the first array of potential wells, an intermediate transfer surface having a second two dimensional array of potential wells on a second surface arranged to face the first surface, and a second voltage source electrically connected to the second array of potential wells.

Abstract: There is provided an alignment system and method for use in an ultrashort pulse duration laser-based Fiber Bragg Grating (FBG) writing system, the alignment system comprising: clamps configured to hold a coated optical fiber in a position perpendicular to a beam path of an ultrashort pulse duration laser-based FBG writing station; an optical detector; and a control system with an input from the optical detector and an output to adjust parameters of an optical source and the FBG writing station adjust a distance between the optical fiber and an optical source of the writing station based on luminescence generated in a core of the optical fiber as indicated in a signal received at the input from the optical detector.

Abstract: A chip having output synchronization includes a phase detector for receiving an external reference clock signal, an input delay path coupled to an output of the phase detector and having an output for providing an internal reference clock signal, an output delay path coupled to the output of the input delay path and having an output coupled to a feedback input of the phase detector, a phase adjustment circuit having a first input coupled to the output of the input delay path, a second input for receiving a local clock signal, and an output coupled to the control input of the input delay path, and a synchronization capture circuit having a first input coupled to the output of said input delay path, a second input for receiving the local clock signal, a third input for receiving a synchronization signal, and an output for providing a synchronization trigger signal.

Abstract: An authentication system and method for an electronic governor of an unmanned aerial vehicle is disclosed. By employing reciprocative authentication and encryption mechanisms between a main control terminal and an electronic governor, the use of a modified electronic governor is prevented and thus the illegal use of UAVs is also prevented. Moreover, the provided electronic governor may be operated in dual-mode to extend its compatibility to conventional main control terminals.

Abstract: The present invention features methods and compositions for the generation of conformation-specific antibodies.

Abstract: The invention features methods of treating a proliferative disorder characterized by elevated Pin1 marker levels and/or reduced Pin1 Ser71 phosphorylation in a subject by administering a retinoic acid compound. Additionally, the invention features methods of treating proliferative disorders (e.g., proliferative disorders characterized by elevated Pin1 marker levels) by administering a retinoic acid compound in combination with another anti-proliferative compound. Finally, the invention also features methods including high-throughput screens for discovering and validating Pin1 inhibitors.

Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

Abstract: A system and method for forming a low cost optical sensor array. The sensor includes an optical fiber; a first nanocomposite thin film along at least a portion of the optical fiber for interrogating a first parameter through a correlated signal having a first wavelength; and a second nanocomposite thin film along at least a portion of the optical fiber for interrogating a second parameter through a correlated signal having a second wavelength different from the wavelength of the first parameter.

Abstract: Provided are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X and m are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula I, or a pharmaceutically acceptable salt thereof.

Abstract: The invention features compositions and methods for inhibiting the Pin1 protein, and the treatment of disorders characterized by elevated Pin1 levels.

Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

Abstract: An electrode array including a substrate. The electrode array includes a first plurality of electrodes disposed above a first zone of the substrate, wherein the first plurality of electrodes has a first range of spacing. The electrode array further includes a second plurality of electrodes disposed above a second zone of the substrate, wherein the second plurality of electrodes has a second range of spacing that is less than the first range of spacing.

Abstract: The method for manufacturing a thin film transistor includes sequentially forming a gate electrode on a surface of a substrate, forming a gate insulating layer covering the surface of the substrate and the gate electrode, forming an active layer and an etching stop layer above the gate electrode, forming a metal layer including a first region covering the etching stop layer and a pair of second regions connecting both sides of the first region on the active layer, and forming a photosensitive layer on the metal layer; removing a portion of the photosensitive layer to expose a portion of the first region; removing the exposed portion of the first region with the remaining first region having a height same as the remaining photosensitive layer located at two opposite sides of the etching stop layer; and removing the remaining photosensitive layer.

Abstract: Biomarkers and driver mutations for diagnosis and prognosis of Pin 1-associated diseases are disclosed. In one embodiment, the methods for diagnosis of Pin 1-associated diseases may include detecting the level of Pin1 to stage abnormal cell growth, such as breast or prostate cancer. In another embodiment, the methods include evaluating the efficacy of a treatment of abnormal cell growth, such as cancer, by monitoring the levels of Pin1. In another embodiment, the methods include using driver mutations to determine the pharmacogenetics of abnormal cell growth, such as cancer. In the present disclosure, elevated active monomeric Pin1 levels may be detected by Pin1 biomarkers, which may include Pin1 Q33K or E100D driver mutations, Pin1 protein or transcript overexpression, dephosphorylation of Pin1 on Ser71, dephosphorylation of S16, phosphorylation of S65, phosphorylation of S138, deacetylation of Pin1 on K13 and deacetylation of K46, and/or desumoylation of Pin1 on K6 and desumolation of K63, among others.

Abstract: Embodiments of the disclosure provide methods and apparatuses for processing information. The method can include: receiving, via a server, an exchange request for a first transaction order associated with a first user and a second user; determining first user information of the first user, second user information of the second user, and information of a first data object associated with the exchange request; verifying the second user; and in response to the second user being verified, creating a second transaction order according to the information of the first data object; and providing the second transaction order to a client terminal of the first user for execution of a delivery of the first data object, wherein the second transaction order is associated with a second data object corresponding to the first data object.

Abstract: Novel tetrahydroisoquinoline derivative compounds are disclosed herein that may be used as an active ingredient for a pharmaceutical composition, and in particular, for a pharmaceutical composition useful for preventing or treating a disease or condition responsive to modulation of the contractility of the skeletal sarcomere. This may be accomplished, for example, by modulation of the troponin complex of the fast skeletal muscle sarcomere through one or more of fast skeletal myosin, actin, tropomyosin, troponin C, troponin I, and troponin T, and fragments and isoforms thereof. The tetrahydroisoquinoline derivative compounds can thus be used as an agent for preventing or treating 1) neuromuscular disorders, 2) disorders of voluntary muscle, 3) CNS disorders in which muscle weakness, atrophy, and fatigue are prominent symptoms, 4) muscle symptoms stemming from systemic disorders, and 5) dysfunctions of pelvic floor and urethral/anal sphincter muscle.

Abstract: A method of manufacturing and using micro assembler systems are described. A method of manufacturing includes disposing a first plurality of electrodes above a first zone of the substrate, wherein the first plurality of electrodes has a first range of spacing. The method further includes disposing a second plurality of electrodes above a second zone of the substrate, wherein the second plurality of electrodes has a second range of spacing that is less than the first range of spacing. A method of using micro assembler systems includes disposing a mobile particle at least partially submersed in an assembly medium above a substrate, a first plurality of electrodes and a second plurality of electrodes. The method further includes conducting a field through individual electrodes of the first plurality of electrodes and the second plurality of electrodes to generate electrophoretic forces or dielectrophoretic forces on the mobile particle.

Abstract: A touch display apparatus having a fan-out side is provided. The touch display apparatus includes a first substrate, a second substrate, a touch sensing element and a display element. The first and the second substrate have a first surface and a second inner surface, respectively. The second substrate is disposed opposite to the first substrate. The second inner surface faces the first inner surface. The second substrate has a convex part and a concave part on the fan-out side. The second inner surface has a second outer lead bonding region in the convex part. The first outer lead bonding region of the first substrate is unshielded by the second substrate through the concave part. The second outer lead bonding region of the second substrate is unshielded by the first substrate. The touch sensing element and the display element are packaged in between the first and the second substrates.

Abstract: An artemisinin analog as represented by formula (A) and application thereof in preparing a pharmaceutical product for promoting lipid catabolism and/or prevention or treatment of metabolism-related disease. The artemisinin analog promotes browning of white fat to achieve body weight reduction and improve metabolism, thereby providing therapeutic effects against hyperglycemia, insulin resistance, dyslipidemia, and/or fatty liver.