Abstract: Provided herein are novel compounds, for example, compounds having a Formula (I), Formula (A), Formula (II), Formula (III), Formula (IV), or Formula (V), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRASG12D in a cancer cell, and/or in treating various cancer such as pancreatic cancer, colorectal cancer, lung cancer (e.g., non-small cell lung cancer) or endometrial cancer.

Abstract: The present invention discloses a pipeline automatic scale removal and storage device. The device comprises a scale remover, a scale storage device and a coupling; the scale remover is composed of a scale breaking mechanism, a cutting mechanism and a grinding mechanism; a plurality of groups of scale breaking teeth of the scale breaking mechanism can preliminarily break scale on an inner wall of a pipeline; the cutting mechanism cuts and eliminates the scale on the inner wall of the pipeline through a plurality of installed cutting blades; and a plurality of groups of grinding blocks of the grinding mechanism further grind and eliminate the scale on the pipeline; and the scale storage device is used for realizing storage for the scale. The scale storage device is hermetically and movably installed in the pipeline. The device of the present invention can automatically thoroughly eliminate the scale in the pipeline.

Abstract: The present invention belongs to the technical field of computer vision, and provides a video semantic segmentation method based on active learning, comprising an image semantic segmentation module, a data selection module based on the active learning and a label propagation module. The image semantic segmentation module is responsible for segmenting image results and extracting high-level features required by the data selection module; the data selection module selects a data subset with rich information at an image level, and selects pixel blocks to be labeled at a pixel level; and the label propagation module realizes migration from image to video tasks and completes the segmentation result of a video quickly to obtain weakly-supervised data. The present invention can rapidly generate weakly-supervised data sets, reduce the cost of manufacture of the data and optimize the performance of a semantic segmentation network.

Abstract: A piston press system and a test method using the same are used for predicting the roll service life of high-pressure grinding rolls. The method is based on the same comminution mechanism of inter-particle layers compression as the heavy equipment high-pressure grinding rolls to simulate the grinding process of the studded high-pressure grinding roll, realizing that the coverage area of studs accounts for 16% to 20% of the compression surface by disposing tungsten carbide upper studs and lower studs, better restoring the simulation process and effectively realizing the roll service life prediction of the heavy equipment high-pressure roller mill with a small quantity of materials.

Abstract: The invention relates to pharmaceutical compositions comprising 4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H- pyrido[3?,4?:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)-1-(4-fluorophenyl)-butan-1-one, and methods of use in the treatment of diseases involving 5-HT2A receptor, serotonin transporter (SERT) pathway and/or the dopamine D2 receptor pathway, and methods of treating conditions of the central nervous system therewith.

Abstract: Provided are a compound that inhibits sodium-glucose co-transporter 1, and a pharmaceutically acceptable salt and stereoisomer thereof. The compound is used in a pharmaceutical composition and preparation and usage methods, which comprise an application of a drug and composition thereof in the preparation for treating and improving diabetes, cardiovascular and cerebrovascular diseases, weight loss, fatty liver disease, constipation, metabolism-related diseases and tumor treatment.

Abstract: A compound inhibiting a sodium-glucose cotransporter 1, and a pharmaceutically acceptable salt and a stereoisomer thereof. The compound is used in a pharmaceutical composition. Also disclosed are methods for preparing and using the pharmaceutical composition, and an application in preparing a drug and a composition of the compound for treating and improving diabetes, cardio-vascular diseases, weight reduction, fatty liver, astriction, and metabolism-related diseases, and cancer therapy.

Abstract: Bifidobacterium animalis and application of a compound bacterium preparation prepared from the Bifidobacterium animalis in the preparation of a medicine for treating or preventing avian influenza virus infection. The invention discovers that Bifidobacterium animalis ATCC Accession No. 25527 can be used for treating animals infected by H7N9, and after the Bifidobacterium animalis ATCC Accession No. 25527 is compounded with Bifidobacterium pseudolongum ATCC Accession No. 25526, the effect is better. The compound preparation can regulate the body immune response, remarkably improve the weight loss and lung tissue injury caused by H7N9 influenza virus infection, and obviously improve the survival rate of mice infected by H7N9 influenza virus. The compound probiotic preparation provided by the invention has a remarkable effect of resisting H7N9 influenza virus infection, and can be effectively used for preventing and treating avian influenza virus infection.

Abstract: A farming method includes: loading a broad spectrum of plant nutrients into a zeolite substrate; using the loaded zeolite substrate to grow crops for a plurality of cycles; and recycling the used zeolite substrate.

Abstract: A PET detector and method thereof are provided. The PET detector may include: a crystal array including a plurality of crystal elements arranged in an array and light-splitting structures set on surfaces of the plurality of crystal elements, the light-splitting structures jointly define a light output surface of the crystal array; a semiconductor sensor array, which is set in opposite to the light output surface of the crystal array and is suitable to receive photons from the light output surface, the semiconductor sensor array comprises a plurality of semiconductor sensors arranged in an array.

Abstract: Embodiments herein relate to a method performed by a radio network node for handling transmission of data from a wireless device in a wireless communication network. The radio network node determines a delay value for a transmission of data from the wireless device based on a transmission type of data from the wireless device or a capability of the wireless device. The capability is related to a processing time for processing received data from the radio network node, or for processing data for transmission to the radio network node. The radio network node further transmits an indication, to the wireless device, which indication indicates the determined delay value.

Abstract: A shuttle vehicle, comprising a vehicle body (100), a travelling apparatus (200) and a box conveying and pickup apparatus (300); two horizontal support plates (110) provided in parallel and spaced apart are fixed on the vehicle body, the two horizontal support plates are located on the same horizontal plane and form a gap therebetween; the box conveying and pickup device comprises a chain assembly (310) and a fork (20), the chain assembly comprises a chain (311), a sprocket group (312) and a chain driving device (350); a first end (321) of the fork is fixedly connected to the chain, and a second end of the fork extends outwards in the normal direction of the chain; and a bent portion (322) bending upwards is formed at the second end, and is used for contacting with the inner wall of a groove (31) at the bottom of a material box (30).

Abstract: A method of using an optical TOF module to determine distance to an object. The method includes acquiring signals in the TOF module indicative of distance to the object, using a first algorithm to provide an output indicative of the distance to the object based on the acquired signals, using at least one second different algorithm to provide an output indicative of the distance to the object based on the acquired signals, and combining the outputs of the first and at least one second algorithms to obtain an improved estimate of the distance to the object. In some implementations, each of the first and at least one second algorithms further provides an output representing a respective confidence level indicative of how accurately distance to the object has been extracted by the particular algorithm.

Abstract: The present invention discloses a composition containing hesperetin and synergistic hypoglycemic application thereof, and belongs to the technical field of natural active compounds. The composition of the present invention contains the hesperetin and a compound X, and the compound X is galangin or formononetin, where a mass ratio of the hesperetin to the galangin is 30:100, and a mass ratio of the hesperetin to the formononetin is 30:20. The composition of the present invention has an obvious synergistic effect of inhibiting ?-glucosidase, and the effect thereof is better than that of using the flavonoid compound alone, and may reduce a dosage of the use of drugs and occurrence of drug resistance.

Abstract: The present application provides a gate driving unit circuit and a method of driving the same, a gate driving circuit and a display apparatus. The gate driving unit circuit includes a shift register and a plurality of driving signal output sub-circuits. Each driving signal output sub-circuit corresponds to one of gate lines on an array substrate, is coupled to a first power supply terminal and a signal output terminal of the shift register, and also coupled to a corresponding one of driving scan signal lines. Each driving signal output sub-circuit is configured to output, under the control of a signal output by the signal output terminal of the shift register, a driving scan signal provided by the corresponding driving scan signal line or an OFF voltage provided by the first power supply terminal to the corresponding gate line.

Abstract: Provided are a data access method and device, a storage medium and an electronic device. The method includes: a first access request used for requesting access to data in a database is received; the first access request is parsed to obtain the following data corresponding to the first access request: a first access parameter, a first request type, and a first controlled field list; a first data protection operation is performed on the first controlled field list based on the first access parameter and the first request type to obtain a target result; and a second access request is synthesized based on the target result, and the data in the database is accessed based on the second access request, so as to obtain an access result.

Abstract: The present application provides a recombinant Pseudorabies virus whose genome contains nucleotide sequences coding the capsid protein P72, the accessory protein B602L and the exterior envelope protein CD2V derived from African swine fever virus. This recombinant Pseudorabies virus can be used to prepare live virus vector vaccine to effectively treat or prevent African swine fever and overcome defects of the existing inactivated vaccines and attenuated live vaccines.

Abstract: A programmable two-dimensional simultaneous multi-beam optically operated phased array receiver chip is manufactured based on silicon-on-insulator (SOI) and indium phosphide (InP) semiconductor manufacturing processes, including the SiN process. The InP-based semiconductor is used for preparing a laser array chip and a semiconductor optical amplifier array chip, the SiN is used for preparing an optical power divider, and the SOI semiconductor is used for preparing a silicon optical modulator, a germanium-silicon detector, an optical wavelength multiplexer, a true delay line, and other passive optical devices. The whole integration of the receiver chip is realized through heterogeneous integration of the InP-based chip and the SOI-based chip. Simultaneous multi-beam scanning can be realized through peripheral circuit programming control.

Abstract: A server configured to determine a fee surge for an on-demand service may include processor(s) that may perform the following upon receiving each request for the service: determine, from the request, a location where the service is required; determine, using a map from the memory, a supply area around the location; determine the surge based on the supply area; compare the surge with a surge lower bound for the supply area and set it as this bound if it is lower than this bound; communicate the surge to the respective requestor computing device and a provider computing device; and allocate the associated service provider to fulfil the request if both the service requestor and service provider accept the surge. The surge lower bound may be based on historical allocation rates, each representing a number of fulfilled requests at a fee surge during historical time interval(s) in a characteristically similar area.

Abstract: The invention belongs to scene segmentation's field in computer vision and is a depth-aware method for mirror segmentation. PDNet successively includes a multi-layer feature extractor, a positioning module, and a delineating module. The multi-layer feature extractor uses a traditional feature extraction network to obtain contextual features; the positioning module combines RGB feature information with depth feature information to initially determine the position of the mirror in the image; the delineating module is based on the image RGB feature information, combined with depth information to adjust and determine the boundary of the mirror. This method is the first method that uses both RGB image and depth image to achieve mirror segmentation in an image. The present invention has also been further tested. For mirrors with a large area in a complex environment, the PDNet segmentation results are still excellent, and the results at the boundary of the mirrors are also satisfactory.