Abstract: Systems and methods for conducting designated reactions that include a fluidic network having a sample channel, a reaction chamber, and a reservoir. The sample channel is in flow communication with a sample port. The system also includes a rotary valve that has a flow channel and is configured to rotate between first and second valve positions. The flow channel fluidically couples the reaction chamber and the sample channel when the rotary valve is in the first valve position and fluidically couples the reservoir and the reaction chamber when the rotary valve is in the second valve position. A pump assembly induces a flow of a biological sample toward the reaction chamber when the rotary valve is in the first valve position and induces a flow of a reaction component from the reservoir toward the reaction chamber when the rotary valve is in the second valve position.

Abstract: A lead frame sheet of flat no-lead lead frames having a semiconductor die on a die pad, terminals, and plastic encapsulation except on a back side of the sheet to provide an exposed thermal die pad, exposed side walls, and exposed back sides of the terminals. A solder wetable metal or metal alloy plating layer is on the back side and on the exposed the walls of the terminals. The exposed thermal pad and the back side of the terminals each include a contact region which lacks the plating layer.

Abstract: A system includes an image sensor structure and a flow cell. The image sensor structure includes an image layer disposed over a base substrate. A device stack is disposed over the image layer. A bond pad is disposed in the device stack. A passivation stack is disposed over the device stack and the bond pad. An array of nanowells is disposed in a top layer of the passivation stack. A through-silicon via (TSV) is in electrical contact with the bond pad. The TSV extends through the base substrate. A redistribution layer (RDL) is disposed on a bottom surface of the base substrate. The RDL is in electrical contact with the TSV. The flow cell is disposed upon the top layer of the passivation stack to form a flow channel therebetween. The flow channel is disposed over the array of nanowells and the bond pad.

Abstract: A catheter or shaft, such as a distal access support or aspiration catheter, is provided that is configured to be advanced at least partially within a patient. The catheter or shaft may include a flexible and hollow shaft including a proximal end and a distal end. The flexible and hollow shaft may include a slotted portion with a plurality of slotted openings, the slotted portion including a first segment with a first pattern of slotted openings and a second segment extending proximally relative the first segment with a second pattern of slotted openings different from the first pattern.

Abstract: A semiconductor package includes a semiconductor die and a ceramic package body covering the semiconductor die. The ceramic package body includes a plurality of contact pads. Each of a first plurality of leads includes a top portion and a bottom portion. The top portion of each of the first plurality of leads is electrically connected to a contact pad of the plurality of contact pads. Each of a second plurality of leads includes a top portion and a bottom portion and an interconnection portion between the top portion and the bottom portion. The top portion of each of the second plurality of leads includes separate finger portions that are electrically connected to at least two of the plurality of contact pads.

Abstract: An interposer for a flow cell comprises a base layer having a first surface and a second surface opposite the first surface. The base layer comprises black polyethylene terephthalate (PET). A first adhesive layer is disposed on the first surface of the base layer. The first adhesive layer comprises methyl acrylic adhesive. A second adhesive layer is disposed on the second surface of the base layer. The second adhesive layer comprises methyl acrylic adhesive. A plurality of microfluidic channels extends through each of the base layer, the first adhesive layer, and the second adhesive layer.

Abstract: One or more computing nodes located in a first region may maintain a first collection of data items. A second set of one or more computing nodes in a second region may maintain a collection of data items that is at least a partial replica of the first collection. Notifications of changes to the first collection may be transmitted, via a broadcast communications channel, to a replication module, which may be included in a client application. The replication module may transmit requests to update the second collection of data based on changes to the first collection. Conflicts may be resolved through a last-write wins policy.

Abstract: The invention relates generally to methods and systems for capturing, filtering, or retrieving obstructions or other particulates from a patient's vasculature. It may relate to integrated thrombectomy and filtering devices and methods of use. The methods and systems may be configured to remove obstructions such as clots or foreign body objects from a neurovascular vessel or other vasculature and/or provide protection from distal emboli. In one aspect, device for retrieving an obstruction from a patient is provided that includes an outer delivery shaft and an expandable basket movable between a collapsed configuration and an expanded configuration. The basket is configured to be in the collapsed configuration during delivery and in the expanded configuration during engagement and retrieval of the obstruction. A proximal end of the basket is configured to be centrally and pivotally coupled to the outer delivery shaft.

Abstract: A multi-wheeled golf push cart is shown that combines the functionality of a conventional pushcart and golf bag into a single piece of equipment. The cart comprises a collapsible multi-wheeled configuration and push bar. These collapsible mechanisms enable the cart to be transformed into two positions: folded or extended. The cart is also equipped with a plurality of golf club slots strategically formed into a U-shaped housing for optimized club organization and protection. For golf equipment storage space, the cart has a main console located in the push bar. In addition, the golf cart has a strap-on bag that comes with multiple pockets for additional storage. In an extended position, the cart is designed for walking similar to using a pushcart and bag combination. In a folded position, the compact designed allow it to fit securely onto the back of a motorized cart for riding, similar to a conventional golf bag.

Abstract: A three-wheeled golf pushcart that combines the usage and benefits of a conventional pushcart and golf bag into a single piece of equipment. The cart comprises a collapsible three wheeled configuration and push bar. These collapsible mechanisms enable the cart to be transformed into two positions: folded or extended. The cart is also equipped with a plurality of golf club slots strategically formed into a V-shaped. In addition to the caddy console and accessories tray, removable storage compartments are also added to the perimeter of the cart's body for additional storage room. In an extended position, the cart is designed to be used for walking similar to using a “pushcart and bag combination”. In a folded position, the cart is compact and designed to fit securely onto the back of a motorized cart for riding, similar to a conventional golf bag. This compact folded position also makes it ideal for handling and stowing.

Abstract: The disclosed embodiments provide a system for processing data. During operation, the system obtains a user-defined function (UDF) that is defined using a standard UDF interface for accessing multiple platforms. Next, the system converts data in a platform into a standard form that is supported by the standard UDF interface using a platform-specific wrapper for the UDF and a platform-specific implementation of the standard UDF interface. The system then generates output data in the standard form by applying one or more operations to the data in the standard form. Finally, the system converts the output data into a platform-specific form that is supported by the platform and returns the output data in the platform-specific form.

Abstract: A computer-implemented method for controlling an electromagnetic energy source is disclosed. Instructions are executed on a processor to display on a computer-human interface display device a user interface region. The user interface region includes a pie-graph. An input is received via the user interface region, where the input is an interaction with the pie-graph that changes one of the radius or a sector of the plurality of the sectors. A power output of one or more of the electromagnetic energy sources is adjusted based on the input.

Abstract: Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.

Abstract: A lead frame sheet of flat no-lead lead frames having a semiconductor die on a die pad, terminals, and plastic encapsulation except on a back side of the sheet to provide an exposed thermal die pad, exposed side walls, and exposed back sides of the terminals. A solder wetable metal or metal alloy plating layer is on the back side and on the exposed the walls of the terminals. The exposed thermal pad and the back side of the terminals each include a contact region which lacks the plating layer.

Abstract: Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.

Abstract: A lead frame sheet of flat no-lead lead frames having a semiconductor die on a die pad, terminals, and plastic encapsulation except on a back side of the sheet to provide an exposed thermal die pad, exposed side walls, and exposed back sides of the terminals. A solder wetable metal or metal alloy plating layer is on the back side and on the exposed the walls of the terminals. The exposed thermal pad and the back side of the terminals each include a contact region which lacks the plating layer.

Abstract: A system and method for deploying an occluding device that can be used to remodel an aneurysm within the vessel by, for example, neck reconstruction or balloon remodeling. The system comprises an introducer sheath and an assembly for carrying the occluding device. The assembly includes an elongated flexible member having an occluding device retaining member for receiving a first end of the occluding device, a proximally positioned retaining member for engaging a second end of the occluding device and a support surrounding a portion of the elongated flexible member over which the occluding device can be positioned.

Abstract: Techniques are disclosed for intelligent management of multiple communications links. One communications link can be used to bring up another communications link with little or no user input. Selective enablement/disablement of one or more of the communications links is based on system needs and other criteria. Utilizing one more-secure communications link to improve security on another less-secure communications link between the same devices is also contemplated.

Abstract: An example of a method includes providing a substrate with an exposed surface comprising a first chemical group, wherein the providing optionally comprises modifying the exposed surface of the substrate to incorporate the first chemical group; reacting the first chemical group with a first reactive group of a functionalized polymer molecule to form a functionalized polymer coating layer covalently bound to the exposed surface of the substrate; grafting a primer to the functionalized polymer coating layer by reacting the primer with a second reactive group of the functionalized polymer coating layer; and forming a water-soluble protective coating on the primer and the functionalized polymer coating layer. Examples of flow cells incorporating examples of the water-soluble protective coating are also disclosed herein.

Abstract: A vascular remodeling device is provided. The device has an anchor portion, sized for deployment in a blood vessel, that is radially expandable from a collapsed state to an expanded state. The device also includes a distal portion sized for deployment in a blood vessel. The distal portion is radially expandable from a collapsed state to an expanded state and has a distal face that is sufficiently occlusive in the distal-to-proximal direction to perform a therapeutic blocking function in an aneurysm neck. The device also has an intermediate portion that interconnects a distal end of the anchor portion and a proximal end of the distal portion. In some embodiments, the anchor portion and/or distal portion has a plurality of interconnected struts.