Abstract: The present invention provides devices, systems, and methods for refilling a refillable fluid applicator, such as but not limited to a refillable dry erase marker. The devices, systems, and methods of the present invention advantageously allow the fluid applicator to be refilled quickly, easily, and inexpensively, and provide the benefit of significantly reducing the quantity of solid plastic waste associated with conventional disposable dry erase markers and other fluid applicators.

Abstract: Mattress assemblies include a mattress core assembly and a nested, zipperless mattress ticking assembly for covering the mattress core assembly and a nested, zipperless mattress ticking assembly for covering the mattress core assembly. The nested, zipperless mattress ticking assembly includes an upper mattress ticking assembly having a top side extending over a top side of the mattress core assembly and a peripheral portion extending over a portion of the peripherally-extending side of the mattress core assembly, and a lower mattress ticking assembly having a bottom side extending over the bottom side of the mattress core assembly and a peripheral portion extending over a portion of the peripherally-extending side of the mattress core assembly. The peripheral portions of the upper and lower mattress ticking assemblies overlap each other along the peripherally-extending side of the mattress core assembly. The mattress assembly meets the flammability standards of the 16 CFR 1633.

Abstract: The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines.

Abstract: A fabric conditioning active composition comprising an esterquat mixture of quaternized mono-, di-, and tri-esters of alkanolamine in which the tri-esterquat content of the quaternized esterquat mixture is greater than 25% by weight of the esterquat mixture, and the combined di-esterquat and tri-esterquat content in the esterquat mixture is greater than 78% by weight of the esterquat mixture. Additionally, the free fatty acid content of the composition is greater than 1% by weight based on the weight of the esterquat mixture. The fabric conditioning active composition provides high viscosity when dispersed into water at low concentrations of 0.5% to 12%, without the need for additional polymeric thickeners or other thickening additives.

Abstract: The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3? untranslated region (3?-UTR) comprising a ?30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the ?30 mutation deleted from the 3?-UTR that removes sequence in the 5? direction as far as the 5? boundary of the TL-3 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, or a replacement of the 3?-UTR of a dengue virus of a first serotype with the 3?-UTR of a dengue virus of a second serotype, optionally containing the ?30 mutation and nucleotides additional to the ?30 mutation deleted from the 3?-UTR; and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus.

Abstract: A method is provided for detecting intrusion into optical fibers of a Passive Optical Network (PON) of the type which includes a multiplexing system at the head end for separating a data signal output at the head end to the plurality of fibers for supply to user end terminals and a data transmission system at each of the user end terminals for entering onto the fiber data as an optical signal. The method includes providing a monitor system having a transmitter at the head end and a monitor signal analysis system for analyzing changes in the optical monitor signal after transmission along the fiber for detecting an intrusion event. A monitor signal analysis system is provided at one or more user end terminals for detection and conversion of data from the analysis into a digital signal which is then transmitted from the user end terminals back to the head end using the data transmission system through the PON system or separately from the PON system.

Abstract: Disclosed are methods of extracting water from a composition of an organic liquid and water, using a polyol which causes a phase separation.

Abstract: The invention relates to vaccine compositions including CEV serogroup immunogens, attenuated and inactivated viruses of the CEV serogroup and chimeric Bunyaviridae. Also disclosed are methods of treating or preventing CEV serogroup infection in a mammalian host, methods of producing a subunit vaccine composition or an immunogenic composition, isolated polynucleotides comprising a nucleotide sequence encoding a CEV serogroup immunogen, methods for detecting La Crosse virus (LACV) infection in a biological sample and infectious chimeric Bunyaviridae.

Abstract: The present disclosure improves upon existing systems and methods by providing a tool for managing processing resources. For instance, the presently described tool may be used to time replacement, plan for uplifts, budget for uplifts/decommissioning of hardware, and/or maintain a plurality of servers. This tool may lead to increased satisfaction, uptime, and a reduction of unexpected costs. The system may include initiating collection of variables to compile a prioritized list of servers, executing, a calculation application for determining a prioritized list of servers' end of life targets based on both technical and business parameters based on the entered variables, and prioritizing uplifts of the servers based on the technical and the business parameters.

Abstract: The invention relates to vaccine compositions including CEV serogroup immunogens, attenuated and inactivated viruses of the CEV serogroup and chimeric Bunyaviridae. Also disclosed are methods of treating or preventing CEV serogroup infection in a mammalian host, methods of producing a subunit vaccine composition or an immunogenic composition, isolated polynucleotides comprising a nucleotide sequence encoding a CEV serogroup immunogen, methods for detecting La Crosse virus (LACY) infection in a biological sample and infectious chimeric Bunyaviridae.

Abstract: A method is provided for detecting intrusion into an optical cable of a single mode optical fiber network comprising where monitoring light signals are transmitted along a telecommunications optical fiber to be monitored either along a fiber additional to a data fiber or by multiplexing onto a common fiber. The received monitoring light signals after transmission along the telecommunications optical fiber are analyzed for changes indicative of movement of the optical fiber for detecting an intrusion event. The monitoring light signals at the receive end of the fiber signals are monitored by feeding the signals from the single mode fiber into a multi-mode fiber in a manner which causes changes in modal power distribution which can be detected by taking a portion only of the modes.

Abstract: A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines.

Abstract: The invention relates to a dengue virus tetravalent vaccine containing a common 30 nucleotide deletion (?30) in the 3?-untranslated region of the genome of dengue virus serotypes 1, 2, 3, and 4, or antigenic chimeric dengue viruses of serotypes 1, 2, 3, and 4.

Abstract: The invention relates to a dengue virus tetravalent vaccine containing a common 30 nucleotide deletion (?30) in the 3?-untranslated region of the genome of dengue virus serotypes 1, 2, 3, and 4, or antigenic chimeric dengue viruses of serotypes 1, 2, 3, and 4.

Abstract: A system for detecting an intrusion of at least one of a monitoring fiber and a detector comprises a sensor having a closure monitor and an intrusion monitor, the closure monitor including a signal generator and at least one detector attached to the monitoring fiber. The signal generator transmits signal light such that the monitoring fiber receives the transmitted signal light and reflects a portion of the signal light via the at least one detector to the closure monitor and transmits a non-reflected portion of the signal light. The intrusion monitor receives the transmitted non-reflected portion of the signal light, and monitors the non-reflected portion of the signal light to detect transient changes in the non-reflected portion of the signal light indicative of at least one of a vibration, a motion and a handling of at least one of the monitoring fiber and the at least one detector.

Abstract: The invention features novel attenuated dengue virus mutants and compositions thereof. The invention further features an attenuated dengue virus comprising a proline to leucine change at amino acid position 2343 of non-structural protein 4B (NS4B), wherein the numbering is based upon the prototypic isolate DEN4 Dominica 1981 and the attenuated mutant DEN virus has at least one of the following properties: improved replication in Vero cells or restricted replication in mosquito cells.

Abstract: Provided herein are recombinant respiratory syncytial viruses that contain mutations that make the disclosed viruses attractive vaccine candidates. The viruses disclosed contain attenuating mutations designed to have increased genetic and phenotypic stability. Desired combinations of these mutations can be made to achieve desired levels of attenation. Exemplary vaccine candidates are described. Also provided are polynucleotides capable of encoding the described viruses, as wells as methods for producing the viruses and methods of use.

Abstract: The invention relates to a dengue virus tetravalent vaccine containing a common 30 nucleotide deletion (?30) in the 3?-untranslated region of the genome of dengue virus serotypes 1, 2, 3, and 4, or antigenic chimeric dengue viruses of serotypes 1, 2, 3, and 4.

Abstract: The invention relates to a dengue virus tetravalent vaccine containing a common 30 nucleotide deletion (?30) in the 3?-untranslated region of the genome of dengue virus serotypes 1, 2, 3, and 4, or antigenic chimeric dengue viruses of serotypes 1, 2, 3, and 4.