Abstract: The invention is related to a dengue virus or chimeric dengue virus that contains a mutation in the 3? untranslated region (3?-UTR) comprising a ?30 mutation that removes the TL-2 homologous structure in each of the dengue virus serotypes 1, 2, 3, and 4, and nucleotides additional to the ?30 mutation deleted from the 3?-UTR that removes sequence in the 5? direction as far as the 5? boundary of the TL-3 homologous structure in each of the dengue serotypes 1, 2, 3, and 4, or a replacement of the 3?-UTR of a dengue virus of a first serotype with the 3?-UTR of a dengue virus of a second serotype, optionally containing the ?30 mutation and nucleotides additional to the ?30 mutation deleted from the 3?-UTR; and immunogenic compositions, methods of inducing an immune response, and methods of producing a dengue virus or chimeric dengue virus.

Abstract: Aspects of the disclosure relate to enhanced check processing systems with improved check validation features and enhanced information security. A computing platform may determine whether a correlation between source data and metadata associated with a check exceeds a predetermined correlation threshold. Based on determining that the correlation does not exceed the predetermined correlation threshold, the computing platform may direct an OCR computing system to perform character recognition on the check. Then, the computing platform may determine whether a discrepancy between the metadata and an OCR output from the OCR computing system exceeds a predetermined resolution threshold. In response to determining that the discrepancy between the OCR output and the metadata does not exceed the predetermined resolution threshold, the computing platform may update stored records associated with the check.

Abstract: The present invention is a DNA expression vector comprising: a toxP; a mutant toxO that blocks Fe-mediated regulation of gene expression; and a DNA sequence encoding a protein, wherein the toxP and the mutant toxO regulate expression of the DNA segment encoding the protein. It is preferred that DNA expression vectors of the present invention include DNA sequences encoding a signal peptide so that a protein expressed is attached to the signal peptide prior to processing. Novel proteins are produced off of the DNA expression vector of the present invention.

Abstract: The invention relates to vaccine compositions including CEV serogroup immunogens, attenuated and inactivated viruses of the CEV serogroup and chimeric Bunyaviridae. Also disclosed are methods of treating or preventing CEV serogroup infection in a mammalian host, methods of producing a subunit vaccine composition or an immunogenic composition, isolated polynucleotides comprising a nucleotide sequence encoding a CEV serogroup immunogen, methods for detecting La Crosse virus (LACV) infection in a biological sample and infectious chimeric Bunyaviridae.

Abstract: A method for manufacturing hand tools, such as wrenches. The method generally includes the steps of providing a flat stock, cutting the flat stock into the desired two-dimension blank using a laser, and three-dimensionally machining the laser-cut 2D blank into the desired three-dimensional workpiece. The tool may undergo a heating treatment process and a surface treatment process. In the context of a wrench, the blank may be laser cut with a laser beam oriented to cut generally perpendicularly to the plane of the flat stock. After laser cutting, the handle and interface region between the handle and jaw(s) are machined to provide the desired three-dimensional shape. For example, the three-dimensional shape may be selected to provide a comfortable grip even when applying a high level of force. The wrench jaw may have an optimized geometry calculated so that there is no excess material or “over-designed” regions of the jaw. The wrench jaw has internal corners with optimized radii.

Abstract: Knitted fire barrier fabrics for use in forming a flame retardant articles having a core, include for example, a unitarily knitted form comprising a plurality of yarns. The plurality of yarns define the unitarily knitted form having a longitudinal knitted direction, and the unitarily knitted form includes a plurality of differential zones of knitted material extending side-by-side in the longitudinal knitted direction. The knitted fire barrier fabric is disposable on the core so that at least one of the plurality of differential zones of knitted material of the knitted fire barrier fabric provides a differential protective capacity to at least one selected portion of the flame retardant article.

Abstract: A method is provided for detecting intrusion into an optical cable of a single mode optical fiber network comprising where monitoring light signals are transmitted along a telecommunications optical fiber to be monitored either along a fiber additional to a data fiber or by multiplexing onto a common fiber. The received monitoring light signals after transmission along the telecommunications optical fiber are analyzed for changes indicative of movement of the optical fiber for detecting an intrusion event. The monitoring light signals at the receive end of the fiber signals are monitored by feeding the signals from the single mode fiber into a multi-mode fiber in a manner which causes changes in modal power distribution which can be detected by taking a portion only of the modes.

Abstract: A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines.

Abstract: A system and method for detecting multiple incidents in a set of flow meter units attached to a set of water consuming units. A plurality of uniquely identified flow meter units are operatively connected to a central control unit. The control unit is programmable to send alerts based on leaking incident status of particular flow meter units so that a responder may receive the alert and timely address the alert. The central control receives and stores data from the multiple flow meter units, including volumetric flow, time, and status and location of each alert. A method of detecting leaking in a building having multiple separate units, each unit having a unit water supply, includes placing a specially configured controller having a flow meter and automatic shut-off valve in each unit of the building. Leak sensors are positioned in water-leak risk areas wherein the controller communicates with both the flow meter and the sensors. A communication is established in between the controller and the sensors.

Abstract: A target spar. A left jaw member. The left guidance portion has a left spiral curve. The left arm portion has a left arm profile, a left arm gear, and a left arm protrusion. A right jaw member. The right guidance portion has a right spiral curve. The right arm portion comprises a right arm gear and a right arm protrusion. A top plate member. A bottom plate member. A drive unit comprising an electric motor within a pressure housing. A drive shaft on the electric motor. The bottom plate member abuts the left jaw member, the right jaw member, and the top plate member. The left jaw member and the right jaw member opened and closed. At the closed position, the target spar is slidably received in the left and right jaw members, the top and bottom plate members, and abuts the left and right arm profiles.

Abstract: The invention relates to vaccine compositions including CEV serogroup immunogens, attenuated and inactivated viruses of the CEV serogroup and chimeric Bunyaviridae. Also disclosed are methods of treating or preventing CEV serogroup infection in a mammalian host, methods of producing a subunit vaccine composition or an immunogenic composition, isolated polynucleotides comprising a nucleotide sequence encoding a CEV serogroup immunogen, methods for detecting La Crosse virus (LACV) infection in a biological sample and infectious chimeric Bunyaviridae.

Abstract: The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines.

Abstract: A method is provided for detecting intrusion into an optical cable of a single mode optical fiber network comprising where monitoring light signals are transmitted along a telecommunications optical fiber to be monitored either along a fiber additional to a data fiber or by multiplexing onto a common fiber. The received monitoring light signals after transmission along the telecommunications optical fiber are analyzed for changes indicative of movement of the optical fiber for detecting an intrusion event. The monitoring light signals at the receive end of the fiber signals are monitored by feeding the signals from the single mode fiber into a multi-mode fiber in a manner which causes changes in modal power distribution which can be detected by taking a portion only of the modes.

Abstract: Systems, methods, and computer-readable media for using an online resource to manage credentials on an electronic device are provided. In one example embodiment, a method, at an electronic device, includes, inter alia, receiving account data via an online resource, accessing commerce credential status data from a secure element of the electronic device, providing initial credential management option data via the online resource based on the received account data and based on the accessed commerce credential status data, in response to the providing, receiving a selection of an initial credential management option via the online resource, and changing the status of a credential on the secure element based on the received selection. Additional embodiments are also provided.

Abstract: Knitted fire barrier fabrics for use in forming a flame retardant article having a core include, for example, a plurality of flame-retardant yarns formed non-uniformly around a circumference of a knitting textile cylinder in a knitting process so as to define the knitted fire barrier fabric having at least one differential zone of material in a longitudinal direction of the knitting textile cylinder, and wherein the knitted fire barrier fabric being disposable on the core so that the at least one differential zone of material of the knitted fire barrier fabric providing a differential protective capacity to at least one selected portion of the flame retardant article.

Abstract: A tool for removal of a spring clip from a nut plate assembly includes an inner sleeve having a first cleat configured to engage a first end of a spring clip and an outer sleeve having a second cleat configured to engage a second end of the spring clip, the outer sleeve being rotatably disposed around a portion of the inner sleeve. The tool includes first and second grip tabs respectively extending radially from a longitudinally extending central axis of the inner sleeve and the outer sleeve. Movement of the first grip tab and the second grip tab towards each other rotates the inner sleeve relative to the outer sleeve, and causes the first cleat and the second cleat to rotate towards each other to engage the first and second ends of the spring clip and to enable the spring clip to be removed from an assembled nut plate.

Abstract: In some aspects, the disclosure relates to thermoset polymeric compositions consisting of functional bio-based epoxies and/or their derivatives (e.g. epoxidized vegetable oil(s)), along with carboxyl functional acrylics and/or polyesters. When cured, example compositions yield high performance products suitable for composite, coating, adhesive, sealant, and/or elastomer applications. When used in stone composite formulations with suitable fillers like quartz and titanium dioxide, example products have high hardness, very low water absorption, and high mechanical strength along with stain, chemical, and heat resistance. When used in coating formulations, example cured films have excellent adhesion, high gloss, clarity, toughness, low water absorption, solvent and chemical resistance, flexibility, and impact resistance without compromising hardness. Coating formulation properties may also include exterior durability.

Abstract: A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines.

Abstract: A computer-implement method may bundle insurance and financial products, and visually depict a current status for an application for each product within the bundle, such as applications related auto, home, life, or renters insurance, and/or vehicle loans. In one aspect, the method may determine a standard status icon or message for each product. A data server may receive a customer identification and selection of a first product offered, and determine a context of an application for the first product, wherein the context represents a state of progress of the application for the first product, and determine a standard status of the application corresponding to the context. The status is selected from a group of statuses standardized across two or more product lines sold by the company. The data server may further generate a status message including the status of the application and transmit the status message to a client device.

Abstract: The present invention relates to attenuated, immunogenic West Nile virus chimeras built on a dengue virus backbone for the production of immunogenic, live, attenuated West Nile virus vaccines.