Patents by Inventor R. Webb

R. Webb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and apparatus for ionization and desorption using a glow discharge
    Patent number: 7893408
    Abstract: A method for ionizing and desorbing a sample for analysis includes energizing a first and second electrode to produce a glow discharge at atmospheric pressure. The method further includes supplying a carrier gas to at least a portion of the glow discharge to create effluents thereof. The method further includes conducting the effluents of the glow discharge to the sample to ionize and desorb the sample for analysis. An associated apparatus is also disclosed.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: February 22, 2011
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Gary M. Hieftje, Steven J. Ray, Francisco J. Andrade, William C. Wetzel, Michael R. Webb, Gerardo Gamez, Jacob T. Shelley
  • Plant-made west nile virus (WNV) vaccines, vectors and plant codon optimized sequences
    Patent number: 7888069
    Abstract: The subject application provides various compositions of matter directed to West Nile virus (WNV) polypeptides and fragments thereof and polynucleotides, vectors and transformed host cells that encode, direct the expression of, or produce WNV polypeptides as set forth herein. Methods of using the polypeptides and polynucleotides for the production of immune responses in individuals or detecting the presence of WNV specific or neutralizing antibodies are also provided herein.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: February 15, 2011
    Assignees: Dow Agrosciences LLC, The United States of America as represented by the Secretary of Argriculture
    Inventors: Kelley A. Smith, Steven R. Webb, Steven L. Evans, Charles A. Mihaliak, Donald J. Merlo, Geoffrey J. Letchworth
  • NANOPARTICLE MEDIATED DELIVERY OF SEQUENCE SPECIFIC NUCLEASES
    Publication number: 20100311168
    Abstract: Provided are methods for introducing a sequence specific nuclease into a plant cell comprising a cell wall. Methods are provided for genetically or otherwise modifying plants and for treating or preventing disease in plant cells comprising a cell wall.
    Type: Application
    Filed: April 7, 2010
    Publication date: December 9, 2010
    Applicant: DOW AGROSCIENCES LLC
    Inventors: Jayakumar P. Samuel, Joseph F. Petolino, Narasimha C. Samboju, Steven R. Webb, Kerrm Y. Yau
  • COMPOUNDS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC MOIETIES TO NERVE CELLS
    Publication number: 20100266492
    Abstract: A compound for delivering a non-cytotoxic therapeutic moiety into nerve cells, the compound having the general formula: B-L-TM where: B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; TM is a therapeutic moiety which has a non-cytotoxic therapeutic effect when absorbed by a nerve cell; and L is a linker coupling B to TM.
    Type: Application
    Filed: March 29, 2010
    Publication date: October 21, 2010
    Inventors: Robert R. Webb, Constance A. McKee
  • CLOSTRIDIUM PERFRINGENS ALPHA TOXIN PROTEINS
    Publication number: 20100261884
    Abstract: This invention pertains in part to the development of a vaccine for poultry against necrotic enteritis (NE). The vaccine utilizes a protective antigen that is a mutated, full-length, non-toxic Clostridium perfringens (Cp) ?-toxin protein (Mcpa). Utility of this vaccine was demonstrated by reduction of lesion severity in NE challenge trails, for example. Also disclosed herein are novel approaches for producing this vaccine in significant quantities. One exemplified approach involves producing NE vaccine (mutated alpha toxin) in bacterial expression systems, preferably utilizing the Pseudomonas fluorescens system, for commercial use in controlling NE in the poultry industry. The subject vaccines can be administered preferably to chickens in several different ways. A novel, Type VI alpha toxin from chicken isolates of Cp is also disclosed.
    Type: Application
    Filed: June 23, 2010
    Publication date: October 14, 2010
    Applicant: Dow AgroSciences LLC
    Inventors: William M. Ainley, Janna Armstrong, Krishna Madduri, Donald J. Merlo, Kelley A. Smith, Mark A. Thompson, Steven R. Webb, Liu Y. Shen
  • Truck Bed Step and Method
    Publication number: 20100181741
    Abstract: The present disclosure is a truck bed step that has a mounting device secured to an inside wall of a tailgate. The truck bed step further has at least one collapsible step hingedly coupled to the mounting device that hingedly collapses and attaches to the mounting device while not in use.
    Type: Application
    Filed: January 16, 2009
    Publication date: July 22, 2010
    Inventor: Allen R. Webb
  • PRODUCTION OF PRODUCTS OF PHARMACEUTICAL INTEREST IN PLANT CELL CULTURES
    Publication number: 20100184128
    Abstract: The present invention relates to transgenic plant cell cultures comprising transgenic plant cells comprising a plurality of nucleic acids heterologous to said plant, each of said nucleic acids comprising a coding sequence encoding a pharmaceutical product of interest operably linked to one or more regulatory elements for directing expression of said coding sequence in said plant cell, said nucleic acids being stably integrated at or adjacent to native rDNA of said plant cell; methods of producing the transgenic plant cell culture; and methods of producing a pharmaceutical product of interest using the transgenic plant cell culture.
    Type: Application
    Filed: September 30, 2009
    Publication date: July 22, 2010
    Applicant: DOW AGROSCIENCES LLC
    Inventors: William M. Ainley, Steven R. Webb, Michael Lindenbaum, Steven Fabijanski, Ping Fu, Elizabeth-France Marillia
  • Polynucleotides encoding alpha toxin proteins
    Patent number: 7745175
    Abstract: This invention pertains in part to the development of a vaccine for poultry against necrotic enteritis (NE). The vaccine utilizes a protective antigen that is a mutated, full-length, non-toxic Clostridium perfringens (Cp) ?-toxin protein (Mcpa). Utility of this vaccine was demonstrated by reduction of lesion severity in NE challenge trails, for example. Also disclosed herein are novel approaches for producing this vaccine in significant quantities. One exemplified approach involves producing NE vaccine (mutated alpha toxin) in bacterial expression systems, preferably utilizing the Pseudomonas fluorescens system, for commercial use in controlling NE in the poultry industry. The subject vaccines can be administered preferably to chickens in several different ways. A novel, Type VI alpha toxin from chicken isolates of Cp is also disclosed.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: June 29, 2010
    Assignee: Dow AgroSciences LLC
    Inventors: William M. Ainley, Janna Armstrong, Krishna Madduri, Donald J. Merlo, Kelley A. Smith, Mark A. Thompson, Steven R. Webb, Liu Y. Shen
  • Compounds for intracellular delivery of therapeutic moieties to nerve cells
    Patent number: 7718605
    Abstract: A compound for delivering a non-cytotoxic therapeutic moiety into nerve cells, the compound having the general formula: B-L-TM where: B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; TM is a therapeutic moiety which has a non-cytotoxic therapeutic effect when absorbed by a nerve cell; and L is a linker coupling B to TM.
    Type: Grant
    Filed: May 7, 2008
    Date of Patent: May 18, 2010
    Assignee: Manzanita Pharmaceuticals, Inc.
    Inventors: Robert R. Webb, Constance A. McKee
  • Compounds for intracellular delivery of therapeutic moieties to nerve cells
    Patent number: 7678378
    Abstract: A compound for delivering a non-cytotoxic therapeutic moiety into nerve cells, the compound having the general formula: B-L-TM where: B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; TM is a therapeutic moiety which has a non-cytotoxic therapeutic effect when absorbed by a nerve cell; and L is a linker coupling B to TM.
    Type: Grant
    Filed: August 28, 2003
    Date of Patent: March 16, 2010
    Assignee: Manzanita Pharmaceuticals, Inc.
    Inventors: Robert R. Webb, Constance A. McKee
  • COMPOUNDS FOR DELIVERY OF THERAPEUTIC AND IMAGING MOIETIES TO NERVE CELLS
    Publication number: 20090286732
    Abstract: The invention features compounds of the general formula: B-L-M where B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; M is a moiety which performs a useful non-cytotoxic function when absorbed by a nerve cell, and can be a therapeutic moiety or an imaging moiety; and L is a linker coupling B to M. The invention also features methods of use of the compounds in, for example, treating conditions such as viral infections and pain, as well as in labeling nerve cells.
    Type: Application
    Filed: November 25, 2008
    Publication date: November 19, 2009
    Inventors: Gordon Craig Hill, Stephen B. Kahl, Robert R. Webb, Constance A. McKee
  • COMPOUNDS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC MOIETIES TO NERVE CELLS
    Publication number: 20090124547
    Abstract: A compound for delivering a non-cytotoxic therapeutic moiety into nerve cells, the compound having the general formula: B-L-TM where: B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; TM is a therapeutic moiety which has a non-cytotoxic therapeutic effect when absorbed by a nerve cell; and L is a linker coupling B to TM.
    Type: Application
    Filed: May 7, 2008
    Publication date: May 14, 2009
    Inventors: Robert R. Webb, Constance A. McKee
  • Compositions and methods for detecting and treating atherosclerosis
    Patent number: 7521198
    Abstract: Methods for detecting atherosclerotic plaque and quantifying the amount of Group V sPLA2 in plasma are disclosed. These methods can be used to assess the risk of cardiovascular pathology in a patient.
    Type: Grant
    Filed: May 27, 2003
    Date of Patent: April 21, 2009
    Assignee: University of Kentucky Research Foundation
    Inventors: Nancy R. Webb, Frederick C. DeBeer
  • PLANT-MADE WEST NILE VIRUS (WNV) VACCINES, VECTORS AND PLANT CODON OPTIMIZED SEQUENCES
    Publication number: 20090069229
    Abstract: The subject application provides various compositions of matter directed to West Nile virus (WNV) polypeptides and fragments thereof and polynucleotides, vectors and transformed host cells that encode, direct the expression of, or produce WNV polypeptides as set forth herein. Methods of using the polypeptides and polynucleotides for the production of immune responses in individuals or detecting the presence of WNV specific or neutralizing antibodies are also provided herein.
    Type: Application
    Filed: December 21, 2007
    Publication date: March 12, 2009
    Inventors: Kelley A. Smith, Steven R. Webb, Steven L. Evans, Charles A. Mihaliak, Donald J. Merlo, Geoffrey Letchworth
  • Human G Protein-Coupled Receptor and Modulators Thereof for the Treatment of Hyperglycemia and Related Disorders
    Publication number: 20080306114
    Abstract: The present invention relates to methods of identifying whether one or more candidate compounds is a modulator of a G protein-coupled receptor (GPCR) or a modulator of blood glucose concentration. In certain embodiments, the GPCR is human. The present invention also relates to methods of using a modulator of the GPCR. A preferred modulator is agonist. Agonists of the invention are useful as therapeutic agents for lowering blood glucose concentration, for preventing or treating certain metabolic disorders, such as insulin resistance, impaired glucose tolerance, and diabetes, and for preventing or treating a complication of an elevated blood glucose concentration, such as atherosclerosis, heart disease, stroke, hypertension and peripheral vascular disease.
    Type: Application
    Filed: April 12, 2005
    Publication date: December 11, 2008
    Applicant: Arena Pharmaceuticals, Inc
    Inventors: Jun Qiu, Robert R. Webb, David J. Unett, Joel E. Gatlin, Daniel T. Connolly
  • MHC class II antigen-presenting systems and methods for activating CD4T cells
    Patent number: 7439335
    Abstract: The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+ T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.
    Type: Grant
    Filed: April 8, 2004
    Date of Patent: October 21, 2008
    Assignee: The Scripps Research Institute
    Inventors: Susan R. Webb, Ola Winqvist, Lars Karlsson, Michael R. Jackson, Per A. Peterson
  • Methods and apparatus for ionization and desorption using a glow discharge
    Publication number: 20080202915
    Abstract: A method for ionizing and desorbing a sample for analysis includes energizing a first and second electrode to produce a glow discharge at atmospheric pressure. The method further includes supplying a carrier gas to at least a portion of the glow discharge to create effluents thereof. The method further includes conducting the effluents of the glow discharge to the sample to ionize and desorb the sample for analysis. An associated apparatus is also disclosed.
    Type: Application
    Filed: October 31, 2007
    Publication date: August 28, 2008
    Inventors: Gary M. Hieftje, Steven J. Ray, Francisco J. Andrade, William C. Wetzel, Michael R. Webb, Gerardo Gamez
  • VOLUME-FILLING MECHANICAL ASSEMBLIES AND METHODS OF OPERATING THE SAME
    Publication number: 20080200570
    Abstract: A method of operating a volume-filling structure, comprising sensing an impact event and expanding the volume-filling structure from a non-expanded state to an expanded state upon the sensed impact event. The volume-filling structure comprises an open celled material, a first end cap connected to one end of the open celled material and a second end cap connected to a second end of the open celled material. The volume-filling structure further includes an activation mechanism regulating expansion of the open celled material from the non-expanded state to expanded state in response to an activation signal, and the activation mechanism includes an actuator interfaced with the end caps. Embodiments may include triggering a pneumatic device to force the second end cap from the first end cap. Additionally, embodiments may include triggering a mechanical event to force the second end cap from the first end cap.
    Type: Application
    Filed: May 1, 2008
    Publication date: August 21, 2008
    Applicant: GM GLOBAL TECHNOLOGY OPERATIONS, INC.
    Inventors: Alan L. Browne, Ching-Shan Cheng, Nancy L. Johnson, Gary L. Jones, Scott R. Webb, Francis D. Wood, Ruth M. Gusko, Chin-Hsu Lin
  • MHC class II antigen-presenting systems and methods for activating CD4T cells
    Patent number: 7402430
    Abstract: The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules with one or more accessory molecules. The matrices are used to activate naive CD4+ T cells as well as shift the ongoing activation state into a preferred differentiated population of either Th1 or Th2 cells.
    Type: Grant
    Filed: July 29, 2004
    Date of Patent: July 22, 2008
    Assignee: The Scripps Research Institute
    Inventors: Susan R. Webb, Ola Winqvist, Lars Karlsson, Michael R. Jackson, Per A. Peterson
  • Volume-filling mechanical assemblies and methods of operating the same
    Patent number: 7401846
    Abstract: A volume-filling mechanical structure for modifying a crash or impact comprising a honeycomb celled material expandable from a compact state to a expanded state and methods for operating the same.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: July 22, 2008
    Assignee: GM Global Technology Operations, Inc.
    Inventors: Alan L. Browne, Ching-Shan Cheng, Nancy L. Johnson, Gary L. Jones, Scott R. Webb, Francis D. Wood, Ruth M. Gusko, Chin-Hsu Lin