Patents by Inventor R. Webb

R. Webb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HUMAN PAPILLOMAVIRUS E7 ANTIGEN COMPOSITIONS AND USES THEREOF
    Publication number: 20130209402
    Abstract: The present invention relates to human papillomavirus E7 antigen compounds and compositions for treating human papillomavirus infection and associated conditions. The invention provides, in part, polypeptide and nucleic acid molecules including sequences substantially identical to the sequences of two or more human papillomavirus (HPV) E7 antigens, where the E7 antigens are selected from at least two different HPV strains, and methods of using the same.
    Type: Application
    Filed: July 15, 2011
    Publication date: August 15, 2013
    Applicant: BRITISH COLUMBIA CANCER AGENCY BRANCH
    Inventors: John R. Webb, Darin Arne Wick
  • Compounds for Delivery of Therapeutic And Imaging Moieties to Nerve Cells
    Publication number: 20130123175
    Abstract: The invention features compounds of the general formula: B-L-M where B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; M is a moiety which performs a useful non-cytotoxic function when absorbed by a nerve cell, and can be a therapeutic moiety or an imaging moiety; and L is a linker coupling B to M. The invention also features methods of use of the compounds in, for example, treating conditions such as viral infections and pain, as well as in labeling nerve cells.
    Type: Application
    Filed: June 27, 2012
    Publication date: May 16, 2013
    Inventors: G. Craig Hill, Stephen B. Kahl, Robert R. Webb, Constance A. McKee
  • PUMPING ASSEMBLY USING ACTIVE MATERIALS
    Publication number: 20130098029
    Abstract: A pumping assembly is provided. The assembly includes a first movable element selectively movable within a first pump housing and an actuator including an active material. The active material is configured to undergo a change in attribute in response to an activation signal. The active material is operatively connected to the first movable element such that the change in attribute causes the first movable element to move within the first pump housing. In one example, the active material is a shape memory alloy material having a crystallographic phase that is changeable between Austenite and Martensite in response to the activation signal.
    Type: Application
    Filed: October 25, 2011
    Publication date: April 25, 2013
    Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Nicholas W. Pinto, IV, Scott R. Webb, Paul W. Alexander, Thomas W. Cox, Xiujie Gao
  • PROTECTIVE DEVICE FOR VEHICLE WIPER ASSEMBLY
    Publication number: 20130069387
    Abstract: A protective device for a vehicle wiper assembly is provided. The protective device is configured to selectively at least partially cover the wiper assembly and prevent the wiper assembly from being pulled away from the vehicle. For example, the protective device may prevent entanglement of the wiper assembly with external elements such as those found in automatic car wash facilities. The device may include a member movable between first and second positions such that the member in the second position is configured to at least partially cover or encapsulate the wiper assembly. An active material actuator may be used to move the member between the first and second positions. In another embodiment, the device includes a member operatively connected to and configured to stiffen a pivot point of the wiper assembly.
    Type: Application
    Filed: September 21, 2011
    Publication date: March 21, 2013
    Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Scott R. Webb, Nicholas W. Pinto, IV, Paul W. Alexander, Wendell G. Summerville
  • ELECTRONIC VEHICLE WIPER BLADE PARKING MECHANISM
    Publication number: 20130042426
    Abstract: A vehicle wiper assembly includes a wiper blade configured to wipe a surface, an armature, and an actuator. The armature has a first end spaced from a second end, and is coupled with the wiper blade at the first end, and coupled to a pivot mechanism at the second end. The pivot mechanism is configured to allow the wiper blade to articulate about the second end in a direction substantially away from the surface and between a wiping position and a parked position. The actuator is provided in mechanical communication with the armature and is configured to receive an electrical actuation signal to transition the wiper blade between a wiping position and the parked position, where the wiper blade is in contact with the surface while in the wiping position, and is separated from the surface while in the parked position.
    Type: Application
    Filed: August 17, 2011
    Publication date: February 21, 2013
    Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: SCOTT R. WEBB, NICHOLAS W. PINTO, IV, PAUL W. ALEXANDER, XIUJIE GAO, WENDELL G. SUMMERVILLE, SCOTT P. CHARNESKY, THOMAS W. COX, KHRISTOPHER S. LEE
  • SHAPE MEMORY ALLOY-BASED DEVICE FOR CONTROLLING OR MONITORING PRESSURE IN A SYSTEM
    Publication number: 20130000776
    Abstract: A device is provided that may be adapted to control or monitor the pressure level of a fluid system. The device includes a member composed of a shape memory alloy in a superelastic state. The member is configured to undergo a phase change from a high modulus Austenitic phase to a low modulus Martensitic phase and stretch in response to an activation stress. In one embodiment, the member defines two ends such that one end of the member is operatively connected to a fixed point. Another end of the member is operatively connected to a movable element. As the member stretches in response to the activation stress, the movable element is translated relative to the fixed point. In another embodiment, the member includes two plates with respective holes that are selectively aligned when the first and second plates stretch or deform in response to the activation stress.
    Type: Application
    Filed: June 30, 2011
    Publication date: January 3, 2013
    Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Nancy L. Johnson, Alan L. Browne, Xiujie Gao, Paul W. Alexander, Nicholas W. Pinto, IV, Richard J. Skurkis, Scott R. Webb
  • ENHANCED VEHICLE WIPER BLADE USING ACTIVE MATERIALS
    Publication number: 20120324671
    Abstract: A vehicle wiper assembly includes a wiper blade having a length, and an active material disposed along the length of the wiper blade and coupled thereto. The active material includes a shape memory alloy material with a crystallographic phase that is changeable between austenite and martensite, and is elastically deformable and operatively applies a spring force against a portion of the wiper blade when the crystallographic phase is martensite.
    Type: Application
    Filed: June 23, 2011
    Publication date: December 27, 2012
    Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Nicholas W. Pinto, IV, Scott R. Webb, Alan L. Browne, Paul W. Alexander, Xiujie Gao, Nancy L. Johnson, Wendell G. Summerville, John A. Cafeo
  • VEHICLE WIPER BLADE INCLUDING ACTIVE MATERIAL DE-ICER
    Publication number: 20120324672
    Abstract: A wiper assembly includes a wiper blade having a length and an active material actuator provided along a portion of the length of the wiper blade and coupled thereto. The active material actuator is configured to impart a degree of motion to a portion of the wiper blade in response to an electrical actuation signal.
    Type: Application
    Filed: June 23, 2011
    Publication date: December 27, 2012
    Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Nicholas W. Pinto, IV, Scott R. Webb, Paul W. Alexandrer, Alan L. Browne, Nancy L. Johnson, Wendell G. Summerville, John A. Cafeo
  • CAM PHASER LOCKING SYSTEMS
    Publication number: 20120318220
    Abstract: A motion limiter system for a cam phaser includes a retractable motion limiter pin that is selectively extendable from a rotor in a cam phaser to contact a lobe on a stator to provide a positive stop for the rotor prior to engagement of a locking pin. Alternatively, the cam phaser may include two pins that are selectively extendable from opposite openings in a hole in the rotor to engage seats that are slightly offset from one another.
    Type: Application
    Filed: May 3, 2012
    Publication date: December 20, 2012
    Applicant: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: William P. Vukovich, Gerald R. Stabel, Brian R. Webb
  • QUANTUM DOT CARRIER PEPTIDE CONJUGATES SUITABLE FOR IMAGING AND DELIVERY APPLICATIONS IN PLANTS
    Publication number: 20120244569
    Abstract: Provided are methods for introducing a molecule of interest into a plant cell having a cell wall by using a QD-peptide conjugate having a quantum dot (QD) with one or more cell penetrating peptides (CPPs). Methods are provided for genetically or otherwise modifying plants and for treating or preventing disease in plant cells comprising a cell wall.
    Type: Application
    Filed: March 22, 2012
    Publication date: September 27, 2012
    Applicant: DOW AGROSCIENCES LLC
    Inventors: Jayakumar P. SAMUEL, Narasimha C. SAMBOJU, Kerrm Y. YAU, Gaofeng LIN, Steven R. WEBB, Frank BURROUGHS
  • MULTIFUNCTIONAL SCAFFOLDING AND PUSHCART CONVERTIBLE UTILITY DEVICE
    Publication number: 20120222913
    Abstract: A multi-functional utility apparatus that is convertible between a scaffold configuration and a pushcart configuration. A pivotal coupling assembly between first and second subframes allows the subframes to be expanded for use as a scaffolding or collapsed for use as a pushcart.
    Type: Application
    Filed: December 1, 2011
    Publication date: September 6, 2012
    Inventors: David C. CALVERT, Christopher R. WEBB, Tsailu LIU, Paul W. HOLLEY, Michael K. THOMPSON, W. Travis LONTZ, Grant L. BITTLE
  • Compounds for delivery of therapeutic and imaging moieties to nerve cells
    Patent number: 8232251
    Abstract: The invention features compounds of the general formula: B-L-M where B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; M is a moiety which performs a useful non-cytotoxic function when absorbed by a nerve cell, and can be a therapeutic moiety or an imaging moiety; and L is a linker coupling B to M. The invention also features methods of use of the compounds in, for example, treating conditions such as viral infections and pain, as well as in labeling nerve cells.
    Type: Grant
    Filed: November 25, 2008
    Date of Patent: July 31, 2012
    Assignee: Manzanita Pharmaceuticals, Inc.
    Inventors: G. Craig Hill, Stephen B. Kahl, Robert R. Webb, Constance A. McKee
  • STACKABLE SEMICONDUCTOR CHIP WITH EDGE FEATURES AND METHODS OF FABRICATING AND PROCESSING SAME
    Publication number: 20120133381
    Abstract: A method of performing a function on a three-dimensional semiconductor chip package as well as on individual chips in the package is disclosed. That method involves the creation of an operative relationship between a function performer and an edge feature on the chip or chips wherein the edge feature consists of one or more of an electrically conductive pad, thermally conductive pad, a probe pad, a fuse, a resistor, a capacitor, an inductor, an optical emitter, an optical receiver, a test pad, a bond pad, a contact pin, a heat dissipator, an alignment marker, a metrology feature and a function performer may be any one or more of a test probe, the laser, a programming device, an interrogation device, a loading device or a tuning device. In addition, a chip per se with edge features is disclosed along with a three-dimensional stack of such chips in either of several different configurations.
    Type: Application
    Filed: November 30, 2010
    Publication date: May 31, 2012
    Applicant: ELECTRO SCIENTIFIC INDUSTRIES, INC.
    Inventors: Kelly BRULAND, Timothy R. WEBB, Andy E. HOOPER, John R. CARRUTHERS
  • Spectroscopic imaging microscopy
    Patent number: 8189191
    Abstract: Disclosed herein are systems that include: (a) an objective lens system configured to collect light from a sample; (b) a first aperture positioned to allow a portion of the collected light received from the objective lens system to pass as input light; (c) a first lens positioned to transmit the input light received from the first aperture; (d) a dispersive element configured to spatially disperse the input light received from the first lens in a first plane; (e) a second lens positioned to transmit the spatially dispersed light; (f) a second aperture positioned to allow a portion of the spatially dispersed light received from the second lens to pass as detection light; and (g) a detector positioned to receive the detection light and configured to form at least one image of the sample.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: May 29, 2012
    Assignee: Tufts University
    Inventors: Michael R. Webb, Christopher Lafratta, David R. Walt
  • ACTIVE DRAIN PLUG FOR HIGH VOLTAGE BATTERY APPLICATIONS
    Publication number: 20120104292
    Abstract: A drain plug assembly that has particular application for sealing a drain hole in a high voltage battery compartment on a vehicle. The plug assembly includes a plug that inserted into the drain hole. The plug assembly further includes a return spring coupled to the plug and causing the plug to be biased into the drain hole. The plug assembly also includes at least one shape memory alloy device coupled to the plug and a support structure. The SMA device receives an electrical current that causes the device to contract and move the plug out of the drain hole against the bias of the return spring.
    Type: Application
    Filed: October 27, 2010
    Publication date: May 3, 2012
    Applicant: GM GLOBAL TECHNOLOGY OPERATIONS, INC.
    Inventors: Craig A. Kollar, Xiujie Gao, Alan L. Browne, Paul W. Alexander, Nancy L. Johnson, Shawn G. Quinn, Milind S. Gandhi, Scott R. Webb
  • PROTEASE INHIBITORS
    Publication number: 20120108529
    Abstract: Compounds useful as protease inhibitors are provided, as are methods of use and preparation of such compounds and compositions containing such compounds. In one embodiment, the compounds are useful for inhibiting HIV protease enzymes, and are therefore useful in slowing the proliferation of HIV.
    Type: Application
    Filed: May 14, 2010
    Publication date: May 3, 2012
    Inventors: Robert R. Webb, II, Mitchell W. Mutz, Kenneth J. Barr
  • Compounds for intracellular delivery of therapeutic moieties to nerve cells
    Patent number: 8138155
    Abstract: A compound for delivering a non-cytotoxic therapeutic moiety into nerve cells, the compound having the general formula: B-L-TM where: B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; TM is a therapeutic moiety which has a non-cytotoxic therapeutic effect when absorbed by a nerve cell; and L is a linker coupling B to TM.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: March 20, 2012
    Assignee: Manzanita Pharmaceuticals, Inc.
    Inventors: Robert R. Webb, Constance A. McKee
  • LINEAR DNA MOLECULE DELIVERY USING PEGYLATED QUANTUM DOTS FOR STABLE TRASFORMATION IN PLANTS
    Publication number: 20120023619
    Abstract: Methods for introducing a linear nucleic acid molecule of interest into a cell comprising a cell wall include use of nanoparticles coated with polyethylene glycol. In some embodiments, the cell comprising a cell wall is a plant cell. Methods include genetically or otherwise modifying plants and for treating or preventing disease in plant cells comprising a cell wall. Transgenic plants include a nucleic acid molecule of interest produced by regeneration of whole plants from plant cells transformed with linear nucleic acid molecules.
    Type: Application
    Filed: July 7, 2011
    Publication date: January 26, 2012
    Applicant: DOW AGROSCIENCES LLC
    Inventors: Narasimha C. Samboju, Kerrm Y. Yau, Frank Burroughs, Jayakumar P. Samuel, Steven R. Webb
  • PRODUCTION OF FUNCTIONALIZED LINEAR DNA CASSETTE AND QUANTUM DOT/NANOPARTICLE MEDIATED DELIVERY IN PLANTS
    Publication number: 20120023620
    Abstract: Methods for introducing a functionalized linear nucleic acid cassette molecule of interest into a plant cell comprising a cell wall include use of nanoparticles. In some embodiments, the cell comprising a cell wall is a cultured plant cell. Methods include genetically or otherwise modifying plant cells and for treating or preventing disease in any plant, especially crop plants. Transgenic plants include a nucleic acid molecule of interest produced by regeneration of whole plants from plant cells transformed with functionalized linear nucleic acid cassette molecules.
    Type: Application
    Filed: July 7, 2011
    Publication date: January 26, 2012
    Applicant: DOW AGROSCIENCES LLC
    Inventors: Kerrm Y. Yau, Jayakumar P. Samuel, Frank Burroughs, Narasimha C. Samboju, Steven R. Webb
  • INDUCTION OF MUCOSAL IMMUNE RESPONSES BY MUCOSAL DELIVERY PENTABODY COMPLEX (MDPC)
    Publication number: 20110318348
    Abstract: The subject invention provides, for example, a novel approach to specifically induce intranasal and/or oral mucosal as well as humoral antibody response by administrating a mucosal delivery pentabody complex (MDPC). The MDPC is a complex formed by mixing a target antigen and a mucosal delivery pentabody (MDP) that has a strong affinity to the target antigen. The MDP is a fusion protein of a single domain antibody (sdAb; which binds to the target antigen specifically) to a pentamerization domain (which can include the B-subunit of an AB5 toxin family, including the B subunit of cholera toxin (CT) or heat-labile toxin (LT)). The pentamerization domain can self-assemble into a pentamer, through which a pentameric single domain antibody, or a pentabody, is formed.
    Type: Application
    Filed: October 13, 2009
    Publication date: December 29, 2011
    Applicants: National Research Council of Canada, Dow AgroSciences LLC
    Inventors: Jianbing Zhang, Matthew J. Henry, Wangxue Chen, Steven R. Webb