Abstract: A system, apparatus, and method for installing fasteners are disclosed involving a fastener installation tool and a socket assembly. The fastener installation tool comprises a tool component and a gear head. The gear head comprises a lever, a retaining slide, a retaining slide housing, and at least one gear. The socket assembly comprises a socket, a hex key, and a hex key retainer. An end of the drive shaft of the socket has an annular groove around the circumference of the exterior surface of the drive shaft. When the retaining slide is slid into a locked position, the retaining slide engages the annular groove of the drive shaft of the socket, thereby attaching the drive shaft of the socket to the gear head of the fastener installation tool. A socket gear of the gear head matingly engages the drive shaft of the socket to rotate the socket.

Abstract: Methods, systems, and computer program products for analyzing an imaging system or an image produced by the imaging system are disclosed. The imaging system is configured to sense a target on a background and the target, background, and imaging system are associated with spatial information and spectral information. The imaging system or image is analyzed by, first, determining two of a spatial confidence level associated with the spatial information, a spectral confidence level associated with the spectral information, and a total confidence level associated with sensing the target on the background. A non-determined one of the spatial confidence level, the spectral confidence level, and the total confidence level is then calculated responsive to the determined confidence levels for use in analyzing the imaging system or image.

Abstract: A bathing apparatus includes an in-line mixing unit and a hand operated injecting unit. The mixing unit is coupled between a water supply pipe and a water dispensing device, such as a showerhead and is in fluid communication with the hand operated injection unit. The injection unit, upon user demand, draws a controllable predetermined quantity of bathing fluid from a standard off the shelf purchased bottle of bathing fluid, such as a bottle of bath oil, and then ejects, upon user demand and in a hands free operation, the drawn bathing fluid, at a user selected flow rate. The ejected bathing fluid passes to the mixing unit which causes the ejected bathing fluid to be mixed within a stream of water being delivered to the water dispensing device.

Abstract: The present invention relates to novel substituted imidazo[1,2-b]pyridazine compounds of Formula (I): pharmaceutical compositions thereof, and the use such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric disorders and neurological diseases.

Abstract: The present invention is directed to compounds represented by the following structural Formula (I), (a) R1 is selected from the group consisting of hydrogen, substituted or unsubstituted group selected from C1-C8 alkyl, aryl-C0-4-alkyl, heteroaryl-C0-4-alkyl, C3-C6 cycloalkylaryl-C0-2-alkyl, and —CH2—C(O)—R17-R18, wherein R17 is O or NH and R18 is optionally substituted benzyl; (b) R2 is selected from the group consisting of C1-C6 alkyl, C1-C6 alkenyl, aryl-C0-4-alkyl, heteroaryl-C0-4-alkyl, C1-C4 alkyl sulfonamide, C1-C4 alkyl amide, OR10 and C3-C6 cycloalkyl; (c) W is O or S; (d) X is an optionally substituted C1-C5 alkylene linker wherein one carbon atom of the linker may optionally be replaced with O, NH, S, and optionally two carbons together may form a double bond; (e) Y is selected from the group consisting of C, O, S, NH and a single bond; and (f) E is selected from the group consisting of C(R3)(R4)A, A, and a substituted or unsubstituted group selected from the group consisting of (CH2)n COOR19.

Abstract: A system and method for detection of alpha particles generated by a test material in proximity to a light atomic weight element. The system includes a neutron detector that is configured to detect a rate of generation of neutrons produced by an (alpha, n) reaction between the test material and the light atomic weight element. There is also at least one gamma-ray detector configured to measure a rate of generation of 511 keV gamma rays produced by an annihilation reaction triggered by a positron emission from a daughter product of the light atomic weight element. A comparator is configured to compare the rate of generation of neutrons and the rate of generation of 511 keV gamma rays.

Abstract: The present invention provides methods of inducing contraception which includes delivering to a female a composition containing a compound of formula I, or tautomers thereof, in a regimen which involves delivering one or more of a selective estrogen receptor modulator, wherein formula I is: and wherein R1-R5 and Q1 are defined as described herein. Methods of providing hormone replacement therapy and for treating carcinomas, dysfunctional bleeding, uterine leiomyomata, endometriosis, and polycystic ovary syndrome is provided which includes delivering a compound of formula I and a selective estrogen receptor modulator are also described.

Abstract: The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is a substituted or unsubstituted group selected from C1-C8 alkyl, aryl-C0-2-alkyl, heteroaryl-C0-2-alkyl, C3-C6 cycloalkylaryl-C0-2-alkyl or phenyl. W is O or S. R2 is H or a substituted or unsubstituted group selected from C1-C6 alkyl, C3-C6 cycloalkyl and heteroaryl. X is a C2-C5 alkylene linker wherein one carbon atom of the linker may be replaced with O, NH or S. Y is C, O, S, NH or a single bond. Furthermore, E is (CH2)nCOOH, wherein n is 0, 1, 2 or 3, or C(R3)(R4)A, wherein A is an acidic functional group such as carboxyl, carboxamide substituted or unsubstituted sulfonamide, or substituted or unsubstituted tetrazole. R3 is H, saturated or unsaturated C1-C5 alkyl, C1-C5 alkoxy.

Abstract: A light unit that includes an internal power supply that may be used in the event of an external power failure to provide power to the light unit. In one aspect, the present disclosure provides a lighting apparatus, comprising (a) a power input configured to receive external power from an external power source; (b) a solid state light element that is interconnected to the power input; and (c) a back-up power source that is interconnected to the solid state light element and the power input and that provides power to the solid state light element when the light element is not provided with power from the power input.

Abstract: The present invention provides methods of inducing contraception which includes delivering to a female a composition containing a compound of formula I, or tautomers thereof, in a regimen which involves delivering one or more of a selective estrogen receptor modulator, wherein formula I is: and wherein R1-R5 and Q1 are defined as described herein. Methods of providing hormone replacement therapy and for treating carcinomas, dysfunctional bleeding, uterine leiomyomata, endometriosis, and polycystic ovary syndrome is provided which includes delivering a compound of formula I and a selective estrogen receptor modulator are also described.

Abstract: An optical parametric oscillator includes a source of coherent energetic pump optical signals and an optical resonator cavity which includes a set of optical parametric amplifying (OPA) crystals and a set of optical elements such as mirrors disposed along an optical path. The optical elements are configured (1) to direct an oscillation optical signal generated by the OPA crystals along the optical path, (2) to provide input coupling of the energetic pump optical signals such that each energetic pump optical signal travels through only one of the OPA crystals to result in a corresponding depleted pump optical signal, and (3) to provide output coupling of the depleted pump optical signals to prevent each depleted pump optical signal from traveling through more than one of the OPA crystals. Resonator cavities have multiple-leg configurations, including “L” and “U” shapes, and either linear (or standing-wave) or ring architectures.

Abstract: An inflatable noisemaker comprising a tubular envelope having first and second ends and constructed to enclose a gas under pressure. A sealable opening is disposed proximate the first end for inflating the envelope. An active light emitting module is enclosed within a transparent chamber disposed within the envelope and configured with an activation device. The active light emitting module may comprise first and second cells stacked in series polarity, a removable insulating strip disposed between the first and second cells, and a light emitting device (LED) having first and second leads coupled to respective negative and positive terminals of the stacked cells. A housing including a spring for biasing the LED, the cells, and the insulating strip together may be provided. In an alternate embodiment, a single cell and a switch may be used in the active light emitting module.

Abstract: A new and distinct regal pelargonium cultivar is disclosed that is with compact, self-branching (without pinching) and early flowering. The flowers are light lavender with a dark pink swirl on all petals.

Abstract: Light units are provided that have a number of different features. In one aspect a light unit comprising a substrate and a display interconnected to the substrate is provided. The substrate includes a power source, a plurality of light elements, a controller operably interconnected to the power source and light elements that activates the light elements to one or more illumination states, and a communications module operably interconnected to the controller and power source. The communications module receives wireless communications and provides information from the wireless communications to the controller, wherein the controller activates the light elements according to information received from the communications module when the communications module receives information related to the activation of the light elements. Other aspects are also disclosed.

Abstract: The present invention relates to novel substituted imidazo[1,2-b]pyridazine compounds of Formula (I): pharmaceutical compositions thereof, and the use such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric disorders and neurological diseases.

Abstract: The present invention provides a process for selectively acylating an A82846A, A82846B, A82846C or PA-42867-A glycopeptide at the N1, N2 or N3 positions and the monoacylated compounds prepared therefrom.

Abstract: A method for generating a software model of a dynamic system takes as input a preliminary software model of the system. Normally, the preliminary software model is based on a system model that is generated by a system designer within a modeling environment. Generally speaking, the preliminary software model does not allow access to the internal variables of the system model from outside the modeling environment, but nonetheless may be executed on a computer platform in the absence of the modeling environment. Interface software is then produced which exposes the internal variables of the system model. The resulting software model, built from both the preliminary software model and the interface software, allows programmatic access to its internal variables, and potentially allows execution control, from outside the modeling environment, thus typically enhancing detailed simulation of the system model beyond the capabilities provided by the modeling environment.

Abstract: The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is a substituted or unsubstituted group selected from C1-C8 alkyl, aryl-C0-2-alkyl, heteroaryl-C0-2-alkyl, C3-C6 cycloalkylaryl-C0-2-alkyl or phenyl. W is O or S. R2 is H or a substituted or unsubstituted group selected from C1-C6 alkyl, C3-C6 cycloalkyl and heteroaryl. X is a C2-C5 alkylene linker wherein one carbon atom of the linker may be replaced with O, NH or S. Y is C, O, S, NH or a single bond. Furthermore, E is (CH2)nCOOH, wherein n is 0, 1, 2 or 3, or C(R3)(R4)A, wherein A is an acidic functional group such as carboxyl, carboxamide substituted or unsubstituted sulfonamide, or substituted or unsubstituted tetrazole. R3 is H, saturated or unsaturated C1-C5 alkyl, C1-C5 alkoxy.

Abstract: An improved air diffuser is provided, including a housing having a bottom and an upwardly extending side wall with air slots to receive air. The housing supports a grille, and a flow regulator fits within the housing. The diffuser is configured to be secured to a floor by a mounting assembly, including a trim ring and a plurality of retaining mechanisms. The trim ring defines a flange and brackets for receiving the retaining mechanisms. Each retaining mechanism defines an L-shaped mount having horizontal and vertical legs. A cantilevered latch extends from a back of the vertical leg so that, when the vertical leg is inserted into one of the brackets, the latch secures the retaining mechanism to the bracket. The horizontal leg and the flange of the trim ring define a space therebetween for engaging a floor and thereby securing the housing to the floor.

Abstract: A new and distinct regal pelargonium cultivar is disclosed that is with compact, self-branching (without pinching) and early flowering. The flowers are light lavender with a dark pink swirl on all petals.