Patents by Inventor Richard A. Craig

Richard A. Craig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5863946
    Abstract: Compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein Y is selected from halogen, alkyl, and haloalkyl; n is 0, 1, 2, or 3; X is absent or is alkylene; A is absent or is selected from optionally substituted alkylene, optionally substituted cycloalkylene, optionally substituted cycloalkylene wherein one or two of the carbon atoms is replaced with one or two heteroatoms independently selected from O, S, and N, optionally substituted alkenylene, and ##STR2## or R.sup.2 and A together define a saturated 5- to 8-membered optionally substituted carbocyclic or heterocyclic ring to which the group Z is attached; Z is selected from (a) hydrogen, (b) COM wherein M is selected from the group consisting of --OR.sup.5, a pharmaceutically acceptable cation, --NR.sup.7 R.sup.8, and a pharmaceutically acceptable, metabolically cleavable group, (c) --OR.sup.3, (d) tetrazolyl, (e) --CH(OR.sup.3)--CH.sub.2 OR.sup.9, (f) --CH(OR.sup.3)--CH.sub.2 --CH.sub.2 OR.sup.9, (g) --CH(OR.sup.
    Type: Grant
    Filed: June 6, 1996
    Date of Patent: January 26, 1999
    Assignee: Abbott Laboratories
    Inventors: Clint D. W. Brooks, Richard A. Craig, Teodozyj Kolasa, Andrew O. Stewart
  • Patent number: 5856157
    Abstract: Isolation and characterization of a novel plant fatty acid desaturase cDNA that encodes a .DELTA..sup.9 14:0-ACP desaturase. Expression of the .DELTA..sup.9 14:0-ACP desaturase is a critical factor for pest resistance in plants of the genus Pelargonium and other plants generally; the desaturase gene is also useful in other contexts and for other purposes such as increasing the percentage of unsaturated fatty acids in oil-producing crops such as soybeans, rapeseed, maize, sunflower, safflower, cotton, cuphea, peanut, coconut and oil-palm, as well as increasing the percentage of unsaturated fatty acids in other plants generally.
    Type: Grant
    Filed: June 4, 1997
    Date of Patent: January 5, 1999
    Assignee: The Penn State Research Foundation
    Inventors: Richard Craig, June I. Medford, Ralph O. Mumma, Diana L. Cox-Foster, David Schultz
  • Patent number: 5843968
    Abstract: Compounds having the formula: ##STR1## wherein W is the same at each occurrence and is selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, optionally substituted pyridyl, optionally substituted pyrimidyl, and optionally substituted thiazolyl; R.sup.1 and R.sup.2 are independently selected from hydrogen, alkyl, halolalkyl, alkoxy, halogen; R.sup.3 is a valence bond or is selected from hydrogen and alkyl; X is a valence bond or is selected from alkylene, alkenylen, and alkynylene; and Z is selected from (a) COM, (b) CH.dbd.N--O--A--COM, (c) CH.sub.2 --O--N.dbd.A--COM wherein A is selected from alkylene and cycloalkylene, and M is selected from (a) a pharmaceutically acceptable metabolically cleavable group, (b) --OR.sup.6, (c) --NR.sup.7 R.sup.8, (d) --NR.sup.6 SO.sub.2 R.sup.
    Type: Grant
    Filed: October 27, 1997
    Date of Patent: December 1, 1998
    Assignee: Abbott Laboratories
    Inventors: Clint D. W. Brooks, Pramila Bhatia, Teodozyj Kolasa, Andrew O. Stewart, David E. Gunn, Richard A. Craig
  • Patent number: 5807407
    Abstract: A medical implant device being operable to replace at least a portion of the natural joint in a human. The medical implant device includes a structural member being composed of a composite material. The medical implant device further includes a metallic porous coating disposed on at least a portion of the exterior of the structural member.
    Type: Grant
    Filed: May 4, 1992
    Date of Patent: September 15, 1998
    Assignee: Biomet, Inc.
    Inventors: Garry Lee England, Richard Craig Blaschke
  • Patent number: 5795900
    Abstract: Compounds having the formula: ##STR1## wherein W is the same at each occurrence and is selected from optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, optionally substituted pyridyl, optionally substituted pyrimidyl, and optionally substituted thiazolyl; R.sup.1 and R.sup.2 are independently selected from hydrogen, alkyl, halolalkyl, alkoxy, halogen; R.sup.3 is a valence bond or is selected from hydrogen and alkyl; X is a valence bond or is selected from alkylene, alkenylen, and alkynylene; and Z is selected from (a) COM, (b) CH.dbd.N--O--A--COM, (c) CH.sub.2 --O--N.dbd.A--COM wherein A is selected from alkylene and cycloalkylene, and M is selected from (a) a pharmaceutically acceptable metabolically cleavable group, (b) --OR.sup.6, (c) --NR.sup.7 R.sup.8, (d)--NR.sup.6 SO.sub.2 R.sup.
    Type: Grant
    Filed: September 17, 1996
    Date of Patent: August 18, 1998
    Assignee: Abbott Laboratories
    Inventors: Clint D. Brooks, Pramila Bhatia, Teodozyj Kolasa, Andrew O. Stewart, David E. Gunn, Richard A. Craig
  • Patent number: 5782045
    Abstract: A dental treatment unit and method for use by dentists and the like, the treatment unit including an isolated aseptic central core component with a positive pressure internal environment, and which contains a work area for a dental dispensing assistant, plumbing, dental mechanical and electrical components, dental equipment and controls, dental instruments, and dental supplies. The supply core component mechanically engages, conveniently accesses, and provides function to an attachable treatment module enabling a dental team to provide treatment to a patient who is physically separated from all dental materials and medicament containers, cabinet and drawer handles, instruments, and dental devices, thereby creating an aseptic environment heretofore nonexistent in the dental profession. The treatment unit and method effectively eliminate all cross-contaminating common surfaces in the treatment module and provides a highly efficient functional design.
    Type: Grant
    Filed: February 13, 1995
    Date of Patent: July 21, 1998
    Assignee: Haynes, Houk, Lewellen, Orr and Paschal, Associates
    Inventor: Richard Craig Paschal
  • Patent number: 5756531
    Abstract: The present invention provides a class of substituted indole and indene iminoxy derivatives of the formula ##STR1## which inhibit leukotriene biosynthesis and are useful in the treatment of allergic and inflammatory disease states.
    Type: Grant
    Filed: April 30, 1996
    Date of Patent: May 26, 1998
    Assignee: Abbott Laboratories
    Inventors: Clint D. W. Brooks, Richard A. Craig, David E. Gunn, Teodozyji Kolasa, Jimmie L. Moore, Andrew O. Stewart
  • Patent number: 5725381
    Abstract: A motivation system for children is provided, which consists of a motivation system board, play money of various denominations, and coupons for various predefined rewards. The motivation system board consists of a flat rectangular rigid sheet with a schedule information area, a rewards information area, and an erasable felt tip marking pen with a pen holder. The schedule information area contains a first column for listing the time of day, a second column for listing the behavior the child is to perform, and a third column for listing the quantity of play money to be received by the child. The rewards information area contains a first column for listing rewards that may be purchased, and a second column for listing the play money purchase price of reward.
    Type: Grant
    Filed: October 3, 1996
    Date of Patent: March 10, 1998
    Inventors: Richard Craig Kollath, Richard Lee Huffman
  • Patent number: 5704890
    Abstract: The invention is a real time sensor for therapeutic radiation. A probe is placed in or near the patient that senses in real time the dose at the location of the probe. The strength of the dose is determined by either an insertion or an exit probe. The location is determined by a series of vertical and horizontal sensing elements that gives the operator a real time read out dose location relative to placement of the patient. The increased accuracy prevents serious tissue damage to the patient by preventing overdose or delivery of a dose to a wrong location within the body.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: January 6, 1998
    Assignee: Battelle Memorial Institute
    Inventors: Mary Bliss, Richard A. Craig, Paul L. Reeder
  • Patent number: 5616596
    Abstract: The invention relates to compounds having activity to inhibit lipoxygenase enzyme activity, to pharmaceutical compositions comprising these compounds, and to a medical method of treating. More particularly, this invention concerns certain substituted arylalkynyl- and ((heteroaryl)alkynyl)-N-hydroxy-ureas which inhibit leukotriene biosynthesis, to pharmaceutical compositions of these compounds and to a method of inhibiting leukotriene biosynthesis.
    Type: Grant
    Filed: April 13, 1995
    Date of Patent: April 1, 1997
    Assignee: Abbott Laboratories
    Inventors: Anwer Basha, Clint D. W. Brooks, Pramila Bhatia, Richard A. Craig, James D. Ratajczyk, Andrew O. Stewart
  • Patent number: 5506261
    Abstract: Compounds of the structure ##STR1## wherein Z is selected from optionally substituted thienyl, thiazolyl, oxazolyl and furyl are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.
    Type: Grant
    Filed: May 9, 1994
    Date of Patent: April 9, 1996
    Assignee: Abbott Laboratories
    Inventors: Dee W. Brooks, Andrew O. Stewart, Richard A. Craig
  • Patent number: 5217370
    Abstract: A single use, disposable infection control barrier for use with dental appliances includes an elongate bag with a first, open end and a second, closed end so that at least a portion of a dental appliance may be inserted through the open end of the bag to the second end of the bag. The bag is transparent so as to permit a user of the dental appliance to observe the dental appliance through the bag and is flexible so as to permit the user of the dental appliance to operate the dental appliance through the bag. The bag includes a lip at the first end of the bag extending from the bag, which lip serves to guide the dental appliance into the bag. An adhesive strip is located on this lip which serves to anchor the infection control barrier to a dental appliance, if desired. A dental appliance having such an infection control barrier, a method of using such a barrier, and a dispenser package for such a barrier are also disclosed.
    Type: Grant
    Filed: January 14, 1991
    Date of Patent: June 8, 1993
    Assignee: Health Park Incorporated
    Inventors: Richard Craig, Brian L. Wilt
  • Patent number: 5169854
    Abstract: Compounds useful in inhibiting the biosynthesis of leukotrienes have the structure ##STR1## where M is hydrogen, a pharmaceutically acceptable cation, or a metabolically cleavable group, R.sup.4 is alkyl, cycloalkyl or --NR.sup.5 R.sup.6, where R.sup.5 and R.sup.6 are hydrogen, alkyl, cycloalkyl or alkanoyl, where A is a valence bond or is a straight or branched divalent alkylene group of from one to twelve carbon atoms, R.sup.2 and R.sup.3 are independently selected from hydrogen, straight or branched alkyl of from one to twelve carbon atoms, halogen, or trifluoroalkyl, and R.sup.1 is selected from phenoxy, phenylthio, 2-, 3-, or 4-pyridyloxy, 1 or 2-naphthyloxy, or 2,4,5, or 8-quinolyloxy, all optionally substituted with alkyl, haloalkyl, alkoxy, hydroxy or halogen.
    Type: Grant
    Filed: February 26, 1992
    Date of Patent: December 8, 1992
    Assignee: Abbott Laboratories
    Inventors: Dee W. Brooks, Andrew O. Stewart, Pramila Bhatia, Richard A. Craig
  • Patent number: PP7576
    Abstract: This invention relates to a new and distinct cultivar of geranium (Pelargonium.times.Xhortorum) named `Centennial` substantially as described herein, characterized as being particularly well adapted to both commercial greenhouse production and garden performance, and as being early flowering, floriferous, self-branching, compact and producing bright scarlet semidouble flowers.
    Type: Grant
    Filed: July 18, 1989
    Date of Patent: July 2, 1991
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Richard Craig, Leon Glicenstein
  • Patent number: PP7620
    Abstract: This invention relates to a new and distinct cultivar of regal Pelargonium (Pelargonium.times.domesticum) named Flair substantially as illustrated and described herein, particularly characterized as being compact and self-branching, early flowering and floriferous, and having flowers which are light orange-red in color with red-purple feathering primarily on the upper petals.
    Type: Grant
    Filed: July 21, 1989
    Date of Patent: August 13, 1991
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Richard Craig, Glenn G. Hanniford
  • Patent number: PP7627
    Abstract: This invention relates to a new and distinct cultivar of geranium (Pelargonium.times.hortorum) named #(81-344-3) substantially as described herein, characterized as having bright, luminescent scarlet flowers and being particularly well adapted to both commercial greenhouse production and garden performance, and as being early flowering, floriferous, self-branching, and compact.
    Type: Grant
    Filed: July 18, 1989
    Date of Patent: August 20, 1991
    Assignee: Research Corporation Technologies, Inc.
    Inventor: Richard Craig
  • Patent number: PP7656
    Abstract: This invention relates to a new and distinct cultivar of regal Pelargonium (Pelargonium.times.domesticum) named `Splendor` substantially as illustrated and described herein, particularly characterized as being compact and self-branching, early flowering and floriferous, and having bright salmon pink flowers with ruby feathering on the upper petals.
    Type: Grant
    Filed: July 21, 1989
    Date of Patent: September 24, 1991
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Richard Craig, Glenn G. Hanniford
  • Patent number: PP8089
    Abstract: This invention relates to a new and distinct cultivar of Geranium Pelargonium.times.hortorum named Jubilee that possesses a flower color that is a unique combination of red-orange and watermelon shades, and is early flowering, floriferous, self-branching, and compact.
    Type: Grant
    Filed: April 10, 1991
    Date of Patent: January 5, 1993
    Assignee: Research Corporation Technologies, Inc.
    Inventor: Richard Craig
  • Patent number: PP10803
    Abstract: The new cultivar maintains a controlled growth habit and is very heat tolerant. The petals are medium pink at the edges and white in the middle with a dark burgundy eye.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: February 23, 1999
    Assignee: The Penn State Research Foundation
    Inventor: Richard Craig
  • Patent number: D409239
    Type: Grant
    Filed: January 7, 1997
    Date of Patent: May 4, 1999
    Inventors: Richard Craig Kollath, Richard Lee Huffman