Abstract: An optical parametric oscillator includes a source of coherent energetic pump optical signals and an optical resonator cavity which includes a set of optical parametric amplifying (OPA) crystals and a set of optical elements such as mirrors disposed along an optical path. The optical elements are configured (1) to direct an oscillation optical signal generated by the OPA crystals along the optical path, (2) to provide input coupling of the energetic pump optical signals such that each energetic pump optical signal travels through only one of the OPA crystals to result in a corresponding depleted pump optical signal, and (3) to provide output coupling of the depleted pump optical signals to prevent each depleted pump optical signal from traveling through more than one of the OPA crystals. Resonator cavities have multiple-leg configurations, including “L” and “U” shapes, and either linear (or standing-wave) or ring architectures.

Abstract: The present invention provides methods of treating skin disorders includes delivering to a mammal a composition containing a compound of formula I, or tautomers thereof, in a regimen, wherein formula I is: and wherein R1-R5 and Q1 are defined as described herein. Specifically, methods for treating acne, hirsutism, and conditioning the skin are described. Also provided are novel PR modulators of formula II.

Abstract: The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is selected from the group consisting of hydrogen, substituted or unsubstituted group selected from C1–C8 alkyl, aryl-C0-4-alkyl, heteroaryl-C0-4-alkyl, and C3–C6 cycloalkylaryl-C0-2-alkyl; W is O or S; X is an optionally substituted C1–C5 alkylene linker wherein one carbon atom of the linker may be replaced with O, NH or S; Y is C, O, S, NH or a single bond; E is C(R3)(R4)A or A

Abstract: The present invention provides methods of inducing contraception which includes delivering to a female a composition containing a compound of formula I or formula II, or tautomers thereof, in a regimen which involves delivering one or more of a selective estrogen receptor modulator, wherein formula I is: and wherein R1–R5 and Q1 are defined as described herein. Methods of providing hormone replacement therapy and for treating carcinomas, dysfunctional bleeding, uterine leiomyomata, endometriosis, and polycystic ovary syndrome is provided which includes delivering a compound of formula I and a selective estrogen receptor modulator are also described.

Abstract: A method for automatically decomposing a dynamic system model into separate submodels for ultimate execution on diverse target platforms is provided. Embodiments of the invention provide a way for a system designer to indicate which portions of a previously-specified system model are to become submodels. Optionally, the designer may also indicate the associated target platform for the execution of each submodel. A system submodel for each portion designated by the designer is generated, keeping all critical system-level information consistent throughout the entire system model. Each of these system submodels may then be employed to generate a software version of each system submodel. Each software submodel may then be transferred to its specified target platform and executed in cooperation with the other software submodels to effect an overall system simulation executing across the associated target platforms.

Abstract: A low-cost infra-red detector is disclosed including a method of making and using the same. The detector employs a substrate, a filtering layer, a converting layer, and a diverter to be responsive to wavelengths up to about 1600 nm. The detector is useful for a variety of applications including spectroscopy, imaging, and defect detection.

Abstract: The present invention provides methods of treating skin disorders includes delivering to a mammal a composition containing a compound of formula I, or tautomers thereof, in a regimen, wherein formula I is: and wherein R1–R5 and Q1 are defined as described herein. Specifically, methods for treating acne, hirsutism, and a composition for conditioning the skin are described.

Abstract: A toss game comprising in combination a multi-panel assembly including generally flat multiple substantially identically shaped panels each having first and second surfaces bearing printed design indicia thereon. Each of the side margins of the middle panel is hinge connected to one side margin of each of the two end panels whereby the end panels are pivotally extendable into a generally planar relation one to another and to the middle panel in an open flat configuration and foldable against the middle panel in a closed configuration. The end panels are also attachable along a distal edge of each of said end panels to form a self-supporting polyhedron shape which is preferably a truncated pyramid. A portion of the panel surfaces is partially covered with a hook and loop material to form target areas at which a throw piece of sufficient weight is thrown.

Abstract: A method for exposing the internal signals of a system model or software model of a dynamic system to a client application outside the original modeling environment is provided. A designer of the system model is provided with a way to select internal signals of the system model in order to expose those internal signals to other computer applications external to the modeling environment. Such computer applications are then able to access the internal signals by way of interfacing software while the system model is being exercised within the modeling environment, or while a software model based on the system model is executed outside of that environment.

Abstract: Compounds having the formula are useful for treating conditions which arise from or are exacerbated by angiogenesis. Also disclosed are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.

Abstract: A low-cost infra-red detector is disclosed including a method of making and using the same. The detector employs a substrate, a filtering layer, a converting layer, and a diverter to be responsive to wavelengths up to about 1600 nm. The detector is useful for a variety of applications including spectroscopy, imaging, and defect detection.

Abstract: A method for controlling a wrapping machine for printed products that includes determining the size of an incoming gap in a printed product stream and controlling a speed of the wrapping machine as a function of the size of the incoming gap. The controlling step includes intentionally leaving, in the printed product stream in the wrapper machine, at least a single product gap corresponding to the incoming gap so as to create at least one empty bag. A newspaper finishing machine and controller are also provided.

Abstract: A biological therapeutic delivery device is provided. In one preferred embodiment, the invention includes a device for effectuating localized tissue injury comprised of a resorbable body having at least one therapeutic agent and a retention device to anchor the agent within a tissue, the therapeutic agent being released into the tissue as the body resorbs. In an additional preferred embodiment, the invention includes a device for effectuating localized tissue injury comprised of a resorbable body having a cavity containing a therapeutic agent and a series of projections extending from the body to anchor the body in a tissue, the therapeutic agent being released into the tissue as the body resorbs.

Abstract: The present invention is directed to N1-acylated derivatives of desleucylA82846B. These derivatives are useful as antibacterials.

Abstract: Compounds having the formula are methionine aminopeptidase type 2 (MetAP2) inhibitors and are useful for inhibiting angiogenesis. Also disclosed are MetAP2-inhibiting compositions and methods of inhibiting angiogenesis in a mammal.

Abstract: Compounds having Formula I or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of inhibiting angiogenesis in a mammal.

Abstract: An improved method and apparatus for the detection of hydrogenated materials. Detection of concealed hydrogenated materials such as organic explosives, drugs, or biological tissue is accomplished by measuring the backscattering of neutrons from hydrogenous material in the targeted environment. The system comprises a neutron source that provides information as to the time at which the neutron is emitted, and a neutron sensor, which provides information as to the time at which the neutron is detected and may provide information as to the location at which the neutron is detected. The invention comprises a timing circuit that deactivates the neutron sensor during a time delay to reject signals from neutrons that have not scattered from hydrogen nuclei. The invention may further cease to detect neutrons after a window to reject signals from neutrons that have scattered off distant hydrogen nuclei, which may represent background noise.

Abstract: The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is selected from the group consisting of hydrogen, substituted or unsubstituted group selected from C1-C8 alkyl, aryl-C0-4-alkyl, heteroaryl-C0-4-alkyl, and C3-C6 cycloalkylaryl-C0-2-alkyl; W is O or S; X is an optionally substituted C1-C5 alkylene linker wherein one carbon atom the linker may be replaced with O, NH or S; Y is C, O, S, NH or a single bond; E is C(R3)(R4)A or A.

Abstract: A method for controlling a wrapping machine for printed products that includes determining the size of an incoming gap in a printed product stream and controlling a speed of the wrapping machine as a function of the size of the incoming gap. The controlling step includes intentionally leaving, in the printed product stream in the wrapper machine, at least a single product gap corresponding to the incoming gap so as to create at least one empty bag. A newspaper finishing machine and controller are also provided.

Abstract: A new and distinct regal geranium plant with white flowers having purple feathering above medium green foliage. The new cultivar exhibits extended flower longevity.