Abstract: A fluidic device for providing analogue output control includes a main channel, a first control channel, a second control channel, a comparator which receives respective input fluid flows from the main, the first and the second control channels. The first control channel is configured such that the input fluid flow therefrom carries an oscillating pressure wave signal, the second control channel includes a flow regulator controllable to vary the mass flow rate of the input fluid flow from the second control channel, and the main channel is configured such that the input fluid flow therefrom is at a reference mass flow rate. The comparator is configured such that the input fluid flows from the first control and the second control channels act in combination on the input fluid flow from the main channel to produce an output fluid flow from the comparator having a PWM mass flow rate characteristic.

Abstract: A method of cutting a tie wrap, bound about at least one wire, using a cutting tool is provided. The method comprising steps of: applying a housing of the cutting tool to the tie wrap, positioning a portion of the tie wrap within a first groove of the housing between first two opposing sidewalls and second two opposite sidewalls of the housing, moving the at least one wire and maintaining the at least one wire a distance away from the tie wrap, moving a circular blade of the cutting tool against the portion of the tie wrap, positioned within the first groove, and at least partially cutting the tie wrap with the circular blade. In some examples, the method further comprises controlling a depth of the circular blade within the tie wrap while the circular blade at least partially cuts the tie wrap.

Abstract: The invention relates to methods of modulating the expression of one or more genes in a cell by modulating the multimerization of a transcription factor and/or modulating the formation of enhancer-promoter DNA loops, and thereby modulating the expression of the one or more genes. The invention also relates to treating diseases and conditions involving aberrant gene expression by modulating the multimerization of a transcription factor and/or modulating the formation of enhancer-promoter DNA loops. The invention also relates to methods for screening for compounds that modulate expression of one or more genes in a cell.

Abstract: There is provided a system for use with a fiber-optic current transducer. The system includes a processing unit configured to transduce a first light signal into a first electrical signal. The processing unit is further configured to transduce a second light signal into a second electrical signal. Furthermore, the processing unit is configured to remove offsets from the first electrical signal and the second electrical signal by forcing the first electrical signal and the second electrical signal to be on the same per unit basis.

Abstract: The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a pluripotent state and/or enhances the speed and/or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway.

Abstract: The invention relates to a method for calibrating a spectroradiometer (1), comprising the following method steps: capture of light measurement data by the measurement of the radiation of at least one standard light source (4) using the spectroradiometer (1) that is to be calibrated; derivation of calibrated data from the light measurement data by the comparison of the captured light measurement data with known data of the standard light source (4); and calibration of the spectroradiometer (1) according to the calibration data. The aim of the invention is to provide a reliable and practical method for calibrating the spectroradiometer (1). In particular, the synchronism of spectroradiometers (1) situated in different locations (9, 10, 11) is to be produced simply and reliably. To achieve this aim, the validity, i.e.

Abstract: Disclosed herein are novel methods and compositions useful for inhibiting interaction between a bromodomain protein and an immunoglobulin (Ig) regulatory element. The methods and compositions are particularly useful for downregulating expression of an oncogene translocated with an Ig locus, as well as for treating a cancer (e.g., hematological malignancy) characterized by increased expression of an oncogene which is translocated with an Ig locus.

Abstract: Packaging for an attachable unit for a smoking article The invention relates to packaging (300) for an attachable unit (3) for a smoking article (2) comprising a receiver (301) to receive an attachable unit and a guide (306) for aligning the smoking article with the attachable unit when the attachable unit is received by the receiver such that the attachable unit can be attached to the smoking article. The invention also relates to packaging for an attachable unit for a smoking article comprising a receptacle or receiver in which the attachable unit is receivable and a gripping mechanism (307) to releasably hold the attachable unit within the receptacle or receiver when the attachable unit is received in the receptacle or receiver.

Abstract: The present invention provides various approaches for disseminating emergency broadcasting messages or other messages of importance (hereinafter “alerts”) within virtual world environments such that interested virtual world residents can be made aware of matters of importance based on their physical world locations (e.g., without respect to the locale of their current virtual world presence).

Abstract: Systems, methods, devices, and techniques for improving the efficiency of selecting digital components to present in electronic documents and reducing latency in rendering digital components in electronic documents. In some implementations, a content distribution system uses predicted metrics for a set of candidate components to determine items to present in an electronic document responsive to a request. A metric prediction model can generate predicted metrics with the aid of a parameter prediction sub-model that predicts a value of a non-observable parameter associated with a request for a digital component.

Abstract: Disclosed herein are methods useful for modulating expression of a target gene by modulating binding between a ribonucleic acid (RNA) transcribed from at least one regulatory element of a target gene and a transcription factor which binds to both the RNA and the regulatory element. Also disclosed herein are methods and assays for identifying agents that interfere with binding between RNA transcribed from at least one regulatory element and a transcription factor which binds to the RNA and to the regulatory element.

Abstract: A fluidic device for providing analogue output control includes a main channel, a first control channel, a second control channel, a comparator which receives respective input fluid flows from the main, the first and the second control channels. The first control channel is configured such that the input fluid flow therefrom carries an oscillating pressure wave signal, the second control channel includes a flow regulator controllable to vary the mass flow rate of the input fluid flow from the second control channel, and the main channel is configured such that the input fluid flow therefrom is at a reference mass flow rate. The comparator is configured such that the input fluid flows from the first control and the second control channels act in combination on the input fluid flow from the main channel to produce an output fluid flow from the comparator having a PWM mass flow rate characteristic.

Abstract: Work described herein reveals 3D regulatory landscapes of hESCs representative of early human development. This work also demonstrates that cohesin-associated CTCF loops, and the cohesin-associate enhancer-promoter loops within them, dominate the organization of TADs. The CTCF-CTCF loops form a chromosomal scaffold of insulated neighborhoods that are largely preserved in vertebrates, and enhancer-promoter interactions occur within these neighborhoods. Genes are regulated in the context of conserved insulated neighborhood structures. Loss of neighborhood structures occurs frequently in cancer cells, and proto-oncogenes can be activated by genetic alterations that disrupt specific 3D chromosome structures.

Abstract: The present invention relates in some aspects to super-enhancers and related compositions, methods, and agents that are useful for modulating expression of cell type-specific genes that are required for maintenance of cell identity (e.g., embryonic stem cell identity) or maintenance of a disease state (e.g., cancer).

Abstract: Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.

Abstract: A method of cutting a tie wrap, bound about at least one wire, using a cutting tool is provided. The method comprising steps of: applying a housing of the cutting tool to the tie wrap, positioning a portion of the tie wrap within a first groove of the housing between first two opposing sidewalls and second two opposite sidewalls of the housing, moving the at least one wire and maintaining the at least one wire a distance away from the tie wrap, moving a circular blade of the cutting tool against the portion of the tie wrap, positioned within the first groove, and at least partially cutting the tie wrap with the circular blade. In some examples, the method further comprises controlling a depth of the circular blade within the tie wrap while the circular blade at least partially cuts the tie wrap.

Abstract: A tool for use in cutting a tie wrap that is bound about at least one wire is provided. The tool includes a housing having a first side and a second side, wherein the first side and the second side are coupled together to define a cavity. The housing further includes a groove formed in the first side and in the second side, wherein the groove is in flow communication with the cavity. A blade is coupled to the first side and positioned with the cavity, wherein the blade includes a cutting surface partially extending into the groove. The tool also includes a spacer coupled to the housing and configured to maintain the wire a distance away from the cutting surface when the housing is applied to the tie wrap.

Abstract: Aspects of this invention are directed toward determining the effectiveness of advertising in a virtual universe. Specifically, under the present invention, a visit by an avatar to a region of the VU that includes targeted advertising content is registered. Then, the following avatar attributes are determined: a proximity to the target advertising content by the avatar; an avatar directionality of the avatar with respect to the target advertising content; a camera directionality of a camera object associated with the avatar; and a time with respect to which the avatar may be exposed to the target advertising content in the region. Thereafter, at least one score is assigned to the visit, the proximity, the directionality, and the time. An effectiveness score is then calculated based on the at least one score. The overall effectiveness of the target advertising content is then calculated based on the at least one score.

Abstract: Disclosed herein are methods and compositions useful for inhibiting interaction between a bromodomain protein and an immunoglobulin (Ig) regulatory element. The methods and compositions are particularly useful for downregulating expression of an oncogene translocated with an Ig locus, as well as for treating a cancer (e.g., hematological malignancy) characterized by increased expression of an oncogene which is translocated with an Ig locus. Also disclosed herein are methods and assays for identifying agents that interfere with binding of bromodomain proteins to Ig regulatory elements, as well as methods and assays for identifying inhibitors of bromodomain.

Abstract: An insertable filter unit for insertion into a smoking article filter having a recess, wherein the insertable filter unit includes an outer casing defining a cavity for storing a smoke modifying agent, and wherein the insertable filter unit is arranged to be inserted into the recess of the smoking article filter by a user.