Abstract: This invention relates to the composition of a chitosan coated paper wherein the chitosan may be derived from a variety of sources. Methods of using chitosan as a surface coating or pulp additive to tune the properties of paper and paperboard products are also described. The chitosan applied is a bio-based and environmentally friendly barrier coating and/or additive material for the manufacture of functional paper and paperboard products, specifically as evaporative cooling media requiring wet strength and structural integrity, wicking, and moisture resistance as an alternative to conventional phenolic-based resins. The solid-state fermentation method to produce chitosan and its derivatives offer renewable bio-based materials towards the manufacture of functional paper products that are eco-friendly but also offer uncompromized performance levels.

Abstract: A cutting tool and method of operating cutting tool. The tool includes a support having a first side and a second side. The tool further includes a handle coupled to at least one of the first side and the second side. The handle includes a blade, wherein the handle is configured to move the blade between a first position and a second position. An alignment guide is coupled to the support. The alignment guide includes a channel configured to receive the blade positioned in the second position.

Abstract: A sleeve (1) for holding a plurality of elongate elements (9) positioned in end-to-end relationship is disclosed. The sleeve has an elongate body (2) with opposite ends (10,11) and a space (3) defined therebetween to receive the elongate elements (9). The elongate body has an opening (4) between the ends (10,11) that is configured to enable a user to contact elongate elements (9) received in the sleeve (1) through the opening (4) and push them along, and out of one end of the sleeve (1).

Abstract: Impact protection structures for vehicles are described. An impact protection structure includes a support structure of the vehicle, an interior rail coupled to the support structure, and an exterior rail coupled to the interior rail. The exterior rail has an inboard boundary wall positioned between an upper mounting region and a lower mounting region. The upper and the lower exterior mounting region of the exterior rail are coupled to an upper and a lower mounting region of the interior rail. At least a portion of the inboard boundary wall is spaced apart from an outboard wall of the interior rail such that when the exterior rail is impacted by a blunt-object barrier, the inboard boundary wall of the exterior rail deforms, thereby damping energy of the impact at the exterior rail and arresting crack propagation between the exterior rail and the interior rail.

Abstract: The invention relates to a method for calibrating a spectroradiometer (1), comprising the following method steps: capture of light measurement data by the measurement of the radiation of at least one standard light source (4) using the spectroradiometer (1) that is to be calibrated; derivation of calibrated data from the light measurement data by the comparison of the captured light measurement data with known data of the standard light source (4); and calibration of the spectroradiometer (1) according to the calibration data. The aim of the invention is to provide a reliable and practical method for calibrating the spectroradiometer (1). In particular, the synchronism of spectroradiometers (1) situated in different locations (9, 10, 11) is to be produced simply and reliably. To achieve this aim, the validity, i.e.

Abstract: Disclosed are methods for identifying the core regulatory circuitry or cell identity program of a cell or tissue, and related methods of diagnoses, screening, and treatment involving the core regulatory circuitry and/or cell identity programs identified using the methods.

Abstract: The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a pluripotent state and/or enhances the speed and/or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway.

Abstract: Provided herein are improved compositions and methods for the directed control of gene expression.

Abstract: The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a pluripotent state and/or enhances the speed and/or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway.

Abstract: The present invention provides compounds of Formula (I-A), (I-B), and (I-C), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting Myc (e.g., c-Myc) activity. The present invention further provides methods of using the compounds described herein for treating Myc-mediated disorders (e.g., cancer and other proliferative diseases). The present invention also provides assays for identifying Myc inhibitors.

Abstract: This invention relates to the composition of a chitosan coated paper wherein the chitosan may be derived from a variety of sources. Methods of using chitosan as a surface coating or pulp additive to tune the properties of paper and paperboard products are also described. The chitosan applied is a bio-based and environmentally friendly barrier coating and/or additive material for the manufacture of functional paper and paperboard products, specifically as evaporative cooling media requiring wet strength and structural integrity, wicking, and moisture resistance as an alternative to conventional phenolic-based resins. The solid-state fermentation method to produce chitosan and its derivatives offer renewable bio-based materials towards the manufacture of functional paper products that are eco-friendly but also offer uncompromised performance levels.

Abstract: The present invention provides compounds of Formula (I-A), (I-B), and (I-C), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting Myc (e.g., c-Myc) activity. The present invention further provides methods of using the compounds described herein for treating Myc-mediated disorders (e.g., cancer and other proliferative diseases). The present invention also provides assays for identifying Myc inhibitors.

Abstract: Provided herein are methods for identifying master transcription factors (TFs) in a cell type of interest and for transdifferentiation of a somatic cell, e.g., a fibroblast to the cell type of interest. Also provided herein are induced retinal pigment epithelium (iRPE) cell, master TFs therefor, methods for making iRPE cell, and methods and compositions for treating an ocular disease such as age-related macular degeneration.

Abstract: There is provided a system for use with a fiber-optic current transducer. The system includes a processing unit configured to transduce a first light signal into a first electrical signal. The processing unit is further configured to transduce a second light signal into a second electrical signal. Furthermore, the processing unit is configured to remove offsets from the first electrical signal and the second electrical signal by forcing the first electrical signal and the second electrical signal to be on the same per unit basis.

Abstract: Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.

Abstract: The present invention relates in some aspects to super-enhancers and related compositions, methods, and agents that are useful for modulating expression of cell type-specific genes that are required for maintenance of cell identity (e.g., embryonic stem cell identity) or maintenance of a disease state (e.g., cancer).

Abstract: The invention provides compositions and methods of use in reprogramming somatic cells. Compositions and methods of the invention are of use, e.g., for generating or modulating (e.g., enhancing) generation of induced pluripotent stem cells by reprogramming somatic cells. The reprogrammed somatic cells are useful for a number of purposes, including treating or preventing a medical condition in an individual. The invention further provides methods for identifying an agent that reprograms somatic cells to a pluripotent state and/or enhances the speed and/or efficiency of reprogramming. Certain of the compositions and methods relate to modulating the Wnt pathway.

Abstract: A cutting tool and method of operating cutting tool. The tool includes a support having a first side and a second side. The tool further includes a handle coupled to at least one of the first side and the second side. The handle includes a blade, wherein the handle is configured to move the blade between a first position and a second position. An alignment guide is coupled to the support. The alignment guide includes a channel configured to receive the blade positioned in the second position.

Abstract: Disclosed herein are methods for identifying the core regulatory circuitry or cell identity program of a cell or tissue, and related methods of diagnoses, screening, and treatment involving the core regulatory circuitry and/or cell identity programs identified using the methods.

Abstract: An impact protection structure for a vehicle impacting a blunt-object barrier includes a support structure of the vehicle, an energy absorbing rail coupled to the support structure, and a localized energy dissipation structure. The energy absorbing rail extends an energy absorbing rail length and includes a plurality of lumens. The localized energy dissipation structure extends a localized energy dissipation structure length less than the energy absorbing rail length.