Abstract: The present invention relates in some aspects to super-enhancers and related compositions, methods, and agents that are useful for modulating expression of cell type-specific genes that are required for maintenance of cell identity (e.g., embryonic stem cell identity) or maintenance of a disease state (e.g., cancer).

Abstract: A medication container with a Fresnel lens formed on its surface is described. The Fresnel lens provides a magnified view of the medication content of the container so that a user such as a pharmacist or a patient can accurately determine the medication content without opening the container. In one embodiment, the medication container is generally cylindrical in shape and a Fresnel lens is formed on the bottom of the container. In other embodiments, the Fresnel lens is formed on the cap of a middle component located between the cap and the body of the container.

Abstract: The present invention relates in some aspects to super-enhancers and related compositions, methods, and agents that are useful for modulating expression of cell type-specific genes that are required for maintenance of cell identity (e.g., embryonic stem cell identity) or maintenance of a disease state (e.g., cancer).

Abstract: Impact protection structures for vehicles are described. An impact protection structure includes a support structure of the vehicle, an interior rail coupled to the support structure, and an exterior rail coupled to the interior rail. The exterior rail has an inboard boundary wall positioned between an upper mounting region and a lower mounting region. The upper and the lower exterior mounting region of the exterior rail are coupled to an upper and a lower mounting region of the interior rail. At least a portion of the inboard boundary wall is spaced apart from an outboard wall of the interior rail such that when the exterior rail is impacted by a blunt-object barrier, the inboard boundary wall of the exterior rail deforms, thereby damping energy of the impact at the exterior rail and arresting crack propagation between the exterior rail and the interior rail.

Abstract: Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.

Abstract: An impact test fixture includes a rolling frame structure, a ballast attachment feature coupled to the rolling frame structure, a position-adjustable attachment assembly coupled to the rolling frame structure, and a specimen attachment member coupled to the position-adjustable attachment assembly. The specimen attachment member is adjustable in a vertical direction and a transverse direction relative to the rolling frame structure.

Abstract: Embodiments of silicone hydrogels, ophthalmic lenses made therefrom, and methods of making the same are described. Fully hydrated silicone hydrogels have relatively high water content and oxygen permeability, along with relatively low modulus of elasticity. Embodiments of the silicone hydrogels in substantially dehydrated condition are adapted to lathe cutting at or above room temperature. Variations of the silicone hydrogels include silicon-containing monomers in an amount of 7.5% or greater by weight, a hydrophilic substituted N-vinyl acetamide monomer, and a hydrophilic non-acetamide monomer in an amount resulting in a hydrophilic substituted N-vinyl acetamide monomer to hydrophilic non-acetamide monomer weight to weight ratio of greater than 2.1 to 1.

Abstract: An impact protection structure for a vehicle impacting a blunt-object barrier includes a support structure of the vehicle, an energy absorbing rail coupled to the support structure, and a localized energy dissipation structure. The energy absorbing rail extends an energy absorbing rail length and includes a plurality of lumens. The localized energy dissipation structure extends a localized energy dissipation structure length less than the energy absorbing rail length.

Abstract: A frame structure is adapted to absorb energy from frontal impacts and extends under a front portion of the body frame. The frame structure includes a rear sub-frame located below and in front of a pair of side frame under-members, and at least one ramp connected to the pair of side frame under-members for directing rearward sliding movement of the rear sub-frame and attached structures downwardly beneath a battery assembly. A catching surface engages a steering gear to improve energy absorption during frontal impacts. A reinforcement bracket attached to the pair of side frame under-members defines a pocket for temporarily catching the rear sub-frame providing an energy absorption path before releasing the rear sub-frame to slide past. A tether is connected between the pair of side frame under-members and the rear sub-frame for holding the rear sub-frame against the ramp to increase energy absorption.

Abstract: A frame structure is adapted to absorb energy from frontal impacts and extends under a front portion of the body frame. The frame structure includes a rear sub-frame located below and in front of a pair of side frame under-members, and a reinforcement bracket attached to the pair of side frame under-members to facilitate formation and control a deformation shape in an energy absorption pocket in the side frame under-member during a frontal impact for temporarily restraining the rear sub-frame before releasing the rear sub-frame to slide past the reinforcement bracket. The energy absorption pocket is formed in the side frame under-member forward of and outboard of the reinforcement bracket during a frontal impact prior to the rear sub-frame be released from B-point bolt connections to the side frame under-members.

Abstract: A vehicle frame structure is adapted to absorb energy from frontal impacts. The frame structure extends under a front portion of the body frame. The frame structure includes a rear sub-frame located below and in front of a pair of side frame under-members, and a catching surface connected to the pair of side frame under-members for engaging the rear sub-frame and attached structures. A steering gear is attached to the rear sub-frame. The catching surface interacts with the steering gear to promote additional crushing energy absorption during sliding movement of the rear sub-frame relative to the catching surface during the frontal impact. The catching surface can be formed on ramps attached to the pair of side frame under-members. A tether can prolong crushing contact of the rear sub-frame with respect to the catching surface.

Abstract: Methods and systems are disclosed for rapid detection of cerebrospinal fluid (CSF) in a sample. In some embodiments, the methods comprise depleting a biological sample of beta-1 transferrin by contacting the sample with a sialic acid-specific lectin bound to a solid support, followed by subjecting the beta-1 transferrin-depleted sample to a lateral flow immunoassay. The methods can be used to detect CSF comprised by a sample in under one hour. Furthermore, the methods can detect CSF in a biological sample such as a plasma sample of a volume as small as about 10 ?l.

Abstract: The present invention relates to a package for smoking articles comprising a container portion (2) and a lid (3). The lid is hingedly connected to the container 5 portion (2) to enclose a space defined by the container portion (2) when the lid (3) is closed. The lid (3) includes an end portion (16) and a wall (12) extending from the end portion (16) that overlaps a wall (6) of the container portion (2) when closed. A flap (26,93,107,120) extends from a face of one of said walls having a free end (29,96,109,125), and a cut-out (51,80,102) is formed in the other of said walls, 10 wherein one of the cut-out (51,80) or the free end (109,125) of the flap (107,120) has a first edge (54,65,73,87,115,127) and a second edge (55,56,66,74,88,90,116,128).

Abstract: A frame structure is adapted to absorb energy from frontal impacts and extends under a front portion of the body frame. The frame structure includes a rear sub-frame located below and in front of a pair of side frame under-members, and a tether is connected between the pair of side frame under-members and the rear sub-frame for prolonging proximity of the rear sub-frame with the side frame under-members. A noise-vibration, ride and handling bracket can be modified to define the tether. The tether attaches to the pair of side frame under-members at two outboard locations and to the rear sub-frame at the two inboard locations positioned forward of the outboard locations. The tether attaches to the pair of side frame under-members providing a limited degree of rotary displacement away from the side frame under-members.

Abstract: A lens accessory for a video game sensor device and a method of adjusting a sensing distance of a video game sensor device. A lens accessory for a video game sensor device includes a first lens configured to cover an infrared light emitter of the video game sensor device, a second lens configured to cover an infrared light receiver of the video game sensor device, and a body portion coupling the first lens and the second lens together, the body portion being removably attachable to the video game sensor device, and the first lens and the second lens having a magnification for adjusting a sensing distance of the video game sensor device.

Abstract: An impact protection structure for a vehicle impacting a blunt-object barrier includes a support structure of the vehicle, an energy absorbing rail coupled to the support structure, and a localized energy dissipation structure. The energy absorbing rail extends an energy absorbing rail length and includes a plurality of lumens. The localized energy dissipation structure extends a localized energy dissipation structure length less than the energy absorbing rail length.

Abstract: Methods and devices for shielding displays from electrostatic discharge (ESD) are provided. In one example, a display of an electronic device may include a high resistivity shielding layer configured to protect electrical components from static charges. The display may also include a conductive layer electrically coupled to the high resistivity shielding layer and configured to decrease a discharge time of static charges from the high resistivity shielding layer. The display may include a grounding layer and a conductor electrically coupled between the conductive layer and the grounding layer to direct static charges from the conductive layer to the grounding layer.

Abstract: A vehicle frame includes an inverter protection brace extending between front and rear sub-frames located below and in front of side under frame members. A gusset of the brace strongly connects to the front sub-frame to load a beam section without overloading attaching bolts. The brace has a bolted connection attaches to the rear sub-frame. The brace deforms forward of the bolted connection creating a safety cage around an inverter during frontal impacts. A reinforcement bracket attaches to the side frame under members to define a pocket for temporarily catching the rear sub-frame. Ramps connect to the reinforcement bracket allowing sliding of the rear sub-frame rearward, and direct movement downwardly beneath a battery assembly. A catching surface defined on the ramp engages at least one rear sub-frame attached structure. A tether connects between the pair of side frame under-members and the rear sub-frame for improving the interaction of the rear sub-frame against the ramps.

Abstract: A vehicle frame structure is adapted to absorb energy from frontal impacts. The frame structure extends under a front portion of the body frame. The frame structure includes a rear sub-frame located below and in front of a pair of side frame under-members, and a catching surface connected to the pair of side frame under-members for engaging the rear sub-frame and attached structures to improve energy absorption response during a frontal impact. A steering gear is attached to the rear sub-frame. The catching surface interacts with the steering gear to promote additional crushing energy absorption during sliding movement of the rear sub-frame relative to the catching surface during the frontal impact. The catching surface can be formed on ramps attached to the pair of side frame under-members. A tether can prolong crushing contact of the rear sub-frame with respect to the catching surface.

Abstract: An impact protection structure for a vehicle impacting a blunt-object barrier includes a support structure of the vehicle, an energy absorbing rail coupled to the support structure, and a localized energy dissipation structure. The energy absorbing rail extends an energy absorbing rail length and includes a plurality of lumens. The localized energy dissipation structure extends a localized energy dissipation structure length less than the energy absorbing rail length.