Abstract: A vehicle entertainment system is for use with wireless headphones, with each wireless headphone being operable via a respective paired wireless connection. The vehicle entertainment system may include video entertainment displays for a vehicle, and a controller for the vehicle. The controller may be configured to establish respective paired wireless connections with the wireless headphones, and provide selectable access to a plurality of different audio/video (A/V) entertainment content streams. Each of the A/V entertainment content streams may include a respective video entertainment stream and an associated audio entertainment stream. The controller may be further configured to send selected video entertainment content streams for viewing at the video entertainment displays, and send selected audio entertainment content streams over the respective paired wireless connections for hearing at the wireless headphones.

Abstract: A vehicle entertainment system is for use with wireless headphones, with each wireless headphone being operable via a respective paired wireless connection. The vehicle entertainment system may include video entertainment displays for a vehicle, and a controller for the vehicle. The controller may be configured to establish respective paired wireless connections with the wireless headphones, and provide selectable access to a plurality of different audio/video (A/V) entertainment content streams. Each of the A/V entertainment content streams may include a respective video entertainment stream and an associated audio entertainment stream. The controller may be further configured to send selected video entertainment content streams for viewing at the video entertainment displays, and send selected audio entertainment content streams over the respective paired wireless connections for hearing at the wireless headphones.

Abstract: The present disclosure relates to a miniature precision clamping assembly driven by a shape memory alloy actuator wire (SMA wire) which may be employed within a braking or clutch system. The clamping assembly includes a first clamping element, a second clamping element and an SMA wire connected to the first and second clamping elements by being interwoven through a plurality of pressure amplifiers located on the exterior surfaces of the first and second clamping elements. Both the first and second clamping elements are configured to be positioned about a rotatable shaft and move in translation to the shaft via a transition action of the SMA wire between a clamping and releasing position. By energizing the SMA wire a contracting or compressing action is generated thereby causing the first and second clamping elements to move into engagement with the one shaft for inhibiting rotational movement.

Abstract: Taxanes having an ethyl ester or cyclopropyl ester substituent at C(10), a keto substituent at C(9), a hydroxy substituent at C(7), a thienyl substituent at C(3?) and a cyclobutyloxycarbamate or cyclopentyloxycarbamate substituent at C(3?), pharmaceutical compositions comprising such taxanes, methods of treatment and administration, and methods of preparation of medicaments comprising the taxanes.

Abstract: A taxane having a cyclopentyl ester substituent at C10, a keto substituent at C9, a hydroxy substituent at C2, a 2-thienyl substituent at C3? and an isopropoxycarbamate substituent at C3?.

Abstract: The present invention provides processes for the production of polycyclic fused ring compounds. The polycyclic fused ring compounds are produced by protecting a polycyclic fused ring polyol with a bridging silicon-based protecting group and attaching a suitable side chain. Novel polycyclic fused ring compounds and intermediate compounds are also described.

Abstract: A taxane having a cyclopentyl ester substituent at C10, a keto substituent at C9, a hydroxy substituent at C2, a 2-thienyl substituent at C3? and an isopropoxycarbamate substituent at C3?.

Abstract: The present invention provides processes for the production of polycyclic fused ring compounds. The polycyclic fused ring compounds are produced by protecting a polycyclic fused ring polyol with a bridging silicon-based protecting group and attaching a suitable side chain. Polycyclic fused ring compounds and intermediate compounds are also described.

Abstract: Taxanes having an ethyl ester or cyclopropyl ester substituent at C(10), a keto substituent at C(9), a hydroxy substituent at C(7), a thienyl substituent at C(3?) and a cyclobutyloxycarbamate or cyclopentyloxycarbamate substituent at C(3?), pharmaceutical compositions comprising such taxanes, methods of treatment and administration, and methods of preparation of medicaments comprising the taxanes.

Abstract: A taxane having a cyclopentyl ester substituent at C10, a keto substituent at C9, a hydroxy substituent at C2, a 2-thienyl substituent at C3? and an isopropoxycarbamate substituent at C3?.

Abstract: The present invention provides processes for the production of docetaxel. Docetaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon-based protecting group. The resulting 7,10-protected 10-DAB derivative is then derivatized and deprotected to form docetaxel.

Abstract: The present invention is directed to a process for the preparation of ?-lactams. Generally, an imine is cyclocondensed with a ketene acetal or enolate to form the ?-lactam product in a “one pot” synthesis, this process is generally performed at a higher temperature than conventional processes.

Abstract: Taxanes having an ester substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.

Abstract: The present invention provides processes for the production of paclitaxel. Paclitaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon-based protecting group. The resulting 7,10-protected 10-DAB derivative is then derivatized and deprotected to form paclitaxel.

Abstract: Processes for the preparation of taxol and other taxanes through selective derivatization of the C(7) and C(10) hydroxyl groups of 10-DAB, particularly a novel process using a new strategy in which the C(10) hydroxyl group is protected or derivatized prior to the C(7) hydroxyl group; and the provision of C(7) and C(10) derivatized 10-DAB compounds.

Abstract: Taxanes having a heterosubstituted acetate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.

Abstract: Taxanes having an ester substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.

Abstract: Taxanes having a methylcarbonate or ethylcarbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(13) side chain substituents.

Abstract: Compositions comprising a taxane having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.