Patents by Inventor Robert A. Holton

Robert A. Holton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C7 lactyloxy-substituted taxanes
    Publication number: 20050209311
    Abstract: A taxane having the formula: wherein X3 is furyl, X5 is t-butoxycarbonyl, Bz is benzoyl, and Ac is acetyl.
    Type: Application
    Filed: March 4, 2005
    Publication date: September 22, 2005
    Applicant: Florida State University Research Foundation, Inc.
    Inventors: Robert Holton, Hyeong Kim
  • C10 carbamoyloxy substituted taxane compositions
    Publication number: 20050182098
    Abstract: Compositions comprising a taxane having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Application
    Filed: February 28, 2005
    Publication date: August 18, 2005
    Applicant: Florida State University
    Inventors: Robert Holton, Weishuo Fang
  • Taxanes having a C7 carbonate substituent
    Publication number: 20050165051
    Abstract: Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Application
    Filed: March 17, 2005
    Publication date: July 28, 2005
    Applicant: Florida State University Research Foundation. Inc.
    Inventor: Robert Holton
  • C10 heterosubstituted acetate taxane compositions
    Publication number: 20050143447
    Abstract: Compositions comprising a taxane having a heterosubstituted acetate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Application
    Filed: February 28, 2005
    Publication date: June 30, 2005
    Applicant: Florida State University Research Foundation, Inc.
    Inventor: Robert Holton
  • C7 heterosubstituted acetate taxane compositions
    Publication number: 20050143446
    Abstract: Texanes having a heterosubstituted acetate substituent at C(7), a hydroxy substitutent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Application
    Filed: February 23, 2005
    Publication date: June 30, 2005
    Applicant: FSU Research Foundation, Inc.
    Inventor: Robert Holton
  • Taxanes having a C10 carbamoyloxy substituent
    Patent number: 6906088
    Abstract: Taxanes having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: July 11, 2003
    Date of Patent: June 14, 2005
    Assignee: FSU Research Foundation, Inc.
    Inventors: Robert A. Holton, Weishuo Fang
  • 14-hydrido-9?-hydroxytetracyclic taxanes
    Patent number: 6878834
    Abstract: Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C9 substituent other than keto in which the C9 keto substituent of taxol, a taxol analog, baccatin III or 10-desacetyl baccatin III is selectively reduced to the corresponding hydroxy group.
    Type: Grant
    Filed: January 27, 2004
    Date of Patent: April 12, 2005
    Assignee: Florida State University
    Inventors: Robert A. Holton, Carmen Somoza, Yukio Suzuki, Mitsuru Shindo
  • Tetraalkylammonium alkoxides
    Patent number: 6878833
    Abstract: A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal or an ammonium alkoxide is reacted with a ?-lactam.
    Type: Grant
    Filed: September 29, 2003
    Date of Patent: April 12, 2005
    Assignee: Florida State University
    Inventor: Robert A. Holton
  • Taxanes having a c10 Heterosubstituted acetate substituent
    Patent number: 6872837
    Abstract: Taxanes having a heterosubstituted acetate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: March 29, 2005
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Butenyl substituted taxanes
    Patent number: 6872842
    Abstract: Taxane derivatives having a 3? butenyl substituted C13 side chain.
    Type: Grant
    Filed: March 29, 2002
    Date of Patent: March 29, 2005
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai, Hossain Nadizadeh
  • C7 heterosubstituted acetate taxane compositions
    Patent number: 6861446
    Abstract: Taxanes having a heterosubstituted acetate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: November 24, 2003
    Date of Patent: March 1, 2005
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Tricyclic and tetracyclic taxane intermediates
    Patent number: 6861537
    Abstract: The synthesis of taxol and other tricyclic and tetracyclic taxanes.
    Type: Grant
    Filed: July 12, 2002
    Date of Patent: March 1, 2005
    Assignee: Florida State University
    Inventors: Robert A. Holton, Carmen Somoza, Hyeong Baik Kim, Mitsuru Shindo, Ronald J. Biediger, P. Douglas Boatman, Chase Smith, Feng Liang, Krishna Murthi
  • C7 carbamoyloxy substituted taxane compositions
    Publication number: 20050020635
    Abstract: Taxanes having a carbamoyloxy substituent at C(7), a hydroxy substituent at C(10, and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Application
    Filed: June 14, 2004
    Publication date: January 27, 2005
    Inventor: Robert Holton
  • 14-Hydrido-9beta-hydroxytetracyclic taxanes
    Publication number: 20040192944
    Abstract: Process for the preparation of a derivative or analog of baccatin III or 10-desacetyl baccatin III having a C9 substituent other than keto in which the C9 keto substituent of taxol, a taxol analog, baccatin III or 10-desacetyl baccatin III is selectively reduced to the corresponding hydroxy group.
    Type: Application
    Filed: January 27, 2004
    Publication date: September 30, 2004
    Applicant: Florida State University
    Inventors: Robert A. Holton, Carmen Somoza, Yukio Suzuki, Mitsuru Shindo
  • C9 hydrido and acyloxy metal alkoxides
    Patent number: 6797833
    Abstract: Taxane derivatives having alternative C9 substituents.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: September 28, 2004
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai, Yukio Suzuki
  • Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
    Patent number: 6794523
    Abstract: Taxane derivatives having an alkoxy, alkenoxy or aryloxy substituted C13 side chain.
    Type: Grant
    Filed: September 17, 2002
    Date of Patent: September 21, 2004
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai, Hamid Idmoumaz, Hossain Nadizadeh, Kasthuri Rengan, Yukio Suzuki, Chunlin Tao
  • C7 carbonate substituted taxanes
    Patent number: 6780879
    Abstract: Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: August 24, 2004
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • C7 carbonate taxane compositions
    Publication number: 20040138267
    Abstract: Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Application
    Filed: December 22, 2003
    Publication date: July 15, 2004
    Applicant: FSU Research Foundation Inc.
    Inventor: Robert A. Holton
  • C7 acyloxy metal alkoxides
    Patent number: 6762309
    Abstract: Taxane derivatives having alternative C7 substituents.
    Type: Grant
    Filed: September 20, 2002
    Date of Patent: July 13, 2004
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-byung Chai
  • C10 carbonate taxane compositions
    Publication number: 20040122055
    Abstract: Taxanes having a carbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Application
    Filed: November 24, 2003
    Publication date: June 24, 2004
    Applicant: FSU Research Foundation Inc.
    Inventor: Robert A. Holton